Cctv newsOn the morning of June 8, the State Council Office held a press conference on "Implementing the Party’s 20 Major Decisions and Deploying and Promoting the Modernization of Emergency Management System and Capacity". Min Yiren, director of the Seismological Bureau of China, introduced at the meeting that at present, the national earthquake intensity quick report and early warning project has completed the main construction task, and 15,391 earthquake early warning stations, 3 national centers, 31 provincial centers and 173 prefecture-level information release centers have been built, forming a China earthquake early warning network composed of five systems: station observation, data processing, information service, communication network and technical support, and carrying out pilot services in Beijing, Tianjin and Hebei, Sichuan, Yunnan and Fujian. It is expected to be completed and accepted by the end of this year. After the project is put into operation, it will play a role in disaster reduction in the following aspects:

The first is to build a "first line of defense" for earthquake relief and reduce earthquake casualties. After the devastating earthquake, China Earthquake Early Warning Network will release earthquake early warning information through various channels such as emergency broadcast, mobile phone, TV, special terminal, etc., so as to provide users in the target area with early warning time of several seconds to dozens of seconds for emergency avoidance; After the earthquake, the distribution of the hardest hit areas can be quickly judged by measuring the measured earthquake intensity in a few minutes, which provides a scientific basis for the decision-making and deployment of earthquake relief. 6.2 seconds after the Luding M6.8 earthquake in Sichuan Province on September 5, 2022, China Earthquake Early Warning Network successfully released the early warning information, realizing the second-level early warning coverage for 1.5 million people in the epicenter and its surrounding areas.

The second is to "escort" lifeline projects and emergency disposal of major infrastructure. Relying on earthquake early warning terminals, emergency broadcasting and special communication lines, we will provide earthquake early warning information for the automatic emergency response of major strategic infrastructure such as high-speed railways, nuclear power plants, oil and gas pipelines and Gaoba reservoirs, and people’s livelihood infrastructure such as high-rise buildings, underground facilities and large-scale complexes, fill the gap in cross-industry earthquake emergency response services, promote the expansion of earthquake monitoring to earthquake disaster risk monitoring and prevention, and strengthen the ability of earthquake prevention and disaster reduction in the whole society.

The third is to provide strong support for earth science progress and international disaster reduction cooperation. Give full play to the advantages of building the world’s largest real-time transmission earthquake monitoring station network, provide high-quality scientific data information for promoting the innovative development of real-time seismology, real-time disaster science and earthquake engineering, and help the development and progress of earth science. At present, China’s earthquake early warning technology has gone abroad and been applied to the construction of Indonesian Jakarta-Bandung High-speed Railway. Seismological Bureau of China will give full play to its professional and technical advantages, better serve the country’s overall diplomacy, strengthen international cooperation in earthquake prevention and disaster reduction, and work together to reduce the risk of earthquake disasters.

In the next step, Seismological Bureau of China will continue to improve the construction of earthquake early warning network in China, continuously improve the safety, reliability and standardization of earthquake early warning service, expand the service field and efficiency, and provide more powerful earthquake safety guarantee for high-quality economic and social development.

This issue of the "Precision Frontier" column shared by Zhao Haitao’s research team published inGenome Medicine(IF =11.12) [1], a mutation signature was constructed and verified to predict the prognosis of patients receiving immunotherapy, and the potential immune response of different subtypes was studied by using multidimensional data.

Research background

Immunocheckpoint inhibitors (ICI) have changed the treatment of many cancers. However, the beneficiaries of ICI treatment are limited, so it is necessary to screen and predict biomarkers to classify patients. At present, many biomarkers, such as tumor mutation load (TMB), have been used as indicative biomarkers in clinic. However, some high TMB patients with gene mutation related to immunotherapy resistance are not sensitive to ICI treatment. Therefore, it is necessary to go beyond TMB and identify the specific genetic determinants of ICI treatment response.

research design

The study included genome and clinical data of 12,647 patients. There were 1572 cases in the training set (immunotherapy patients with 9 kinds of cancer) and 932 cases in the verification set (immunotherapy patients with 5 kinds of cancer). The training set was sequenced by MSK-IMPACT panel containing 468 genes.

The authors identified a set of 11 genes based on mutation, which can divide patients into high-risk and low-risk groups. The mutation of these 11 genes is related to the better response to ICI treatment, and this gene set has been proved to be an independent prognostic factor after ICI treatment.

research results

1. Identify mutant gene sets that can predict the outcome of immunotherapy.

Firstly, the survival differences of 468 genes in the training set were compared between wild type and mutant type, and 98 genes related to OS (global survival) were obtained. After that, LASSO COX regression analysis was further screened and 11 important genes were finally obtained. Through COX regression analysis, the risk score of each patient was quantified on the basis of 11 mutant gene sets. In the training concentration, the OS of patients in the high-risk group is shorter than that of patients in the low-risk group (Figure 1B). In order to study whether the gene set is limited to a specific population or suitable for different populations, the subgroup analysis regardless of age, drug use type and cancer species shows that the gene set is significantly related to the OS of patients treated with ICI (Figure 1C-E).

Figure 1. Generation and Verification of Gene Set Based on Mutation

2. Verification of predictable immunotherapy results

In order to further confirm the value of mutation-based gene set in predicting the results of immunotherapy, it was found that the OS of low-risk group was higher than that of high-risk group (Figure 1F). The research results of predicting ICI treatment response in gene set show that the DCB(durable clinical benefit) of ICI treatment in low-risk group is significantly increased compared with that in high-risk group (Figure 1G), and low-risk patients are more likely to respond to ICI treatment (Figure 1H). These results get the same results in the verification set (Figure 1I, J).

3. Gene set is an independent prognostic predictor of immunotherapy.

Next, the author verifies whether the gene set based on mutation is an independent predictor of immunotherapy response. In the training and validation set, univariate COX regression analysis showed that the gene set was related to OS. After adjusting for drug type, tumor type and TMB, multivariate COX regression analysis showed that the gene set was still an independent predictor, which confirmed the stability of its independent prediction of ICI prognosis (Figure 2A, B). In order to determine which factor has the best predictive performance, C-index is used to compare the performance of mutation-based gene sets with TMB and drug types. The results of C-index show that the gene set based on mutation can predict the prognosis more accurately than TMB and drug type in both training set and validation set (Figure 2C, D).

Fig. 2. Relationship between mutation-based gene sets and other characteristics

4. The clinical benefit of ICI treatment can be predicted based on the mutant gene set, disease stage, CTL and 6-IFN-g gene signature.

Considering the stage of disease, CTL and 6-gene IFN-g signature have been proved to be highly predictive of the response to ICI treatment, the authors speculate that they may play a synergistic role in predicting the response to immunotherapy. The author combined the gene set based on mutation with disease stage, CTL and 6-gene IFN-g signature through Nomotograph, and provided a method for clinicians to quantitatively predict the OS of patients treated by ICI. Fig. 2E is the nomogram of Riaz cohort construction, and the calibration curve of fig. 2F shows the consistency of actual and predicted results, indicating that these signature should be integrated into the predicted nomogram of ICI treatment.

5. Potential external immune landscape of high and low risk groups

In order to further explore the relationship between immune system and mutation-based gene set, the authors conducted a multi-group analysis of TCGA cohort, and the risk score divided TCGA cohort into high and low risk groups (Figure 3A). At the genome level, the proportion of white blood cells, lymphocytes and TIL in the low-risk group was significantly higher than that in the high-risk group (Figure 3B-D). The H&E staining results of TIL ratio are consistent with the above results (Figure 3E). In addition, the proportion of immunostimulatory cells (such as CD8 T cells) in the low-risk group is also significantly higher than that in the high-risk group (Figure 3F). The above results were further tested by Danaher et al.’ s immune infiltration score (figure 3G) and immune characteristic score (figure 3H), and it was found that the abundance of immune cells in low-risk group was higher. Then unsupervised clustering was used to cluster the immune characteristic scores of patients in TCGA cohort, and the results were clustered into two immune infiltration modes (Figure 3I), and the high immune infiltration was significantly enriched in the low-risk group (Figure 3J).

