Increased ultraviolet radiation during the Permian extinction? Evidence of "sunscreen" in fossil pollen grains

The extinction at the end of Permian 252 million years ago caused the extinction of about 81% marine species and 89% terrestrial species. The main reason is believed to be the environmental change caused by large-scale volcanic eruption, but there is still no direct evidence that environmental factors affect terrestrial ecosystems. In cooperation with foreign counterparts, researchers in China discovered the direct evidence that the destruction of the ozone layer led to the extinction of terrestrial life at the end of Permian by studying the changes of "sunscreen" content in fossil pollen grains during this period.

The research results were published online in the internationally renowned journal Science Advances on January 6, 2023.

Black shale at the end of Permian in Qubu section of southern Tibet. Photo courtesy of Nanjing Institute of Geology and Paleontology, CAS

Pollen fossils found in Permian-Triassic transitional strata in Qubu section. Photo courtesy of Nanjing Institute of Geology and Paleontology, CAS

Volcanic eruption led to mass extinction of land? There was a lack of direct evidence

The extinction event at the end of Permian was the largest extinction event in Phanerozoic. Scientists generally believe that the increase of global greenhouse gases caused by the eruption of Siberian igneous province at the end of Permian, global warming and ocean acidification may be the main causes of this extinction. However, there are still many debates about how these environmental factors affect terrestrial ecosystems.

Some palynologists have found some deformed spores and pollen in the continental Permian-Triassic transition section. It is speculated that these deformed spores or pollen may be caused by the increase of ultraviolet radiation induced by the destruction of the global ozone layer caused by halogen elements ejected from the Siberian igneous province. However, the study of abnormal spores and pollen produced in modern plants shows that the environmental background of these abnormal pollen and spores is very complicated, and drought, air pollution and plant trauma may all induce abnormal spores or pollen to be produced in plants. Therefore, the discovery of a small number of abnormal spores and pollen in the continental Permian-Triassic transition section cannot directly prove that there was an increase in ultraviolet radiation caused by the global ozone hole during the extinction at the end of Permian.

Using the content of "sunscreen" to deduce the intensity of atmospheric ultraviolet radiation

Plants need sunlight for photosynthesis to provide energy for plant growth, but at the same time, it is necessary to avoid the damage of harmful ultraviolet rays in sunlight to genetic information in plants, especially in plant reproductive cells (spores and pollen). In order to adapt to the terrestrial radiation environment, terrestrial plants have evolved some regulatory mechanisms to reduce the damage of ultraviolet rays to plants. In the germ cells of plants, this mechanism is manifested in that there are a large number of compounds-coumaric acid and ferulic acid-in the outer walls of plant spores and pollen, which are very similar in function to "sunscreen cream". These compounds can form resonance-stable phenol free radicals and resist the oxidation caused by ultraviolet rays, thus protecting fragile spores and pollen and providing guarantee for the spread and reproduction of terrestrial plants.

Modern botanists have observed that plants can automatically adjust the content of "sunscreen" on the outer wall of their germ cells according to the surrounding ultraviolet radiation environment, and these "sunscreen" can be stored in the outer wall of inert spores and pollen for a long time. Therefore, in theory, researchers can determine the content of "sunscreen" in these spores and pollen, and deduce the intensity of atmospheric ultraviolet radiation in geological history.

"Sunscreen" is difficult to digest and has low nutrition, or leads to the extinction of insects.

According to Liu Feng, a researcher at Nanjing Institute of Geology and Paleontology, Chinese Academy of Sciences, the research team quantitatively measured coumaric acid and ferulic acid in 1011 pollen grains from Permian-Triassic transition section in southern Tibet, China. Through the big data analysis of infrared spectra produced by these pollen, the research team found that during the extinction at the end of Permian, the contents of coumaric acid and ferulic acid in the outer wall of pollen in the stratum were significantly higher than those in fossil pollen before and after extinction, which directly proved that there was an increase in global ultraviolet radiation during the extinction at the end of Permian.

The increase of ultraviolet radiation in the air has a far-reaching impact on the whole terrestrial ecosystem. Because ultraviolet rays not only have a strong killing effect on plant germ cells, but also cause damage to plant mesophyll cells. In order to resist the damage of ultraviolet rays to mesophyll cells, plants will synthesize lutein, coumaric acid and ferulic acid in their leaves, which will reduce the synthesis of chlorophyll accordingly, leading to the weakening of photosynthesis of plants, which will further weaken the absorption capacity of plants for greenhouse gases, further aggravating the global greenhouse gas increase caused by volcanic eruption at the end of Permian.

In addition, lutein, coumaric acid and ferulic acid in mesophyll are compounds that are difficult to digest and have low nutritional value for herbivores and insects, so the increase of ultraviolet radiation indirectly affects the terrestrial food chain, which may be the main reason for the extinction of terrestrial herbivores and insects at the end of Permian.

Beijing News reporter Zhang Lu

Editor Liu Qianxian proofreads Wu Xingfa.

Illegal addition of western medicine to Chinese patent medicine is harmful and deadly. "Tangzhining" rings the alarm bell.

  On January 17th and 19th, two patients in Xinjiang died after taking Tangzhining Capsule (batch number "081101") labeled "Guangxi Pingnan Pharmaceutical Factory". After investigation, the "Tangzhining Capsule" that caused the patient’s death was a counterfeit drug, and the chemical component "glibenclamide" was illegally added. According to industry analysts, patients with chronic diseases such as diabetes and hypertension are huge, which has become a "gold mine" for many black-hearted drug dealers to make money. Some products advertised as pure Chinese medicine have illegally mixed western medicine ingredients, or added pharmaceutical ingredients to health foods, which is harmful to patients’ health. This has also become a focus of supervision by law enforcement departments in various places, including Guangdong Province.


  Three chemical components are often illegally added.


  According to reports, although the current medical level has made rapid progress, there is no major breakthrough in some difficult diseases, such as diabetes, chronic hepatitis, malignant tumors, etc., and neither traditional Chinese medicine nor western medicine can achieve a complete cure. Wei Hua, deputy director of the Department of Endocrinology, Guangdong Provincial Hospital of Traditional Chinese Medicine, said that as far as Chinese medicine is concerned, its composition is complex and its effect is mild and slow, while western medicine has continuously developed some chemical drugs which are more effective, but its side effects are relatively large. In this regard, some lawless people, taking advantage of the psychological trust of patients in traditional Chinese medicine, promote so-called pure Chinese medicine and health food, and secretly add western medicine chemical components to them, so that patients feel obvious curative effect after taking it, thus increasing sales. For example, the "Tangzhining Capsule" that went wrong this time is under the banner of Chinese patent medicine.


  Wei Hua said that in addition to the glibenclamide added in the "Tangzhining Capsule" that went wrong this time, gliclazide and glipizide are the most commonly added hypoglycemic western medicine ingredients in those illegal products. According to the relevant regulations, chemical substances are not allowed to be added to traditional Chinese medicine. "Glibenclamide" has a strong hypoglycemic effect, and its pharmacological function is to promote insulin secretion and improve human insulin deficiency through metabolism after entering the blood. However, serious overdose may cause shock and even death.


  It is understood that the Xinjiang Uygur Autonomous Region Institute for Drug Inspection found that the drugs taken by the deceased during his lifetime contained about 10.33 mg of "glibenclamide" per pill. "Glibenclamide" is a second-generation sulfonylurea, which has a strong hypoglycemic effect, but adults should not take more than l5 mg per day, otherwise it will endanger the life safety of users. According to the instructions of the seized drugs, the normal dosage is 9 capsules per day, which has exceeded the maximum daily dosage by 6 times.


