Text/Yangcheng Evening News All-Media Reporter Li Zhiwen

At 0: 50 on January 7th, the K4562/3 train with 1813 passengers left Guangzhou Station slowly. This is Guangdong-Hong Kong-Macao Greater Bay Area’s first passenger train during Spring Festival travel rush in 2023, which marks the official start of the 40-day Spring Festival travel rush.

This year, Spring Festival travel rush is the first Spring Festival travel rush after the introduction of the "New Ten Articles" for epidemic prevention and control. The reporter observed in railway stations, airports, passenger stations and other transportation hubs that compared with the previous epidemic period, there have been many new changes in Spring Festival travel rush this year: the green code has not been checked, the nucleic acid has not been looked at, and the passenger pit stop process has become simpler; Wearing masks, protective clothing and gloves-there are fewer fully armed passengers or even out of sight; There are more and more passengers with their families, big bags and small bags, and smiling faces … In order to make passengers travel safely and smoothly, they do this.

Guangdong Provincial Department of Transportation

This year, the Provincial Department of Transportation further strengthened the linkage between departments, improved the working mechanism of Spring Festival travel rush, further sorted out the traffic jams and toll stations, strengthened the road network detection, dispatching and emergency response of important transportation corridors, key nodes and traffic jams and bottlenecks, and improved the rapid response capability.

In order to build a safe Spring Festival travel rush, the Provincial Department of Transportation will continue to implement the "one-day-one-judge" Spring Festival travel rush working mechanism, and coordinate the prevention and control of Spring Festival travel rush epidemic and the guarantee of transportation services. Do a good job in the dynamic intelligent monitoring of operating vehicles, focusing on strengthening the safety supervision of long-distance passenger transport, tourist chartered cars, rural passenger transport and dangerous goods transportation. Do a good job in the source management of passenger stations, and urge passenger stations to strictly implement the "three no-stops and six no-exits" system. Keep a close eye on key nodes such as "passenger ro-ro transportation in Qiongzhou Strait" and "four types of key ships" and strengthen waterway safety supervision.

In order to further improve the service level of Spring Festival travel rush, the transportation system of the whole province will actively carry out voluntary services such as "Warm Winter Action", "Warm Migrant Workers in Spring" and "Spring Breeze Action" to provide information consultation, civilized guidance, tea supply and other services for drivers and passengers in the past, so as to warm passengers’ way home. Strengthen the sanitation and cleaning of transportation stations, provide waiting areas and consulting services for pregnant women, children, sick and disabled passengers, and further improve the waiting environment for passengers. At the same time, strengthen the transportation service guarantee in key periods, and actively organize "point-to-point" transportation such as chartered cars, special trains and charter flights to meet the needs of people returning to work and returning to school.

This year, Spring Festival travel rush’s transportation system will fully implement the latest epidemic prevention and control optimization measures and "Class B and B management" measures of the joint prevention and control mechanism of the State Council, continue to do a good job in the normalization prevention and control of "two stations, one field, one port and one service area", strictly implement measures such as disinfection of passenger stations, service areas and means of transportation, and do a good job in cleaning the environment, ventilation and ventilation. In principle, disinfection and ventilation should be no less than once a day.

At the same time, strengthen the passenger flow organization of passenger stations, guide passengers to wait for passengers and sit in scattered places when conditions permit, and reduce the concentration of people. Long-distance road passenger drivers should try to fix the lines and vehicles during their work, and drivers of long-distance passenger lines and drivers and passengers of important energy transportation channels should try to arrange fixed rest places to prevent cross-infection.

All localities will further optimize the ticketing organization, actively provide contactless services such as mobile terminal ticket purchase and ID card checking, and guide passengers to wait for the bus (ship) and board the bus (ship) in an orderly manner. Strengthen the connection of various modes of transportation, effectively improve the efficiency of combined transport and continuous transfer, and effectively solve the "first and last mile" of passenger travel. Increase the organization and management of rural passenger transport and the delivery of transport capacity, improve the coverage of rural passenger transport lines, and ensure the travel needs of the masses.

Guangzhou Railway Group: The renovation and inspection of locomotives, vehicles, line equipment and station equipment have been completed in an all-round way.

In terms of hardware, Guangzhou Railway Group has strengthened the inspection and maintenance of service facilities and equipment. In front of Spring Festival travel rush, the ticket vending machines, elevators, air conditioners and seats were thoroughly inspected and rectified to ensure that basic services such as environmental sanitation, toilet use and boiled water supply were in place. At the same time, before New Year’s Day, the service "Keep Smooth" project in Guangdong Province was put into use as scheduled. For example, Guangzhou South Railway Station also completed the construction of Spring Festival travel rush Security Project, the west platform completed the optimization of compound security check and exit streamline, and eight channels were added at the security check and exit.

