Since the beginning of this year, innovative pharmaceutical companies have gone out to sea again. Pharmaceutical companies such as Yaoming Bio, Maiwei Bio and Anrui Bio have announced that they have reached overseas authorized transactions. The insiders believe that intensive overseas authorized transactions fully prove that the R&D strength of innovative pharmaceutical enterprises in China has been recognized by international pharmaceutical companies. The ecological pattern of domestic biomedical industry is being reshaped, and the mode of cooperation with foreign pharmaceutical companies will be more diversified in the future. With the adjustment of industry structure, it is expected that 2024 will be a year in which transactions and mergers and acquisitions among pharmaceutical enterprises will become more frequent.

　　R&D strength continues to increase.

　　With the rapid development of the industry, the research and development strength of biomedical enterprises in China has been continuously enhanced. According to incomplete statistics, there were at least 120 overseas authorized transactions of innovative drugs in China from 2021 to 2023, with a total transaction amount of nearly $85 billion. In 2024, innovative drugs went out to sea to speed up. As of January 14th, domestic enterprises have completed more than 10 foreign authorization transactions, including many transactions exceeding 1 billion US dollars.

　　Genxi Bio has announced that AstraZeneca has completed the acquisition of the company. After the merger, Genxi Bio became a wholly-owned subsidiary of AstraZeneca. AstraZeneca previously said that the acquisition of Genxi Bio will further consolidate AstraZeneca’s strength in the field of cell therapy.

　　Since the beginning of this year, several products of Anrui Bio have obtained overseas authorization, including an exclusive option and a global license agreement with AstraZeneca, and the development and commercialization of a new allosteric inhibitor targeting the mutation of epidermal growth factor receptor (EGFR)L858R as a potential new treatment for advanced EGFR mutation non-small cell lung cancer (NSCLC). With the transfer agreement with Avenzo Therapeutics,Inc.(Avenzo) of the United States, Avenzo will gain the global (except Greater China) development and commercialization rights of a cyclin-dependent kinase 2(CDK2) selective inhibitor ARTS-021 independently developed by Anrui Bio, and another pre-clinical project will be submitted to IND (new drug clinical trial) in early 2025.

　　Ding Qiang, co-founder and CEO of Anrui Bio, said that through cooperation, the company can obtain significant economic benefits and accelerate the development and listing of innovative drugs.

　　Chen Kan, a partner of Qiming Venture Capital, said that the cooperation between Anrui Bio and foreign pharmaceutical companies all involved small-molecule drugs, which on the one hand proved Anrui Bio’s research and development strength, and on the other hand reflected that small-molecule drugs could also be "put out to sea".

　　In addition to well-known biotech listed companies, there have been an increase in overseas authorized transactions of small biotech companies such as Yilian Bio, Anrui Bio and Bowang Pharmaceutical, as well as traditional pharmaceutical companies such as Hengrui Pharma and Haosen Pharmaceutical.

　　In Chen Kan’s view, China pharmaceutical companies and overseas pharmaceutical companies have reached a heavy cooperation, reflecting the recognition of domestic new drugs by international pharmaceutical companies. At the same time, domestic pharmaceutical companies can get cash support. In the process of cooperation with large international pharmaceutical companies, including joint promotion of clinical trials, China Biotechnology Company can also learn a lot of experience.

　　Share risks and obtain resources.

　　Ding Qiang said that cooperation with overseas pharmaceutical companies should be based on comprehensive consideration of the company’s strategic objectives, research and development capabilities and market demand. The cooperation between the company’s two pipelines and AstraZeneca and Avenzo Therapeutics is based on comprehensive considerations. Drug R&D costs a lot and risks are high. Cooperation with large pharmaceutical companies can share risks to a certain extent, especially in clinical trials and marketing stages. In addition, cooperation with overseas pharmaceutical companies can obtain many resources, including funds and market channels, which is very important for accelerating product development and commercialization. Of course, cooperation needs to consider whether the goals of both parties are the same, whether they can support their long-term development strategy, and how to protect their intellectual property rights and avoid the loss of core technologies.

　　Sinopharm plays an important role in two overseas authorized projects reached by Anrui Bio. It is reported that Sinopharm is an innovative company focusing on helping domestic biomedical enterprises to authorize projects overseas. Ding Qiang introduced that Sinopharm provided the whole process service for the company, from the preparation and modification of materials, strategic analysis and optimization, to assisting Anrui to connect and communicate with potential partners, and to negotiate and negotiate relevant terms, which greatly helped the company to reach overseas authorization.

　　For pharmaceutical companies planning to "go out to sea", Jung Lee, senior vice president of business development of Sinogold Pharmaceuticals, suggested that China Biotechnology Company must ensure that the product lines are differentiated and meet the unfinished medical needs. In addition, setting up branches overseas can better understand the current biotechnology trends and cutting-edge scientific progress.

　　Ding Qiang said that enterprises planning to go to sea need to have the world’s leading scientific research strength and unique product innovation. At the same time, it is necessary to deeply understand the situation of potential partners, especially the pipeline layout and the overall strategy of the enterprise. Multinational pharmaceutical companies have their own strategic direction and different layouts in different fields of disease treatment. A deep understanding of the business scope, market strategy and corporate culture of their partners can help the two sides establish closer and more efficient cooperative relations. In the cooperation agreement, many terms and details need special attention, including key factors such as intellectual property ownership, economic sharing, milestone payment, etc. It is necessary to make legal risk assessment and compliance preparation in advance to ensure that the cooperation activities meet the requirements of local laws and regulations.