Fig. 3. Immune status of high and low risk population in TCGA cohort.

In addition, the immune signature in the low-risk group was significantly higher than that in the adjacent cancer tissue; On the contrary, the immune signature in the high-risk group was significantly lower than that in the adjacent tissues (Figure 4A). The correlation of immune activity in low-risk group was significantly higher than that in high-risk group (Figure 4B, C). GSEA results showed that 13 pathways were significantly enriched in the low-risk group, including 6 immune-related pathways, such as "cytotoxicity mediated by natural killer cells" (Figure 4D). Tumors in the low-risk group are associated with significantly higher CYT scores, and the number of fibroblasts in the high-risk group is now increasing (Figure 4E, F). According to these results, the low-risk group is rich in immune cells, which can respond to ICI treatment, and fibroblasts may help the high-risk group escape. The expression of chemokines in the low-risk group is higher (Figure 4G, H), so the author speculates that the enrichment of chemokines in the low-risk group may trigger an immune response.

Figure 4. Potential external immune landscape of high and low risk groups　

6. Potential inherent immune landscape of high and low risk groups

Some potential factors determining tumor immunogenicity between the two groups were compared. Mutation, new antigen load, TCR and BCR diversity in low-risk group were significantly higher than those in high-risk group, but CNV load and aneuploidy in high-risk group were higher than those in low-risk group (Figure 5A). This result is consistent with previous studies, that is, tumor aneuploidy is related to immunotherapy and decreased immune escape marker response. In addition, the heterogeneity of tumor in high-risk group is higher than that in low-risk group, which further supports the view that tumor will promote the development of heterogeneity in the presence of cytolytic activity and less active infiltration of immune cells. In order to further understand the mutation process of high and low risk groups, the mutation characteristics were described according to somatic mutation data, and four different mutation patterns were determined in TCGA cohort (Figure 5B). The frequency of these four mutation signals in the low-risk group is significantly higher than that in the high-risk group (Figure 5C). In addition, it was also found that immune checkpoint molecules (such as PD-1, PD-L1 and CTLA4) and costimulatory molecules were more highly expressed in the low-risk group (Figure 5E).

Figure 5. Potential innate immune response and escape landscape in high and low risk groups.　

7. Copy number characteristics of high and low risk groups

Significant differences in chromosome variation were detected in high and low risk groups (fig. 6A). Local amplification peaks of immune genes with good characteristics, such as PD-L1 (9p24.1) and PD-L2 (9p24.1), were observed in the low-risk group (fig. 6B, C). GO function annotation of the specifically amplified genes showed that the low-risk group was significantly enriched in two immune-related biological processes, while the high-risk group was significantly enriched in the biological process of "positive regulation of fibroblast proliferation", but not in any immune-related biological processes (Figure 6E). At the level of mRNA expression in TCGA cohort, the expression of PD-L1 and PD-L2 mRNA in low-risk group increased significantly (Figure 6G), which was consistent with CNV data. This finding suggests that CNVs in tumor contributes to the observed difference in immune infiltration.

Figure 6. Variation of copy number in high and low risk groups

discuss

This study is the first time to use an independent cohort to study the comprehensive mutant gene sets of different tumor types. Through PSM algorithm, hierarchical analysis and multivariate COX regression analysis, the application performance of mutation-based gene sets in different types of tumors was tested, and the results showed that mutation-based gene sets were reliable.

This study has the following innovation and practical application value. First, different types of tumors (such as NSCLC (non-small cell lung cancer), melanoma and renal cell carcinoma) are used, which represent the most common types of cancer treated with ICI. Secondly, the application of multiple biomarker prediction model needs to understand the factors that affect the accuracy and precision of Qualcomm analysis in clinical practice. The risk score formula and threshold of mRNA expression calculation are not suitable for verification with other types of data. Therefore, this study developed a gene set based on mutation to predict the clinical efficacy of ICI treatment. The composition of the above mutations is neither affected by tissue types nor adjusted by any other biomarkers. The risk score formula and threshold of gene set based on mutation can be verified by other tumor analysis methods, such as DNA sequencing and single nucleotide polymorphism microarray analysis. Therefore, mutation-based gene sets are not affected by technological changes, even when different platforms are used in different centers. Thirdly, in practice, gene sets based on mutations avoid exposing patients to potential immune-related adverse reactions when they are unlikely to respond, and enable patients to match to potentially more effective treatments more quickly. Fourthly, the prediction performance of gene set based on mutation is compared with other factors that can predict immunotherapy, and it is found that the prediction performance of gene set based on mutation is better than all these factors.

Several limitations of this study. First of all, because some mutations may be enriched in some tumor types, the initial goal of this study is to create a panel instead of identifying a single gene (such as BRAF), because the former can contain more genes to predict the prognosis of different types of tumors. Secondly, although the immune landscape of 11 genes in the gene set based on mutation has been explored, it is still necessary to clarify the molecular mechanism of each gene affecting immunotherapy in vivo and in vitro functional experiments. Thirdly, the enrichment scores of carcinogenic pathways and the expression patterns of immune checkpoints should also be detected by immunohistochemistry.

tag

The mutation-based gene set proposed in this study is the first comprehensive genomic marker systematically identified, which can be used to evaluate the ICI treatment effect of pan-cancer species. This study is also the largest prognostic model discovery project for cancer patients receiving ICI treatment (whether single drug treatment or combined treatment of anti-PD-1 and anti-CTLA-4). Nomoto, which combines mutation-based gene set with TMB and drug types, can help clinicians choose patients who may have a strong response to ICI treatment. In addition, it also reveals the different immune conditions of high and low risk groups, and specific genomic changes may drive the formation of these microenvironments. In a word, this work puts forward a new tumor classification method, which may guide the decision-making of ICI treatment.　END　

References:

[1]　Long, J., Wang, D., Wang, A. et al. A mutation-based gene set predicts survival benefit after immunotherapy across multiple cancers and reveals the immune response landscape. G enome Med 14, 20 (2022). https://doi.org/10.1186/s13073-022-01024-y

Write Liu Hua Hua

Editing and typesetting SX

Yin Xiaotian’s cheating marriage incident has once again turned over the knife door a few years ago. Today, people at that time responded in succession.

As the man in charge of the two incidents, Yin Xiaotian publicly responded to the divorce incident in Weibo, saying that he reflected on the failed marriage and missed his children very much.

It seems that the mood is really stable and good as the agent said.

However, compared with Yin Xiaotian who lost his marriage but won the hearts of the people, it is hard for the backbone of the knife gate.

The public opinion of the whole network is basically the same, supporting Xiaotian to stab the knife.

Under the anger of the public, most members of the Knife Inserting Sect kept silent, but some of them took the initiative to jump out and complain.

Like Huang Jue.

I have a lot of complaints about having to be fired every time there is news in Yin Xiaotian.

He sent a long microblog about what he knew.

Huang Jue said that what Bian Xiaoxiao told him was that Yin Xiaotian couldn’t turn his back on her, but he supported Bian Xiaoxiao in Weibo because he believed in her. He also contacted Yin Xiaotian and the crew, but they didn’t get a response.

Now Huang Jue said that he hoped the two sides would reach an understanding and loved Yin Xiaotian himself.

As for Jerry Lee, it is much more intense.

Li Chenfang directly issued a lawyer’s letter saying that he had suffered cyber violence, saying that the so-called knife-inserting incident was pure slander and rumor.

But netizens don’t buy it.

Jerry Lee cries injustice, but netizens don’t believe him. Why don’t we just tell the evidence?

Today, I want to tell you these contents. First, the whole process of resuming knife-inserting teaching and knife-inserting incident. Second, what will happen to King Yin Xiaotian?

The great influence of the knife-inserting teaching event can be seen from Baidu Encyclopedia’s special filing for him.

The list of key members is as follows, and netizens also arranged posts in a spoof.

Let me introduce the parties to the incident first, if Yin Xiaotian and Bian Xiaoxiao are both very close.