Increase investment in safety equipment. Spring Festival travel rush Former Group Company has completely completed the renovation and inspection of locomotives, vehicles, line equipment and station equipment, so as to ensure that these equipment can run safely and smoothly during their stay in Spring Festival travel rush.

In terms of service upgrading, we adhered to the standards of demand orientation and passenger satisfaction, coordinated Spring Festival travel rush, epidemic prevention, transportation and safety, focused on the service needs of passengers, and introduced 15 measures to facilitate the people and benefit the people, such as adjusting the preferential standard for children’s tickets to age according to their height, and canceling the restriction that students can only buy student discount tickets in winter and summer vacations.

Baiyun Airport: "Spring Breeze Service" Helps Passengers Travel Well

While ensuring the safe operation, Baiyun Airport practiced the "Spring Breeze Service" and launched a series of warm service measures in view of the "key and difficult points" in Spring Festival travel rush’s security work. All units in the frontcourt will strengthen the deployment of manpower, and the security inspection channels will be opened in advance according to the passenger flow situation, and all channels will be opened during the peak passenger flow period to quickly check and release passengers.

During the security inspection in Spring Festival travel rush, according to the actual demand on site, passages for "first passengers", "students returning from winter vacation" and "late passengers" were set up to provide convenience for special passengers such as those who arrive late for some reason and those who are old, weak, sick and pregnant.

Air Service Branch has set up a special service counter and a love counter at the duty officer’s counter at Gate 2 of Terminal 1 and the check-in counter at No.17 on M Island, respectively, to give priority to check-in procedures for passengers in need. For special international passengers, assist in making electronic health declaration and provide customs clearance guidelines.

The customer service center provides "artificial+intelligent" service, responds to passengers’ needs 24 hours a day, and patiently answers questions for passengers. The customer service counters at the airport provide convenient boxes for passengers, and the maternal and child rooms provide free emergency services of baby products for passengers returning home from Spring Festival travel rush. A number of warm-hearted measures meet the needs of the vast number of passengers for a beautiful trip.

Central South Air Traffic Control Bureau: Ensuring the Smooth Lifeline of Air Traffic Control Transmission during Spring Festival travel rush.

In view of the increase in flight volume, parallel epidemic prevention support, and outstanding complex weather during Spring Festival travel rush this year, the Central South Air Traffic Control Bureau properly formulated the support plan, set up the Spring Festival travel rush Support Working Group, organized a mobilization meeting for air traffic control support in Spring Festival travel rush, implemented safety responsibilities, paid close attention to the operation situation, rationally arranged the personnel on duty according to the characteristics of flight flow distribution in Spring Festival travel rush, and established a reserve team for key posts to respond to emergencies at all times.

The Technical Support Center ensures the stability and reliability of air traffic control equipment. Before Spring Festival travel rush, the new version of "Equipment Image Recognition System" was upgraded and deployed to realize intelligent monitoring of air traffic control equipment status and build a "firewall" for equipment support. The Communication Network Center will carry out special inspection of Spring Festival travel rush for air traffic control equipment, strengthen inspection of transmission pipelines, closely monitor the safety of pipelines and cables in construction sections, and ensure the smooth "lifeline" of air traffic control transmission during Spring Festival travel rush.

The Central South Air Traffic Control Bureau is also actively doing a good job in publicizing and training the new version of the emergency plan system and emergency handling cards to ensure that Spring Festival travel rush is foolproof.

Guangzhou Maritime Department: Provide 24-hour information supervision service.

It is understood that the Guangzhou Maritime Department has carried out a comprehensive safety "physical examination" on 105 passenger ferry vessels that have been put into Spring Festival travel rush, focusing on passenger-related vessels and material transport vessels such as Pearl River cruise ships and high-speed passenger ships, preventing vessels from operating "with diseases", and making full use of information means such as VTS, CCTV video surveillance system and supervision and command system, strengthening dynamic control of vessels, and releasing early warning information of bad weather in time to ensure the safety of navigation.

At the same time, we will open up a green channel for the transportation of key materials, strengthen the water transportation organization, provide 24-hour all-weather information supervision service, improve the efficiency of ship turnover and operation, ensure the safe and smooth transportation of key materials such as electric coal and grain, and ensure the production of enterprises and the living needs of residents during Spring Festival travel rush.

In addition, combined with the navigation situation of ships in the jurisdiction, Guangzhou Maritime Department rationally deployed emergency rescue forces in key waters such as the Pearl River Estuary, and did a good job in duty and emergency response to emergencies to fully ensure the safety of people’s water travel.

China Eastern Airlines: Improve the service guarantee for special passengers and actively assist passengers.

