Illustration Wang Chen Jun

　　Transfer money during love, do you need to return it after breaking up? Buying a wedding room and registering your girlfriend’s name is a gift or a joint house purchase? Buying a car before marriage is a bride price or a gift. Can I ask for a return after breaking up? Recently, Haidian court tried many such cases, and the judge explained them in detail and gave a prompt.

　　Case:

　　Forced by his girlfriend to write an iou? If "coercion" is not proved, it will be returned.

　　Xiao Na said that during her love with Xiaolei, Xiaolei borrowed 600,000 yuan from her on the grounds of revolving business, and then repaid 30,000 yuan. In July 2015, Xiaolei issued a debit note to her, promising to repay it at maturity, but failed to fulfill the repayment promise after the expiration. She repeatedly urged for no results, so she sued Xiaolei for repaying the loan principal of 570,000 yuan and paying interest.

　　During the trial, Xiao Na submitted the IOUs and transfer records to the court. The content of the loan shows: "Xiaolei borrowed 600,000 yuan from Xiaona today, and has already paid back 30,000 yuan, leaving 570,000 yuan to be paid off before October 2015. On July 30, 2015, the borrower Xiao Lei. " According to the personal account statement of Xiao Na Bank, Xiao Na transferred RMB 600,000 to Xiaolei from 2014 to 2015 by mobile phone.

　　Xiaolei recognized the transfer record, but said that he and Xiao Na were originally in love, and they often transferred money to each other during their love. He did not borrow money from Xiaona. The two parties originally planned to hold a wedding in August 2015, but a few days before the wedding, Xiao Na and several people forced him to write this IOU.

　　The court held that according to the evidence submitted by Xiao Na, it can be concluded that there is a private loan relationship between her and Xiaolei, and Xiaolei should fulfill the repayment obligation, but the failure to repay all the loans so far has constituted a breach of contract. Xiaolei claimed that the IOU was issued under the coercion of Xiao Na, but no evidence was provided, so the court refused to accept it. Finally, the court ordered Xiaolei to repay Xiao Na’s loan of 570,000 yuan and pay corresponding interest.

　　The judge suggested that the lender should keep the payment voucher.

　　Hu Meiqing of Haidian Court said that it is very common for lovers to transfer money to each other. After the relationship ends, it is not uncommon for one party to advocate "transferring money to borrow money" and sue. Because many lovers write IOUs to each other for emotional reasons, but no loans actually occur, it is more complicated to identify such loan relationships.

　　Is it a loan relationship to transfer money during the relationship? The judge believes that the party who advocates the establishment of the loan relationship generally bears the burden of proof on whether the loan relationship is true and the actual delivery of the loan. Therefore, it is particularly important for lenders to keep relevant payment vouchers. Borrowing between lovers, it is best to leave traces by means of transfer, etc., and at the same time pay attention to keeping the bank’s running water and transaction records. If you need to pay a large amount of cash, you should keep the bank’s withdrawal records, and if necessary, you should ask the other party to issue an iou or sign a loan agreement.

　　Case:

　　Before marriage, the court awarded 50% of the property rights under the name of one registered person.

　　Another pair of lovers, Zhou Yang and Li Ting, have been dating since they were in college, and they broke up in 2015. In October 2012, the two parties jointly invested to buy a house in Haidian District, Beijing. Because Zhou Yang was not qualified to buy a house at that time, they negotiated and signed a sales contract with the real estate company in the name of Li Ting. After that, Zhou Yang paid the down payment of 1,588,519 yuan, the purchase price of 160,000 yuan, and Li Ting paid the remaining house price of 440,000 yuan. The house was registered in the name of Li Ting. On June 30, 2016, after obtaining the qualification to buy a house, Zhou Yang contacted Li Ting to handle the house transfer, but Li Ting ignored it. Zhou Yang found out that she planned to sell the house through an intermediary company.

　　In this regard, Zhou Yang believes that the joint purchase of a house by both parties and Li Ting’s unauthorized sale have seriously infringed on their legitimate rights and interests, so he sued his ex-girlfriend and demanded that the house be divided according to law, with himself and Li Ting accounting for 78.3% and 21.7% respectively.

　　However, Li Ting said that the house was registered in her personal name and belonged to personal property, and Zhou Yang had no right to divide it; Moreover, the purchase price paid by Zhou Yang is a gift to her, and there is no common property between the two parties.

　　During the trial, both of them said that they intended to buy a house as a wedding room, but later they broke up due to emotional reasons, and the house has been occupied by Li Ting. The court held that it was an act of jointly purchasing property with marriage intention to jointly invest and buy a house in the name of Li during their love. Now the two sides have failed to get married and end their love relationship, and the purpose of buying a house has been impossible to achieve. Although the property right is registered in the name of the woman, it should still be recognized as common property. In the end, the court ruled that the house was jointly owned by two people, with each party holding 50% of the property rights, and Li Ting assisted Zhou Yang in the registration of the property rights.

　　The judge suggested that buying a house together during love is regarded as common property.

　　It is more and more common to buy a house jointly before marriage. Hu Meiqing believes that houses, cars and furniture jointly invested by both parties during the period of love should be regarded as common property. At the termination of the joint ownership relationship, the division of the joint property shall be handled according to the agreement if there is an agreement, and if there is no agreement, the factors such as the contribution of the co-owners, the contribution to the joint property and the actual needs of the co-owners in production and life shall be considered. In order to avoid disputes in the future, we should be cautious in buying a house together during the period of love. We can sign a capital contribution agreement in advance to stipulate their respective shares, and at the same time, we should keep relevant evidence such as bank transfer records and payment vouchers.

　　Case:

　　Buying a car, registering in the name of the prospective mother-in-law, breaking up, and the court awarded the refund of the car.

　　A couple decided to get married. Li Wen said that he spent 226,856.9 yuan to buy an SUV as a wedding gift at the request of his girlfriend Zhang Xia. Because they were not qualified to buy a car in Beijing, they registered the car in the name of Zhang Xia’s mother Wang. However, the two sides broke up soon due to personality and other reasons. Li Wen’s request for Zhang Xia to return the car purchase fee was rejected, so he sued Zhang Xia’s mother and daughter for returning the engagement price of more than 230,000 yuan.

　　During the trial, Zhang Xia’s mother and daughter argued that there was no engagement between Li Wen and Zhang Xia, and the vehicle involved in the case that Li Wen invested and registered under Wang’s name was not an engagement bride price. Because of their long relationship, Li Wen mentioned breaking up many times. Before buying a car, Li Wen broke up with Zhang Xia again. This time, he proposed to buy a car for Zhang Xia to make up for his feelings. Moreover, when buying a car, the old car under Wang’s name is discounted to 8000 yuan, so the newly bought car also has Wang’s rights and interests, which should be divided before disposal. The used car has been depreciated and should not be returned at the new car price.

　　The court held that the car purchase money should belong to Li Wen’s expenditure for the purpose of marriage and has the nature of bride price. Although Zhang Xia’s mother and daughter claimed that Li Wen’s contribution was a gift, they did not provide sufficient evidence and the court did not support it. In view of their failure to get married, Li Wen has the right to demand that the other party return the corresponding expenses incurred for marriage. Regarding the amount of money to be refunded, it should be judged according to Li Wen’s actual expenses for purchasing the car. Finally, the court ruled that Zhang Xia’s mother and daughter returned Li Wen’s car purchase price of 232,983.79 yuan.

　　Judge’s tip: unmarried people ask for the support of the bride price court.

　　Hu Meiqing said that the phenomenon of paying bride price before marriage is a custom, which is popular in many parts of China. If both parties fail to go through the marriage registration formalities, and one party requests to return the bride price, it shall be supported. If unmarried men and women have indeed lived together but are not registered to get married in the end, the court can determine whether to return and the amount of the bride price according to the time of their living together, the amount of the bride price and the local rural customs and habits. In addition, the actual payers and recipients of the bride price are not limited to men and women themselves. If the actual recipients of the bride price are the parents of the woman or other people, when the man sues for the return of the bride price, the woman and the actual recipients can be listed as co-defendants. (The parties in the text are all pseudonyms) (Reporter Lin Jing)

Today (11th), the official announcement of the comedy film "Big Anti-Faction" will be released nationwide on April 4th. It is reported that the film has assembled more than 20 gold medal comedians, which will bring a relaxed and joyful work to the audience during the Qingming small holiday.

The movie "The Great Anti-Faction" tells the story of the little actor Bi Chao (Bao Beier) who finally got the chance to play the big villain after all the hardships. However, Bi Chao accidentally lost his memory and mistakenly thought that he was a suspect in the kidnapping case. With amnesia, he was determined to "go against the sky and change his life" and continue his plan of "kidnapping the richest man", but he did not expect to be crushed in action. Bi Chao, who was unarmed, was not only starved and beaten along the way, but also offended three gangsters who wanted money and didn’t want to die. Can Bi Chao’s goal be achieved in the end, and what kind of jokes will he encounter? It remains to be seen.