Yin Xiaotian’s representative works are "One Meter of Sunshine" with Sun Li and "What can I do to save you and my love" with Liu Ye.

Bian Xiaoxiao’s masterpiece is the incident of being beaten by Yin Xiaotian.

The specific process is as follows:

On February 24th, 2012, in Weibo, the assistant of actor Bian Xiaoxiao publicly accused Yin Xiaotian of playing a big role in the crew and hitting Bian Xiaoxiao because of his disagreement.

But Yin Xiaotian denied hitting anyone, saying that he had never touched Bian Xiaoxiao with a finger.

Later, Bian Xiaoxiao personally accused Yin Xiaotian of being cruel, saying that Yin Xiaotian pushed her and scratched her hair, and finally appealed to girls to know how to protect themselves when they were outside.

As soon as the eye-catching event of a famous actor hitting a woman came out, the heat immediately went up.

To add fuel to the fire, Bian Xiaoxiao’s star classmates stood up and accused Yin Xiaotian of demanding an apology, which formed a siege wind, which instantly detonated the whole network by holding a group.

Jerry, who had a good personal relationship with Bian Xiaoxiao, was the first to make a statement, saying that he had confirmed the incident as true and asked Yin Xiaotian to reflect.

Jerry’s close lover, Li XiaoLu, kept up with her, saying that good people have discerning eyes.

Yin Xiaotian’s brokerage firm said that Bian Xiaoxiao’s swearing first and beating the rake was malicious speculation, while Yin Xiaotian exercised restraint all the time and didn’t start work.

Bian Xiaoxiao denied the hype, saying that swearing was a counterattack against Yin Xiaotian.

When the two sides held their own words, Yang Zi, the overbearing president of the entertainment circle, appeared.

Need to introduce, his wife Eva Huang is also a classmate of Bian Xiaoxiao.

Yang Zi sent out two fuzzy screenshots in Weibo, saying that he got the video, which can confirm that the shoving incident did happen.

Later, Yin Xiaotian denied that the pusher in the screenshot was himself, and requested that the video be released.

But Yang Zi said, I have no obligation to publish the video.

In the absence of video, as soon as the screenshot of Yang Zi came out, people in the circle supported Bian Xiaoxiao with confidence and boldness like reassurance.

Jerry Lee, Du Chun, Huang Jue and Xue Jia’ ning forwarded them one by one, demanding an apology from Yin Xiaotian.

Weibo of Wang Luodan et al. can’t be found at present because of its age and long deletion.

Among them, Du Chun is the happiest one.

Among the people who supported Bian Xiaoxiao, Du Chun and Jerry Lee were also the most criticized.

The reason is very simple. Others may stand in line because of their close relationship or women’s position.

But Du Chun and Jerry Lee, and Yin Xiaotian used to be very intimate.

Usually it’s all kinds of blessings and praises.

But in the stabbing incident, they were the ones who lashed Yin Xiaotian the most fiercely.

How did it end in the end?

It’s also ridiculous to say.

The video was released, and it is impossible to prove that Yin Xiaotian was rough on Bian Xiaoxiao from the video content.

The crew also replied that it was just a quarrel and no violence.

The administrator of the shooting scene also said that he didn’t see anyone hitting him, but only heard the actress screaming and leaving.

Judging from the situation of all parties, there are definitely conflicts, but there is no such thing as everyone being rough.

And the two sides have different confessions. The man said that the woman lost her temper and hit people for no reason, and the woman said that Yin Xiaotian wanted to soak up her attempted lynching.

Finally, things are strangely reconciled.

Yin Xiaotian and Bian Xiaoxiao openly interacted with Weibo, and performed a happy ending.

Bian Xiaoxiao said, we will be more loving in the future.

What the hell is this?

Onlookers have also deleted Weibo.

But Li Chenze Weibo continued to plead for himself, saying that he had not wronged Yin Xiaotian.

Now Jerry Lee has come out to plead for himself and send a lawyer’s letter, looking forward to seeing him really sue someone and see how to provoke him.

The second question is how Yin Xiaotian got burnt.

There has always been a legend in the Jianghu. Yin Xiaotian, who used to be called the "Four Youngsters" with Huang Xiaoming, Nie Yuan and David, would have become a superstar if it hadn’t been for the knife-inserting incident.

Is this really the case?

It doesn’t seem certain.

In "What Can I Save You My Love", which is always on everyone’s lips, Yin Xiaotian is only male No.2, and male No.1 is Liu Ye.

Another of his masterpieces, One Meter of Sunshine, is Peter Ho.

That is to say, Yin Xiaotian is actually no masterpiece of the male master.

What’s more, what can I do to save you and my lover was already in 2002, and in the next 10 years, his plays almost didn’t respond.

Accurately speaking, it takes luck to become popular. Yin Xiaotian’s paste has nothing to do with the knife-inserting incident.

On the contrary, the knife insertion incident was the last climax of his career.

There’s nothing wrong with Yin Xiaotian being the victim of the stabbing incident, but it’s also an exaggeration for the masses to say that without this incident, Yin Xiaotian would be very popular.

Everyone who read the article last night should have found that when I wrote about Yin Xiaotian’s marriage change, I didn’t mention the teaching of inserting knives.

To tell the truth, I think career and love are two different fields. Yin Xiaotian’s cheating on marriage and his encirclement by the knife-inserting teaching are completely unrelated events. In addition, his ex-wife Ha Linna was a carefully selected marriage partner under various conditions offered by Yin Xiaotian’s family. I really can’t find a reason to force this cheating farce and knife-inserting.

Reasoning is one yard at a time.

Yin Xiaotian was the victim of the Daoism incident, but the decline of his career had nothing to do with the incident. On the contrary, the incident was quickly reversed and netizens supported him.

The woman didn’t reply to the cheating incident. Yin Xiaotian’s personal mood was very stable, and he was in a good mood, and he didn’t want to seek justice at all. There was no need for us to take sides too early.

The only feeling is that the winner of this world has never been a kind person.

This article comes from Phoenix and only represents Phoenix’s viewpoint from the media.

　　Xinhua Online Hai, August 14th (Reporter He Xinrong, Joline) The home is too messy, please ask someone to help you "break away"; Running at night, there are people who accompany the guidance; I can’t find bike-sharing when I go out, and someone will come and put it in a few days … … Have you ever thought that there are rich new job opportunities behind these increasingly familiar scenes?

　　It’s not that I don’t understand, it’s that the world is changing too fast. The surging new economy makes the definition of "work" richer and more exciting. More and more post-80s and post-90s have started different careers. While showing personality, it also brings more vitality to society.

　　The Magic of New Economy: From 360 Lines to 3600 Lines

　　Bike-sharing operator, shared office housekeeper, credit manager, quantitative trader, fashion blogger, family organizer, food stylist, escort runner, genetic tester, UP owner, drone trainer & HELIP; … The degree of "brain holes" in new occupations is beyond imagination.

　　Rome was not built in a day, and new occupations did not emerge overnight. The booming new economy in recent years is a fertile ground for these new occupations.

　　Although there is no accurate official definition, the coverage of "new economy" is very extensive. It not only refers to internet plus, Internet of Things, cloud computing and other emerging industries and formats in the tertiary industry, but also includes intelligent manufacturing and mass customization production in industry, and also involves family farms in the primary industry, and the integrated development of rural primary, secondary and tertiary industries.

　　In the past two years, the "new economy" has accelerated its growth, showing amazing "magic power": China’s employment indicators (including newly employed population, survey unemployment rate, etc.) rank first among 63 major economies in the world, while the macroeconomic growth rate is slowing down.

　　There is no doubt that the "new occupation" spawned by the "new economy" has absorbed a large number of employed people. The constantly updated list of national vocational qualifications shows that the number of jobs is moving from the original 360 to the new 3600. More and more people are creating new values for society while releasing their individuality.

　　Five rules of new career: see how many you have.