During Spring Festival travel rush, the number of elderly tourists and unaccompanied children tourists is expected to increase significantly. China Eastern Airlines has improved various service guarantees from the ground to the air since passengers purchased tickets; At present, an electronic system has been established for unaccompanied children. During the flight, flight attendants record and photograph the details and photos of small passengers, and parents can know the flight situation in real time through China Eastern Airlines official website.

This year, in Spring Festival travel rush, Shenzhen Base of China Eastern Airlines Guangdong Branch cooperated with Shenzhen Airport to launch an accurate tracing service for late-arrival passengers. During the morning rush hour, a special tracing post was set up to accurately find late-arrival passengers through the tracing system based on passengers’ appearance characteristics and security check time, and the attendants at the tracing post and boarding gate formed an effective linkage to actively assist passengers to make the trip.

In addition, passengers who take China Eastern Airlines flights at Shenzhen Airport, if they find that their ID cards and paper boarding passes have been lost after security check, can make a trip smoothly with their electronic boarding passes, and there is no need to leave the airport control area and reissue their boarding passes at the check-in counter.

Air China: Strengthen operation supervision, and continue to do a good job in production organization and emergency response under complex operation environment.

Air China scientifically co-ordinates aircraft, crew and other operational resources, strengthens flight plan management, and formulates detailed flight support plans and emergency plans in combination with weather characteristics such as frequent low temperature, rain, snow and low visibility in winter. By strengthening meteorological accurate forecast, strict flight release standards, and strengthening flight dynamic monitoring and information notification, it integrates Excellence, professionalism, efficiency and sincere service into every link of ensuring passengers’ travel, and fully guarantees the safe, stable and smooth flight operation during Spring Festival travel rush.

The front face of the 2022 overbearing 4000 adopts a larger thick air intake grille with an exaggerated front bumper, which gives a very strong sense of oppression, and the headlights are further elongated and extended to the bottom of the air intake grille, making the front face more domineering. Toyota overbearing 4000 brand-new image cross-country rough character, creating a completely different king style.

The off-road performance, reliability and comfort of 22 overbearing 4000s are all in by going up one flight of stairs, powered by a 4.0-liter V6 engine with a maximum power of 183/5600(Kw/rpm) and equipped with a 6-speed automatic manual transmission. Non-loaded body, low-speed four-wheel drive, all-terrain tires, middle and rear differential locks, and excellent data of contact angle and departure angle, Toyota Overbearing 4000 has all the rigidity necessary for a professional off-road vehicle.

The comfort of the interior space of the 2022 Toyota Overbearing 4000 shows another image. The steering wheel is novel and stout, with control keys such as audio and telephone arranged on it, which makes it feel outstanding. The new car is equipped with a very popular holographic imaging system. With the help of these cameras, no matter how crude the driving skills are, drivers can easily and confidently cope with various environmental road conditions.

Although the 2022 brand-new Middle East Toyota Overbearing 4000 adopts the design of 7 seats, it still has spacious rear space, and the electronic equipment in the car has also increased a lot, which meets the all-round needs of drivers and passengers, and the elegant new body. In addition, a big change is that the third row of seats adopts the bottom storage design, which can fold the seats into a flat storage platform, and the trunk with larger space can both store things and carry people.

Configuration: 2022 Toyota overbearing 4000 GXR configuration: sunroof, 265/55 R19 aluminum wheels, 150-liter fuel tank, rear-mounted spare tire with shell, body color electric rearview mirror, tail wing, integrated luggage rack, LED front fog lights, front and rear electric eyes Internal features: three-zone automatic air conditioning, center console, refrigerator, leather steering wheel, fabric seat, 9-inch navigation screen, 6 stereo, multifunction. Manual headlight adjustment, smart card, keyless entry safety features: 7 airbags, active traction system, reversing image, cruise control, ramp assist, Towson differential lock.

22 Middle East versions of Toyota Overbearing 4000 have simple and atmospheric design, perfect seat layout with three rows and seven seats, high utilization rate and excellent legroom performance. The four multi-function steering wheels with larger size are comfortable to use, more convenient to control and safer to drive. Although it adopts the setting of seven seats, it still has quite spacious usable space, and the electronic equipment in the car has also increased a lot to meet the all-round needs of drivers and passengers.

　Displacement (l): 3, 956. Maximum speed (km/h): 180, fuel consumption (L/100 km): 15L Engine: 6-cylinder V-type overhead double camshaft with 24 valves (connected with VVT-i intelligent timing variable valve control system), maximum power: 179(243 HP) /5200 Kw/rpm, and maximum torque: 376/. Fuel tank capacity: 87L Emission standard: driving mode: four-wheel drive, steering mode: power steering, suspension mode: front double fork independent suspension, rear four-bar linkage suspension, tires: 265/70R16, minimum steering radius: 5.7m..