In the preview of the film’s "This villain is not very clever" version, a news report confessed that "kidnapper" Bi Chao was running around the city, but it was completely inconsistent with the description of "extremely vicious" in the report. Bi Chao not only had no money to be sent back to his original place by taxi driver, but also was caught by the security guard and ate several "big pockets" in the process of secretly stepping on the spot. The robber Bi Chao experienced all kinds of oolong events in the process of completing the goal of "kidnapping the richest man", and the unreasonable storyline also attracted the audience to burst into laughter, all of which revealed the film purpose of "making fun". And dazzling female stars, resplendent party scenes and other "eye-catching" pictures are also very eye-catching.

At the same time, there are also big scenes of "package stimulation" such as drifting around the corner and flying car blasting, which instantly boost the adrenaline of the audience. At the end of the preview, the richest man was not afraid of the robbers who caught up, and even boasted that "this is bulletproof glass", but he didn’t expect to be backhand. Bi Chao directly opened the car door, raised his pistol and said, "Get off!" It will break the game in an instant, and the relationship between the robbers and the rich will be reversed instantly. Subverting the brain hole and constantly reversing the comedy burden has also made the audience increasingly look forward to what interesting plots will follow.

The film assembled more than 20 golden comedy lineups that made people "smile", and all the performers staged a "drama in the play" that was constantly reversed. Bao Beier, the leading actor, became a distinctive "villain" this time, which was crushed by reality and brought a refreshing hilarious experience to the audience. The actors such as Xiao Spicy Li Jiaqi, Dayong Zhou, Clara, Wei Xiang, Jia Bing, Yang Haoyu and Andrew, who all appeared in the preview, are even more eye-catching. The super comedy lineup joined forces to attack, and everyone collectively shook their burdens and pulled the "laugh" fruit full.

Yangzi Evening News/Zi Niu Journalist Kong Xiaoping

　　Guangzhou Daily News (all-media reporters Jessica Fong Ching correspondent Li Xiaoyuan and Zhou Bo) On March 23rd this year, a movie-like "car-chasing and intercepting play" was staged on Jinsha Road in Haizhu District, Guangzhou. In order to stop a car, two large trucks did not hesitate to chase the car for one kilometer, cross the line, turn around and even hit the other car’s head. It turned out that the driver of this car had beaten with another car driver, Zhou, because of the problem of not giving way to each other in the narrow road. When Zhou was angry, he called relatives driving big trucks to intercept each other. On the morning of July 30th, Guangzhou Haizhu District People’s Court held a public hearing on Zhou’s case of suspected trouble-making, and pronounced a sentence in court. Zhou was sentenced to seven months’ imprisonment.

　　According to the prosecution’s allegations, at 22: 40 on March 23 this year, when the defendant Zhou drove a car out of Innovation Road via Xinmin Sixth Street in Haizhu District, he met Kuang Mouming driving a car from Innovation Road to Xinmin Sixth Street. Because of the narrow road, two cars cannot pass at the same time. Due to the problem of avoiding the car, the defendant Zhou had an argument with Kuang Mouming and his co-pilot Kuang Mouhua, and then the two sides beat each other.

　　After a "scuffle", Kuang Mouming and Kuang Mouhua drove away first, and the defendant Zhou immediately left a voice message on his relatives’ WeChat group using WeChat, claiming that he was injured in Xinmin Sixth Street and asked his relatives to come over to help chase him by car. At the same time, he also called relatives to inform them to drive to the scene.

　　Later, two large trucks called by the defendant Zhou arrived at the scene, and Zhou sat on one of the large trucks and commanded to catch up with the car for nearly one kilometer. When chasing after the Jinsha gas station near Jinsha Road in Haizhu District, Zhou’s big truck intercepted the small car driven by Kuang Mouming. When Kuang Mouming saw it, he turned around and fled. At this time, another big truck rushed from the opposite lane and crossed the line and crashed into the small car driven by Kuang Mouming, causing damage to the left front of the car and the left rear mirror.

　　After Kuang Mouming was hit and stopped, Zhou’s big truck immediately stepped forward to intercept. Zhou and others got off the cab and wanted to rush to the vehicle driven by Kuang Mouming. When Kuang Mouming saw it, he immediately drove away from the scene and called the police for help. Subsequently, the defendant Zhou was arrested by the police. After identification, the injuries of Kuang Mouming and Kuang Mouhua were all minor injuries, and the loss price of the car driven by Kuang Mouming was RMB 8663.22.

　　The prosecutor asked in court, "Do you know the consequences of chasing cars on the main road?" "Why didn’t you call the police immediately?" Zhou argued that the reason why he informed his relatives to chase and intercept Kuang Mouming’s driving vehicle was that Kuang Mouming and Kuang Mouhua beat him and fled. He didn’t remember their license plates, only recognized cars and people, "just wanted to intercept the other vehicle and call the police", but there was no alarm after the collision.

　　After trial, Haizhu District People’s Court held that the defendant Zhou chased and intercepted others, and the circumstances were bad; Arbitrary destruction of public or private property, if the circumstances are serious, has constituted the crime of stirring up trouble. The defendant Zhou confessed his crime truthfully after arriving at the case and voluntarily pleaded guilty, which can be given a lighter punishment according to law. The defendant, Zhou, had an altercation with Kuang Mouming’s party because of the meeting, and then beat each other. After Kuang Mouming’s party left, he still called others to drive the truck to catch up with and intercept the vehicle driven by Kuang Mouming. His behavior of catching up and intercepting had a great impact on traffic order, and he was given a heavier punishment as appropriate. Considering that Kuang Mouming was at fault, and the defendant Zhou had actively compensated Kuang Mouming for his losses, he was given a lighter punishment as appropriate. In the end, the court ruled that the defendant Zhou constituted a crime of seeking trouble and sentenced him to seven months in prison.

In the domestic household scooter market, it is a hot model. Since then, this car has been favored by many consumers because of its close price and good product strength. At present, 16 models have been launched for consumers to choose from, and the price range is 99,800-145,800 yuan. So is this car suitable for starting? Today, we will take the entry-level model with a price of 99,800 yuan-2024 Plus 310 Xingyao Edition as an example to analyze with you.

First of all, look at the appearance. As a new energy vehicle, AION Y does not adopt a closed front face like many pure electric vehicles, but retains the design of the air intake grille. The front of the car adopts front headlights with split design, and the interior presents a fan-shaped arrangement, which improves the recognition of the front of the car.

The side of the car body benefits from its short suspension and long wheelbase design, so when you look at it from the side, there will be an MPV atmosphere. The style of the hub is relatively simple, and it is equipped with 215/55 R17 specifications.

In the rear part, the word "AION Y" is placed in the middle of the tailgate, which looks more conspicuous. The rear design of "AION Y" is simpler, with a rich sense of hierarchy and a fuller look. The tail wing with the same color as the car body at the top has been hollowed out, and the shape of the taillight is relatively slender.

Entering the car, the interior design of AION Y is relatively simple. The center console is mainly covered by a black plaque, and the air outlet of the air conditioner is hidden under this plaque, which looks very regular. It adopts the design style of flat bottom and double spokes, and it feels good to hold. The main driver is equipped with a 10.25-inch full LCD instrument panel, and the display effect is relatively clear.

In addition, AION Y is also equipped with a 14.6-inch central control screen with built-in ADiGO 4.0 intelligent interconnection ecosystem, which supports navigation system, navigation road information display, service, Bluetooth/car phone and other functions. Moreover, the response speed of this system is relatively fast, and it is very convenient for daily use.

In terms of other configurations, AION Y comes standard with practical functions such as body stability system, brake assist, keyless start, remote start, uphill assist, and remote control of mobile App. At the same time, the whole system comes standard, which can detect the working state of tires in real time, and its performance in safety is quite good.

In terms of seats, AION Y is made of imitation leather, the front seats all support manual four-way adjustment, and the main driving seat is equipped with the function of height adjustment. The rear seats support a 40:60 ratio, which can further expand the space of the luggage compartment.

In terms of space, AION Y has a body length of 4,535 mm, a width of 1,870 mm, a height of 1,650 mm and a wheelbase of 2,750 mm. Although it is positioned as a compact SUV, such data performance has reached the new standard. Therefore, the ride space of this car is relatively spacious. The experiencer with a height of 1.75 meters sits in the front row, and after adjusting the seat to a suitable position, the head space is about one punch and three fingers. At this time, the seat is kept still and comes to the back row. There are still more than two punches in the head space and more than two punches in the legs.

In terms of storage capacity, AION Y’s luggage compartment has a volume of 405 liters, a depth of 880 mm, a width of 1020 mm and a height of 700 mm. After putting down two 28-inch suitcases, there is still room for some small items. In addition, the second row of seats in this car can be almost flat after being put down, and it can be easily handled if you need to pull some big items occasionally.

In terms of chassis, AION Y adopts the body structure, the front suspension is McPherson type, and the rear suspension is longitudinal arm torsion beam type. This configuration is also a common configuration at this price. When passing through the potholed road, AION Y’s shock absorption effect is still quite good, without the feeling of "hitting hard", and the comfort performance is not bad. However, due to the high center of gravity, this car will have obvious inclination when cornering at high speed, and its handling is relatively average.