　　Watch the three subdivided tracks

　　Looking forward to 2024, Chen Kan judged that the number of pharmaceutical companies "going out to sea" in China will remain high. From the past transactions, the clinical data of pharmaceutical companies in China have gained more and more global recognition. Overall, we are optimistic about the three sub-segments of tumor, metabolism and autoimmune.

　　Chen Kan believes that it is necessary for most new drug R&D companies to "go out to sea", especially to develop some small varieties of new drugs that are less suitable for people. Drug pricing in overseas markets is relatively high, and pharmaceutical companies "going out to sea" can expand the market and improve the input-output ratio. The domestic pharmaceutical industry will improve in 2024.

　　From the perspective of cooperation modes, Chen Kan said that there are more and more cooperation modes for domestic and foreign pharmaceutical companies, including obtaining down payment through overseas authorization, acquisition and joint development. Jung Lee believes that more and more innovative drugs from China will go global, and there will be more transactions between China biotechnology companies and multinational pharmaceutical companies than before.

　　Great Wall Securities believes that the "going out to sea" mode of Chinese pharmaceutical enterprises is mainly based on overseas authorization. From January 1 to February 4, 2024, the amount of overseas authorized transactions in China reached 9.146 billion US dollars. In 2024, China’s pharmaceutical "going out to sea" is expected to explode.

　　Cctv news(Reporter Wei Junhao) As the first dictionary in China, how many words are included in Shuo Wen Jie Zi? How to build a bridge between ancient characters and later generations?

　　On February 20th, "Freehand brushwork in China — — Exploring the Origin of Chinese Characters ",the online theme propaganda interview group entered the Xu Shen Cultural Park in Luohe City, Henan Province, to see how Xu Shen, the sage of Chinese characters, explained Chinese characters and opened the door to Chinese characters.

　　In September 121 AD, Xu Chong, the son of Xu Shen, a famous Confucian scholar and philologist in the Eastern Han Dynasty, presented Shuo Wen Jie Zi to Emperor Han An. China’s first dictionary came out.

　　This book, which took Xu Shen’s life’s efforts, has 15 volumes, including 9353 words, 1163 "tautology" (i.e. variant characters), and 133441 words for explanation and explanation. Zhang Han, deputy director of Xu Shen Cultural Research and Protection Center, said that Xu Shen put the original scattered Chinese characters into 540 radicals by analyzing the font structure, and created a dictionary compilation method with radicals as the command, which made the shape, sound and meaning of Chinese characters tend to be standardized and unified.

　　Since then, there has been a unified standard and norm for Chinese character writing, both official and folk, which has been followed by future generations and has been used to this day.

　　According to reports, the earliest writing system in China, represented by Oracle Bone Inscriptions, has undergone profound changes for thousands of years and has written a profound history of Chinese civilization, among which Shuo Wen Jie Zi played an important role.

　　Shuo Wen Jie Zi has also become the first most authoritative Chinese dictionary in China. It is highly praised by emperors and literati in previous dynasties for its ladder and bridge to study pre-Qin characters. After reading this book, Zeng Guofan in Qing Dynasty spoke highly of it: "Xu Shu has only 200 words, and the ancient mirror has swept away the dust for thousands of years. Seal script has become popular, and the explanation is especially refreshing. The old Confucianism in Ganjia is elegant and elegant, and the strict section in the southeast is unparalleled. " After reading this set of Shuowen Jiezi, you will be familiar with the history of languages for thousands of years.

　　Xu Shen was also honored as "the sage of Chinese characters" and "the master of Chinese characters" by later generations. Today, more than 1000 years later, in order to carry forward Xu Shen culture and inherit Chinese character civilization, Luohe, the hometown of Zisheng, has built Xu Shen Cultural Park, a national 4A-level cultural tourist attraction, held many international seminars on Xu Shen culture, organized and carried out projects such as Xu Shen culture entering the campus, family and community all the year round, started the construction of a famous Chinese character cultural city, and promoted Chinese characters and Xu Shen spirit with the help of the whole city.

Yin Xiaotian’s cheating marriage incident has once again turned over the knife door a few years ago. Today, people at that time responded in succession.

As the man in charge of the two incidents, Yin Xiaotian publicly responded to the divorce incident in Weibo, saying that he reflected on the failed marriage and missed his children very much.

It seems that the mood is really stable and good as the agent said.

However, compared with Yin Xiaotian who lost his marriage but won the hearts of the people, it is hard for the backbone of the knife gate.

The public opinion of the whole network is basically the same, supporting Xiaotian to stab the knife.

Under the anger of the public, most members of the Knife Inserting Sect kept silent, but some of them took the initiative to jump out and complain.

Like Huang Jue.

I have a lot of complaints about having to be fired every time there is news in Yin Xiaotian.

He sent a long microblog about what he knew.

Huang Jue said that what Bian Xiaoxiao told him was that Yin Xiaotian couldn’t turn his back on her, but he supported Bian Xiaoxiao in Weibo because he believed in her. He also contacted Yin Xiaotian and the crew, but they didn’t get a response.

Now Huang Jue said that he hoped the two sides would reach an understanding and loved Yin Xiaotian himself.

As for Jerry Lee, it is much more intense.

Li Chenfang directly issued a lawyer’s letter saying that he had suffered cyber violence, saying that the so-called knife-inserting incident was pure slander and rumor.

But netizens don’t buy it.

Jerry Lee cries injustice, but netizens don’t believe him. Why don’t we just tell the evidence?

Today, I want to tell you these contents. First, the whole process of resuming knife-inserting teaching and knife-inserting incident. Second, what will happen to King Yin Xiaotian?