　The off-road performance, reliability and comfort of 22 Toyota Overbearing 4000 are all in by going up one flight of stairs, powered by a 4.0-liter V6 engine with a maximum power of 183/5600(Kw/rpm) and equipped with a 6-speed automatic manual transmission. Non-loaded body, low-speed four-wheel drive, all-terrain tires, middle and rear differential locks, and excellent data of contact angle and departure angle, Toyota Overbearing 4000 has all the rigidity necessary for a professional off-road vehicle.

The rear space of 22 Middle East Toyota Overbearing 4000 is also remarkable. In order to make the capacity of the trunk change with the use, the Overbearing 4000 is equipped with a hidden third row of seats, which facilitates the space arrangement in the car to the maximum extent. Overbearing 4000 not only has amazing off-road performance, but also has excellent road driving performance and comfortable performance of high-end cars.

In the domestic household scooter market, it is a hot model. Since then, this car has been favored by many consumers because of its close price and good product strength. At present, 16 models have been launched for consumers to choose from, and the price range is 99,800-145,800 yuan. So is this car suitable for starting? Today, we will take the entry-level model with a price of 99,800 yuan-2024 Plus 310 Xingyao Edition as an example to analyze with you.

First of all, look at the appearance. As a new energy vehicle, AION Y does not adopt a closed front face like many pure electric vehicles, but retains the design of the air intake grille. The front of the car adopts front headlights with split design, and the interior presents a fan-shaped arrangement, which improves the recognition of the front of the car.

The side of the car body benefits from its short suspension and long wheelbase design, so when you look at it from the side, there will be an MPV atmosphere. The style of the hub is relatively simple, and it is equipped with 215/55 R17 specifications.

In the rear part, the word "AION Y" is placed in the middle of the tailgate, which looks more conspicuous. The rear design of "AION Y" is simpler, with a rich sense of hierarchy and a fuller look. The tail wing with the same color as the car body at the top has been hollowed out, and the shape of the taillight is relatively slender.

Entering the car, the interior design of AION Y is relatively simple. The center console is mainly covered by a black plaque, and the air outlet of the air conditioner is hidden under this plaque, which looks very regular. It adopts the design style of flat bottom and double spokes, and it feels good to hold. The main driver is equipped with a 10.25-inch full LCD instrument panel, and the display effect is relatively clear.

In addition, AION Y is also equipped with a 14.6-inch central control screen with built-in ADiGO 4.0 intelligent interconnection ecosystem, which supports navigation system, navigation road information display, service, Bluetooth/car phone and other functions. Moreover, the response speed of this system is relatively fast, and it is very convenient for daily use.

In terms of other configurations, AION Y comes standard with practical functions such as body stability system, brake assist, keyless start, remote start, uphill assist, and remote control of mobile App. At the same time, the whole system comes standard, which can detect the working state of tires in real time, and its performance in safety is quite good.

In terms of seats, AION Y is made of imitation leather, the front seats all support manual four-way adjustment, and the main driving seat is equipped with the function of height adjustment. The rear seats support a 40:60 ratio, which can further expand the space of the luggage compartment.

In terms of space, AION Y has a body length of 4,535 mm, a width of 1,870 mm, a height of 1,650 mm and a wheelbase of 2,750 mm. Although it is positioned as a compact SUV, such data performance has reached the new standard. Therefore, the ride space of this car is relatively spacious. The experiencer with a height of 1.75 meters sits in the front row, and after adjusting the seat to a suitable position, the head space is about one punch and three fingers. At this time, the seat is kept still and comes to the back row. There are still more than two punches in the head space and more than two punches in the legs.

In terms of storage capacity, AION Y’s luggage compartment has a volume of 405 liters, a depth of 880 mm, a width of 1020 mm and a height of 700 mm. After putting down two 28-inch suitcases, there is still room for some small items. In addition, the second row of seats in this car can be almost flat after being put down, and it can be easily handled if you need to pull some big items occasionally.

In terms of chassis, AION Y adopts the body structure, the front suspension is McPherson type, and the rear suspension is longitudinal arm torsion beam type. This configuration is also a common configuration at this price. When passing through the potholed road, AION Y’s shock absorption effect is still quite good, without the feeling of "hitting hard", and the comfort performance is not bad. However, due to the high center of gravity, this car will have obvious inclination when cornering at high speed, and its handling is relatively average.