　　It is precisely because it resonates with the new economy at the same frequency that new occupations that look colorful actually have rules to follow. If you don’t want to be bound by the "cubicle", you may wish to refer to the following five rules:

　　[Internet Gene] The sharing economy has created operators, shared office housekeepers and shared house landlords in bike-sharing, while the platform economy has brought car drivers, couriers and take-away workers. Nowadays, most of the hottest entrepreneurial fields have Internet genes. With the Internet "connecting everything", people’s "career map" is being refreshed rapidly.

　　The current Internet applications are mainly concentrated in the fields of consumption and services. With the Internet becoming an infrastructure like hydropower and coal, and expanding to manufacturing and agriculture, new jobs with Internet genes will continue to emerge.

　　Su Hainan, vice president of china association for labour studies, said that the new occupation in the Internet era has some new features. If the task is fragmented, the working hours are not fixed; Diversified labor relations, such as the traditional employment relationship between platform and employees; Products and services are personalized, and labor output is more suitable for the specific needs of consumers.

　　[Subdivide and subdivide] A food can’t be nutritious, but it must be delicious. It’s not good just to eat, but to look good. As a result, the food stylist was born gorgeous. It must be said that the escalating demand of consumers has created new occupations in many seemingly inconspicuous segments.

　　"Professional people do professional things", with the east wind of consumption upgrading, new demands are constantly being stimulated: running and exercising with runners, traveling in personal tailor … … Because of China’s huge domestic demand market, any small demand may contain infinite potential.

　　[People behind "Nobody"] Unmanned driving, unmanned supermarket, drone delivery … … The rapid development of artificial intelligence technology makes the concept of "nobody" hot, and also makes many people worry that they will become a "useless" class. The statement that "50% of jobs will disappear in the next decade" has scared many fragile hearts.

　　In fact, no matter how developed artificial intelligence is and how many "unmanned" technologies are, there are still people behind it who are studying and manipulating it. However, their work changed from being in front of the stage to being behind the scenes. Tommy, Vice Minister of Science and Technology, said that in the long run, the employment brought by science and technology is far greater than unemployment. Take artificial intelligence for example, the algorithm engineer behind it is now in a state of extreme shortage. Instead of worrying about being replaced in the future, it is better to charge it now.

　　[Hobby is work] A few years ago, the old people would say, "Humor can’t be a meal", and no one regarded "telling jokes" as a job. Nowadays, "Duan Zishou" has really appeared. A few years ago, it was just a pastime to like the secondary culture and be good at making barrage videos. Today, the studio of "UP Master" has completed commercial realization in the real world of three dimensions.

　　Turning hobbies into jobs has become a new choice for many post-90s and post-90s. There are not so many instructions, and there is no strict index assessment. I do things with interest and "make money by playing." Therefore, parents who are eager to enroll their children in extracurricular training classes should see how important it is to respect their children’s nature and cultivate their interests!

　　[Rejuvenation of old crafts] It sounds that new occupations are often related to new knowledge and new skills? It’s not exactly like this. People always have some urgent needs, such as eating. From the ancient skilled worker to the modern chef, the professional "vest" is changing, but the core of pursuing delicious food has not changed.

　　Therefore, in the era of vigorous development of the new economy, the story of "rejuvenation of old crafts" has been staged again and again, even more moist than before. Bike-sharing is on fire, which has ruined the manufacturing workshop and the mechanic. There are fewer tailors on the street, but the old masters who come to order are popular. Once regarded as an unpopular veterinary graduate, she is now a pet beautician in MengMeng … … Society will not mistreat people with skills.

　　New employment concept: the boundary between white collar with gold collar and blue collar with gray collar is blurring.

　　The new economy gives birth to new occupations, and new occupations bring new employment concepts. In the past, people habitually divided their occupations into gold collar, white collar, gray collar and blue collar according to the working environment and income. Nowadays, more and more people find that the boundaries between these "collars" are becoming increasingly blurred.

　　"I earn 15,000 yuan a month. Will I lose this job for a gift of 2,000 yuan?" A few years ago, the story of a SF Express courier "getting angry" in a white-collar office was circulated around the Internet. Between words, full of professional pride. According to the traditional concept, the courier is a "blue-collar" position, which can make the courier stand at the scene of the bell ringing ceremony of listed companies due to the rapid growth of social demand and increasing technical content.

　　In the interview, the reporter was also exposed to many touching stories. Han Yien, a 28-year-old lawyer, was a financial company in Lujiazui, Shanghai. When she switched to be a home organizer, her mother cried. Because in the eyes of the older generation, this is a job of "serving people". But after more than two years of accumulation, Han Yien made a name for himself in the circle. Not only on-site service, but also receiving students and giving lectures, the "Qian Jing" is quite impressive. More and more elders gradually understand and recognize her choice of "not doing housework".

　　From farming society, industrial society, information society and intelligent age, the development of new technology has rapidly changed the traditional labor pattern. When mobile payment replaces cashier, artificial intelligence replaces repetitive workers, just as car drivers replaced coachmen.

　　It can be predicted that in the future, the social division of labor will become more and more detailed and the occupations will become more and more diversified. "Tall" jobs, such as investment bank traders, may be replaced by artificial intelligence if they don’t work hard. And more jobs without innate aura can live a wonderful life as long as they are willing to make sincere efforts.

　　The future has come. Embrace the new economy and fall in love with the new occupation. You, are you ready?

This Spring Festival holiday, the weather is quite awesome.

Yesterday, many places in our province also received a "warm weather package"

I believe that everyone should be very satisfied.

Let’s review first ↓

Yesterday’s package: warming up+sunny

On the last day of the holiday (February 17th), we drew a happy ending for this "Spring Festival" holiday in a warm atmosphere, with sunshine and "12℃+" everywhere. Among them, the southeast and Zhangjiakou even broke through the 15℃ line, among which Shexian County in Handan topped the whole province with 18.3℃.

Do you think it will warm down?

How can cold air leave it at that!

On the first day after the holiday,

Cold air patted you,

Take this weather "luxury package":

What’s in it? Please slide the package cover)

In the next few days,

Our province will receive a copy.

Weather "luxury package"

Sandstorm+cooling+rain and snow

Not a few.

What’s the trend of this weather "luxury package"?

Let Beibei tell you something ↓

Weather trend specification

It is expected that from today to the 23rd, cold air will sweep across our province with sandstorms, cooling and rain and snow!

This cold air is fierce, the temperature is fierce, the wind is strong, and the local area is accompanied by sand blowing or floating dust weather. Don’t be careless!

How can sandstorm+cooling+rain and snow move?

The answer is revealed ↓

Parcel 1

gale

The Hebei Meteorological Observatory continued to issue the gale blue warning signal at 11: 00 on February 18, 2024: due to the influence of cold air, it is expected that there will be northerly winds of 4 to 6 in Zhangjiakou, western Chengde and western Baoding from this afternoon to tomorrow, with gusts of 7 to 8, accompanied by sand blowing or dusty weather in the local area; During the day from today’s night to the 21st, there are 6-7 winds from north to northeast and 8-10 gusts in Bohai Sea and coastal areas. Please take precautions!

Parcel 2

cold wave

Hebei Meteorological Observatory issued a yellow warning signal of cold wave at 11: 00 on February 18th, 2024: Due to the influence of cold air moving eastward and southward from Mongolia, the lowest temperature in most parts of the province dropped by 8 ~ 14℃ on 19th-21st, with Bashang area dropping by 14 ~ 18℃. On the morning of 20-21, the lowest temperature in the northwest of Zhangjiakou, Chengde and Baoding can drop to-23 ~-10℃, and in other areas it can drop to-9 ~-5℃. Please take precautions!

The highest temperature will also drop! Take Handan as an example, it can still reach 15℃ today, and it will drop to -3℃ on the 21st! Great changes in temperature and warmth, everyone needs to add clothes to keep warm in time.

(Handan temperature chart)

Forecast of Cardiovascular and Cerebrovascular Disease Index on 19th.

Cooling weather can easily lead to the induction and aggravation of cardiovascular and cerebrovascular diseases, and sensitive people with cardiovascular and cerebrovascular diseases should be protected more.