  You can’t add western medicine to Chinese medicine at random.


  A person in charge of a pharmaceutical factory told reporters that the incident was not accidental, and illegal drugs, health foods, western medicines and illegal propaganda occurred from time to time. According to National Medical Products Administration, they found that it is not uncommon to add sildenafil, a component of Viagra, to the "pure Chinese medicine" for treating male sexual dysfunction, and to add thyroid hormone to diet food, which can cause hyperthyroidism, so that patients who don’t know the truth suffer from side effects of drugs for no reason. This exposes a problem: most Chinese people believe that "natural drugs" have the advantages of low toxicity and side effects, and it is inevitable that they are not alert to side effects such as dependence.


  Wang Dahong, Secretary-General of the Market Working Committee of China Health Food Association, said that illegal addition of western medicine ingredients in traditional Chinese medicine or chemical ingredients in health food will do great harm to patients and should not be added indiscriminately. Doctors and patients use mixed Chinese and western medicines without knowing it, which can easily lead to repeated adverse drug reactions. For example, if diabetic patients don’t know that the Chinese patent medicine for lowering blood sugar is added with glibenclamide, they mistakenly think it is a "Chinese medicine with no toxic and side effects" and take it in excess, or take the western medicine for lowering blood sugar at the same time for "integrated Chinese and western medicine treatment", which will lead to overdose of hypoglycemic drugs and hypoglycemia, and even lead to blood sugar fluctuation of patients if they stop taking the medicine suddenly. Therefore, Wang Dahong said that the timely discovery and investigation of the problem "Tangzhining Capsule" has eliminated another safety hazard that harms consumers’ health, and the industry has been further eliminated.


  Illegal addition has four characteristics.


  Most Chinese patent medicines or health foods illegally added with western medicine ingredients have the following characteristics: First, they claim that they can cure or greatly improve certain diseases in a short period of time, and their efficacy is remarkable. Second, most drugs are sold through online advertisements, mail advertisements or health knowledge lectures. Third, most drugs or health care products are covered with legal coats. Some products are pure Chinese medicine ingredients when applying for batch number, but western medicine ingredients are added during production. Fourth, the means of addition is very secret. Knowing that the routine drug testing only examines the internal substances of drugs, criminals add western medicine ingredients to the external carriers of drugs such as capsule shell. Finally, it is suggested that consumers can check the authenticity of drugs through the official website of the State Food and Drug Administration.


  -Medical files


  glibenclamide


  Glibenclamide, alias glibenclamide, Daanning, etc., is a prescription drug and must be taken under the guidance of a doctor. It is an islet hormone and a drug that affect blood sugar, and can be used to treat mild and moderate non-insulin-dependent diabetes mellitus with unsatisfactory therapeutic effect only by diet control, but the patient’s islet β cells need to have certain insulin secretion function without serious complications, such as diarrhea, nausea, headache, stomachache, liver function damage, thrombocytopenia and other adverse symptoms. If you take glibenclamide in large quantities for a long time, it will eventually lead to hypoglycemia, nephropathy and even death.


  -Related links


  Which drugs illegally add glibenclamide?


  According to experts, in the drug treatment of diabetes, except insulin, most of them are oral drugs. Oral hypoglycemic drugs are usually divided into three categories: western medicine hypoglycemic drugs, pure Chinese medicine hypoglycemic drugs and Chinese and Western medicine hypoglycemic drugs. Generally, pure Chinese medicine has weak hypoglycemic effect, slow onset and high safety. Western medicine hypoglycemic agents take effect quickly and have great toxic and side effects. The combination of Chinese and western hypoglycemic agents is based on the pure traditional Chinese medicine hypoglycemic agents, and incorporates the ingredients of western medicine hypoglycemic agents, which not only has the advantages of rapid hypoglycemic effect of western medicine, but also has the advantages of high safety of traditional Chinese medicine. According to the person in charge of the provincial drug evaluation center, at present, only three kinds of oral hypoglycemic drugs, such as Yikai Xiaoke Pill, are officially registered in China. It is not the first time to illegally add glibenclamide. In 2005, the Ministry of Health investigated and dealt with two cases-


  ○ On June 15th, 2005, the Ministry of Health issued a notice, requiring all localities to investigate and deal with some batch numbers of "Ku Le Kang Capsule" produced by Liaoning Healthy Weiye Biotechnology Co., Ltd.. The Ministry of Health pointed out that when the relevant departments of Jilin Province supervised and inspected the health food "Ku Le Kang" capsules (approval number: Wei Shi Jian Zi [2002] No.0588) produced by Liaoning Health Weiye Biotechnology Co., Ltd., they found that the products marked with certain batch numbers contained chemical drugs. The capsule shells of samples with batch numbers of 20041201 (not for sale), 20040902 and 20041201 contain the chemical drug glibenclamide, and the capsule contents with batch number of 20050401 contain the chemical drug gliclazide.


  ○ On October 9, 2005, Jiangxi Food and Drug Administration announced that the law enforcement officers of Nanchang Food and Drug Administration had tested the drug "Tangbikang Jiangtangning Capsule" labeled as batch number 20050403082 produced by Jilin Shenhui Pharmaceutical Co., Ltd.: glibenclamide was illegally added to this Chinese patent medicine. (Reporter Roger Lee)

Editor: Liu Li

How to screen breast cancer? The screening standard suitable for Chinese is coming.

Recently, the China Breast Cancer Screening Standard (T/CPMA 014-2020) proposed by China National Cancer Center was published online in chinese journal of cancer prevention and treatment. The correspondent is Professor He Jie, director of National Cancer Center and academician of China Academy of Sciences.

As a common cancer, according to the latest global cancer burden data released by the International Agency for Research on Cancer (IARC) of the World Health Organization in 2020, there were 2.26 million new breast cancer cases in the world in 2020, surpassing lung cancer (2.21 million cases) for the first time, becoming the largest cancer in the world, accounting for 11.7% of new cancer cases. Among the newly diagnosed cancer patients, one in every eight is a breast cancer patient. China is a big country with breast cancer. In 2020, there will be about 420,000 new cases of breast cancer and nearly 120,000 deaths.

Screening, improving the detection rate of early breast cancer and precancerous lesions, and timely and effective treatment are important measures to improve the prognosis of breast cancer and reduce the risk of death. The standards put forward suggestions on the population, measures, results and management of breast cancer screening in China. We have sorted out the relevant contents, hoping to help you better understand the knowledge of breast cancer screening.

Image source: 123RF

Who should have breast cancer screening?

The standard suggests that people at high risk of breast cancer should be screened from the age of 40; The general risk population (all school-age women except the high-risk population) should be screened for breast cancer between 45 and 70 years old.

High-risk population

Women who meet any of the following conditions 1, 2 and 3 are at high risk of breast cancer.

1. Women with genetic family history, that is, women with any of the following: 1) First-degree relatives (mothers, daughters and sisters) have a history of breast cancer or ovarian cancer; 2) Among the second-degree relatives (aunts, grandmothers and grandmothers), two or more people suffered from breast cancer before the age of 50; 3) Among the second-degree relatives, 2 or more have ovarian cancer before the age of 50; 4) At least one first-degree relative carries a known pathogenic genetic mutation of BRCA1/2 gene, or carries a pathogenic genetic mutation of BRCA1/2 gene himself.