In terms of power, the AION Y we test-drive is equipped with a permanent magnet synchronous single motor, with a total power of 100 kW and a total horsepower of 136, with a total of 176. The transmission system is matched with an electric vehicle single-speed gearbox. The battery pack has a capacity of 37.9 kWh and a pure electric cruising range of 310km, which is enough for urban transportation, and the cost of daily vehicles will be much lower than that of fuel vehicles.
From the perspective of vehicle driving, AION Y provides a smooth, comfortable and sporty driving experience, which is suitable for daily home and work. It has a variety of driving modes and steering modes to meet different driving needs. Suspension system and chassis are tuned to comfort, which can effectively filter road vibration and provide a comfortable ride experience. The power output is linear and delicate, providing a good push back feeling at low speed, and the influence of wind noise and tire noise is relatively amplified at high speed. I-PEDAL mode can adjust the strength of kinetic energy recovery in real time, realize reasonable control of vehicle speed by opening and closing the accelerator pedal in low-speed traffic jams, and provide different driving experiences. The adjustment of accelerator pedal and accelerator pedal is linear, which makes AION Y very comfortable to drive as a whole. Summary: Through this test drive of AION Y, we found that this car does have a good performance in terms of space, and both the riding space and the loading space meet the needs of most people. In terms of driving experience, the power output of this car is relatively linear, and the steering feel is also very light, so it is not difficult to drive. For novice drivers who just got their driver’s license, AION Y should be a good choice. Of course, if you just want to buy a daily scooter, then AION Y is also worth considering.

This issue of the "Precision Frontier" column shared by Zhao Haitao’s research team published inGenome Medicine(IF =11.12) [1], a mutation signature was constructed and verified to predict the prognosis of patients receiving immunotherapy, and the potential immune response of different subtypes was studied by using multidimensional data.

Research background

Immunocheckpoint inhibitors (ICI) have changed the treatment of many cancers. However, the beneficiaries of ICI treatment are limited, so it is necessary to screen and predict biomarkers to classify patients. At present, many biomarkers, such as tumor mutation load (TMB), have been used as indicative biomarkers in clinic. However, some high TMB patients with gene mutation related to immunotherapy resistance are not sensitive to ICI treatment. Therefore, it is necessary to go beyond TMB and identify the specific genetic determinants of ICI treatment response.

research design

The study included genome and clinical data of 12,647 patients. There were 1572 cases in the training set (immunotherapy patients with 9 kinds of cancer) and 932 cases in the verification set (immunotherapy patients with 5 kinds of cancer). The training set was sequenced by MSK-IMPACT panel containing 468 genes.

The authors identified a set of 11 genes based on mutation, which can divide patients into high-risk and low-risk groups. The mutation of these 11 genes is related to the better response to ICI treatment, and this gene set has been proved to be an independent prognostic factor after ICI treatment.

research results

1. Identify mutant gene sets that can predict the outcome of immunotherapy.

Firstly, the survival differences of 468 genes in the training set were compared between wild type and mutant type, and 98 genes related to OS (global survival) were obtained. After that, LASSO COX regression analysis was further screened and 11 important genes were finally obtained. Through COX regression analysis, the risk score of each patient was quantified on the basis of 11 mutant gene sets. In the training concentration, the OS of patients in the high-risk group is shorter than that of patients in the low-risk group (Figure 1B). In order to study whether the gene set is limited to a specific population or suitable for different populations, the subgroup analysis regardless of age, drug use type and cancer species shows that the gene set is significantly related to the OS of patients treated with ICI (Figure 1C-E).

Figure 1. Generation and Verification of Gene Set Based on Mutation

2. Verification of predictable immunotherapy results

In order to further confirm the value of mutation-based gene set in predicting the results of immunotherapy, it was found that the OS of low-risk group was higher than that of high-risk group (Figure 1F). The research results of predicting ICI treatment response in gene set show that the DCB(durable clinical benefit) of ICI treatment in low-risk group is significantly increased compared with that in high-risk group (Figure 1G), and low-risk patients are more likely to respond to ICI treatment (Figure 1H). These results get the same results in the verification set (Figure 1I, J).

3. Gene set is an independent prognostic predictor of immunotherapy.

Next, the author verifies whether the gene set based on mutation is an independent predictor of immunotherapy response. In the training and validation set, univariate COX regression analysis showed that the gene set was related to OS. After adjusting for drug type, tumor type and TMB, multivariate COX regression analysis showed that the gene set was still an independent predictor, which confirmed the stability of its independent prediction of ICI prognosis (Figure 2A, B). In order to determine which factor has the best predictive performance, C-index is used to compare the performance of mutation-based gene sets with TMB and drug types. The results of C-index show that the gene set based on mutation can predict the prognosis more accurately than TMB and drug type in both training set and validation set (Figure 2C, D).

Fig. 2. Relationship between mutation-based gene sets and other characteristics

4. The clinical benefit of ICI treatment can be predicted based on the mutant gene set, disease stage, CTL and 6-IFN-g gene signature.

Considering the stage of disease, CTL and 6-gene IFN-g signature have been proved to be highly predictive of the response to ICI treatment, the authors speculate that they may play a synergistic role in predicting the response to immunotherapy. The author combined the gene set based on mutation with disease stage, CTL and 6-gene IFN-g signature through Nomotograph, and provided a method for clinicians to quantitatively predict the OS of patients treated by ICI. Fig. 2E is the nomogram of Riaz cohort construction, and the calibration curve of fig. 2F shows the consistency of actual and predicted results, indicating that these signature should be integrated into the predicted nomogram of ICI treatment.

5. Potential external immune landscape of high and low risk groups

In order to further explore the relationship between immune system and mutation-based gene set, the authors conducted a multi-group analysis of TCGA cohort, and the risk score divided TCGA cohort into high and low risk groups (Figure 3A). At the genome level, the proportion of white blood cells, lymphocytes and TIL in the low-risk group was significantly higher than that in the high-risk group (Figure 3B-D). The H&E staining results of TIL ratio are consistent with the above results (Figure 3E). In addition, the proportion of immunostimulatory cells (such as CD8 T cells) in the low-risk group is also significantly higher than that in the high-risk group (Figure 3F). The above results were further tested by Danaher et al.’ s immune infiltration score (figure 3G) and immune characteristic score (figure 3H), and it was found that the abundance of immune cells in low-risk group was higher. Then unsupervised clustering was used to cluster the immune characteristic scores of patients in TCGA cohort, and the results were clustered into two immune infiltration modes (Figure 3I), and the high immune infiltration was significantly enriched in the low-risk group (Figure 3J).

Fig. 3. Immune status of high and low risk population in TCGA cohort.

In addition, the immune signature in the low-risk group was significantly higher than that in the adjacent cancer tissue; On the contrary, the immune signature in the high-risk group was significantly lower than that in the adjacent tissues (Figure 4A). The correlation of immune activity in low-risk group was significantly higher than that in high-risk group (Figure 4B, C). GSEA results showed that 13 pathways were significantly enriched in the low-risk group, including 6 immune-related pathways, such as "cytotoxicity mediated by natural killer cells" (Figure 4D). Tumors in the low-risk group are associated with significantly higher CYT scores, and the number of fibroblasts in the high-risk group is now increasing (Figure 4E, F). According to these results, the low-risk group is rich in immune cells, which can respond to ICI treatment, and fibroblasts may help the high-risk group escape. The expression of chemokines in the low-risk group is higher (Figure 4G, H), so the author speculates that the enrichment of chemokines in the low-risk group may trigger an immune response.

Figure 4. Potential external immune landscape of high and low risk groups　

6. Potential inherent immune landscape of high and low risk groups

Some potential factors determining tumor immunogenicity between the two groups were compared. Mutation, new antigen load, TCR and BCR diversity in low-risk group were significantly higher than those in high-risk group, but CNV load and aneuploidy in high-risk group were higher than those in low-risk group (Figure 5A). This result is consistent with previous studies, that is, tumor aneuploidy is related to immunotherapy and decreased immune escape marker response. In addition, the heterogeneity of tumor in high-risk group is higher than that in low-risk group, which further supports the view that tumor will promote the development of heterogeneity in the presence of cytolytic activity and less active infiltration of immune cells. In order to further understand the mutation process of high and low risk groups, the mutation characteristics were described according to somatic mutation data, and four different mutation patterns were determined in TCGA cohort (Figure 5B). The frequency of these four mutation signals in the low-risk group is significantly higher than that in the high-risk group (Figure 5C). In addition, it was also found that immune checkpoint molecules (such as PD-1, PD-L1 and CTLA4) and costimulatory molecules were more highly expressed in the low-risk group (Figure 5E).

Figure 5. Potential innate immune response and escape landscape in high and low risk groups.　

7. Copy number characteristics of high and low risk groups

Significant differences in chromosome variation were detected in high and low risk groups (fig. 6A). Local amplification peaks of immune genes with good characteristics, such as PD-L1 (9p24.1) and PD-L2 (9p24.1), were observed in the low-risk group (fig. 6B, C). GO function annotation of the specifically amplified genes showed that the low-risk group was significantly enriched in two immune-related biological processes, while the high-risk group was significantly enriched in the biological process of "positive regulation of fibroblast proliferation", but not in any immune-related biological processes (Figure 6E). At the level of mRNA expression in TCGA cohort, the expression of PD-L1 and PD-L2 mRNA in low-risk group increased significantly (Figure 6G), which was consistent with CNV data. This finding suggests that CNVs in tumor contributes to the observed difference in immune infiltration.