In terms of power, the AION Y we test-drive is equipped with a permanent magnet synchronous single motor, with a total power of 100 kW and a total horsepower of 136, with a total of 176. The transmission system is matched with an electric vehicle single-speed gearbox. The battery pack has a capacity of 37.9 kWh and a pure electric cruising range of 310km, which is enough for urban transportation, and the cost of daily vehicles will be much lower than that of fuel vehicles.
From the perspective of vehicle driving, AION Y provides a smooth, comfortable and sporty driving experience, which is suitable for daily home and work. It has a variety of driving modes and steering modes to meet different driving needs. Suspension system and chassis are tuned to comfort, which can effectively filter road vibration and provide a comfortable ride experience. The power output is linear and delicate, providing a good push back feeling at low speed, and the influence of wind noise and tire noise is relatively amplified at high speed. I-PEDAL mode can adjust the strength of kinetic energy recovery in real time, realize reasonable control of vehicle speed by opening and closing the accelerator pedal in low-speed traffic jams, and provide different driving experiences. The adjustment of accelerator pedal and accelerator pedal is linear, which makes AION Y very comfortable to drive as a whole. Summary: Through this test drive of AION Y, we found that this car does have a good performance in terms of space, and both the riding space and the loading space meet the needs of most people. In terms of driving experience, the power output of this car is relatively linear, and the steering feel is also very light, so it is not difficult to drive. For novice drivers who just got their driver’s license, AION Y should be a good choice. Of course, if you just want to buy a daily scooter, then AION Y is also worth considering.

For example, this car is often mentioned as a space problem. Let’s take a look at it together.

First of all, from the appearance, the front face of Model 3 adopts a very avant-garde personality design and is equipped with a blackened air intake grille, which looks sporty. Then a simple headlight design is adopted, and the design looks very exquisite. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Coming to the side of the car, the body size of the car is 4724MM*1848MM*1430MM, and the car adopts lines with flamboyant personality. The side circumference looks very fashionable and atmospheric, and with large-sized thick-walled tires, it looks full of sports. In the rear part, the overall shape of the rear of Model 3 echoes the front face, and the taillights give people a very dynamic feeling and create a good gas field.

In terms of interior, the interior looks cool and the overall design is fashionable and concise. With the three-spoke steering wheel, it is equipped with electric up and down+front and rear adjustment, steering wheel memory, steering wheel heating and other functions, giving people an impulse to control it. From the central control point of view, the car is equipped with a touch-sensitive LCD central control screen, which makes the interior style impressive and looks young. Let’s take a look at the dashboard and seats again. The car is equipped with a delicate dashboard, and the information can be read easily and clearly. The car uses imitation leather seats, which are wide and thick and very comfortable to ride.

Model 3 is matched with the gearbox, which is 343KW and 723N.m, and its power performance is good.

The space size of the trunk of Model 3 is in line with its household positioning, and the storage space for family travel can be satisfied, with excellent space flexibility. In addition, the car is equipped with anti-lock braking (ABS), LED daytime running lights, brake assist (EBA/BAS, etc.), braking force distribution (EBD), traction control (ASR/TCS, etc.), main driving airbag, co-pilot airbag, side airbag curtain, front side airbag and other safety configurations.

The model class introduced today is the most considered class when many people buy their first car, mainly because the size of this class is moderate and the price is reasonable. Today, you can go to the 4S shop to experience this car.

With the expectation of the Fed’s interest rate hike gradually declining, and it is almost certain that it will stop raising interest rates this year, small and medium-sized pharmaceutical stocks with historically low valuations are expected to usher in a wave of mergers and acquisitions this year. Combined with the merger situation in 2022, we believe that ten companies such as Argenx, Apellis and Sarepta have great potential to be merged by large pharmaceutical companies.

In addition to the ten pharmaceutical companies listed in this article, the following pharmaceutical companies or technical fields deserve attention:

ADC domain：Mersana Therapeutics、ImmunoGen；

CNS domain：Intra-cellular、Neurocrine、Sage Therapeutics;

Rare disease field：Mirum、Krystal Biotech；

Other fields：Halozyme、Prometheus、Viridian Therapeutics.

1、Argenx(NASDAQ:ARGX)

ARGX is a Dutch pharmaceutical company specializing in the research and development of alpaca-derived antibodies. It has three patented technologies related to the transformation of antibody Fc region, namely SIMPLE Antibody platform, NHance, ABEDEG and POTELLIGENT, and has the property of technology platform.

The drug VYVGART, which has been marketed by ARGX for treating myasthenia gravis, sells well, recording a sales income of US$ 131 million only in the third quarter of last year. It is estimated that the annual income will reach US$ 402 million, and the rights and interests of VYVGART in China have also beenZaiding medicineTake it. In 2023, ARGX also had some important milestones:

The company has submitted the subcutaneously injected version (SC) of EFGARTIMOD, which will be listed for approval on June 20th. Considering that VYVGART has been listed and sold well, the subcutaneously injected version of EFGARTIMOD has a high probability of being approved, and the sales revenue is more considerable.