2. Have any of the following: 1) Age of menarche ≤12 years old; 2) menopausal age ≥55 years old; 3) Have a history of breast biopsy or surgery for benign breast diseases, or a history of atypical hyperplasia of breast (lobules or ducts) confirmed by pathology; 4) Use hormone replacement therapy of "estrogen and progesterone combination" for not less than half a year; 5) X-ray examination of breast after 45 years old suggests that the type of breast parenchyma (or breast density) is uneven compactness or compactness.

Note: Breast parenchyma types can be divided into fat type, scattered fibrous gland type, heterogeneous dense type (which may cover small masses) and dense type (which reduces the sensitivity of breast cancer detection).

3. Those who have any of the following two items: 1) No breast-feeding history or breast-feeding time less than 4 months; 2) No history of live birth (including never giving birth, abortion or stillbirth) or the age of first live birth ≥30 years old; 3) hormone replacement therapy using only "estrogen" for not less than half a year; 4) Abortion (including natural abortion and induced abortion) shall not be less than 2 times.

Image source: 123RF

How to screen?

General risk population: breast ultrasound examination should be performed every 1-2 years; If you do not have the conditions for breast ultrasound examination, you should use mammography.

High-risk population: breast ultrasound combined with mammography is performed once a year.

How to understand the screening results?

Classification of diagnostic results of mammography

The diagnostic results of mammography are usually classified by the Breast Imaging Reporting and Data System (BI-RADS), which is formulated by American Radiological Society (ACR) and widely used internationally.

1. BI-RADS 0: The existing image failed to complete the evaluation, and other image examinations need to be added.

2. BI-RADS 1: normal, no abnormality was found in mammography. The possibility of malignancy is 0%.

3. BI-RADS 2: Benign findings, with definite benign changes and no malignant signs. The possibility of malignancy is 0%.

4. BI-RADS 3: Benign lesions that may be large. 0% < malignant possibility ≤2%.

5. BI-RADS 4: Suspected malignant lesions, but without typical malignant signs. 2% < malignant possibility < 95%.

6. BI-RADS 4A: low-grade suspected malignancy. 2% < malignant possibility ≤10%.

7. BI-RADS 4B: moderately suspected malignant. 10% < malignant possibility ≤50%.

8. BI-RADS 4C: highly suspected malignant. 50% < malignant possibility < 95%.

9. BI-RADS 5: Highly suggestive of malignant lesions with typical imaging features of breast cancer. Malignant possibility ≥95%.

Image source: 123RF

Classification of ultrasonic diagnosis results of breast

The classification of ultrasound evaluation refers to the screening of National Comprehensive Cancer Network (NCCN) and the BI-RADS classification standard proposed by American Radiological Society.

1. BI-RADS 0: The diagnostic information obtained by ultrasound is incomplete and cannot be evaluated, and it needs to be evaluated after other imaging examinations.

2. BI-RADS 1: negative, no abnormality was found by ultrasound. The possibility of malignancy is 0%.

3. BI-RADS 2: Benign lesions, with definite benign changes and no malignant signs. The possibility of malignancy is 0%.

4. BI-RADS 3: Benign lesions that may be large. 0% < malignant possibility ≤2%.

5. BI-RADS 4: Suspected malignant lesions, but without typical malignant signs. 2% < malignant possibility < 95%.

6. BI-RADS 4A: low-grade suspected malignancy. 2% < malignant possibility ≤10%.

7. BI-RADS 4B: moderately suspected malignant. 10% < malignant possibility ≤50%.

8. BI-RADS 4C: highly suspected malignant. 50% < malignant possibility < 95%.

9. BI-RADS 5: Highly suggestive of malignant lesions with typical imaging features of breast cancer. Malignant possibility ≥95%.

Image source: 123RF

Screening result management

1. BI-RADS 1 and BI-RADS 2 need no special treatment.

2. BI-RADS 3:

The evaluation of mammography is BI-RADS 3, so it is advisable to reexamine the breast on the lesion side at the next 6 months, and reexamine the breast on both sides at the 12th and 24th months.

If the lesion remains stable, it can continue to be reexamined, and if it has not changed for 2-3 years, it can be reduced to BI-RADS 2. If the lesion disappears or shrinks during the reexamination, it can be directly evaluated as BI-RADS 2 or BI-RADS 1. Biopsy should be considered if suspicious findings are found in the lesions during the reexamination.

The breast ultrasound evaluation is BI-RADS 3, so it is advisable to have breast ultrasound reexamination in 3-6 months, and it can be reduced to BI-RADS 2 if there is no change after 2 years of follow-up.

3. BI-RADS 4A: Further imaging examination and biopsy are needed.

4. BI-RADS 4B: Further imaging examination is needed, and biopsy is appropriate.

5. BI-RADS 4C and BI-RADS 5: Biopsy should be performed.

Image source: 123RF

tag

According to the standard, the breast physiological characteristics and breast cancer epidemic characteristics of women in China are quite different from those in western countries, so we can’t copy foreign experience. Establishing breast cancer screening standards suitable for women in China will play an important role in improving the scientificity, feasibility and practicability of breast cancer screening and reducing the incidence and mortality of breast cancer.

reference data

[1] He Jie, et al.,(2021). China female breast cancer screening standard (T/CPMA 014-2020). chinese journal of cancer prevention and treatment, DOI: 10.16073/J.CNKI.CJCPT.2021.01.02.

[2] Latest global cancer data: Cancer burden rises to 19.3 million new cases and 10.0 million cancer deaths in 2020. Retrieved Nov 16 ,2020, from https://www.iarc.fr/fr/news-events/latest-global-cancer-data-cancer-burden-rises-to-19-3-million-new-cases-and-10-0-million-cancer-deaths-in-2020/

Note: The purpose of this article is to introduce the progress of medical health research, not to recommend treatment schemes. For guidance on treatment plan, please go to a regular hospital.

How much impact will China’s industrial chain suffer when the United States announces the cancellation of Hong Kong’s "special treatment"?

  This article was originally written by "Suning Financial Research Institute" in WeChat official account. The author is Tao Jin, Assistant Director of Macroeconomic Research Center of Suning Financial Research Institute. The first picture is from Yitu. com.

  Recently, official website, the US Department of Commerce, issued a statement saying that the special relevant treatment for Hong Kong has been cancelled, including the suspension of export license exemption, and the differential treatment is being evaluated, while the export policy of related technologies to Hong Kong is being adjusted. These changes mean that the United States began to restrict its exports to Hong Kong.

  Under the background of the COVID-19 epidemic, the actions of the US Department of Commerce are quite damaging to the global industrial chain system. The epidemic is wrapped in trade protectionism and continues to impact the global industrial chain system, and the risk of industrial chain interruption is accumulating.

  Compared with the global economic recession is affected by short-term external events, the impact of the industrial chain is more worrying, because the destruction of the global industrial chain system is more like a long-term and more difficult to recover.

  The industrial chain system has been destroyed, and the epidemic situation is only a fuse, but this fuse may evolve into a major blow to the globalization process. Today, globalization has a history of 600 years. Will it end because of this epidemic?

  A brief history of globalization

  Globalization originated from the great geographical discovery. During the 600 years from the 15th century to the present, globalization has been affected and hindered in various ways, but the overall trend is deepening.

  1. Great geographical discovery

  From the 15th century to the 17th century, European fleets appeared in the oceans all over the world, looking for new trade routes and trading partners to develop Europe’s nascent capitalism.

  Sailors led by Columbus and da Gama have opened up many new sea routes, and also created the "era of great navigation", which is also called "geographical discovery" in history.