Figure 6. Variation of copy number in high and low risk groups

discuss

This study is the first time to use an independent cohort to study the comprehensive mutant gene sets of different tumor types. Through PSM algorithm, hierarchical analysis and multivariate COX regression analysis, the application performance of mutation-based gene sets in different types of tumors was tested, and the results showed that mutation-based gene sets were reliable.

This study has the following innovation and practical application value. First, different types of tumors (such as NSCLC (non-small cell lung cancer), melanoma and renal cell carcinoma) are used, which represent the most common types of cancer treated with ICI. Secondly, the application of multiple biomarker prediction model needs to understand the factors that affect the accuracy and precision of Qualcomm analysis in clinical practice. The risk score formula and threshold of mRNA expression calculation are not suitable for verification with other types of data. Therefore, this study developed a gene set based on mutation to predict the clinical efficacy of ICI treatment. The composition of the above mutations is neither affected by tissue types nor adjusted by any other biomarkers. The risk score formula and threshold of gene set based on mutation can be verified by other tumor analysis methods, such as DNA sequencing and single nucleotide polymorphism microarray analysis. Therefore, mutation-based gene sets are not affected by technological changes, even when different platforms are used in different centers. Thirdly, in practice, gene sets based on mutations avoid exposing patients to potential immune-related adverse reactions when they are unlikely to respond, and enable patients to match to potentially more effective treatments more quickly. Fourthly, the prediction performance of gene set based on mutation is compared with other factors that can predict immunotherapy, and it is found that the prediction performance of gene set based on mutation is better than all these factors.

Several limitations of this study. First of all, because some mutations may be enriched in some tumor types, the initial goal of this study is to create a panel instead of identifying a single gene (such as BRAF), because the former can contain more genes to predict the prognosis of different types of tumors. Secondly, although the immune landscape of 11 genes in the gene set based on mutation has been explored, it is still necessary to clarify the molecular mechanism of each gene affecting immunotherapy in vivo and in vitro functional experiments. Thirdly, the enrichment scores of carcinogenic pathways and the expression patterns of immune checkpoints should also be detected by immunohistochemistry.

tag

The mutation-based gene set proposed in this study is the first comprehensive genomic marker systematically identified, which can be used to evaluate the ICI treatment effect of pan-cancer species. This study is also the largest prognostic model discovery project for cancer patients receiving ICI treatment (whether single drug treatment or combined treatment of anti-PD-1 and anti-CTLA-4). Nomoto, which combines mutation-based gene set with TMB and drug types, can help clinicians choose patients who may have a strong response to ICI treatment. In addition, it also reveals the different immune conditions of high and low risk groups, and specific genomic changes may drive the formation of these microenvironments. In a word, this work puts forward a new tumor classification method, which may guide the decision-making of ICI treatment.　END　

References:

[1]　Long, J., Wang, D., Wang, A. et al. A mutation-based gene set predicts survival benefit after immunotherapy across multiple cancers and reveals the immune response landscape. G enome Med 14, 20 (2022). https://doi.org/10.1186/s13073-022-01024-y

Write Liu Hua Hua

Editing and typesetting SX

　　How do new Chinese immigrants overcome the difficulty of studying?

　　When new Chinese immigrants come to foreign countries and work hard, it is often difficult to take care of their children’s studies. In recent years, some young Chinese immigrants have gone abroad to study, but they are also faced with challenges such as different study environments in foreign countries and family financial difficulties, resulting in some dropouts. Let the children of new immigrants and young new immigrants better integrate into the new learning environment and ensure their academic success, which requires better home-school cooperation and better system design at the social level.

　　It is not common to play truant and work.

　　When new Chinese immigrants first arrive in the United States, they face many difficulties, and the education of their children is one of them.

　　According to the US "World Journal" report, due to the large number of young shop assistants recruited by Chinese restaurants and retail stores in new york, the problem of many new immigrant Chinese students dropping out of school is more serious.

　　According to Zhao Hongfang, a bilingual psychological counselor at Jiangbang High School in Flushing, some Chinese students are in Internet cafes all day and night. When they are familiar with the store, they actually help to watch the store at night. When asked by their parents how they have money to spend, they lie about working after class.

　　Some Chinese students don’t get along well with their parents, so they moved out at the age of 17 and watched the shop at night to earn living expenses. In particular, the owners of new Chinese restaurants in Flushing are looking for young clerks who know English, attracting a large number of dropouts. The school said that they would go to the restaurant to bring these students back.

　　However, the lack of diplomas will only bring more difficulties for new immigrants to seek a living in the United States in the future. According to the report, a survey in new york in 2015 showed that the annual salary of those without a high school diploma was only $21,121, those with a high school diploma was $31,038 and those with a bachelor’s degree was about $60,000.

　　It is worth noting that although new Chinese immigrants have played truant, worked or even dropped out of school, this is not the norm.

　　In an interview with this newspaper, Liang Guanjun, chairman of the American East Asian Association, believes that some students in every school play truant or drop out of school for some reason. "Flushing is so big, and employment opportunities are still limited. We can only say that this phenomenon exists among the new immigrants in new york, but the size of the’ large number’ in the report is debatable."

　　Even so, the difficulty in adapting to new Chinese immigrants still needs attention.

　　Inadvertence in discipline and difficulty in adaptation

　　Different from the "Chinese" born and raised in the United States, behind the new Chinese immigrants who came to the United States to work and play truant is the helplessness of their families’ inability to discipline and adapt to the environment.

　　"This is an old problem, which exists in big cities in the east and west of the United States and is quite difficult to solve." Chinese lawyer Sun Lantao said in an interview with this newspaper that Chinese in the United States often choose school districts to send their children to school. All the above phenomena occur in bad school districts. There, parents are forced to survive, sometimes working hard for 12 hours every day, and have no time to ask about their children’s learning. Children’s own English is not enough, and they are under bilingual pressure, so they are discouraged and unwilling to learn.

　　For new immigrant students, the financial hardship of their families is also a major incentive to play truant and work. "Nowadays, in the United States, it is not easy for restaurants to recruit people, so the salaries are relatively high." Liang Guanjun introduced that the monthly salary of Flushing Restaurant is about 2,800 dollars, which attracts students who can’t go on studying, and there are also cases where individual families have financial difficulties and need their children to make money.

　　The educational environment and allocation of educational resources in American society are also very different from those in China.

　　Sun Lantao introduced that the US Constitution and the constitutions of all states stipulate that any school-age children must receive compulsory education before the age of 18, regardless of whether they or their parents have immigration status. That is to say, even the children of illegal immigrants, as long as they are school-age children, no matter where they live, public schools must accept them and must not refuse them to go to school on the grounds of poor English and insufficient test scores. However, at the implementation level, the imbalance of educational resources has greatly reduced the effect of ensuring the enrollment rate of immigrant children.

　　"American culture is different from that of China, where the whole people attach importance to education. Ordinary public schools often have poor basic education. Psychological counseling and bilingual guidance advocated by the education department cannot be put in place at all because of the lack of human resources. " Sun Taotao introduced.

　　The negligence of family discipline and the difference of social environment bring poor communication between home and school, which eventually leads to inefficiency in the academic management cooperation of new immigrant children. "Chinese immigrants, Chinese new immigrants, survival is a problem, and the language is unreasonable. I don’t know how to start." Sun Lantao said that the communication information between parents and school teachers is seriously poor, which reduces the effectiveness of cooperation between schools and parents.

　　Multi-party cooperation to promote studies together

　　How to help new Chinese immigrants better integrate into the new learning environment and ensure their enrollment rate? Experts said that the joint efforts and effective cooperation of all parties are needed.

　　On the one hand, new immigrant families need to integrate into the new study environment more actively. Cai Wenyao, consultant of the American Chinese Chamber of Commerce, said in an interview with this newspaper: "Children need to get out of the comfort zone and consult more local students. Parents can also make good use of community resources and communicate with other immigrant parents who have experienced difficult stages instead of resting on their laurels."

　　At the same time, home and school also need to better cooperate, psychologically appease their children, and more effectively prevent students who want to skip classes and work from drilling loopholes in the system.

　　In an interview with the World Journal, Zhao Hongfang said that parents can take the initiative to provide contact information to the school and learn to check attendance records and grades online. If parents leave their children completely unattended, the school can report it and ask the Children’s Service Administration to intervene in the investigation.

　　On the other hand, the society can also make efforts in promoting the children of Chinese new immigrants to study.

　　"In a short time, it is still a luxury to solve the problem of young Chinese immigrants going to school." Lawyer Sun Lantao said that despite this, from the legislative point of view, with the increasing proportion of Chinese in politics, this phenomenon will attract the attention of political circles, and the education department will also strengthen investment in this group and training bilingual teachers. With the increase of corresponding educational resources and infrastructure, the current situation may gradually change.