Examples of cardiovascular and cerebrovascular disease index:

Level 1: Less hair.

Grade 2: It is easy to occur.

Level 3: easy to send.

Level 4: Very easy to send.

Parcel 3

Rain and snow

It is expected that there will be rain and snow in some areas of our province from this afternoon to the night, and from tomorrow to the 23rd. Among them, from the night of 20th to 21st, there will be heavy snowfall, and there will be moderate snow in the central and southern regions, with heavy snow to blizzard in the southern region.

Rain and snow weather, the road is slippery, which coincides with the peak of the return trip. Everyone needs to pay attention to travel safety.

Specific forecast

Hebei Meteorological Observatory issued the weather forecast at 11: 00 on February 18th, 2024:

From this afternoon to night, there were sporadic sleet or light snow in the north of Zhangjiakou and Chengde, light rain turned to sleet in the east of Chengde, Tangshan and Qinhuangdao, light rain or sporadic rain in Langfang, Cangzhou, Hengshui, Xingtai and Handan, and cloudy and cloudy in other areas.

During the daytime tomorrow, Shijiazhuang, Cangzhou and the south will be cloudy, while other areas will be cloudy and sunny.

From tomorrow night to the 20th, the whole province will turn cloudy, with light snow or sporadic light snow in Zhangjiakou and Baoding, Langfang and the south, and moderate snow in the local area.

From the night of the 20th to the 21st, there was moderate snow in the cloudy, central and southern parts of the province, with heavy snow to heavy snow in the southern part and light snow or sporadic snow in other areas.

Comes with a warm little package 1

01

Beware of windy and dusty weather

In windy weather, go out away from temporary structures such as billboards and beware of falling objects; In addition, dusty weather will cause the air quality to decline. The elderly, children, pregnant women, people with respiratory diseases and cardiovascular diseases are sensitive people, so we should try our best to avoid going out in dusty weather.

02

The temperature fluctuates greatly, so pay attention to keep warm.

In the next few days, the sharp fluctuation of temperature is the main theme of the weather stage in our province. Don’t hurry to collect thick clothes. The cooling weather coincides with the return of the Spring Festival and the school season. Everyone needs to pay attention to the temperature change in time, increase or decrease clothes in time, and beware of colds and cardiovascular and cerebrovascular diseases.

03

Take more precautions in rainy and snowy weather

From this afternoon to the night, and from tomorrow night to the 23rd, the rainy and snowy weather in our province is frequent, and now it is at the peak of Spring Festival travel rush’s return trip. Everyone needs to pay close attention to the latest weather and road traffic information, and make travel arrangements in advance to prevent the adverse effects of slippery roads, icing and low visibility weather on traffic travel.

Warm little package 2

[Read the warning signal in one minute-gale warning signal! 】

[Read the warning signal in one minute-cold wave warning signal! 】

Forecast of major cities in Hebei Province

Original title: "@ Hebei gale+cold wave warning signal is issued, rain and snow are on the road! 》

Read the original text

　　In 2021, China’s economy will continue to recover steadily, economic development and epidemic prevention and control will maintain a leading position in the world, the main indicators will achieve the expected goals, fixed assets investment will recover steadily, and the structure will continue to be optimized; The scale of market sales continued to expand, and the consumption structure was optimized and upgraded; The total population has maintained growth and the level of urbanization has steadily increased; The employment situation is generally stable, and the employment situation of migrant workers is constantly improving; Residents’ income continued to grow steadily; Prices in the consumer sector rose moderately.

　　Continuous optimization of investment structure

　　Zhai Shanqing, Director of Statistics Department of Fixed Assets Investment of National Bureau of Statistics

　　In 2021, investment in fixed assets recovered steadily and the structure continued to be optimized. The investment in fixed assets (excluding farmers) was 54,454.7 billion yuan, an increase of 4.9% over the previous year, and the growth rate was 2.0 percentage points higher than that of the previous year; Taking 2019 as the base period, the average growth rate is 3.9% in two years.

　　The scale of investment in the first and third industries continued to expand.

　　In 2021, the investment in the primary industry was 1,427.5 billion yuan, an increase of 9.1% over the previous year; The average growth rate was 13.7% in two years, and the growth rate was 0.7 percentage points faster than that from January to November. The investment in the secondary industry was 16,739.5 billion yuan, an increase of 11.3% over the previous year; The average growth rate was 5.8% in two years, and the growth rate was accelerated by 0.6 percentage points. The investment in the tertiary industry was 36,287.7 billion yuan, an increase of 2.1% over the previous year; The average growth rate in two years was 2.7%, and the growth rate dropped by 0.2 percentage points.

　　Second, the investment in the three major areas has recovered steadily.

　　In 2021, manufacturing investment increased by 13.5% over the previous year; Average growth of 4.8% in two years. Investment in real estate development increased by 4.4% over the previous year; Average growth of 5.7% in two years. Infrastructure investment increased by 0.4% over the previous year; Average growth of 0.3% in two years.

　　Third, investment in high-tech industries plays an obvious role.

　　In 2021, the investment in high-tech industries increased by 17.1% over the previous year, the growth rate was 0.5 percentage points faster than that from January to November, 12.2 percentage points higher than that of the total investment, and the total investment increased by 1.2 percentage points.

　　Investment in high-tech manufacturing increased by 22.2%, which was the same as that from January to November. Investment in high-tech service industry increased by 7.9%, and the growth rate was 1.5 percentage points faster than that from January to November.

　　Fourth, the investment in the short-board area of people’s livelihood continued to increase.

　　In 2021, investment in social fields increased by 10.7% over the previous year. Investment in agriculture, forestry, animal husbandry and fishery increased by 9.3% over the previous year, and the growth rate was 0.1 percentage point faster than that from January to November. Investment in transportation, warehousing and postal services increased by 1.6% over the previous year, and the growth rate was 0.5 percentage points faster than that from January to November. Investment in the production and supply of electricity, heat, gas and water increased by 1.1% over the previous year, and the growth rate was 0.9 percentage points faster than that from January to November.

　　V. Steady growth of private investment

　　In 2021, private investment increased by 7.0% over the previous year; The average growth rate in two years was 3.8%, and the growth rate was the same as that from January to November. Among them, private investment in education increased by 24.9%, private investment in manufacturing increased by 14.7%, private investment in infrastructure increased by 12.0%, and private investment in agriculture, forestry, animal husbandry and fishery increased by 9.9%.

　　The consumer market maintained a recovery trend.

　　Dong Lihua, Director of the Department of Foreign Trade and Economic Statistics of the National Bureau of Statistics

　　In 2021, the scale of market sales continued to expand, the consumption structure was optimized and upgraded, and the overall consumer market maintained a recovery trend.

　　I. The scale of the consumer market has steadily expanded.

　　In 2021, the total retail sales of social consumer goods was 44.1 trillion yuan, an increase of 12.5% over the previous year and 8% over 2019. After deducting the price factor, the total retail sales of social consumer goods actually increased by 10.7%.

　　In the first quarter, due to the low base in the same period of last year, the total retail sales of social consumer goods increased by 33.9% year-on-year, with an average growth rate of 4.2% in two years; In the second quarter, the market sales accelerated, and the average growth rate in two years was 0.4 percentage points faster than that in the first quarter; In the third quarter, the two-year average growth rate declined; In the fourth quarter, the consumer market continued to recover, and the total retail sales of social consumer goods increased by 4% on average for two years.

　　Second, the urban market continued to recover.

　　In 2021, the retail sales of urban consumer goods increased by 12.5% over the previous year, with an average increase of 3.9% in two years. Quarterly, the urban market in the fourth quarter increased by 3.3% over the same period of last year, with an average growth rate of 3.9% in two years, and the average growth rate was 1 percentage point faster than that in the third quarter. In 2021, the per capita disposable income of rural residents actually increased by 9.7% over the previous year, and the growth rate was 2.6 percentage points higher than that of urban residents.

　　Third, the retail sales of goods grew steadily

　　The growth of retail sales of commodities is good. In 2021, the retail sales of commodities increased by 11.8% over the previous year, by 9.2% over 2019, and by 4.5% on average in two years. From the two-year average growth rate, the retail sales of all categories of goods have maintained growth.