  After the era of great navigation, colonialism and free trade began to appear, and globalization experienced intermittent development, reaching its peak in the 1910s, but then came World War I, when the process of globalization was paused, and then fascism appeared, which led to World War II.

  2. Globalization after World War II

  After World War II, many international organizations, such as GATT, have greatly reduced the barriers to international trade, especially the World Trade Organization, which evolved from GATT in 1995, has obviously accelerated the process of free trade and globalization in the past 30 years.

  After stagflation and local wars in 1980s, globalization began to exert its strength in 1990s and continued until the global financial crisis in 2008. During this period, the proportion of global trade in the global economy increased from less than 15% to nearly 26%.

  In 2008, the global financial crisis had a direct impact on global trade, which made countries start to consider the chain reaction of risk events brought by global contact again. However, this impact was not fatal to globalization, and trade remained large in the following years.

  In addition to trade in goods and services, international capital flows are also a major manifestation of globalization. The core member and leader of the WTO is the United States. In fact, the United States has indeed exported dollars and economic hegemony through globalization, and gained a lot of benefits. In particular, American multinational companies have made use of low-cost production factors to produce and sell nearby all over the world and made a lot of profits.

  Similar to international trade, the scale of foreign direct investment in countries around the world has been increasing since the 1990s. Despite the impact of events such as the bursting of the Internet bubble, the September 11th incident and the global financial crisis, the general trend of increasing capital flows has not changed.

  3. Globalization and China’s Reform and Opening-up.

  The accelerated globalization in recent decades has just matched the process of reform and opening up in China. China’s economic growth has experienced a rare high-speed growth in human history.

  After the reform and opening up, China actively integrated into the global free trade system led by the United States, and continued to enhance its economic strength through the strategies of "export orientation" and "import substitution". At that time, the United States was busy with the cold war with the Soviet Union. After the disintegration of the Soviet Union, it was busy exporting political, military and economic hegemony, cleaning up the "backyard" of South America, fighting two Gulf wars and catching bin Laden everywhere, which made it "too busy to look east" and its attitude towards China’s integration into the global economy was open and welcome.

  In the process of integrating into the free trade system, China’s trade scale has continued to grow, even reaching 4.62 trillion US dollars in 2018, surpassing the United States (4.28 trillion US dollars) to become the world’s largest trading country, which is quite a bit like "doing something for another". It should be said that China may be one of the countries that have benefited most from globalization in recent decades.

  Epidemic situation impacts trade and industrial chain.

  Under the epidemic, production activities in many places around the world stagnated, which directly hit trade. Since March, the increase in unemployment, the decrease in income and the suspension of production activities have caused the trade between the United States and the European Union to shrink significantly. Even Japan, which has done a good job in epidemic prevention and control, has experienced a relatively obvious decline.

  In the case of global recession and trade contraction, although China’s current domestic demand accounts for a larger proportion, it can resist the greater impact of external demand, but it is still inevitably impacted in both demand and industrial chain. What is even more worrying is that the contraction of foreign trade has caused a large number of enterprises in the foreign trade field, especially small and medium-sized enterprises, to go bankrupt and potential unemployment.

  From the historical data, the fluctuation of China’s export growth is highly consistent with the fluctuation of GDP growth. According to statistics, if the global economic growth rate drops by 1 percentage point, China’s export growth rate will drop by 6-8 percentage points. Such a large-scale contraction of export business will inevitably lead to the contraction and even bankruptcy of a large number of foreign trade enterprises.

  Because China and the global industrial chain system have formed a criss-crossing deep connection, the blow to the industrial chain also involves a very wide range of industries in China. In a large number of industries (especially automobile industry and electronics industry), China is an exporter of other countries in some links, but in other links, China is an importer of other countries. The stagnation of one link may affect the normal production of the whole industry.

  Here, give an example of my personal experience to illustrate:

  Once, the author took Didi, talked with the driver’s master, and learned that he was a builder working in a nearby construction site. He used to use his spare time to start Didi, but after the epidemic came, the construction site stopped working and he began to start Didi full-time.

  He said that the shutdown was not due to the fact that it was not allowed to resume work at home, but because a foreign key device manufacturer stopped working. Without this device, the construction process had to be suspended.

  This subverts the author’s understanding of the degree of integration of the global industrial chain, because when it comes to international trade, it is often not associated with the construction industry, but even the construction industry is now deeply bound to the global industrial chain.

  In addition, there are two factors that aggravate this influence:

  First, in the process of globalization, China is more and more deeply involved in the transmission process of global value chain. China’s participation in global value chains has reached 62% in 2017. Therefore, all kinds of raw materials and energy are cut off due to the global epidemic, which has also brought a big impact to China’s industrial chain.

  Second, China is downstream in the global value chain. The upstream degree of China in the global value chain is 1%, far lower than the 4% of open economies and 29% of the United States (in 2017). The interruption of import supply chain of upstream products, especially energy and raw materials, will have a great impact on some industries in China.

  From the import data over the years, it can be found that the import scale of raw materials, energy and primary products in China shows an overall upward trend, and a large number of export products in China are manufactured goods. It can be seen that China’s trade field is highly dependent on foreign upstream products, and the risk of "grain shortage" in China’s industrial production caused by supply shortage is still relatively high.

  Behind the impact of industrial chain: anti-globalization

  The impact of industrial chain not only comes from external events such as epidemic situation, but also is the result of intensified anti-globalization in recent years.

  1, the epidemic is the fuse.

  In January and February, after China’s production activities stopped due to the epidemic, the European and American economies were greatly affected. The supply of intermediate products and materials needed for production activities in many countries was interrupted, and more seriously, the supply of final consumer goods was interrupted, which affected the basic consumption of residents.

  In March and April, European and American countries urgently needed masks, protective clothing, ventilators and other anti-epidemic materials, but suddenly found that not only did they not have the production capacity of ventilators, but even the simplest masks could not be produced, and finally they had to rely on China for export, which not only led to an increase in prices, but also failed to guarantee the supply in time. At this time, European and American countries were alert: "You can’t put eggs in the basket of China".

  2. Trade protectionism is on the rise

  In recent years, in developed countries, due to their own reasons, such as the solidification of social class and the widening gap between the rich and the poor, most ordinary people have not enjoyed the benefits brought by globalization, and more benefits have been divided by large industrial groups and multinational companies.

  In order to safeguard the interests of the people, leaders of many countries have opposed free trade and global industrial division of labor, which has led to the rise of populism and trade protectionism, and also the phenomenon of anti-globalization. The global epidemic will inevitably lead to more intensified internal contradictions and increased social instability in Europe and the United States. This will in turn stimulate populism and trade protectionism, further aggravating the degree of anti-globalization. China has gained great benefits from globalization after its accession to the WTO, and these benefits may be reduced by the above changes in the future.

  How serious will the industrial chain impact be?

  Generally speaking, there are three forms of industrial chain impact: manufacturing industry moves to emerging markets such as India and Southeast Asia; The manufacturing industry in developed countries has returned and the industrial chain has been localized; Western countries’ restrictions on China’s imports and exports in certain fields.

  However, these three forms of shocks either have conditions that do not fully meet the reality, or have corresponding countermeasures. In the long run, China still has great opportunities and space to meet these challenges.

  1. Manufacturing industry moves out.

  Now it seems that the destination of manufacturing migration is nothing more than India, Vietnam and other markets. However, there are more or less three fatal problems in these markets: First, although the labor cost is low, the scale and quality of the labor force cannot be compared with China in the short term, the economies of scale are not obvious, and the production efficiency is not high; Second, poor infrastructure conditions, poor transportation, production equipment and other facilities, production quality can not be guaranteed; Third, the lack of producer services can not provide high-quality supporting services for the manufacturing industry. Therefore, in the short term, these countries cannot effectively undertake large-scale manufacturing.