　　On June 1st, several experts attending the 13th Oriental Cardiology Conference (OCC) held a live breakfast in the Oriental Live Room. Why did the experts at the cardiology conference talk about breakfast first?

　　In April 2019, a study published by JACC, an authoritative academic journal, prospectively proved that skipping breakfast is related to higher cardiovascular mortality. Eating the right breakfast can protect your heart! Let’s listen to the advice of these experts.

　　Academician Ge Junbo of Zhongshan Hospital affiliated to Fudan University: Eating the right breakfast can protect your heart.

　　Someone once called breakfast "the first expectation in a day", but with the acceleration of the pace of life, we have less expectation for breakfast. In order to catch up with the time, we either make do with two people or have two meals with lunch and make one meal.

　　Previous studies have shown that skipping breakfast may lead to the risk of obesity, diabetes and hyperlipidemia. OCC held an activity such as "Healthy Heart Breakfast" at the meeting, inviting cardiovascular experts and nutrition experts to interpret the reasonable diet structure together. On the one hand, it popularized the importance of breakfast to the public, and at the same time, it released a reference recipe of "Healthy Heart Breakfast" for the general public to refer to and improve the level of cardiovascular disease prevention in China. On the other hand, it also reminds doctors and media reporters not to forget to eat breakfast when they are busy with their work.

　　Professor Huo Yong of Peking University First Hospital: Eat breakfast like an emperor.

　　"As the saying goes, you should eat like an emperor for breakfast, like a commoner for lunch and like a beggar for dinner." Why do you value breakfast so much? Because for most people, this meal is about ten hours away from the last meal and needs more energy. Fasting for a long time will lead to an increase in blood pressure in the morning. Not eating breakfast all the year round will inevitably lead to the disorder of related hormones, making it easier to overeat and obesity, and also causing fluctuations in blood lipid levels.

　　Related studies have found that eating breakfast helps to lower blood pressure, thus preventing various cardiovascular events such as blood vessel blockage.

　　Qian Juying, Chairman of Cardiovascular Branch of Shanghai Medical Association: Regulating blood lipid can’t rely solely on diet therapy.

　　It is generally believed that the increase of low density lipoprotein cholesterol (LDL-C) will increase cardiovascular risk. Will improving eating habits significantly improve blood lipid levels?

　　Diet therapy and lifestyle improvement are the basic measures for the treatment of dyslipidemia, and they are "fighting" together. Diet control and active exercise should be continued even after medication, but lifestyle intervention should not be relaxed because of medication. But we should also avoid entering a misunderstanding, that is, we only hope that diet can improve blood lipids. (Yin Wei)

　　Director Gao Jian, Department of Nutrition, Zhongshan Hospital affiliated to Fudan University: An excellent breakfast must contain four kinds of food.

　　The choice of breakfast in different regions is rich and varied. The traditional breakfast food provided by restaurants outside is single, mostly high-calorie food. Although it can satisfy the stomach, its nutritional value is not high. An excellent breakfast should include the following four kinds of food:

　　The first kind of food should be a bit like whole wheat bread and coarse grains. Because breakfast should have a staple food first, but now the staple food is too fine, so eat some miscellaneous grains for breakfast.

　　The second category of food, there is an animal food, such as boiled eggs.

　　The third category of food is soybean milk and milk. Generally, a bag of milk basically meets this requirement.

　　The fourth category of food is vegetables and fruits, so today we have some fruits.

　　All four are called excellent breakfasts, only three are called good breakfasts, and only two and one are called poor breakfasts. At present, many people have only one or two kinds of breakfast, so it is suggested that breakfast should be as diverse as possible, at least there are some of the four categories of food. (Yin Wei)

Cctv newsOn the afternoon of May 24th, Beijing held the 344th press conference on epidemic prevention and control to introduce the situation and answer questions from reporters. Wu Hao, head of the expert group of the community prevention and control group of the leading group for epidemic prevention and control in COVID-19, Beijing, gave epidemic prevention tips to the citizens when they went shopping in supermarkets, vegetable markets and other places. He said that supermarkets, vegetable markets and other public places are relatively closed, people are easy to gather, and there is a great risk of epidemic spread, which is the focus and difficulty of community epidemic prevention and control. In the past, many epidemics were spread and infected in these places.

It is necessary to strictly implement the epidemic prevention management in public places. Under the current situation that the social situation is not completely cleared, citizens should strictly do personal protection when going shopping, and prepare protective equipment such as masks and disinfectants. It is best to list the purchase list in advance and strictly control the number of people who go out to purchase. It is recommended that infants and the elderly try not to participate in shopping. Choose the nearest shopping spot, travel at the wrong peak, and try to avoid taking public transport. It is recommended to choose travel modes such as self-driving, cycling and walking.

When entering the vegetable market, supermarkets and other public places, you should cooperate with epidemic prevention measures such as temperature measurement and code inspection, wear a mask all the time, avoid pulling down the mask to communicate with the stall owner or taste food, and do not touch your eyes, mouth and nose directly with your hands. You should quickly select materials according to the list to minimize the stay time. Don’t go to the shelves and stalls where people gather, try to choose self-checkout and contactless payment to keep a safe social distance of more than one meter from others.

After purchasing, the used masks should be put into the relevant trash can, and hand disinfection should be done in time. If the packaging is suspected of being contaminated, disinfection should be done.

　　In 2021, China’s economy will continue to recover steadily, economic development and epidemic prevention and control will maintain a leading position in the world, the main indicators will achieve the expected goals, fixed assets investment will recover steadily, and the structure will continue to be optimized; The scale of market sales continued to expand, and the consumption structure was optimized and upgraded; The total population has maintained growth and the level of urbanization has steadily increased; The employment situation is generally stable, and the employment situation of migrant workers is constantly improving; Residents’ income continued to grow steadily; Prices in the consumer sector rose moderately.

　　Continuous optimization of investment structure

　　Zhai Shanqing, Director of Statistics Department of Fixed Assets Investment of National Bureau of Statistics

　　In 2021, investment in fixed assets recovered steadily and the structure continued to be optimized. The investment in fixed assets (excluding farmers) was 54,454.7 billion yuan, an increase of 4.9% over the previous year, and the growth rate was 2.0 percentage points higher than that of the previous year; Taking 2019 as the base period, the average growth rate is 3.9% in two years.

　　The scale of investment in the first and third industries continued to expand.

　　In 2021, the investment in the primary industry was 1,427.5 billion yuan, an increase of 9.1% over the previous year; The average growth rate was 13.7% in two years, and the growth rate was 0.7 percentage points faster than that from January to November. The investment in the secondary industry was 16,739.5 billion yuan, an increase of 11.3% over the previous year; The average growth rate was 5.8% in two years, and the growth rate was accelerated by 0.6 percentage points. The investment in the tertiary industry was 36,287.7 billion yuan, an increase of 2.1% over the previous year; The average growth rate in two years was 2.7%, and the growth rate dropped by 0.2 percentage points.

　　Second, the investment in the three major areas has recovered steadily.

　　In 2021, manufacturing investment increased by 13.5% over the previous year; Average growth of 4.8% in two years. Investment in real estate development increased by 4.4% over the previous year; Average growth of 5.7% in two years. Infrastructure investment increased by 0.4% over the previous year; Average growth of 0.3% in two years.

　　Third, investment in high-tech industries plays an obvious role.

　　In 2021, the investment in high-tech industries increased by 17.1% over the previous year, the growth rate was 0.5 percentage points faster than that from January to November, 12.2 percentage points higher than that of the total investment, and the total investment increased by 1.2 percentage points.

　　Investment in high-tech manufacturing increased by 22.2%, which was the same as that from January to November. Investment in high-tech service industry increased by 7.9%, and the growth rate was 1.5 percentage points faster than that from January to November.

　　Fourth, the investment in the short-board area of people’s livelihood continued to increase.

　　In 2021, investment in social fields increased by 10.7% over the previous year. Investment in agriculture, forestry, animal husbandry and fishery increased by 9.3% over the previous year, and the growth rate was 0.1 percentage point faster than that from January to November. Investment in transportation, warehousing and postal services increased by 1.6% over the previous year, and the growth rate was 0.5 percentage points faster than that from January to November. Investment in the production and supply of electricity, heat, gas and water increased by 1.1% over the previous year, and the growth rate was 0.9 percentage points faster than that from January to November.

　　V. Steady growth of private investment

　　In 2021, private investment increased by 7.0% over the previous year; The average growth rate in two years was 3.8%, and the growth rate was the same as that from January to November. Among them, private investment in education increased by 24.9%, private investment in manufacturing increased by 14.7%, private investment in infrastructure increased by 12.0%, and private investment in agriculture, forestry, animal husbandry and fishery increased by 9.9%.

　　The consumer market maintained a recovery trend.

　　Dong Lihua, Director of the Department of Foreign Trade and Economic Statistics of the National Bureau of Statistics

　　In 2021, the scale of market sales continued to expand, the consumption structure was optimized and upgraded, and the overall consumer market maintained a recovery trend.