　　In 2021, catering revenue increased by 18.6% compared with the previous year, decreased by 1.1% compared with 2019, and decreased by 0.5% on average in two years. The scale of catering consumption has not yet recovered to the pre-epidemic level. In the fourth quarter, the catering revenue decreased by 0.5% on average for two years, which was 1.1 percentage points narrower than that in the third quarter, and the recovery of catering consumption was accelerated.

　　Fourth, online consumption maintained rapid growth.

　　In 2021, the national online retail sales increased by 14.1% over the previous year. Judging from the development of postal express delivery industry closely related to online shopping, driven by the rapid growth of online consumption, the express delivery business volume and business income in 2021 maintained a double-digit rapid growth compared with 2020.

　　5. The retail sales of basic life commodities are growing well.

　　Sales of grain, oil, food and daily necessities increased rapidly. In 2021, the retail sales of grain, oil, food and daily necessities of units above designated size increased by 10.8% and 14.4% respectively over the previous year, with an average annual increase of 10.4% and 10.9% respectively.

　　The level of urbanization has steadily increased.

　　Wang Pingping, Director of Population and Employment Statistics Department of National Bureau of Statistics.

　　In 2021, China’s total population maintained growth, the growth rate continued to slow down, the degree of aging further deepened, and the level of urbanization steadily improved.

　　First, the total population maintained growth.

　　By the end of 2021, the national population was 1,412.6 million, an increase of 480,000 over the end of 2020; The annual birth population was 10.62 million, a decrease of 1.4 million compared with 2020; The death toll was 10.14 million, an increase of 160,000 compared with 2020.

　　In 2021, the natural population growth rate will be 0.34‰ , down 1.11 thousandths from 2020. The continuous slowdown in population growth is due to the continuous decline in the number of births, which is mainly affected by two factors: first, the number of women of childbearing age continues to decrease; Second, the fertility level continues to decline. The total fertility rate of women of childbearing age will continue to decline in 2021 due to the change of fertility concept and the delay of the age of first marriage and first childbearing.

　　Second, the short-term increase in the working-age population

　　By the end of 2021, the population aged 0-15 was 263.02 million, accounting for 18.6% of the national population. The population aged 16 to 59 is 882.22 million, accounting for 62.5%; The population aged 60 and over is 267.36 million, accounting for 18.9%. Compared with 2020, the population aged 0-15 decreased by 5.28 million, the population aged 16-59 increased by 2.47 million, and the population aged 60 and over and the population aged 65 and over increased by 3.29 million and 9.92 million respectively. The increase in the working-age population aged 16 to 59 is mainly due to the small number of people born in 1961. The proportion of the population aged 60 and over and the population aged 65 and over increased by 0.2 and 0.7 percentage points respectively compared with 2020, and the degree of aging further deepened.

　　It is predicted that the number and proportion of working-age population will continue the previous downward trend in the future. Although the working-age population tends to decrease, the total number is still nearly 900 million, and the labor resources are still abundant. From the quality point of view, the quality of the working-age population has improved significantly, and the average length of education has increased from 9.67 years in 2010 to 10.75 years in 2020, and the new advantages of talent bonus have gradually emerged.

　　Third, the level of urbanization has steadily improved.

　　By the end of 2021, China’s urban resident population reached 914.25 million, an increase of 12.05 million over the end of 2020; The resident population in rural areas was 498.35 million, a decrease of 11.57 million. The urbanization rate of permanent residents was 64.72%, an increase of 0.83 percentage points over the end of 2020.

　　Employment improvement of key groups

　　Wang Pingping, Director of Population and Employment Statistics Department of National Bureau of Statistics.

　　In 2021, with the sustained recovery of the national economy and the implementation of the employment priority policy, the national urban survey unemployment rate was lower than the expected target, and the employment situation was generally stable.

　　First, the urban survey unemployment rate remained generally stable

　　In 2021, the average urban unemployment rate was 5.1%, which was lower than the macro-control target of about 5.5%. In the first quarter, affected by the Spring Festival and the epidemic situation in some areas, the urban unemployment rate was relatively high, rising to a high of 5.5% in February. After the holiday, with the stable recovery of enterprise production and operation, the unemployment rate gradually declined. In the second quarter, the urban survey unemployment rate remained in the range of 5.0% to 5.1% in each month; In the third quarter, affected by the graduation season and the epidemic situation in some areas, the unemployment rate fluctuated. With the graduates entering jobs one after another and the impact of the epidemic situation weakened, the urban survey unemployment rate fell back to 4.9% in September. In the fourth quarter, the survey unemployment rate remained in the range of 4.9% to 5.1%.

　　Second, the overall improvement of the employment situation of key groups

　　In 2021, various policies and measures to stabilize employment and promote employment continued to be implemented, and the policy of reducing burdens, stabilizing posts and expanding employment continued to be implemented, and all-round employment services continued to exert strength. In the second half of 2021, the unemployment rate of the employed population aged 25 to 59 has been stable below 4.5%, which is lower than the same period of last year.

　　The employment situation of migrant workers has been continuously improved. After the Spring Festival in 2021, the unemployment rate of foreign agricultural registered population continued to fall, and by December, the unemployment rate of foreign agricultural registered population was 4.6%. By the end of 2021, the number of migrant workers nationwide had reached 292.51 million, an increase of 6.91 million over the end of last year, and it has returned to the same level in 2019. The employment situation of college graduates is generally stable. From June to July, the unemployment rate of young people aged 16 to 24 increased significantly due to the concentrated job hunting of college graduates. After September, with the implementation of graduate work, the youth unemployment rate gradually declined.

　　Third, employment stability still faces challenges

　　We must see that employment stability still faces challenges and pressures. Increased downward pressure on the economy will have a certain impact on employment. At the same time, the impact of the epidemic continues, and the production and operation of some industries and enterprises may be affected or impacted. It should also be noted that the number of college graduates will reach 10.76 million in 2022, an increase of 1.67 million over the previous year, with both scale and increment reaching record highs; The long-standing structural contradictions in some employment fields such as "difficulty in recruiting workers" and "difficulty in finding jobs" have not been fundamentally alleviated.

　　In 2022, it is necessary to continue to strengthen the employment priority policy, promote the implementation of measures to reduce burdens, stabilize posts and expand employment, increase employment assistance for key groups such as college graduates, strengthen vocational skills training, promote entrepreneurship to drive employment, and ensure a stable employment situation.

　　Residents’ consumption demand is gradually released.

　　Fang Xiaodan, Director of Household Survey Department of National Bureau of Statistics.

　　In 2021, the per capita disposable income growth of the national residents is basically synchronized with economic growth, the consumption expenditure of residents continues to recover, and the basic living consumption grows rapidly, realizing the mutual promotion and common progress of steady growth and benefiting people’s livelihood.

　　First, the per capita disposable income growth of residents is basically in sync with economic growth.

　　Residents’ income growth is basically synchronized with economic growth. In 2021, the per capita disposable income of the national residents was 35,128 yuan, a nominal increase of 9.1% over the previous year. After deducting the price factor, the per capita disposable income of the national residents actually increased by 8.1%, faster than the per capita GDP growth rate, and the income growth of the residents was basically in sync with the economic growth.

　　Second, the steady growth of wage income and transfer income lays the foundation for the steady growth of urban and rural residents’ income.

　　Wage income continued to grow steadily. In 2021, the per capita wage income of the national residents was 19,629 yuan, an increase of 9.6% over the previous year, with an average increase of 6.9% in two years. In terms of urban and rural areas, the per capita wage income of urban residents increased by 8.0%, with an average increase of 5.5% in two years. The per capita wage income of rural residents increased by 14.1%, with an average increase of 9.9% in two years.

　　Third, residents’ consumption expenditure continued to recover, and basic living consumption continued to grow rapidly.