In the second quarter, the SC version of efgartigimod will also release the phase III data for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP).

ARGX-113, a drug under research, will release two three-phase heavy data on the treatment of primary immune thrombocytopenia (ITP) and pemphigus vulgaris (PV) in the second half of the year.

ARGX is rich in pipelines, its technology platform has been verified, its sales revenue has risen rapidly, and with the blessing of many heavy catalysts this year, many Wall Street investment banks have listed ARGX as one of the promising biomedical enterprises this year.

2、Apellis(NASDAQ:APLS)

APLS is a biomedical company with complement technology, and its main drug is C3 inhibitor APL-2. At present, the drug has been approved for two indications: paroxysmal hemoglobinuria (PNH) and geographic atrophy (GA) secondary to age-related macular degeneration, among which the PNH indication was approved in mid-2021, and it sold for 65.1 million US dollars in the United States only last year (authorized to SOBI outside the United States).

APL-2 was recently approved for the treatment of GA, with a wide range of labels (including foveal and extrafoveal), and GA has a large market. The Wall Street investment bank even gave a peak sales forecast of $5 billion. At the same time, the doctor survey conducted by the investment bank showed that doctors and patients had high expectations for APL-2. It is estimated that doctors will use the drug in 20-50% of patients, with an estimated EOD of 70-80%.

In addition to the above-mentioned approved indications, the company has a layout in the fields of rare diseases, ophthalmology, nervous system, gene therapy, etc., among which gradual freezing disease (ALS) in cooperation with SOBI is the most important. APLS is a very suitable choice for large pharmaceutical companies that want to enter the field of complement technology or GA.

3、Alnylam(NASDAQ:ALNY)

Founded in 2002, Alnylam is a leading enterprise in the field of RNAi therapy. In the past five years, it has successfully brought five RNAi drugs to the market, and in 2022, it achieved sales revenue of 892 million US dollars, up 35% year-on-year.

According to product classification, ONPATTRO and AMVUTTRA, which have the same indications, recorded revenues of $122 million and $69 million respectively in the fourth quarter of last year, with annual revenues of $558 million and $94 million respectively.

GIVLAARI recorded a revenue of $47 million in the fourth quarter of last year and achieved a revenue of $173 million in the whole year; OXLUMO recorded a revenue of $24 million in the fourth quarter of last year and achieved a revenue of $70 million for the whole year.

In addition to the strong performance of existing products, relying on the RNAi therapy technology platform, ALNY is rich in research pipelines, and many pipelines are in the later stage, which has great commercialization potential in the short term:

Patisiran’s supplementary marketing application for the treatment of ATTR amyloidosis cardiomyopathy, and the approval time is October 8; This year, the third phase data of Fitusiran in treating hemophilia and the third phase data of Vutrisiran in treating ATTR amyloidosis cardiomyopathy will also be released.

In addition, the market for indications of some early pipelines of the company is extremely broad, such as Zilebesiran for treating mild and moderate hypertension, ALN-APP for treating Al Harmo’s disease, ALN-KHK for treating NASH, etc.

Whether it is the technology platform, sales performance, and future potential, ALNY is the target of mergers and acquisitions by large pharmaceutical companies.

4、Axsome Therapeutics(NASDAQ:AXSM)

AXSM is a model of Biotech in the field of central nervous system in recent years. Its share price has risen more than 30 times in the past four years, and it has also enabled CFO Nick Pizzie, who defected from Pierre Fabre USA in 2018, to gain wealth freedom. At that time, the market value of AXSM was less than 100 million US dollars.

Behind the stock price rise is AXSM’s successive clinical trials:

The third phase trial of AXS-05 in the treatment of major depression (MDD) and bipolar disorder in Az Harmo was successful, and the indication of MDD has been approved for marketing.

The third phase trial of AXS-07 for migraine was successful, and it is planned to submit NDA； this year;

The drug AXS-12, which is used to treat narcolepsy, has also been certified by FDA as a breakthrough therapy. It is currently in the second phase of clinical practice, and data will be released this year.

In addition to its own research and development, the company is also adept at business development (BD): in March 2022, AXSM bought Sunosi, a listed drug for treating narcolepsy, from JAZZ for $53 million, and in February this year, AXSM announced that it would grant Sunosi’s rights and interests in Europe, the Middle East and North Africa to Pharmanovia, and AXSM would receive an advance payment of $66 million and a milestone payment of up to $101 million.

For large pharmaceutical companies that favor the commercialization stage, AXSM with two CNS drugs on sale and multiple later pipelines is undoubtedly one of the most worthy M&A targets.