The great influence of the knife-inserting teaching event can be seen from Baidu Encyclopedia’s special filing for him.

The list of key members is as follows, and netizens also arranged posts in a spoof.

Let me introduce the parties to the incident first, if Yin Xiaotian and Bian Xiaoxiao are both very close.

Yin Xiaotian’s representative works are "One Meter of Sunshine" with Sun Li and "What can I do to save you and my love" with Liu Ye.

Bian Xiaoxiao’s masterpiece is the incident of being beaten by Yin Xiaotian.

The specific process is as follows:

On February 24th, 2012, in Weibo, the assistant of actor Bian Xiaoxiao publicly accused Yin Xiaotian of playing a big role in the crew and hitting Bian Xiaoxiao because of his disagreement.

But Yin Xiaotian denied hitting anyone, saying that he had never touched Bian Xiaoxiao with a finger.

Later, Bian Xiaoxiao personally accused Yin Xiaotian of being cruel, saying that Yin Xiaotian pushed her and scratched her hair, and finally appealed to girls to know how to protect themselves when they were outside.

As soon as the eye-catching event of a famous actor hitting a woman came out, the heat immediately went up.

To add fuel to the fire, Bian Xiaoxiao’s star classmates stood up and accused Yin Xiaotian of demanding an apology, which formed a siege wind, which instantly detonated the whole network by holding a group.

Jerry, who had a good personal relationship with Bian Xiaoxiao, was the first to make a statement, saying that he had confirmed the incident as true and asked Yin Xiaotian to reflect.

Jerry’s close lover, Li XiaoLu, kept up with her, saying that good people have discerning eyes.

Yin Xiaotian’s brokerage firm said that Bian Xiaoxiao’s swearing first and beating the rake was malicious speculation, while Yin Xiaotian exercised restraint all the time and didn’t start work.

Bian Xiaoxiao denied the hype, saying that swearing was a counterattack against Yin Xiaotian.

When the two sides held their own words, Yang Zi, the overbearing president of the entertainment circle, appeared.

Need to introduce, his wife Eva Huang is also a classmate of Bian Xiaoxiao.

Yang Zi sent out two fuzzy screenshots in Weibo, saying that he got the video, which can confirm that the shoving incident did happen.

Later, Yin Xiaotian denied that the pusher in the screenshot was himself, and requested that the video be released.

But Yang Zi said, I have no obligation to publish the video.

In the absence of video, as soon as the screenshot of Yang Zi came out, people in the circle supported Bian Xiaoxiao with confidence and boldness like reassurance.

Jerry Lee, Du Chun, Huang Jue and Xue Jia’ ning forwarded them one by one, demanding an apology from Yin Xiaotian.

Weibo of Wang Luodan et al. can’t be found at present because of its age and long deletion.

Among them, Du Chun is the happiest one.

Among the people who supported Bian Xiaoxiao, Du Chun and Jerry Lee were also the most criticized.

The reason is very simple. Others may stand in line because of their close relationship or women’s position.

But Du Chun and Jerry Lee, and Yin Xiaotian used to be very intimate.

Usually it’s all kinds of blessings and praises.

But in the stabbing incident, they were the ones who lashed Yin Xiaotian the most fiercely.

How did it end in the end?

It’s also ridiculous to say.

The video was released, and it is impossible to prove that Yin Xiaotian was rough on Bian Xiaoxiao from the video content.

The crew also replied that it was just a quarrel and no violence.

The administrator of the shooting scene also said that he didn’t see anyone hitting him, but only heard the actress screaming and leaving.

Judging from the situation of all parties, there are definitely conflicts, but there is no such thing as everyone being rough.

And the two sides have different confessions. The man said that the woman lost her temper and hit people for no reason, and the woman said that Yin Xiaotian wanted to soak up her attempted lynching.

Finally, things are strangely reconciled.

Yin Xiaotian and Bian Xiaoxiao openly interacted with Weibo, and performed a happy ending.

Bian Xiaoxiao said, we will be more loving in the future.

What the hell is this?

Onlookers have also deleted Weibo.

But Li Chenze Weibo continued to plead for himself, saying that he had not wronged Yin Xiaotian.

Now Jerry Lee has come out to plead for himself and send a lawyer’s letter, looking forward to seeing him really sue someone and see how to provoke him.

The second question is how Yin Xiaotian got burnt.

There has always been a legend in the Jianghu. Yin Xiaotian, who used to be called the "Four Youngsters" with Huang Xiaoming, Nie Yuan and David, would have become a superstar if it hadn’t been for the knife-inserting incident.

Is this really the case?

It doesn’t seem certain.

In "What Can I Save You My Love", which is always on everyone’s lips, Yin Xiaotian is only male No.2, and male No.1 is Liu Ye.

Another of his masterpieces, One Meter of Sunshine, is Peter Ho.

That is to say, Yin Xiaotian is actually no masterpiece of the male master.

What’s more, what can I do to save you and my lover was already in 2002, and in the next 10 years, his plays almost didn’t respond.

Accurately speaking, it takes luck to become popular. Yin Xiaotian’s paste has nothing to do with the knife-inserting incident.

On the contrary, the knife insertion incident was the last climax of his career.

There’s nothing wrong with Yin Xiaotian being the victim of the stabbing incident, but it’s also an exaggeration for the masses to say that without this incident, Yin Xiaotian would be very popular.

Everyone who read the article last night should have found that when I wrote about Yin Xiaotian’s marriage change, I didn’t mention the teaching of inserting knives.