　　Consumer spending continued to recover. With the continuous recovery growth of residents’ income, residents’ consumption demand is gradually released, and consumption expenditure keeps a recovery rebound trend. In 2021, the per capita consumption expenditure of the national residents was 24,100 yuan, a nominal increase of 13.6% on the basis of a low base in the previous year; After deducting the price factor, the actual increase was 12.6%.

　　Basic living consumption continued to grow rapidly. In 2021, the average per capita expenditure on food, tobacco and alcohol in China increased by 8.6% in two years, which was 2.9 percentage points faster than the average growth rate of all consumption expenditure in two years. The implementation of the policy of ensuring supply and stabilizing prices has been continuously strengthened, the food supply in the market is sufficient, and the food consumption of residents continues to grow steadily.

　　Prices in the consumer sector have risen moderately.

　　Wang Youfen, Director of Urban Social and Economic Investigation Department of National Bureau of Statistics.

　　In 2021, people’s livelihood security was strong and effective, the consumer market was generally stable, and CPI rose moderately; Actively respond to the sharp rise in energy and raw material prices, and the PPI rose at a high level.

　　First, prices in the consumer sector have risen moderately.

　　The monthly CPI is generally fluctuating upward year-on-year. In 2021, the CPI rose by 0.9%, which was 1.6 percentage points lower than the previous year, and the overall operation was in a reasonable range.

　　The rise in non-food prices pushed CPI up moderately. In 2021, non-food prices rose by 1.4%, an increase of 1.0 percentage points over the previous year, which affected the increase of CPI by about 1.17 percentage points.

　　The decline in food prices slows down the increase in CPI. In 2021, the price of food changed from 10.6% in the previous year to 1.4%, which affected the decrease of CPI by about 0.26 percentage points, mainly driven by the change of pork price.

　　Second, the price in the production field fell back at a high level.

　　The monthly year-on-year increase of PPI showed a downward trend. In 2021, PPI changed from 1.8% in the previous year to 8.1%.

　　The structural rise is obvious. In 2021, the price of means of production changed from 2.7% in the previous year to 10.7%, which affected the PPI increase by about 7.97 percentage points, exceeding 98% of the total increase. The price of means of subsistence rose by 0.4%, which was 0.1 percentage points lower than that of the previous year, affecting the PPI to rise by about 0.09 percentage points, and the overall situation was relatively stable.

　　Input factors boosted PPI. Since 2021, the demand for international commodities has recovered faster than the supply, and with the influence of abundant liquidity and other factors, the prices of crude oil and non-ferrous metals in the international market have risen, pushing up the ex-factory prices of related domestic industries and driving up the PPI.

　　Tight supply pushes PPI up. In the second half of the year, due to the tight supply and relatively strong demand, the price of coal mining and washing industry rose sharply, and the year-on-year increase expanded from 37.4% in June to 103.7% in October.

　　Text/a big wave

　　Appraisal object: The Big Secret of Love Pets 2. Release date: July 5.

　　The audience of "pet secrets 2" is very clear, that is, there are two categories. One of them is a pet lover like me, and the other is the "Xiong Haizi" that makes most adult audiences feel shocked when they see it.

　　I chose a very tricky time to watch movies, a non-weekend afternoon. However, it’s summer vacation now, and there’s basically no way to avoid the cute little audience except choosing the zero-point file. Therefore, although there were only ten spectators in the audience, apart from me and a couple, it was a "family fun" combination of two couples with three children, and this 3/10 audience had brought three live broadcasts with different themes before the opening of the commercial, including the "brothers throwing drinks at each other" with the most intense drama conflict.

　　I was worried that I would definitely not be able to watch the film well, and even prepared for the worst when I left midway. But it turns out that I worry too much — — Except for an episode in which a baby lost patience in the back row because of too long English lines, he climbed over three rows to look at me. Generally speaking, I gained a quite peaceful and comfortable viewing experience when I watched "Pet Secret 2".

　　This is what I think, the essential quality of mature cartoons — — It can make the small audience converge on the exuberant energy that needs to gush out all the time and consciously focus on the screen in front of them. This is not easy to do, especially when young children come across the original English. This means that films can only be captured by faster pace and more information, and for this reason, you have to spend more time and money on production.

　　There is no doubt that in this respect, this sequel to Universal is as sincere as the previous one.

　　So, is the other audience satisfied? The answer should also be yes. Like the previous work, the sequel focuses on "What is your pet doing when you are not at home". Meng Chong continues to personify, and it also continues to bring the contrast of "the owner is in and out". For the audience who naturally like pets, the whole film is a very qualified scene of "cloud sucking dogs" and "cloud sucking cats". The film obviously pays great attention to the feelings of this audience, and many jokes are tailored for them. For example, the dog who went out was originally in high spirits. When he walked halfway, he found that he was going to see a doctor, fearing that he would fall to the ground on the spot. For example, the talkative dog boss has the only lamella, "moving my basin is hurting my dignity"; For example, all cats love to chase little red dot and regard catching it as the highest achievement of cat life … … These terriers, people who have owned cats and dogs or cared about pets, know better and can laugh more.

　　And if you are the third group of people besides this, Pet Secret 2 may not be suitable for you. It doesn’t provide thinking space for you to rise from "dog life" and "cat life" to "life", so you may only leave an impression of being too naive after reading it. It doesn’t matter, it’s not a product made for you, just avoid it.

　　BEIJING, April 18 (Reporter Cheng Chunyu) On April 17, the People’s Bank of China decided to reduce the deposit reserve ratio of some financial institutions from April 25 to replace the medium-term lending facilities. Experts believe that this move will reduce the cost of bank capital and corporate financing, benefit the bond market, and help stabilize the stock market and the macro economy.

　　On the 17th, the People’s Bank of China decided to lower the deposit reserve ratio of some financial institutions to replace the medium-term lending facilities. Photo by Yang Mingjing

　　Which banks are involved in this move?

　　According to the notice of the central bank, the RMB deposit reserve ratio will be lowered by 1 percentage point from 25th, involving large commercial banks, joint-stock commercial banks, city commercial banks, non-county rural commercial banks and foreign banks.

　　At present, the benchmark level of these banks’ deposit reserve ratio is relatively high at 17% or 15%, and institutions that borrow MLF are also among these banks.

　　At the same time, the central bank requires that on the same day, the above-mentioned banks will use the funds released by the RRR cut to repay the medium-term lending facilities (MLF) borrowed by the central bank in the order of "borrowing first and returning first".

　　Pan Xiangdong, chief economist of New Era Securities, thinks that MLF cannot completely replace RRR cut. Specifically, MLF has a time limit, which will aggravate liquidity stratification, and MLF needs to pay interest, and financial institutions will pass the cost on to enterprises. By replacing MLF with RRR reduction, the interest payment cost of commercial banks is reduced, which is conducive to reducing the financing cost of enterprises.

　　Why is this time point implemented?

　　The relevant person in charge of the central bank said that at present, China’s small and micro enterprises still face the problem of financing difficulties and expensive financing. In order to increase support for small and micro enterprises, we can replace part of the central bank’s borrowing funds by appropriately lowering the statutory deposit reserve ratio, further increase the stability of the banking system’s funds, optimize the liquidity structure, and appropriately release incremental funds.

　　Pan Xiangdong told reporters that the reason for not lowering the RRR in recent two years is to prevent risks. However, after deleveraging, China’s macro leverage ratio has been controlled, and the RMB exchange rate has been relatively stable and even appreciated since 2017. China’s economic and financial risks have been well controlled, and the constraints on monetary policy have been alleviated.

　　According to Zhang Ming, chief economist of Ping An Securities, the central bank’s move is a "neutral" RRR cut. He believes that the timing of the relaxation of the central bank’s liquidity operation is advanced, which makes the probability of possible tightening of financial regulatory policies in the second quarter decline.

　　How much incremental funds will be released?

　　The relevant person in charge of the central bank said that based on the data at the end of the first quarter of 2018, the MLF was repaid about 900 billion yuan on the day of operation, and the incremental funds were released about 400 billion yuan. Most of the incremental funds were released to city commercial banks and non-county rural commercial banks.