  2. The return of manufacturing industry in developed countries.

  After the outbreak, Japan plans to allocate 243.5 billion yen from the economic stimulus plan to adjust its production line in China, of which 220 billion yen will be used to help Japanese enterprises move their production lines back to China.

  Developed countries, such as the United States, have been calling on their manufacturing enterprises to move back, but the effect is not very satisfactory. Because this kind of relocation faces two problems: first, because foreign capital has been invested in China, the cost of relocation is very large. Of course, this "moving fee" enterprise is unwilling to bear, and even the government will feel great financial pressure; Second, the cost and benefit evaluation often does not support relocation. Under the huge relocation cost, the cost of local manpower and supporting services after relocation is obviously higher than that of China, and the products produced are sold to China, and there is an extra tariff out of thin air, which is not cost-effective.

  In addition, for China, after the economy developed to a certain level, the proportion of service industry increased, while the proportion of manufacturing industry decreased, and the overall impact brought by the relocation of manufacturing industry was also discounted.

  3. Western countries’ restrictions on China’s imports and exports in certain fields.

  This may be the most intractable problem facing China in the short term, and the US Department of Commerce’s actions against Hong Kong fall into this category. However, China has a relatively complete industrial system, which can resist this risk to some extent.

  In the United Nations industrial classification, all industries can be divided into 39 industrial categories, 191 medium categories and 525 subcategories. China has 39 industrial categories, 191 middle categories and 525 sub-categories, making it the only country in the world with all the industrial categories listed in the United Nations Industrial Classification, and all the industrial categories listed in the United Nations Industrial Classification can be found in China. Among more than 500 major industrial products announced by the United Nations, China ranks first in the world in terms of output of about 220 kinds.

  Therefore, it is preliminarily judged that the impact of global supply chain interruption on China’s industrial production can be controlled in the field of foreign trade, and the risk of spreading to internal larger-scale manufacturing industry is still controllable.

  How to deal with it?

  Although in the long run, the impact of industrial chain can be effectively alleviated, but in the short term, China’s economy, especially China’s enterprises, still have to face the challenges of trade and industrial chain turmoil. In addition to the government’s hedging and rescue policies, China enterprises can adjust their business and development strategies in the face of increasingly harsh internal and external environment in order to tide over the difficulties through the following methods.

  1. Streamline business and shrink the development front.

  Faced with the shrinking demand and the interruption of supply chain, enterprises need to strictly control the business content, strengthen the management of the main business, and at the same time shrink the development front, so as to avoid more potential risks. If enterprises increase investment against the trend and implement diversified development, they may face operational risks in many fields. For example, failure in a specific market often leads to a chain reaction, which breaks through the cash flow of enterprises, resulting in damage to the main business.

  Streamlining business, at the same time, also means "reducing expenditure", strictly controlling investment, eliminating redundant phenomena, and even involving appropriate downsizing and salary reduction, so as to retain more concentrated energy to develop major businesses and enhance core competitiveness.

  2. Adjust the target market to meet the change of market direction.

  In a worse external environment, a large number of foreign trade enterprises are facing the challenge of exporting to domestic sales. Fortunately, the domestic demand market in China is constantly expanding, and new market demands are constantly emerging. Enterprises need to seize these opportunities, find the right market direction on the basis of their own operating advantages, and actively cater to the future development trend of emerging industries, such as offline to online, and seize opportunities such as Internet and platform transformation.

  3. Maintain cash flow and persist in survival.

  China’s role as a safe haven for financial assets is more obvious. Under the logic of economic development, China’s economy and assets are more attractive than before, and foreign capital continues to flow into China. It is obviously less difficult for China to stabilize its economy than other countries. Once the economy stabilizes, it is still possible for China to upgrade its position in the global economy, and continue to maintain the first position in the global consumer market scale and economic activity. At that time, China enterprises will also have broad demand again.

This article was first published on WeChat WeChat official account: Suning Financial Research Institute. The content of the article belongs to the author’s personal opinion and does not represent Hexun.com’s position. Investors should operate accordingly, at their own risk.

(Editor: Dong Yunlong)

Highlight the word "research" and make better use of teaching materials.

  Authors: Yang Haojie (Ph.D., Institute of Curriculum Textbooks, Ministry of Education) and He Chenggang (Researcher, Institute of Curriculum Textbooks, Ministry of Education)

  Recently, Publicity Department of the Communist Party of China, together with the Ministry of Education, has published an Introduction to Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era (hereinafter referred to as "Introduction"), which is a key measure to further promote the introduction of Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era into teaching materials, into the classroom and into the mind, to better implement the fundamental task of educating people, and to meet the people’s needs for high-quality teaching materials. The publication of Introduction is an important event in the political life of the party and the country, an important event in the teaching work of teachers and a happy event in the study of hundreds of millions of young students. It is necessary to fully understand the great significance of the textbook Introduction in cultivating people with the innovative theory of the party, guiding young students to establish a correct world outlook, outlook on life and values, and striving to become a new person of the times who is responsible for national rejuvenation, highlighting the word "research" and further using the textbook well.

  Adhere to the "three bases" and study the teaching materials in depth.

  Introduction consists of three parts: introduction, 17 chapters and conclusion, which comprehensively reflects the latest achievements of the modernization of Marxism in China, great practice and great changes in the new era, and is a consensus research achievement in academic circles, with authority. The vast number of front-line teachers at all levels and schools in China should study textbooks, not only by reading one step first, but also by studying one level in depth, and even more by understanding one level in detail, so as to get into their minds and hearts.

  First of all, based on the history of the party’s unity and leading the people for more than a hundred years, we should study the teaching materials comprehensively.Grasp the theme, main line and main content of the textbook "Introduction" as a whole, grasp the theoretical panorama of the latest achievements in the modernization of Marxism in China, and make sure that you really learn, believe and use it.

  Secondly, based on the great practice and great changes in the new era in the past ten years, we should study the teaching materials in depth.Summarize and clarify the basic context of the textbook "Introduction", strengthen the thinking of historical logic in great practice, realistic logic in great change and theoretical logic in great achievements, so that history, reality and theory can "complement each other" in the textbook.

  Thirdly, based on the overall situation of the great rejuvenation strategy of the Chinese nation and the unprecedented changes in the world for a hundred years, systematically study the teaching materials.Under the guidance of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, we will study and analyze the complex international situation and great risks and challenges we are facing with a developmental vision and a comparative attitude, deepen our understanding of the great struggle, great project, great cause and great dream of the Party leading the people in the new era, constantly enhance our road, theory, system and cultural identity, and strengthen our "four self-confidences".

  Adhere to the "three unifications" and study textbooks on special topics.

  The textbook "Introduction" adheres to the educational law, highlights the teaching orientation, pays attention to being close to the cognitive characteristics of young students, and adapts to the acceptance habits of young people. It is an essential book and core textbook for cultivating young students to become builders and successors of Socialism with Chinese characteristics, and has applicability. As the first unified textbook that comprehensively and systematically expounds the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, colleges and universities across the country should adhere to the "three unifications" to organize special research textbooks, and generally explain the background and actual needs of the unified compilation of textbooks, the framework and theoretical innovation of textbook compilation, so as to provide scientific methodological guidance for teaching courses and using textbooks well.