To tell the truth, I think career and love are two different fields. Yin Xiaotian’s cheating on marriage and his encirclement by the knife-inserting teaching are completely unrelated events. In addition, his ex-wife Ha Linna was a carefully selected marriage partner under various conditions offered by Yin Xiaotian’s family. I really can’t find a reason to force this cheating farce and knife-inserting.

Reasoning is one yard at a time.

Yin Xiaotian was the victim of the Daoism incident, but the decline of his career had nothing to do with the incident. On the contrary, the incident was quickly reversed and netizens supported him.

The woman didn’t reply to the cheating incident. Yin Xiaotian’s personal mood was very stable, and he was in a good mood, and he didn’t want to seek justice at all. There was no need for us to take sides too early.

The only feeling is that the winner of this world has never been a kind person.

This article comes from Phoenix and only represents Phoenix’s viewpoint from the media.

　　How do new Chinese immigrants overcome the difficulty of studying?

　　When new Chinese immigrants come to foreign countries and work hard, it is often difficult to take care of their children’s studies. In recent years, some young Chinese immigrants have gone abroad to study, but they are also faced with challenges such as different study environments in foreign countries and family financial difficulties, resulting in some dropouts. Let the children of new immigrants and young new immigrants better integrate into the new learning environment and ensure their academic success, which requires better home-school cooperation and better system design at the social level.

　　It is not common to play truant and work.

　　When new Chinese immigrants first arrive in the United States, they face many difficulties, and the education of their children is one of them.

　　According to the US "World Journal" report, due to the large number of young shop assistants recruited by Chinese restaurants and retail stores in new york, the problem of many new immigrant Chinese students dropping out of school is more serious.

　　According to Zhao Hongfang, a bilingual psychological counselor at Jiangbang High School in Flushing, some Chinese students are in Internet cafes all day and night. When they are familiar with the store, they actually help to watch the store at night. When asked by their parents how they have money to spend, they lie about working after class.

　　Some Chinese students don’t get along well with their parents, so they moved out at the age of 17 and watched the shop at night to earn living expenses. In particular, the owners of new Chinese restaurants in Flushing are looking for young clerks who know English, attracting a large number of dropouts. The school said that they would go to the restaurant to bring these students back.

　　However, the lack of diplomas will only bring more difficulties for new immigrants to seek a living in the United States in the future. According to the report, a survey in new york in 2015 showed that the annual salary of those without a high school diploma was only $21,121, those with a high school diploma was $31,038 and those with a bachelor’s degree was about $60,000.

　　It is worth noting that although new Chinese immigrants have played truant, worked or even dropped out of school, this is not the norm.

　　In an interview with this newspaper, Liang Guanjun, chairman of the American East Asian Association, believes that some students in every school play truant or drop out of school for some reason. "Flushing is so big, and employment opportunities are still limited. We can only say that this phenomenon exists among the new immigrants in new york, but the size of the’ large number’ in the report is debatable."

　　Even so, the difficulty in adapting to new Chinese immigrants still needs attention.

　　Inadvertence in discipline and difficulty in adaptation

　　Different from the "Chinese" born and raised in the United States, behind the new Chinese immigrants who came to the United States to work and play truant is the helplessness of their families’ inability to discipline and adapt to the environment.

　　"This is an old problem, which exists in big cities in the east and west of the United States and is quite difficult to solve." Chinese lawyer Sun Lantao said in an interview with this newspaper that Chinese in the United States often choose school districts to send their children to school. All the above phenomena occur in bad school districts. There, parents are forced to survive, sometimes working hard for 12 hours every day, and have no time to ask about their children’s learning. Children’s own English is not enough, and they are under bilingual pressure, so they are discouraged and unwilling to learn.

　　For new immigrant students, the financial hardship of their families is also a major incentive to play truant and work. "Nowadays, in the United States, it is not easy for restaurants to recruit people, so the salaries are relatively high." Liang Guanjun introduced that the monthly salary of Flushing Restaurant is about 2,800 dollars, which attracts students who can’t go on studying, and there are also cases where individual families have financial difficulties and need their children to make money.

　　The educational environment and allocation of educational resources in American society are also very different from those in China.

　　Sun Lantao introduced that the US Constitution and the constitutions of all states stipulate that any school-age children must receive compulsory education before the age of 18, regardless of whether they or their parents have immigration status. That is to say, even the children of illegal immigrants, as long as they are school-age children, no matter where they live, public schools must accept them and must not refuse them to go to school on the grounds of poor English and insufficient test scores. However, at the implementation level, the imbalance of educational resources has greatly reduced the effect of ensuring the enrollment rate of immigrant children.

　　"American culture is different from that of China, where the whole people attach importance to education. Ordinary public schools often have poor basic education. Psychological counseling and bilingual guidance advocated by the education department cannot be put in place at all because of the lack of human resources. " Sun Taotao introduced.

　　The negligence of family discipline and the difference of social environment bring poor communication between home and school, which eventually leads to inefficiency in the academic management cooperation of new immigrant children. "Chinese immigrants, Chinese new immigrants, survival is a problem, and the language is unreasonable. I don’t know how to start." Sun Lantao said that the communication information between parents and school teachers is seriously poor, which reduces the effectiveness of cooperation between schools and parents.

　　Multi-party cooperation to promote studies together

　　How to help new Chinese immigrants better integrate into the new learning environment and ensure their enrollment rate? Experts said that the joint efforts and effective cooperation of all parties are needed.

　　On the one hand, new immigrant families need to integrate into the new study environment more actively. Cai Wenyao, consultant of the American Chinese Chamber of Commerce, said in an interview with this newspaper: "Children need to get out of the comfort zone and consult more local students. Parents can also make good use of community resources and communicate with other immigrant parents who have experienced difficult stages instead of resting on their laurels."