　　I. The scale of the consumer market has steadily expanded.

　　In 2021, the total retail sales of social consumer goods was 44.1 trillion yuan, an increase of 12.5% over the previous year and 8% over 2019. After deducting the price factor, the total retail sales of social consumer goods actually increased by 10.7%.

　　In the first quarter, due to the low base in the same period of last year, the total retail sales of social consumer goods increased by 33.9% year-on-year, with an average growth rate of 4.2% in two years; In the second quarter, the market sales accelerated, and the average growth rate in two years was 0.4 percentage points faster than that in the first quarter; In the third quarter, the two-year average growth rate declined; In the fourth quarter, the consumer market continued to recover, and the total retail sales of social consumer goods increased by 4% on average for two years.

　　Second, the urban market continued to recover.

　　In 2021, the retail sales of urban consumer goods increased by 12.5% over the previous year, with an average increase of 3.9% in two years. Quarterly, the urban market in the fourth quarter increased by 3.3% over the same period of last year, with an average growth rate of 3.9% in two years, and the average growth rate was 1 percentage point faster than that in the third quarter. In 2021, the per capita disposable income of rural residents actually increased by 9.7% over the previous year, and the growth rate was 2.6 percentage points higher than that of urban residents.

　　Third, the retail sales of goods grew steadily

　　The growth of retail sales of commodities is good. In 2021, the retail sales of commodities increased by 11.8% over the previous year, by 9.2% over 2019, and by 4.5% on average in two years. From the two-year average growth rate, the retail sales of all categories of goods have maintained growth.

　　In 2021, catering revenue increased by 18.6% compared with the previous year, decreased by 1.1% compared with 2019, and decreased by 0.5% on average in two years. The scale of catering consumption has not yet recovered to the pre-epidemic level. In the fourth quarter, the catering revenue decreased by 0.5% on average for two years, which was 1.1 percentage points narrower than that in the third quarter, and the recovery of catering consumption was accelerated.

　　Fourth, online consumption maintained rapid growth.

　　In 2021, the national online retail sales increased by 14.1% over the previous year. Judging from the development of postal express delivery industry closely related to online shopping, driven by the rapid growth of online consumption, the express delivery business volume and business income in 2021 maintained a double-digit rapid growth compared with 2020.

　　5. The retail sales of basic life commodities are growing well.

　　Sales of grain, oil, food and daily necessities increased rapidly. In 2021, the retail sales of grain, oil, food and daily necessities of units above designated size increased by 10.8% and 14.4% respectively over the previous year, with an average annual increase of 10.4% and 10.9% respectively.

　　The level of urbanization has steadily increased.

　　Wang Pingping, Director of Population and Employment Statistics Department of National Bureau of Statistics.

　　In 2021, China’s total population maintained growth, the growth rate continued to slow down, the degree of aging further deepened, and the level of urbanization steadily improved.

　　First, the total population maintained growth.

　　By the end of 2021, the national population was 1,412.6 million, an increase of 480,000 over the end of 2020; The annual birth population was 10.62 million, a decrease of 1.4 million compared with 2020; The death toll was 10.14 million, an increase of 160,000 compared with 2020.

　　In 2021, the natural population growth rate will be 0.34‰ , down 1.11 thousandths from 2020. The continuous slowdown in population growth is due to the continuous decline in the number of births, which is mainly affected by two factors: first, the number of women of childbearing age continues to decrease; Second, the fertility level continues to decline. The total fertility rate of women of childbearing age will continue to decline in 2021 due to the change of fertility concept and the delay of the age of first marriage and first childbearing.

　　Second, the short-term increase in the working-age population

　　By the end of 2021, the population aged 0-15 was 263.02 million, accounting for 18.6% of the national population. The population aged 16 to 59 is 882.22 million, accounting for 62.5%; The population aged 60 and over is 267.36 million, accounting for 18.9%. Compared with 2020, the population aged 0-15 decreased by 5.28 million, the population aged 16-59 increased by 2.47 million, and the population aged 60 and over and the population aged 65 and over increased by 3.29 million and 9.92 million respectively. The increase in the working-age population aged 16 to 59 is mainly due to the small number of people born in 1961. The proportion of the population aged 60 and over and the population aged 65 and over increased by 0.2 and 0.7 percentage points respectively compared with 2020, and the degree of aging further deepened.

　　It is predicted that the number and proportion of working-age population will continue the previous downward trend in the future. Although the working-age population tends to decrease, the total number is still nearly 900 million, and the labor resources are still abundant. From the quality point of view, the quality of the working-age population has improved significantly, and the average length of education has increased from 9.67 years in 2010 to 10.75 years in 2020, and the new advantages of talent bonus have gradually emerged.

　　Third, the level of urbanization has steadily improved.

　　By the end of 2021, China’s urban resident population reached 914.25 million, an increase of 12.05 million over the end of 2020; The resident population in rural areas was 498.35 million, a decrease of 11.57 million. The urbanization rate of permanent residents was 64.72%, an increase of 0.83 percentage points over the end of 2020.

　　Employment improvement of key groups

　　Wang Pingping, Director of Population and Employment Statistics Department of National Bureau of Statistics.

　　In 2021, with the sustained recovery of the national economy and the implementation of the employment priority policy, the national urban survey unemployment rate was lower than the expected target, and the employment situation was generally stable.

　　First, the urban survey unemployment rate remained generally stable

　　In 2021, the average urban unemployment rate was 5.1%, which was lower than the macro-control target of about 5.5%. In the first quarter, affected by the Spring Festival and the epidemic situation in some areas, the urban unemployment rate was relatively high, rising to a high of 5.5% in February. After the holiday, with the stable recovery of enterprise production and operation, the unemployment rate gradually declined. In the second quarter, the urban survey unemployment rate remained in the range of 5.0% to 5.1% in each month; In the third quarter, affected by the graduation season and the epidemic situation in some areas, the unemployment rate fluctuated. With the graduates entering jobs one after another and the impact of the epidemic situation weakened, the urban survey unemployment rate fell back to 4.9% in September. In the fourth quarter, the survey unemployment rate remained in the range of 4.9% to 5.1%.

　　Second, the overall improvement of the employment situation of key groups

　　In 2021, various policies and measures to stabilize employment and promote employment continued to be implemented, and the policy of reducing burdens, stabilizing posts and expanding employment continued to be implemented, and all-round employment services continued to exert strength. In the second half of 2021, the unemployment rate of the employed population aged 25 to 59 has been stable below 4.5%, which is lower than the same period of last year.

　　The employment situation of migrant workers has been continuously improved. After the Spring Festival in 2021, the unemployment rate of foreign agricultural registered population continued to fall, and by December, the unemployment rate of foreign agricultural registered population was 4.6%. By the end of 2021, the number of migrant workers nationwide had reached 292.51 million, an increase of 6.91 million over the end of last year, and it has returned to the same level in 2019. The employment situation of college graduates is generally stable. From June to July, the unemployment rate of young people aged 16 to 24 increased significantly due to the concentrated job hunting of college graduates. After September, with the implementation of graduate work, the youth unemployment rate gradually declined.

　　Third, employment stability still faces challenges

　　We must see that employment stability still faces challenges and pressures. Increased downward pressure on the economy will have a certain impact on employment. At the same time, the impact of the epidemic continues, and the production and operation of some industries and enterprises may be affected or impacted. It should also be noted that the number of college graduates will reach 10.76 million in 2022, an increase of 1.67 million over the previous year, with both scale and increment reaching record highs; The long-standing structural contradictions in some employment fields such as "difficulty in recruiting workers" and "difficulty in finding jobs" have not been fundamentally alleviated.

　　In 2022, it is necessary to continue to strengthen the employment priority policy, promote the implementation of measures to reduce burdens, stabilize posts and expand employment, increase employment assistance for key groups such as college graduates, strengthen vocational skills training, promote entrepreneurship to drive employment, and ensure a stable employment situation.

　　Residents’ consumption demand is gradually released.

　　Fang Xiaodan, Director of Household Survey Department of National Bureau of Statistics.

　　In 2021, the per capita disposable income growth of the national residents is basically synchronized with economic growth, the consumption expenditure of residents continues to recover, and the basic living consumption grows rapidly, realizing the mutual promotion and common progress of steady growth and benefiting people’s livelihood.

　　First, the per capita disposable income growth of residents is basically in sync with economic growth.

　　Residents’ income growth is basically synchronized with economic growth. In 2021, the per capita disposable income of the national residents was 35,128 yuan, a nominal increase of 9.1% over the previous year. After deducting the price factor, the per capita disposable income of the national residents actually increased by 8.1%, faster than the per capita GDP growth rate, and the income growth of the residents was basically in sync with the economic growth.

　　Second, the steady growth of wage income and transfer income lays the foundation for the steady growth of urban and rural residents’ income.

　　Wage income continued to grow steadily. In 2021, the per capita wage income of the national residents was 19,629 yuan, an increase of 9.6% over the previous year, with an average increase of 6.9% in two years. In terms of urban and rural areas, the per capita wage income of urban residents increased by 8.0%, with an average increase of 5.5% in two years. The per capita wage income of rural residents increased by 14.1%, with an average increase of 9.9% in two years.

　　Third, residents’ consumption expenditure continued to recover, and basic living consumption continued to grow rapidly.