  First, we must adhere to the unity of politics and academic rationality.Deal with the dialectical relationship between firm ideals and beliefs and firm truth and beliefs. Believing in truth is the basis and premise of firm ideals and beliefs. Studying textbooks is to profoundly understand the truth power and practical power of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, strengthen Marxist beliefs, the lofty ideals of communism and the common ideals of Socialism with Chinese characteristics, and further strengthen ideals and beliefs.

  Second, we must adhere to the unity of value and knowledge.Deal with the dialectical relationship between the principle of reading the original text and learning the course materials. Studying the course materials should be combined with learning the basic principles of Marxism, the principle of reading the original text and learning the "five histories". We should not only learn the main contents of the teaching materials, but also grasp the ideological science system and understand the theoretical philosophy of truth contained in the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era.

  Third, we must adhere to the unity of theory and practice.Dealing with the dialectical relationship between theoretical guidance and practical development, the purpose of learning is to apply it, and to talk about the theoretical value of Socialism with Chinese characteristics Thought, the supreme leader in the new era, guiding practical development to achieve historic changes and achievements in detail, so as to enhance the sense of practical acquisition, ability improvement and motivation of young people in the new era.

  Adhere to the "three focuses" and organize research teaching materials

  Introduction is an important achievement in promoting the construction of the teaching material system of philosophy and social sciences with China characteristics, which reflects the requirements for the integrated education of ideological and political courses in universities, primary and secondary schools, and provides a model for strengthening the construction and management of teaching materials in the new era. The professional research platform of national curriculum textbooks, the key research bases of textbook construction and the textbook research institutions in colleges and universities should gather capable forces to study the textbook Introduction, focus on the major theoretical and practical problems of textbook construction, sort out and summarize mature experiences, summarize and refine basic laws, and promote the construction of a high-quality textbook system to serve and support the high-quality development of education.

  First, focus on the innovation of teaching material construction mechanism,Carefully sort out all the links in the whole process of management research for editing and reviewing the textbook Introduction, and study the innovative practices and effective experiences in the mechanism of the textbook Introduction from the aspects of writing needs, implementation plan, team formation, discussion and review, publication and use tracking, so as to create an era model for the construction and management of the textbook.

  Second, focus on the realization of teaching materials to educate people.Accurately grasp the functional orientation of the textbook "Introduction" to cultivate new people in the era, and study the core leading role of the textbook "Introduction" in curriculum integration, teaching integration, evaluation integration and goal integration according to the requirements of ideological and political courses integration in universities, primary and secondary schools, so as to lay the foundation for the realization of all-round education, whole-process education and all-round education.

  Third, focus on the construction of teaching material discourse system,Fully understand the theoretical value of "Introduction" as an important achievement in the construction of teaching material system of philosophy and social sciences with China characteristics, accelerate the strategic goal of building a discourse system of philosophy and social sciences with China characteristics by benchmarking, study the active exploration of teaching materials in the construction of Marxist discourse system with China characteristics and times, and gradually highlight the China characteristics, China style and China style in the construction of teaching material discourse system.

Haier commander refrigerator and Haier refrigerator difference Haier commander refrigerator and Haier refrigerator introduction [detailed explanation]

  The brand awareness of Haier refrigerator is very high. Many people have heard that Haier Commander Refrigerator and Haier Refrigerator are the same. What is the difference between Haier Commander Refrigerator and Haier Refrigerator? Why is the price gap so big? The following small series will give you a specific analysis. Let’s take a look.

  Haier tongshuai refrigerator

  Commander-in-Chief is the third sub-brand of Haier Group after Haier and casarte, and it is a customized home appliance brand launched by Haier Group under the background of the Internet era. In 1998, the commander-in-chief brand was exported to the European market as an overseas marketing platform.

  Haier Group products have three brands, Haier, casarte and Commander-in-Chief. Haier refrigerator and Haier Commander refrigerator are both brands of Haier refrigerators, but they are put into different markets. Commander series belongs to Haier’s low-end and mid-end brands. In the early stage, home appliances went to the countryside as Commander refrigerators, and casarte series was the high-end brand of refrigerators.

  The product appearance of Haier refrigerator and Haier commander refrigerator may be different. Haier staff said that Haier’s commander-in-chief brand and Haier brand refrigerator are the same in terms of development and production technology, but the brands are different and the materials of some refrigerators are different. The product quality is the same, and the commander-in-chief also provides product customization.

  Generally, Haier refrigerators have refrigerator specification labels (or refrigerator nameplates) attached to the inner wall of the refrigerating room or the back of the refrigerator, which indicate the specifications, models (such as "BCD-216YH silver gray" for a 216-liter silver gray refrigerator), power, circuit diagram and so on. Haier’s products exclusively used in urban and rural areas are generally not fully labeled or not labeled at all, but the performance of the products is the same as other products. For the refrigerators exclusively used, only the refrigerators are more suitable for the supply and demand sides.

  The difference between Haier commander refrigerator and Haier refrigerator is here for everyone. You should be able to distinguish between the two refrigerators now, and also introduce the relationship between them. In the future, you can clearly distinguish when buying Haier refrigerator. I hope the content introduced above can help those in need.

Golden Horse Poster Gong Li Hou Xiaoxian’s side face is so beautiful! Creative signboard has not been smashed for ten years.

The 55th Golden Horse Poster


1905 movie network news Today, the main visual poster of the 55th Golden Horse Award was released, which once again firmly attracted the attention. This poster with blue and gold as the main color looks like staring at the sleeping sand dunes in the middle of the night from a distance. If you look closely, you will find that it is four faces lined up in turn. This poster was designed by Fang Xuzhong, the poster designer and visual director of the ceremony last year. It extends the concept of "everyone plays a supporting role in the film" and draws the facial contours of Ang Lee (Chairman of the Executive Committee of Taipei Golden Horse Film Festival), Hou Xiaoxian (Dean of Golden Horse Film Academy), Gong Li (Chairman of the Golden Horse Award Jury) and Xiao Ye (Judge of Golden Horse Venture Capital Conference) into dune shapes. The picture made up of tiny particles of light and shadow also seems to imply the ambiguous connection between retaining the instantaneous image with light and shadow and the passing time.

 

The main visual posters of the Golden Horse Awards pay attention to convey the understanding of Chinese movies with rich imagination and bold creativity, which has always been a highlight of the Golden Horse Awards. In recent years, almost all the main visual posters have paid tribute to Taiwan Province’s old films and filmmakers.

 

In 2017, the main visual posters of the 54th Golden Horse Awards were the "Shadow Idiot Edition" and "Fan Edition" posters with the stills of "Spring Breeze" as the main elements. The two posters project the pictures from the stills onto various screens to convey the real and illusory feeling brought by the film, which is similar to the 53rd brighter summer day designed by Huang Hai, in which the junior four illuminates the night sky with a flashlight to show that "the light of the film never goes out".

 "Shadow Idiot Edition" (54th edition) by square sequence

"Fan Edition" (54th session)


The 53rd Tribute to Guling Street by Yellow Sea

Even more amazing is the 50th Golden Horse, a Maggie Cheung-themed poster designed by Taiwan Province graphic designer Nie Yongzhen (who designed album covers for Jay Chou, Yoga Lin and others). The image of Maggie Cheung is partially cut to show different areas of the face, which means that the film is like a slice of time, so it can’t really keep time, so it can only intercept fragments.

 The 50th Maggie Cheung by Nie Yongzhen

In addition, it is worth noting that cartoonist Jimmy has designed the main visual poster for the Golden Horse Award twice. At the 39th Taipei Golden Horse Film Festival, he gathered his characters in the cinema and opened a small door under it. It not only means that the film blurs the boundary between reality and illusion, but also outlines the pleasant atmosphere of watching movies.