5、Ascendis(NASDAQ:ASND)

Ascendis Pharma is a long-acting drug company with a long-acting drug technology platform TransCon. At present, it mainly focuses on various rare diseases, reducing the frequency of drug use, improving patients’ compliance, reducing side effects, and thus improving the treatment effect. With the success of the third phase clinical trials of several drugs, the technical platform of ASND has also been verified.

At present, the company has three drugs under research: TransCon hGH (long-acting growth hormone), TransCon PTH (treatment of hypothyroidism) and TransCon CNP (treatment of achondroplasia).

In 2021, Skytrofa, the company’s drug for treating children’s growth hormone deficiency (GHD), has been approved for marketing. On April 30 this year, the FDA will approve the marketing of TransCon PTH, the company’s drug for treating adult hypoparathyroidism, and will also release Phase III data of TransCon hGH for treating adult growth hormone deficiency before the end of the year. In addition, the company also has pipeline promotion in the field of achondroplasia and tumor, and will provide updates of related clinical trials this year.

The performance of Skytrofa, a drug listed by ASND, grew well. In 2022, it achieved a revenue of 35.7 million euros, with a quarterly revenue growth rate of 39%.

In 2018, ASND also co-founded VISEN Pharmaceuticals with Vivo Capital, and Visen Pharmaceuticals acquired the rights and interests of ASND in Greater China. In November 2022, Weisheng Pharmaceutical submitted a prospectus to the Hong Kong Stock Exchange, intending to be listed on the main board of Hong Kong. In view of the vast domestic long-acting growth hormone market, Changchun Gaoxin, anke biotechnology and other companies have already laid out, and the arrival of Weisheng Pharmaceutical will intensify the competition in the industry.

In view of the company’s long-term drug technology platform and the pipeline in the late stage of commercialization and research and development, Ascendis Pharma is also one of the potential acquisition targets of large pharmaceutical companies.

6、Sarepta(NASDAQ:SRPT)

Sarepta Therapeutics is a leading enterprise in the field of treating Duchenne muscular dystrophy (DMD). At present, the company has three approved DMD drugs: EXONDYS 51, AMONDYS 45 and Vyondys 53. In addition to the drugs already on the market, the company is developing new therapeutic drugs such as gene therapy and gene editing around DMD, and at the same time, it has a layout for the indications such as limb muscular dystrophy (LGMD).

In the third quarter of 2022, the company recorded a product sales income of 207 million US dollars, and it is estimated that the annual income will reach 843 million US dollars, a year-on-year increase of 38%. In addition to strong sales performance, the company’s R&D pipeline is also worth looking forward to.

In the third quarter of last year, the company submitted the application for the marketing of gene therapy drug SRP-9001 for treating DMD, which was jointly developed with Roche. The FDA granted it priority approval, and the approval time was May 29th. The marketing application of SRP-9001 is supported by many clinical trial data, and the probability of approval is high.

For large pharmaceutical companies that want to enter the DMD field, SRPT is the best choice. However, the overseas rights and interests of SRP-9001 were authorized to Roche, which may lower the expectations of the acquirer.

7、Karuna Therapeutics(NASDAQ:KRTX)

KRTX is a company that develops drugs for the treatment of nervous system diseases. KarXT, its main drug, is an oral first-choice muscarinic agonist for M1/M4. It consists of xanomeline, a muscarinic agonist, and trospium, a muscarinic antagonist. It aims to preferentially stimulate muscarinic receptors in the central nervous system, and has the potential to treat serious mental diseases without relying on dopaminergic or serotonin, including schizophrenia and psychosis in Alzheimer’s disease.

In August, 2022, the company released the phase III clinical data of KARST in the treatment of schizophrenia, which not only reached the end of the trial, but also was superior to the existing therapies in terms of therapeutic effect, safety and patient coverage, and solved the problems of poor compliance and less coverage in the existing therapies, especially the clinical P value of KARST < 0.0001, which is extremely rare in the CNS field.

This data has been released, and KarXT is regarded as a game changer in the field of schizophrenia by investment banks such as Mizuho. It is estimated that it will reach $1.7 billion by 2028, and its peak sales will be above $5 billion.

The company plans to submit the listing application of KarXT in the middle of this year, and release the results of another phase III test named Buergent-3 in the first quarter of this year. This experiment is similar to the previous studies of EMERGENT1(Ph2b) and EMERGENT-2(Ph3), with a high probability of success, but initially the experiment was mainly conducted in Ukraine, and now most of the research is transferred to the United States, which has certain uncertainties.