　　Consumer spending continued to recover. With the continuous recovery growth of residents’ income, residents’ consumption demand is gradually released, and consumption expenditure keeps a recovery rebound trend. In 2021, the per capita consumption expenditure of the national residents was 24,100 yuan, a nominal increase of 13.6% on the basis of a low base in the previous year; After deducting the price factor, the actual increase was 12.6%.

　　Basic living consumption continued to grow rapidly. In 2021, the average per capita expenditure on food, tobacco and alcohol in China increased by 8.6% in two years, which was 2.9 percentage points faster than the average growth rate of all consumption expenditure in two years. The implementation of the policy of ensuring supply and stabilizing prices has been continuously strengthened, the food supply in the market is sufficient, and the food consumption of residents continues to grow steadily.

　　Prices in the consumer sector have risen moderately.

　　Wang Youfen, Director of Urban Social and Economic Investigation Department of National Bureau of Statistics.

　　In 2021, people’s livelihood security was strong and effective, the consumer market was generally stable, and CPI rose moderately; Actively respond to the sharp rise in energy and raw material prices, and the PPI rose at a high level.

　　First, prices in the consumer sector have risen moderately.

　　The monthly CPI is generally fluctuating upward year-on-year. In 2021, the CPI rose by 0.9%, which was 1.6 percentage points lower than the previous year, and the overall operation was in a reasonable range.

　　The rise in non-food prices pushed CPI up moderately. In 2021, non-food prices rose by 1.4%, an increase of 1.0 percentage points over the previous year, which affected the increase of CPI by about 1.17 percentage points.

　　The decline in food prices slows down the increase in CPI. In 2021, the price of food changed from 10.6% in the previous year to 1.4%, which affected the decrease of CPI by about 0.26 percentage points, mainly driven by the change of pork price.

　　Second, the price in the production field fell back at a high level.

　　The monthly year-on-year increase of PPI showed a downward trend. In 2021, PPI changed from 1.8% in the previous year to 8.1%.

　　The structural rise is obvious. In 2021, the price of means of production changed from 2.7% in the previous year to 10.7%, which affected the PPI increase by about 7.97 percentage points, exceeding 98% of the total increase. The price of means of subsistence rose by 0.4%, which was 0.1 percentage points lower than that of the previous year, affecting the PPI to rise by about 0.09 percentage points, and the overall situation was relatively stable.

　　Input factors boosted PPI. Since 2021, the demand for international commodities has recovered faster than the supply, and with the influence of abundant liquidity and other factors, the prices of crude oil and non-ferrous metals in the international market have risen, pushing up the ex-factory prices of related domestic industries and driving up the PPI.

　　Tight supply pushes PPI up. In the second half of the year, due to the tight supply and relatively strong demand, the price of coal mining and washing industry rose sharply, and the year-on-year increase expanded from 37.4% in June to 103.7% in October.

Hunan Provincial Department of Financepiece

Xiang Cai Gou [2015] No.5

Hunan Provincial Department of Finance on Further Standardization

Notice of government procurement work

Provincial budget units:

The Regulations on the Implementation of the Government Procurement Law of People’s Republic of China (PRC) (hereinafter referred to as the Regulations) came into force on March 1, 2015. forFurther standardize the government procurement work, improve the efficiency of government procurement, and build a standardized and transparent government procurement mechanism with fair competition, proper supervision and strict accountability.The relevant matters concerning the standardization of government procurement of provincial budget units (hereinafter referred to as purchasers) are hereby clarified as follows, please follow them.

First, clear responsibilities and establish an effective internal control mechanism for government procurement.

1, the implementation should be exhausted.The purchaser’s use of fiscal funds (that is, funds included in budget management) to purchase goods, projects and services within the centralized procurement catalogue or above the procurement limit standard should be included in government procurement. Borrowing funds with fiscal funds as the source of repayment are regarded as fiscal funds; If the procurement project uses both financial funds and non-financial funds, the part purchased with financial funds is applicable to government procurement; Where fiscal funds and non-fiscal funds cannot be purchased separately, government procurement shall be uniformly applied.

Should the project of government procurement be implemented without government procurement according to law, the Provincial Department of Finance shall not go through the government procurement procedures, and shall not pay the procurement funds, and shall be investigated for the legal responsibility of the relevant units and responsible persons according to law. Procurement projects involving national security and secrets shall be identified by the Provincial State Secrecy Bureau, and the purchaser shall report to the Provincial Department of Finance for the record.

2. Purchase in strict accordance with the law.The purchaser should establish the concept of "legal duty must be, and the law cannot be authorized", carry out government procurement activities in strict accordance with the provisions of the Government Procurement Law and its implementing regulations and relevant rules and regulations, and implement the relevant duties of the procurement subject.

The purchaser shall, in accordance with the provisions of the government centralized procurement catalogue and procurement quota standards promulgated by the Provincial Department of Finance, implement centralized procurement and decentralized procurement according to law. For the procurement projects within the centralized government procurement catalogue, if the system of agreed supply, fixed-point service, online bidding, electronic mall or batch centralized procurement is not implemented, and the single purchase amount does not exceed 50,000 yuan, and the annual cumulative amount does not exceed 200,000 yuan, the purchaser can organize the procurement by himself.

3. Establish internal control mechanism.The purchaser should follow the principle of "exercising power in different cases and establishing power in different posts".Clear procurement, finance, business related departments in government procurement activitiesJob responsibilities, set up incompatible posts such as demand confirmation, organization review and contract acceptance, and strengthen internal process control of government procurement. The purchaser shall strengthen the demand research, and the demand of the procurement project shall be confirmed by the purchaser in writing. The purchaser’s representative shall be authorized in writing by the unit to participate in the evaluation activities, and legal documents such as procurement documents, contracts and questions and answers shall be made after the legality audit in the unit.

4、Establish a dispute handling mechanism.The purchaser should seriously deal with,appropriateHandle supplier inquiries,Questioning and reporting cases, establishingPrevention and communication mechanism to resolve disputes according to law and avoid escalation of disputes; When dealing with procurement disputes, the purchaser should seek the opinions of the legal institution of the unit or the entrusted lawyer. If the procurement agency is entrusted to answer questions, it must be confirmed in writing before the reply is issued.

5. Strengthen file management.The purchaser and the procurement agency shall properly keep the procurement documents of each procurement activity. After the procurement activities are completed, the procurement agency shall hand over the procurement documents to the purchaser for archiving. Procurement documents can be saved in the form of electronic files.

Two, standardize the operation, establish a transparent and efficient government procurement mechanism.

6. Strengthen budget management.The purchaser shall, in accordance with the requirements of "all the staff should be compiled", compile the government procurement budget of the procurement project in the current year in the departmental budget, confirm the source of funds for the procurement project, clarify the procurement demand, and refine the procurement items to the last level of the Catalogue of Government Procurement Items. For the procurement projects included in the government procurement budget at the beginning of the year, the purchaser shall strictly follow the approved government procurement budget and be responsible for the implementation results according to law.

If the purchaser adds new government procurement projects, changes or adjusts the procurement items, procurement quantity and budget amount of the approved government procurement projects, it shall correspondingly add and adjust the government procurement budget within the total budget expenditure of the approved department, and shall fill in the Adjustment Form for the Implementation of Government Procurement Budget (Annex 1) and submit it to the Provincial Department of Finance for examination and approval before implementation. Involving future annual departmental budget funding arrangements or the use of fiscal funds for repayment of borrowing funds procurement projects, it is necessary to obtain the consent of the budget management offices of the relevant departments of the Provincial Department of Finance, and implement the funding sources before filing the government procurement implementation plan.

The unused government procurement budget and departmental budget at the end of the year are carried forward synchronously, and the approved government procurement budget will be cancelled if the budget indicators are recovered; If the budget indicators are agreed to be carried forward, the purchaser shall implement it according to the government procurement budget issued after the carry-forward, and apply the centralized government procurement catalogue and procurement quota standard and open tender amount standard in the new budget year.

7. Strict planning and management.The purchaser shall prepare the government procurement implementation plan according to the approved government procurement budget and approved fund plan (see Annex 2 for the format), and report it to the Provincial Department of Finance for the record and obtain the plan number. The procurement items, quantity, budget amount and other contents of the government procurement implementation plan should be consistent with the approved government procurement budget and fund plan. The purchaser’s filing of engineering (Class B) projects shall also be in accordance with the "Implementation Measures for the Evaluation and Management of Financial Investment in Hunan Province"(Xiang Cai Ban [2011] No.16)Conduct financial investment review, and determine the budget amount of the procurement project implementation plan according to the conclusion of the financial investment review.

The purchaser’s adjustment of the implementation plan should be re-filed in time, and the budget adjustment and approval procedures should be performed first if it involves the adjustment of the government procurement budget.

8. Strict examination and approval management.Government procurement projects that meet the standard of public bidding amount need to adopt procurement methods other than public bidding, and purchase imported products, should be submitted to the Provincial Department of Finance for examination and approval in writing before the preparation of the government procurement implementation plan. The Provincial Department of Finance implements the time-limited settlement: from the date of receiving the application, it will give a written reply within 10 working days; If the material does not meet the requirements, it shall be revised and supplemented within 3 working days.