How many meters is the 39th by?

Another time was the 49th Golden Horse Award 10 years later. He created in oil painting for the first time in public and handed in three design drawings at one time. Two of them are a pair of dressed-up "hot horses and handsome horses", and the final picture is the picture of a little boy and a horse flying on the sea. According to Jimmy himself, this means "the pursuit of light and shadow".

 How many meters is the 49th by?

Next, please enjoy the main visual poster of the Golden Horse Award from 2008 to this decade &mdash; &mdash;


The 45th Session (2008), which rejected complexity and chose simple color blocks.

The 45th by Nie Yongzhen


         A camera head who is always running, 46th (2009)

The 46th by Wang Zhihong


          Seconds of Glass Breaking, 47th (2010)

The 47th by Wang Zhihong

       Inspired by Hou Hsiao-hsien, the 48th session (2011) is based on the essential old camera which may be closer to gaze.

The 48th by Lin Xiaoyi (cover designer of Kawabata Yasunari series)


      The Pursuit of Light and Shadow, 49th (2012)

The 51st by Xiao Qingyang (album cover artist)


       Chivalrous women with stick figures, hidden in gilded lines, 52nd (2015).

The 52nd, by Zhang Shuping.


        "The Light of Movies: Looking Back, Illuminating Forward", 53rd (2016)

The 53rd Tribute to Guling Street by Yellow Sea


       To pay tribute to the 20th anniversary of the publication of "Spring Break", selected by Wong Kar-wai himself, the 54th (2017).

The 54th session By square order

        The 2018 Golden Horse Film Festival will be held from November 8 to 25.

 

From 20: 00 on the 10th to 16: 00 on the 11th, two cases of positive infection were detected in Pinghu, Zhejiang Province.

  According to the "Pinghu Release" WeChat WeChat official account news, the Office of the Leading Group for Prevention and Control of Pneumonia in Covid-19 City, pinghu city reported on the 11th that there were two new cases of COVID-19-positive infection in pinghu city from 20: 00 on April 10th to 16: 00 on April 11th, all of which were detected at centralized isolation points and were transferred to designated hospitals for isolation treatment in a closed loop. As of 16: 00 on April 11th, 13 cases of COVID-19-positive infection have been diagnosed in this round of epidemic in pinghu city.

  Infected person 12: Li Moumou, now living in Building 1, Mingyue House, Anqiao Community, xinchang town.

  April 4th.

  13: 42 Near China Bank (Pinghu Xincang Sub-branch)

  13: 54 xinchang town Baiguo Fresh Fruit (Luchuan Xinjie Branch)

  13: 57 Near China Bank (Pinghu Xincang Sub-branch)

  14: 20 xinchang town Mingyue House

  18: 30 Xincang Town East Street

  18: 40 xinchang town Mingyue House

  April 5

  11: 41 East Street of Xincang Town

  16: 38 xinchang town Mingyue House

  April 6

  9: 31 xinchang town Cultural Square nucleic acid sampling point

  9: 59 Xincang Town East Street

  10: 19 xincang old food market qunqun grocery store

  10: 24 xinchang town Bailaoquan Brewery (pinghu city Liu’s Brewery)

  10: 30 xinchang town Mingyue House

  14: 01 East Street of Xincang Town

  16: 13 No.32 Hujiaqiao, Luchuan Community, xinchang town

  16: 40 xinchang town Mingyue House

  19: 44 Xiangyi Convenience Store (opposite to Pinghu Longdu Jiahua International Hotel)

  19: 53 xinchang town Mingyue House

  April 7th

  5: 40 xinchang town Hongguang Village Garbage Transfer Station Site

  10: 08 xinchang town Mingyue House

  10: 48 xinchang town Luchuan community nucleic acid sampling point No.5 collection site

  11: 02 xinchang town Mingyue House

  12: 54 xinchang town Hongguang Village Garbage Transfer Station Site

  13: 18 pinghu city Bamianxi Fresh Supermarket

  13: 25 xinchang town Mingyue House

  At 21: 27, it is transported to the isolation point for centralized isolation control.

  Infected person 13: Meng Moumou, female, now lives in Building 1 of Huasheng Apartment in Qinsha Village, xinchang town.

  April 5

  11: 05 xinchang town Huasheng Apartment

  11: 18 Town East Street Public Toilet in Xincang

  11: 40 Near the Cultural Auditorium of Shilu Village, xinchang town.

  14: 14 nucleic acid sampling point near xinchang town Jiaxing Deyong Textile Co., Ltd.

  14: 51 xinchang town Huasheng Apartment

  April 6

  13: 52 xinchang town Huasheng Apartment

  14: 06 Town East Street Public Toilet in Xincang

  14: 20 Near the Cultural Auditorium of Shilu Village, xinchang town

  15: 43 at the entrance of Xincang Hualian Supermarket (Jianxin Road Store)

  16: 00 Near the Cultural Auditorium of Shilu Village, xinchang town.

  18: 38 xinchang town Huasheng Apartment

  April 7th

  9: 44 xinchang town Huasheng Apartment

  10: 00 Xincang Town East Street Public Toilet

  10: 35 xinchang town Huasheng Apartment

  12: 11 xinchang town Anqiao Community Party-mass Service Center nucleic acid sampling point

  18: 58 Xincang Town East Street Public Toilet

  20: 36 van booth at the entrance of xinchang town Huasheng Apartment

  20: 41 xinchang town Huasheng Apartment

  April 8

  7: 32 xinchang town Huasheng Apartment

  7: 38 xinchang town Qinshayuan Community East Gate Nucleic Acid Detection Point

  8: 17 xinchang town Huasheng Apartment

  April 9

  8: 17 xinchang town Huasheng Apartment

  8: 25 outside Qinshayuan, xinchang town

  8: 45 xinchang town Huasheng Apartment

  18: 37 near Daiwei, xinchang town

  18: 59 xinchang town Huasheng Apartment

  April 10th

  6: 35 xinchang town Huasheng Apartment

  6: 38 xinchang town Qinshayuan nucleic acid sampling point

  7: 29 xinchang town Huasheng Apartment

  At 17: 00, it will be transported to the isolation point for centralized isolation control.

  Please take the initiative to report to the unit, the village community or the hotel at the first time if you have contact with the person or have a track intersection at the above time and place, and cooperate with the flow adjustment and related health management measures. If you conceal, report late or make a false report, you will be investigated for relevant responsibilities according to law.

  The general public are requested not to spread rumors, disbelieve in rumors or spread rumors, actively cooperate with epidemic prevention and control work, implement personal health protection measures, develop sanitary habits such as wearing masks, washing hands frequently, keeping a safe social distance, take the initiative to vaccinate Covid-19 vaccine, reduce the risk of infection and morbidity, and jointly build an immune barrier for the population.

Fine design of epidemic prevention health code

COVID-19 is still spreading around the world, and prevention and control will become the norm. How to prevent and control it efficiently and finely, and minimize the impact on people, maybe we can make a fuss about health codes.

Now the function and significance of various health codes is actually mainly to provide data by big data statistics. But not fine enough. There are mainly the following problems:

  • How to ensure the authenticity of information
  • People in high-risk areas are not necessarily high-risk, so high-risk areas should not be divided, but high-risk people should be defined.
  • Only people who are in close contact with the confirmed patients are high-risk people. It is most important to inform these people in time and check them out.
  • The core of prevention and treatment of infectious diseases is early detection and early isolation. How to find it and isolate it as soon as possible is the most important thing.