　　At the same time, home and school also need to better cooperate, psychologically appease their children, and more effectively prevent students who want to skip classes and work from drilling loopholes in the system.

　　In an interview with the World Journal, Zhao Hongfang said that parents can take the initiative to provide contact information to the school and learn to check attendance records and grades online. If parents leave their children completely unattended, the school can report it and ask the Children’s Service Administration to intervene in the investigation.

　　On the other hand, the society can also make efforts in promoting the children of Chinese new immigrants to study.

　　"In a short time, it is still a luxury to solve the problem of young Chinese immigrants going to school." Lawyer Sun Lantao said that despite this, from the legislative point of view, with the increasing proportion of Chinese in politics, this phenomenon will attract the attention of political circles, and the education department will also strengthen investment in this group and training bilingual teachers. With the increase of corresponding educational resources and infrastructure, the current situation may gradually change.

CCTV News:According to the news of @ Fujian Meteorological Weibo, Fujian Meteorological Observatory continued to issue "rainstorm warning level IV": yesterday, there were scattered rainstorms in Fujian Province, and some of them were extremely heavy. From 06: 00 on August 19 to 06: 00 on August 20, the cumulative rainfall in 212 townships in 58 counties (cities, districts) exceeded 50 mm, of which 41 townships in 20 counties (cities, districts) exceeded 100 mm, and there was a torrential rain (rainfall of 269.9 mm) in Pingtan Haitan Street, with the maximum hourly rainfall of 132.5 mm.

Today, there are showers or thunderstorms in most parts of the province, including Zhangzhou (Zhangpu, Yunxiao, Pinghe and Huaan), Quanzhou (Nan ‘an, Anxi, Jinjiang and Huian), Xiamen (Tongan and Xiang ‘an), Fuzhou (Minqing, Minhou and Changle), Ningde (Shouning, Zhouning, Fuan and Xiapu) and Sanming (Jiangle). Local heavy rain occurred in other areas (see attached figure 2). The accumulated rainfall in 24 hours is 50 ~ 100mm, with local rainfall of 180mm and maximum hourly rainfall of 100mm. Thunderstorms are accompanied by strong convective weather such as short-term heavy precipitation and strong winds of magnitude 7-9. On the 21st, there were showers or thunderstorms in most parts of the province, and there were scattered heavy rains and local heavy rains in various cities. On the 22nd, there were showers or thunderstorms in most parts of the province, heavy rain in the northwest, local heavy rain and local heavy rain in other areas.

　　Central Meteorological Observatory (in China)At 18: 00 on October 2,continueIssue a cold wave blue warning:Affected by strong cold air, it is estimated that the temperature will generally drop by 8 ~ 12℃ in most parts of central and eastern China from 20: 00 on October 2 to 20: 00 on October 6, and the temperature will drop by 12 ~ 16℃ in central and eastern Inner Mongolia, northeast China, most of Shaanxi, southwestern Shanxi, Huanghuai, Jianghuai, northern Hunan, northwestern Jiangxi, southern Anhui, southern Jiangsu and northern Zhejiang, among which, central Inner Mongolia and southeastern Heilongjiang. On the morning of 6th to 7th, the lowest temperature 0℃ line will be located in the northern part of North China and the central part of Northeast China, and the lowest temperature 10℃ line will be located in the northeastern part of Sichuan, the central part of Hubei, the southern part of Henan and the southern part of Shandong. There will be 4~6 winds in the Yangtze River basin and its north, and gusts in high altitude areas and rivers and lakes can reach 7~8. There will be 7-8 strong winds and 9-10 gusts in the northern and eastern seas of China.

Defense guide：

1, personnel should pay attention to add clothes to keep warm; In production, be prepared for the defense against strong winds and cool weather;

2, doors and windows, hoardings, scaffolding, temporary structures and other structures that are easily blown by strong winds are fastened, and outdoor items that are easily affected by strong winds are properly placed;

3. Take shelter from the wind in sheltered places and notify outdoor workers to pay attention to safety;

4, pay attention to the latest information about the media reports of gale cooling, so as to take further measures;

5, transportation, public security and other departments should do a good job in preparing for road icing in accordance with their duties.

　　[Learning on the Road] In the first seven months of this year, General Secretary of the Supreme Leader visited and investigated six provinces, covering Chongqing, Jiangxi, Anhui, Heilongjiang, Ningxia and Hebei. In Fengyang, Anhui, when the General Secretary presided over the symposium on rural reform, he emphasized that China must strengthen agriculture, China must be beautiful in rural areas, and China must be rich in farmers. In Guyuan, Ningxia, the General Secretary said with deep affection that the Red Army’s Long March led by our party has written a heroic epic full of lofty sentiments. The new Long March to promote the cause of Socialism with Chinese characteristics should be carried out continuously and for a long time, and every generation of us should take our own long March.

　　On the way to study, I specially combed 12 sentences investigated by the Supreme Leader General Secretary outside Beijing in July this year for readers to read.

　　Chongqing investigation

　　From January 4th to 6th, the Supreme Leader made an investigation in Chongqing. On the afternoon of January 4th, the Supreme Leader had a cordial conversation with the field workers in Orchard Port, Liangjiang New Area, Chongqing. Xinhua News Agency reporter Li Tao photo

　　1. Advocating innovation, paying attention to coordination, advocating green, open planting and promoting sharing.

　　The Supreme Leader pointed out that the development concept of innovation, coordination, green, openness and sharing put forward by the Fifth Plenary Session of the 18th CPC Central Committee is a prescription for China’s economic development to enter a new normal and the world economic recovery to be sluggish. The new development concept is baton, which should be resolutely implemented. The understanding of inadaptability, inappropriateness or even violation of the new development concept should be adjusted immediately, and the behaviors that are unsuitable, unsuitable or even contrary to the new development concept should be resolutely corrected, and the practices that are unsuitable, unsuitable or even contrary to the new development concept should be completely abandoned. At the same time, the five development concepts are an inseparable whole, which are interrelated, interconnected and mutually promoted. They must be adhered to and implemented as a whole, and they cannot be neglected or replaced.