If the government procurement project intends to adopt the bidding procurement method, the purchaser shall specify the bid evaluation method in the procurement implementation plan; The lowest bid evaluation method should be adopted for goods and services with uniform standards such as technology and services; If the comprehensive scoring method is adopted, the score setting in the evaluation criteria should correspond to the quantitative indicators of the evaluation factors. If the government procurement project intends to adopt the non-tendering procurement method, the purchaser shall clearly invite suppliers in the procurement implementation plan.

9. Standardize agency behavior.The projects in the centralized procurement catalogue should be entrusted to the government procurement center of Hunan provincial organs to organize procurement; The project purchaser outside the catalogue may entrust a procurement agency to purchase, or organize the procurement by itself. Entrust a procurement agency, should comprehensively consider the client’s professional ability, management level and fees, and choose the best. The purchaser shall organize the procurement activities by himself, and shall not charge the supplier for the cost of procurement documents.

When the purchaser entrusts a procurement agency, it shall sign an agency agreement (for the format, see the Detailed Rules for the Implementation of the Measures for the Administration of Non-tendering Procurement by Hunan Provincial Government) to clarify the entrusted matters and the rights and responsibilities of both parties. The legal responsibilities of the purchaser, such as confirming the procurement documents, recommending suppliers, confirming the evaluation report, and confirming the successful bidder (transaction), shall not be entrusted to the procurement agency.

If a procurement agency collects agency service fees from the successful bidder (clinch a deal), it shall clearly inform the supplier of the limit and collection method of agency service fees in the tender (supplier invitation) announcement and project procurement documents.

10. Standardize expert extraction.In addition to the provisions of the Ministry of Finance, the evaluation experts should be drawn from the government procurement expert database. The purchaser and the procurement agency shall submit the extraction application online 3 working days in advance, and the system will randomly extract it within 24 hours before the evaluation and notify the evaluation experts. The evaluation of bidding documents, the demonstration of imported products and the demonstration of single-source procurement need not be drawn from the expert database of government procurement.

11. Relax access conditions.The purchaser and procurement agency shall clearly define the basic qualifications of suppliers participating in government procurement in strict accordance with paragraph 1 of Article 22 of the Government Procurement Law and paragraph 1 of Article 17 of the Regulations. Only the conditions mandated by laws and regulations or set for realizing the functions of government procurement policies can be regarded as specific qualification conditions. The purchaser and the procurement agency shall not require the supplier to provide certification materials other than the basic qualifications and specific qualifications for any reason. The registered capital, total assets, operating income, employees, profits, tax payment and authorization of manufacturers shall not be set as supplier qualification conditions, and small and medium-sized enterprises shall not be hindered or restricted from freely entering the government procurement market in their own regions and industries.

12, standardize the project review.In addition to the qualification examination identified errors, score summary calculation errors, sub-item scores beyond the scope of scoring standards, objective scores are inconsistent, and the evaluation committee unanimously identified the scores as abnormally high and abnormally low, the purchaser and procurement agency shall not organize re-evaluation. Under the above circumstances, if the result of winning the bid (clinch a deal) is changed after the purchaser reorganizes the review, or if the result of winning the bid (clinch a deal) is changed due to the query reply, the purchaser shall timely report the relevant information to the Provincial Department of Finance for the record, and inform the suppliers involved in the procurement activities and announce the reasons.

13. Implement policy functions.The purchaser shall implement the relevant policy functions of government procurement in the process of government procurement budget preparation and project review. The compulsory procurement items in the List of Government Procurement of Energy-saving Products shall be subject to government compulsory procurement; The products of prison enterprises and welfare enterprises can be given targeted support by setting specific qualifications; Non-mandatory procurement items in the List of Government Procurement of Energy-saving Products, products in the List of Government Procurement of Environmental Labeling Products, products listed in the Catalogue of Government Procurement of Two-type Products in Hunan Province and products of small and medium-sized enterprises shall be subject to preferential evaluation measures such as price deduction and extra points in bid evaluation in accordance with relevant policies and regulations. At the same time, for energy saving, environmental labeling and two-type products, the supplier shall choose one of them to enjoy the preferential evaluation; Only those who meet the national policy of promoting the development of small and medium-sized enterprises can enjoy the preferential review again. Only part of the products in the same project belong to the scope of preferential policies for evaluation, and only this part of the products will be given preferential treatment during evaluation.

14. Standardize the agreed supply and fixed-point procurement.Except that the designated intermediary service for official travel abroad (border) is changed to the designated official air ticket, the agreed supply and designated procurement of provincial units will continue to be implemented until June 2016.It ends on the 30th of June. When the purchaser selects the short-listed supplier or the short-listed supplier with the lowest quotation according to the regulations, it shall announce the closing result and contract within 2 working days from the date of closing, and put the contract on record within 7 working days from the date of signing the contract. The scattered fixed-point procurement with a cumulative amount of no more than 50,000 yuan can be announced and put on record after being merged regularly. The purchaser can organize the bidding of the shortlisted suppliers by himself, or entrust the government procurement center of the provincial government of Hunan Province to organize it.

Third, strengthen supervision and establish a strict accountability supervision mechanism for government procurement

15. Promote information disclosure.The purchaser and procurement agency shall, within 2 working days from the date of determining the supplier who won the bid (clinch a deal), announce the result of winning the bid (clinch a deal) and the tender documents, competitive negotiation documents or inquiry notice on the Hunan government procurement website, and the announcement period shall not be less than 3 working days; Within 2 working days from the date of signing the government procurement contract, the government procurement contract will be announced on the Hunan government procurement website, except for the contents involving state secrets and commercial secrets. If the purchaser entrusts an agency to issue an announcement, it shall review the contents of the announcement and bear corresponding responsibilities.

The contents of the announcement of the winning bid (transaction) results shall include:

(1) the name, address and contact information of the purchaser and the procurement agency, the project name and project number, the name and address of the supplier who won the bid (clinch a deal) and the bid (clinch a deal) amount;

(2) For goods procurement projects, the name, specifications, brand, manufacturer, quantity, unit price and service requirements of the goods shall be announced; For service procurement projects, the service list, service content and staffing list shall be published; For engineering procurement projects, the bill of quantities, material quantity and unit price, labor cost, etc. shall be published;

(3) List of suppliers participating in procurement activities, quotation, rating and qualification, compliance review and list of review experts. If the supplier is recommended in writing to participate in procurement activities, the recommendation opinions of the purchaser and evaluation experts shall also be announced.

The publicity of single-source procurement that meets the standard of public bidding amount, and the announcements of goods and services procurement projects with more than 10 million yuan (including: bidding announcement, pre-qualification announcement, competitive negotiation, invitation of inquiry procurement suppliers, announcement of bid winning and transaction results, announcement of procurement contract, etc.) shall be released simultaneously on Hunan Provincial Government Procurement Network (www.ccgp-hunan.gov.cn) and Red Net Government Procurement Channel (zfcg.rednet.cn).

The purchaser shall complete the contract filing within 7 working days from the date of signing the procurement contract, and the original method of signing the electronic contract online shall be stopped.

For government procurement construction projects and goods and services procurement projects related to the project construction to which the tendering and bidding law is applicable, the purchaser shall issue tender announcements, pre-qualification announcements and publicity of successful candidates in accordance with the regulations for the implementation of the tendering and bidding law, and provide links to relevant information for simultaneous reprinting on Hunan government procurement network. The purchaser shall, in accordance with the provisions of this notice, publish the winning contract online and put it on record.

16. Strengthen daily supervision.The Provincial Department of Finance will strengthen the supervision and inspection of government procurement activities of purchasers and procurement agencies according to law. Specific methods include: organizing special inspections, regularly sampling the bid-winning (clinched) projects, and irregularly checking the procurement activities of purchasers and agencies. The competent budget unit of the purchaser shall strengthen the guidance of the government procurement work in this system and perform the corresponding supervisory duties.

17. Build a credit system.The Provincial Department of Finance further refines relevant measures and formulates government procurement agencies and evaluation experts.andSupplier credit record standard; The establishment of bad behavior record management and publicity system, the illegal agency, evaluation experts.And suppliers, included in the list of bad behavior records, and to the public.

18, strict accountability.For violations of laws and regulations found in supervision and inspection, the Provincial Department of Finance will promptly handle and report them according to law, and urge rectification; For serious illegal acts and dishonesty in government procurement activities, the Provincial Department of Finance will jointly implement joint punishment with relevant departments according to law.

This notice shall be implemented as of the date of promulgation. The Hunan Provincial Government Procurement Work Standard (Xiangcai Purchase [2012No.14), "Detailed Rules for the Implementation of the Measures for the Administration of Non-tendering Procurement of Hunan Provincial Government Procurement" (Xiangcai Purchase [2014] No.15) and other documents that are inconsistent with the "Regulations" and the provisions of this notice shall be suspended.

Attachment: 1. Adjustment Table of Government Procurement Budget Implementation

2, the government procurement implementation plan for the record table

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 Hunan Provincial Department of Finance

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 July 10th, 2015