　　The person in charge pointed out that this measure will increase the long-term capital supply and reduce the cost of bank funds. The replacement of MLF can reduce the interest payment cost of commercial banks and help reduce the financing cost of enterprises. The released incremental funds have increased the low-cost sources of loans for small and micro enterprises.

　　Pan Xiangdong also pointed out that cost reduction is the focus of supply-side structural reform this year, and reducing the financing cost of enterprises is the top priority. Previously, the central bank has been implementing the targeted cuts to required reserve ratios, but the release of liquidity is limited, and the problems of difficult and expensive financing for small and micro enterprises have not been effectively solved. This RRR cut can increase the support for small and micro enterprises.

　　What is the impact on financial markets such as the stock market?

　　Zhang Ming said that the direct impact of the central bank’s move is to benefit the bond market and help stabilize the stock market and the macro economy. Pan Xiangdong expressed the same view that the RRR cut is conducive to economic stability and the capital market.

　　Pan Xiangdong added: First, the RRR cut will help ease the pressure on banks’ debt side, reduce the financing costs of enterprises, expand investment and increase the growth rate of manufacturing investment, which has been at a low level for a long time. Second, the RRR cut is conducive to expanding domestic demand and hedging the uncertainty faced by China’s external demand. Third, while supplementing liquidity, it will stimulate the capital market.

　　On the 17th, the four major A-share indexes in China all fell, and the representative Shanghai Composite Index fell 1.41% to close at 3,066.80 points, a record low for the year.

　　Yang Delong, chief economist of Qianhai Kaiyuan, said that the economic fundamentals have not changed. Recently, many high-quality stocks in the A-share market have been wrongly killed. The central bank’s downgrade will boost market confidence, and the market outlook is expected to rebound and gradually repair the previous downward trend.

　　Does the RRR cut mean that the orientation of monetary policy has changed?

　　The reporter noted that some institutions believe that the loose space of monetary policy is open, "the central bank’s move means that monetary policy is fine-tuning."

　　Pan Xiangdong believes that risk prevention is one of the three major battles in 2018, and the prudent neutral monetary policy will not change. In March, the central bank followed the Federal Reserve to raise the short-term money market interest rate, and the government proposed structural deleveraging, all of which have clearly conveyed the determination to prevent risks.

　　"The stable and neutral monetary policy orientation remains unchanged." The relevant person in charge of the central bank made it clear that most of the funds released by the RRR cut were used to repay the medium-term loan facilities, which were substitutes for two liquidity adjustment tools, while the remaining small amount of funds were hedged with the tax period in the middle and late April. Therefore, while optimizing the liquidity structure, the total amount of liquidity in the banking system remained basically unchanged and remained neutral.

　　At the same time, the person in charge said that China is a developing country, and in order to prevent financial risks, it still needs to maintain a relatively high deposit reserve ratio. The People’s Bank of China will continue to implement a prudent and neutral monetary policy, maintain a reasonable and stable liquidity, guide a steady and moderate increase in the scale of monetary credit and social financing, and create a suitable monetary and financial environment for high-quality development and supply-side structural reform. (End)

CCTV News:In October this year, the prices of some varieties of vegetables in some parts of China rose sharply, and it was once more expensive to eat vegetables than meat. The rise in the price of fresh vegetables affected the consumer price index by about 0.34 percentage points, accounting for nearly 50% of the total increase. In order to ensure stable supply and price, a series of measures have been taken from the central government to the local government to promote production and smooth circulation. How about the price of vegetables in the near future?

Every winter and spring is the peak consumption of vegetables and other "vegetable basket" products in China. Driven by consumption, vegetable prices ushered in a high-level operation stage in a year. However, this autumn, due to the rare autumn flood and flood disaster in the northern producing areas, coupled with factors such as rising production and circulation costs, the average wholesale price increase of 28 kinds of vegetables with large market demand in October was greater than that in the same period of last year, especially leafy vegetables. The reporter recently found in interviews in many places that the prices of vegetable varieties with large increase in the previous period have fallen sharply in the near future.

Anhui is one of the advantageous vegetable producing areas in winter and spring in China. When interviewed by some local supermarkets, the reporter learned that due to the recent increase in market supply, the prices of vegetable varieties with a large increase in the previous period have fallen back to near normal levels.

Jilin is one of the main vegetable sales areas in China. The reporter learned from the largest vegetable wholesale market in the local area that the supply here mainly comes from Liaoning, Hebei and Shandong, and the recent daily purchase volume is around 2,000 tons, which is basically the same as in previous years.

According to the monitoring data of the Ministry of Agriculture and Rural Affairs, vegetable prices have gradually stabilized with the increase in market volume.

Increasing area and capacity to improve vegetable supply capacity

In order to ensure the effective supply of vegetables in winter and spring, especially in New Year’s Day and Spring Festival, the main producing areas have increased the area of vegetables in the field, strengthened technical guidance and improved the supply capacity of vegetables. In China, the seven provinces and regions of "transporting vegetables from south to north" and the six provinces of protected vegetables in the north are the main forces to ensure the supply of winter and spring vegetables, and the area and output of winter and spring vegetables account for more than 80% of the country.

Anhui, the northern vegetable producing area, has used facilities such as winter fallow fields and rice seedling greenhouses to increase seasonal and emergency vegetable production. At present, the vegetable area in the province is nearly 5 million mu, an increase of more than 6% over the previous year. Chaotian is an important vegetable production base in Sichuan, a big province of "transporting vegetables from south to north". In order to ensure the vegetable production in winter and spring, the local farmers are provided with seeds free of charge, and an agricultural technology service team is sent to guide the whole process. In order to ensure the supply of vegetables, many sales areas have also continuously improved the level of vegetable self-sufficiency production. In Jilin, there are 45,000 mu of greenhouses in the local area, with a year-on-year increase of 7.1%.

According to the latest agricultural dispatch of the Ministry of Agriculture and Rural Affairs, at present, the area of vegetables in the country has reached 103 million mu, up 4 million mu year-on-year. It is estimated that the supply of vegetables will reach 200 million tons before and after the Spring Festival next year, up 7 million tons year-on-year.

It is unlikely that two "vegetable basket" products will increase their prices significantly.

The Ministry of Agriculture and Rural Affairs predicts that with the approach of the New Year’s Day and the Spring Festival, the price of "vegetable basket" products will remain high overall, but it is unlikely to rise sharply.

Since New Year’s Day and Spring Festival are the traditional consumption peak seasons of "vegetable basket" products, and the prices are generally the high points of the whole year, this year, the factors of increasing production and transportation costs caused by the sharp increase in prices of fertilizers and diesel will be superimposed. Therefore, it is expected that with the approach of the two festivals, the prices of "vegetable basket" products will generally remain at a high level. If there is no large-scale disastrous weather in the later period, it is unlikely that the overall "vegetable basket" products will rise sharply.

Take measures to ensure the supply of vegetables in winter and spring

The relevant person in charge of the Ministry of Agriculture and Rural Affairs also said that in the coming period, four measures will be taken to ensure the supply of winter and spring vegetables, especially the "vegetable basket" products on New Year’s Day and Spring Festival.

In terms of production and supply, we will pay close attention to key areas and main varieties, do a good job in the production of vegetables in the "South Vegetable Transportation to the North" base and facilities in the north, stabilize pig production, formulate and implement emergency plans for extreme weather in time, strengthen guidance services, and ensure market supply.

In the connection between production and marketing, we will implement the green channel policy for fresh agricultural products and guide advantageous producing areas and large and medium-sized cities to establish stable supply channels.

In terms of monitoring and early warning, the monitoring and early warning of the whole industrial chain will be strengthened, and information on the production, circulation, consumption and price of vegetable basket products will be released in time to stabilize market expectations and promote the balance between supply and demand.

In terms of responsibility implementation, we will strictly implement the mayor responsibility system of "vegetable basket", and urge and guide local governments, especially municipal governments, to do a good job in ensuring the supply and price stability of "vegetable basket" products within their jurisdiction.

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　　(Reporter Wang Xiaobo)