Universal testing, screening out all patients, and then centralized treatment, this is the most ideal method. However, based on the actual situation, it is more difficult to realize this. Then set up more detection links, such as the temperature detection of residential buildings, which is this role. When the abnormality is detected, further nucleic acid detection will be conducted. If the diagnosis is confirmed, all close contacts will be screened again to find the car infected person. This should be done quickly and accurately. You can realize all accounts receivable, and you should check everything.

National epidemic prevention requires a national epidemic prevention system. Everyone and each unit play different roles in the whole system. These categories are probably needed in this system:

  • Brain center cloud computing platform:Such a large amount of data and responsible data storage certainly need a powerful data storage and technical platform, and China, which has experienced the test of Spring Festival travel rush and the Double Eleven, is not lacking in this ability.
  • All-round primary inspection:This requires our Zu Guoqiang’s strong organizational ability to do a good job of detection at every small, building subway and other personnel flow nodes. The main function is to find people with fever and abnormal health codes, and send them for inspection in time if abnormal conditions are found. Do early detection and early isolation.
  • Nucleic acid detection:Rapid and convenient detection can expand the detection range. In South Korea, PCR nucleic acid detection method was adopted on January 31st, and the diagnosis result can be obtained in 6 hours. The "drive-through" detection station can detect about 380 people every day. This practice can quickly deal with a large number of testers and effectively reduce the contact between medical staff and high-risk groups. It used to take 30 minutes for each person to test, but now it only takes 10 minutes to complete. This may be used for reference.

Face recognition real name login:Nowadays, whether it is the card opening of financial banks or the real-name authentication of the three major operators, remote face recognition verification has been realized, and the uniqueness of the national ID cards provides a data basis for face recognition. Relying on the camera of smart phone, face recognition login is completed. Thereby ensuring the correctness of the information. Face recognition login+mobile phone verification code. Don’t enter complicated information such as the place of entry, the place of household registration, and the place of residence.

Close contacts real-time storage:Fine epidemic prevention is to accurately find infected people and close contacts with confirmed patients. Now the way to find close contacts is too rude. One person is diagnosed, the whole building belongs to close contacts, and someone in a train is diagnosed and needs close contacts to check the relevant trains themselves. This greatly misses these potential threat groups. Or accidentally injure someone who is not really close to you. Using the Bluetooth technology of mobile phone, you can search for additional Bluetooth devices in real time and upload them for filing. Bluetooth can search for devices within 10-20 meters, and record the contact time of storage devices and the MAC address of devices. Within 10-20 meters, those who have been in contact for more than 60 seconds are close contacts in the true sense.

Real-time location information:The record of real-time location information of mobile phone can tell you where you have been in contact with close contacts when pushing information, and provide information judgment for self-infection rate through self-judgment of personal protective measures at that time.
Real-time push of abnormal information: when someone in close contact with an individual is diagnosed on the 14th, the mobile phone will automatically push the message. The message template involves the following information: time, place, number of contacts, contact duration, and the nearest nucleic acid detection point.

For example:

Hello; At 3:50 p.m. on April 6, 2020, a confirmed patient met with you for about 10 meters for 300 seconds near Chaoyangmen subway in Chaoyang District, Beijing.

Now the nearest nucleic acid detection point is the outpatient department of Chaoyang Hospital. It is recommended that you do a good job of protection and see a doctor immediately.

There are only two states of health code, no abnormality and abnormal. Face recognition login shows the status, which will be invalid after 1 minute. You need to log in again. All residential buildings only need to check the health code, and if there is any abnormal state, they will not pass, and urge them to do nucleic acid testing. If the testing is negative, the hospital data will be restored to no abnormal state after synchronization.

Exception definition:Within 14 days, if there is a confirmed case in the Bluetooth information record, it will be displayed as abnormal.

Eliminate anomalies:Go to the hospital for nucleic acid detection. If it is negative, the hospital data will be uploaded and the abnormal state will be automatically lifted. If it is positive, the system will automatically inform the user to contact the confirmed user, and then inform the contacted user to do nucleic acid testing.

At present, the health code is too rough, and the overall structure is centralized. From top to bottom, it lacks a dimension, that is, information communication between groups. Adding this dimension can realize timely tracking and timely push, and the whole process is more automated, reducing a lot of manual intervention.

To prepare for a protracted war, make full use of existing technical means, give full play to data intelligence, and fine epidemic prevention means to minimize the impact on personnel activities on the premise of accurate positioning. I didn’t mention the issue of data security in the whole article because we can’t give up eating because of choking at this stage. The whole design is still described by big lines. If you have any shortcomings, please brainstorm and comment.

Lao Zhang, everyone is a product manager columnist. AI product manager, focusing on natural language processing and image recognition. Now he is a partner of smart insurance startup company, hoping to communicate with entrepreneurs in the field of artificial intelligence.

This article was originally published by everyone as a product manager, and it is forbidden to reprint without permission.

The title map comes from Unsplash and is based on CC0 protocol.

Excellent days are over 80%! China’s air pollution control has achieved remarkable results.

  Xinhua News Agency, Beijing, October 8 (Reporter Gao Jing) During the National Day holiday this year, Gao Lei, who works in Beijing, found that his hometown had changed a lot when he went home to visit relatives. Gaoyang County, Baoding City, Hebei Province, where his hometown is located, is undergoing the transformation from coal to gas. Gao Lei saw that the small coal-fired boiler used for heating in winter at home disappeared, and the kitchen was newly connected with natural gas pipelines and installed with wall-hung boilers. The home looked much cleaner and brighter than before.

  Replacing loose coal by changing gas and electricity is one of the important measures to control air pollution in northern China.

  Since the "Thirteenth Five-Year Plan", China’s air pollution control has achieved remarkable results. According to the data from the Ministry of Ecology and Environment, compared with 2015, the average annual concentration of fine particulate matter (PM2.5) in cities at or above the prefecture level fell by 23.1% in 2019, and the proportion of excellent days in 337 cities at or above the prefecture level reached 82%.

  In the closing year, the achievements of the blue sky defense war were even more eye-catching. From January to August this year, the average number of excellent days in 337 cities at or above the prefecture level was 86.7%, up 5 percentage points year-on-year; The concentration of PM2.5 was 31 μ g/m3, down 11.4% year-on-year. Good weather with blue sky and white clouds is becoming the norm.

  Behind more and more blue sky is a series of "combination boxing" that China has played to control air pollution. In recent years, China’s air pollution control work has been closely focused on key areas such as Beijing-Tianjin-Hebei and surrounding areas, the Yangtze River Delta region, and the Fenwei Plain, focusing on key pollutants such as PM2.5, focusing on key periods in autumn and winter, and key areas such as loose coal combustion and "scattered pollution" enterprises, and continuing to implement tough actions.

  The pilot cities of clean heating in the northern region will achieve full coverage of Beijing-Tianjin-Hebei and surrounding areas and Fenwei Plain; 86% of coal-fired power units have achieved ultra-low emissions, and about 780 million tons of crude steel production capacity has been transformed into ultra-low emissions; Carry out in-depth rectification of "scattered pollution" enterprises, industrial furnaces and key industries to control volatile organic compounds; Strengthen the pollution control of diesel trucks and vigorously promote the "revolving iron"; Deepen the joint prevention and control of air pollution in key areas and strengthen the response to heavy pollution weather.

  "The nearby village used natural gas for heating last year, which is said to be clean and warm." Gao Lei said that he believes that after coal is changed to gas, there will be more blue sky and less smog in winter.