　　2. The success or failure of poverty alleviation and development depends on precision. We must identify the "poor roots" and stick to maturity and pick one.

　　The supreme leader pointed out that the success or failure of poverty alleviation and development depends on precision, and it is necessary to identify the "poor roots", clearly target, tailor-made, and prescribe the right medicine, and truly help the point and help the roots. To get rid of poverty, we should stick to maturity and pick one at a time, which will not only prevent us from not making progress, waiting for what we need, but also prevent us from overextending ourselves and seeking false reputation.

　　Jiangxi investigation

　　From February 1 to 3, the Supreme Leader came to Jiangxi to visit and express condolences to the broad masses of cadres and the troops stationed in Jiangxi. On February 2nd, the Supreme Leader paid a New Year greeting to the villagers in Shenshan Village, Mao Ping Township, Jinggangshan City, wishing them a happy life and a lucky Year of the Monkey. Xinhua News Agency reporter Xie Huanchi photo

　　3. In our country, the people are masters of their own affairs, and all leading cadres are people’s servants.

　　In the poor household Zhang Chengde’s home, the supreme leader visited room by room, sat down with the couple to calculate the income and expenses, and asked what was planted and raised at home, and what difficulties and needs were there. The fellow villagers served steaming rice fruit and asked the general secretary to taste it. The hostess said that the general secretary has done a good job for the people of the whole country and the people feel very happy. The supreme leader responded that our country is the people who are the masters of the country, and all leading cadres, including me, are people’s servants.

　　4. Proceed from reality, concentrate on the construction of inclusive, basic and comprehensive people’s livelihood.

　　The supreme leader pointed out that there is no end to safeguarding and improving people’s livelihood, only a continuous new starting point, and measures with stronger pertinence, wider coverage, more direct effect and more obvious effect should be taken to really help the masses solve problems, increase their welfare and let them enjoy fairness. We should proceed from reality, concentrate our efforts on building an inclusive, basic and comprehensive livelihood, continuously improve the co-construction capacity and sharing level of public services, weave a "safety net" for people’s livelihood, eliminate hidden dangers, and ensure that the people live and work in peace and contentment and the social order is stable and orderly.

　　Anhui investigation

　　From April 24th to 27th, the Supreme Leader made an investigation in Anhui. This is the afternoon of April 24, when the Supreme Leader learned about poverty alleviation from the villagers in Dawan Village, Huashi Township, Jinzhai County, Lu ‘an City. Xinhua News Agency reporter Li Xueren photo

　　5. To deepen reform in an all-round way, it is essential to stimulate motivation and let the people have a sense of gain.

　　The supreme leader stressed that the new round of reform is characterized by more hard bones, more tough battles and more cheese. To deepen the reform in an all-round way, we must first cut the blade inward and dare to make self-revolution. The key point is to break the word and face difficulties. We must fundamentally stimulate motivation and let the people have a sense of gain. Party committees and governments at all levels, as well as leading cadres at all levels, should put themselves into thinking, discussing and grasping reform, and strive to be the pioneers of reform. List reform topics and set reform measures, closely meet the needs of the masses, listen carefully to their opinions, and let the people make contributions and gain more benefits in the reform.

　　6. China must be strong in agriculture, China must be beautiful in rural areas, and China must be rich in farmers.

　　The Supreme Leader emphasized that China must be strong in agriculture, China must be beautiful in rural areas, and China must be rich in farmers. We must persist in taking solving the "three rural issues" as the top priority of the whole party’s work, intensify rural reform under the new situation, strengthen urban and rural planning, fully implement the policy of strengthening agriculture, benefiting farmers and enriching farmers, and promote a solid agricultural foundation, rural harmony and stability, and farmers live and work in peace and contentment.

　　Heilongjiang investigation

　　From May 23rd to 25th, the Supreme Leader made an investigation in Heilongjiang. On the afternoon of May 23rd, the Supreme Leader had a cordial conversation with his family and neighbors at the home of Liu Yangshun (fifth from left), an employee of Xishui Management Office of Shangganling Forestry Bureau in Yichun. Xinhua News Agency reporter Li Tao photo

　　7, food security is an important foundation of national security, protect farmers’ enthusiasm for growing grain.

　　The supreme leader pointed out that farmers’ professional cooperatives are an effective organizational form to drive farmers to increase their income and develop modern agriculture. It is necessary to sum up and popularize advanced experience and further run the cooperatives. The Supreme Leader stressed that food security is an important foundation of national security, and it is necessary to innovate the grain production and operation mode, optimize production technical measures, implement various support policies, protect farmers’ enthusiasm for growing grain, and strive to improve the efficiency of grain production.

　　8. Changing the mode and adjusting the structure is hard work, not hard work.

　　The supreme leader pointed out that at present, China’s economic development is at a critical juncture of changing the mode and adjusting the structure, which is not only a critical period for climbing over the ridge, but also a window period for making great achievements. Only by making a concerted effort to promote the supply-side structural reform in a down-to-earth manner can China’s industrial structure level and social productivity level make a big leap. If you look around in policy and dabble in work, you will delay the opportunity. Changing the mode and adjusting the structure is hard work, not hard work. We must turn policies into actions and make every effort to fight a tough battle.

　　Ningxia investigation

　　From July 18th to 20th, the Supreme Leader made an investigation in Ningxia. On the afternoon of July 18th, the Supreme Leader had a cordial conversation with his family and villagers’ representatives at Mark Jun’s home in Yangling Village, Dawan Township, Jingyuan County, Guyuan City. Xinhua News Agency reporter Li Tao photo

　　9. Every generation of us should take our own long March.

　　The Supreme Leader said with deep affection that the Long March of the Red Army led by our Party wrote a heroic epic full of lofty sentiments. The great Long March spirit is a vivid reflection of the Communist Party of China (CPC) people’s revolutionary style, and we should continue to combine the new reality to inherit and carry forward it. The new Long March to promote the cause of Socialism with Chinese characteristics should be carried out continuously and for a long time, and every generation of us should take our own long March.

　　10. We should adhere to the principle that time is subordinate to quality, scientifically determine the time to get rid of poverty, and do not make layers of overweight.

　　The Supreme Leader pointed out that poverty alleviation and development have reached the stage of conquering the last bastion, and most of them are poor in poverty and trapped in poverty, which requires greater determination, clearer thinking and more precise measures. We must adhere to the principle that time is subordinate to quality, scientifically determine the time to get rid of poverty, and do not engage in layers of overweight. We must really help the poor, help the poor, and get rid of poverty.

　　Hebei investigation

　　On July 28th, the Supreme Leader visited Tangshan City, Hebei Province. This is the supreme leader visiting paraplegic patients in the activity room of Tangshan paraplegic sanatorium and enjoying the erhu accompaniment "Singing a Folk Song for the Party". Xinhua News Agency reporter Xie Huanchi photo

　　11, improve the national awareness of disaster prevention and relief, and comprehensively improve the national comprehensive disaster prevention, mitigation and relief capabilities.

　　The supreme leader emphasized that fighting against natural disasters is an eternal topic for human survival and development. We should handle the relationship between good people and nature more consciously, correctly handle the relationship between disaster prevention, mitigation and relief and economic and social development, constantly sum up experience from the practice of resisting various natural disasters, implement responsibilities, improve the system, integrate resources and make overall efforts, improve the national awareness of disaster prevention and relief, and comprehensively improve the country’s comprehensive disaster prevention, mitigation and relief capabilities. The Supreme Leader emphasized that disaster prevention, mitigation and relief are related to the safety of people’s lives and property, social harmony and stability, and an important aspect of measuring the leadership of the ruling party, testing the government’s execution, judging the national mobilization and embodying national cohesion.

　　12. Let the party’s flag fly high in the minds of the community.

　　The supreme leader pointed out that the community is the "last mile" for the party and the government to contact and serve the residents. It is necessary to improve the community management and service system, integrate various resources, and enhance the public service capacity of the community. Community work should always carry out the Party’s purpose everywhere, let the Party’s banner fly high in the minds of the community masses, and let the party member in the community give full play to its role in serving the masses and show a good image.

　　Text/a big wave

　　Appraisal object: The Big Secret of Love Pets 2. Release date: July 5.

　　The audience of "pet secrets 2" is very clear, that is, there are two categories. One of them is a pet lover like me, and the other is the "Xiong Haizi" that makes most adult audiences feel shocked when they see it.

　　I chose a very tricky time to watch movies, a non-weekend afternoon. However, it’s summer vacation now, and there’s basically no way to avoid the cute little audience except choosing the zero-point file. Therefore, although there were only ten spectators in the audience, apart from me and a couple, it was a "family fun" combination of two couples with three children, and this 3/10 audience had brought three live broadcasts with different themes before the opening of the commercial, including the "brothers throwing drinks at each other" with the most intense drama conflict.

　　I was worried that I would definitely not be able to watch the film well, and even prepared for the worst when I left midway. But it turns out that I worry too much — — Except for an episode in which a baby lost patience in the back row because of too long English lines, he climbed over three rows to look at me. Generally speaking, I gained a quite peaceful and comfortable viewing experience when I watched "Pet Secret 2".

　　This is what I think, the essential quality of mature cartoons — — It can make the small audience converge on the exuberant energy that needs to gush out all the time and consciously focus on the screen in front of them. This is not easy to do, especially when young children come across the original English. This means that films can only be captured by faster pace and more information, and for this reason, you have to spend more time and money on production.

　　There is no doubt that in this respect, this sequel to Universal is as sincere as the previous one.

　　So, is the other audience satisfied? The answer should also be yes. Like the previous work, the sequel focuses on "What is your pet doing when you are not at home". Meng Chong continues to personify, and it also continues to bring the contrast of "the owner is in and out". For the audience who naturally like pets, the whole film is a very qualified scene of "cloud sucking dogs" and "cloud sucking cats". The film obviously pays great attention to the feelings of this audience, and many jokes are tailored for them. For example, the dog who went out was originally in high spirits. When he walked halfway, he found that he was going to see a doctor, fearing that he would fall to the ground on the spot. For example, the talkative dog boss has the only lamella, "moving my basin is hurting my dignity"; For example, all cats love to chase little red dot and regard catching it as the highest achievement of cat life … … These terriers, people who have owned cats and dogs or cared about pets, know better and can laugh more.

　　And if you are the third group of people besides this, Pet Secret 2 may not be suitable for you. It doesn’t provide thinking space for you to rise from "dog life" and "cat life" to "life", so you may only leave an impression of being too naive after reading it. It doesn’t matter, it’s not a product made for you, just avoid it.

　　Guangming Daily, Beijing, November 2 (Reporter Yang Shu) A critical developmental period of mammalian fertilized eggs after implantation in uterus is called "gastrula movement". On October 31st, 2019, the international journal Science published a research achievement from China Academy of Sciences online. The research team successfully reproduced the development process of primordial movement of primate embryos for the first time by culturing cynomolgus monkey embryos in vitro.

　　The research results were jointly completed by Institute of Zoology, Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, and Innovation Institute of Stem Cell and Regenerative Medicine, China Academy of Sciences. Many scientists have commented that uncovering the mystery of this critical stage will provide important data for human beings to deeply understand embryo development and optimize assisted reproductive technology.

　　Wang Hongmei, a researcher at the Institute of Zoology, Chinese Academy of Sciences, said that gastrula movement is one of the most important stages in the early development of animal embryos, and abnormality in this process can easily lead to pregnancy failure or organ development defects, and human women of childbearing age often have a risk of spontaneous abortion of 20% ~ 30% at this stage, so gastrula movement has high research value. However, the gastrula movement occurs after the embryo is implanted in the uterus. Due to technical and ethical restrictions, scientists are "invisible and intangible" about this development stage of primate embryos.

　　This time, the research team selected a primate close to human beings — — Crab-eating monkeys as the research object. By establishing a mature embryo culture system in vitro, the researchers successfully cultured the cynomolgus monkey embryos to 20 days after fertilization, thus highly reproducing the development process of embryo gastrulation, and proving for the first time that primate embryos can develop to gastrulation in vitro without maternal support. At the same time, researchers have also obtained the gene expression characteristics of amniotic cells during the early embryonic development of primates, and redefined various cell types of early embryos of primates.

　　Qiao Jie, an academician of China Academy of Engineering, said: "Monkeys are considered as reliable animal models for studying human physiology and pathology. This achievement will greatly improve our understanding of primate and human early embryonic development, especially for the discussion of the causes of adverse pregnancy and fetal malformation."

　　Sha Jiahao, a professor at the State Key Laboratory of Reproductive Medicine of Nanjing Medical University, said that this achievement is an important basic breakthrough in the field of biology, which not only fills the theoretical gap in the mechanism of embryo development in higher animals, but also provides basic theoretical guidance and develops new treatment methods for clinical treatment of infertility and prevention of birth defects. In addition, it is also of great significance to the research of regenerative medicine and will promote the development of human reproductive medicine.

　Today, King of Barbecue released a preview and poster, and the film will be launched on November 12th. The film is directed by Cui Zhijia, co-directed by Zi Wang and starring Cui Zhijia, Sun Yue, Lao Si, Zhang Qi and Guo Xiangpeng. The film vividly depicts that Li Yanxi, a humble migrant worker, was forced to switch to a barbecue shop, presenting the audience with a unique barbecue culture and wine table culture in Northeast China.

Cui Zhijia Sun Yue HappyAssemble,barbecuelarge-scale warbe poised for

In today’s preview, Li Yanxi, played by Cui Zhijia, returned to the company as soon as possible in order to alleviate the contradiction between Zheng Yan and his son, and tried his best to interfere with Zheng Neng’s barbecue restaurant. After frequent failures, he decided to compete fairly, so he and his partner triggered a barbecue war in a series of fancy operations. The bold character of the Northeastern people is perfectly presented in the joyful and funny atmosphere, and the humorous lines with a strong Northeast accent are also in stitches. The overall point of view and laughter are both wonderful.

The fixed poster exposed together with the notice is also very eye-catching. The poster mainly adopts two colors of red and yellow, which is very pyrotechnic with warm lighting. Cui Zhijia at the barbecue table laughed heartily with kebabs in his hand, and the objects in the hands of the other four people also conveyed a lot of information. The dazzling "big gold chain" on Old Four’s body, the barbecue held high by He Yutong, the beer in Sun Yue’s hand and the banner of "Opening for Business" in Zhang Qi’s hand fully showed the lively atmosphere and strong northeast atmosphere of the barbecue shop, and it was really expected that the title of "King of Barbecue" would fall.

The best taste in the world is barbecue, and some people have feelings and stories.

Some people say that if the barbecue has an ID card, then its household registration must be in the northeast, which shows that the status of the northeast in the barbecue industry is really unshakable. "King of Barbecue" takes barbecue as the carrier, and tells the story of Li Yanxi, who accidentally became the owner of barbecue shop, who fought fiercely with her competitor Zheng Neng to become the king of barbecue. In the competition between the two barbecue shops, the fancy "marketing" of Li Yanxie and Zheng Energy shows a strong human fireworks and authentic comedy culture in Northeast China.

Not only that, but there is also a warm core hidden under the humorous shell of the film. Behind Zheng Yanpai’s employee Li Yanxie’s ruining his father’s barbecue shop is his rare filial piety, and his father’s hard persistence is because the barbecue shop carries the memories of him and his son, and Li Yanxie also gains the understanding and support of his close comrades-in-arms and his wife in the process. Can Zheng Yanxie and his son, who lack communication, be reconciled with Li Yanxie’s help? The answer has yet to be revealed by the audience themselves after the film is released. The King of Barbecue, by depicting three main emotional lines, shows the delicate and warm side of the generous and humorous character of the Northeast people, making people feel the deep warmth in the film while enjoying the joy.

Comedians are United, and high-energy laughter never stops.

Through a small barbecue, the film shows people the barbecue culture and wine table culture with Northeast characteristics, and the stories of laughter and tears also let people know the positive and optimistic attitude and warm and generous personality of the Northeast people.