8、Revance(NASDAQ:RVNC)

RVNC is a pharmaceutical company dedicated to developing cosmetic medical products. Relying on the unique TransMTS? peptide technology, it has developed a differentiated botulinum toxin for injection, which was approved in the third quarter of last year.

Different from the existing Dysport, Xeomin, Jeuveau and other products on the market, DAXXIFY is a new product that is truly different from BOTOX, the number one product in the field of botulinum toxin. In the treatment of brow wrinkles, the curative time of DAXXIFY is almost 1.5 to 2 times that of BOTOX, while the annual income of the latter is 14.6 billion US dollars.

Because of its remarkable effect, DAXXIFY aims at the top one-third of the existing users. Investment banks predict that DAXXIFY will occupy 30% of the US market and its annual sales will exceed $1 billion. In the first quarter (the fourth quarter of last year) just after it was approved, the sales of DAXXIFY experience users were already expected to be between $10.5 million and $11.5 million.

In addition to DAXXIFY, the company also has RHA fillers with less side effects and better effects than hyaluronic acid. The sales revenue in the first year after listing was more than 70 million US dollars, and the growth rate last year remained at 40%+. Different from other small pharmaceutical companies, the company also has a commercial platform OPUL?, which is a cloud platform integrating customer relationship maintenance and financial payment functions, providing services for all kinds of medical and beauty businesses. As of the third quarter of last year, the total platform GPV in the past 12 months exceeded 630 million US dollars.

In the environment of raising interest rates, large pharmaceutical companies facing the cliff of heavy drug patents are likely to be interested in mergers and acquisitions of RVNC with great sales revenue potential and quick results.

9、Krystal Biotech(NASDAQ:KRYS)

KRYS is a unique gene therapy company, which does not use the common adeno-associated virus or lipid nanoparticles to deliver genetic material, but loads the gene into herpes simplex virus (HSV-1) to make it reach its target in vivo. HSV-1 has higher carrying capacity than other gene therapy technologies, which not only broadens the scope of potential diseases that KRYS may treat, but also can realize repeated administration.

KRYS has developed a series of drugs for dermatoses and respiratory diseases on its gene therapy technology platform, among which the most important one is B-VEC for the treatment of dystrophic epidermolysis bullosa (DEB), which is currently in the waiting stage for PDUFA.

B-VEC has obtained the priority evaluation qualification granted by FDA. Due to CMC, the approval time was postponed to May 19th this year, and the probability of approval was high. If approved, this will be the first approved gene therapy for DEB.

Although the market of DEB is not very large, B-VEC has proved the feasibility of the company’s technology platform to some extent. Besides the skin diseases and respiratory diseases that have been laid out at present, the company has also started clinical trials to treat cystic fibrosis. In addition, Jeune Aesthestics, a subsidiary of KRYS, is still trying to enter the field of medical beauty.

With its unique technology platform value and several promising research pipelines, KRYS is expected to become an M&A option for large pharmaceutical companies.

10、Xenon(NASDAQ:XENE)

XENE is a company that focuses on the treatment of neurological diseases by regulating ion channels. The main indication is epilepsy. At present, there are four drugs under research in the pipeline, XEN1101, XEN496, XEN901 and XEN007, which have cooperated with well-known enterprises in CNS field, Neurocrine and Alexion (acquired by AstraZeneca).

In October, 2021, the company announced that XEN1101, the main pipeline, announced the success of the second phase of the clinical treatment of adult local epilepsy, and the FDA required the company to make another third phase to apply for listing. XEN496, another treatment for infantile epilepsy, is also in the third clinical stage, and it also needs a greater probability of success.

In addition, the company’s drug XEN1101 is still in the second phase of clinical treatment for major depression (MDD), and the market of MDD is bigger than that of epilepsy. If the data released in the second half of the year is good, it will increase the probability of the company being acquired.

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Tan Dun

Tan Dun won the 73rd Academy Award for Best Composition.

Tan Dun directed the Song Mountain Music Festival "Zen Shaolin" in China

　　What kind of music will the world hear at the 2008 Beijing Olympic Games? Is it rock music that stirs Guo Jingjing’s diving sound, Yao Ming’s dribbling sound and Liu Xiang’s starting rhythm? Or the Shaolin Zen music of Zhong Mingshan Forest and Crouching Tiger, Hidden Dragon? Or the mysterious music of a village tribe in China?

　　Tan Dun, an international musician who is famous for his innovation, always blends rich oriental charm with western pop elements.

　　This background undoubtedly made him a popular music planner for the opening ceremony of the Beijing 2008 Olympic Games. Recently, our reporter interviewed Tan Dun, who has just successfully completed the planning and creation of "Zen Shaolin Music Grand Ceremony", by email, hoping to give you an answer.

　　Tan Dun Music Creativity

　　How romantic it is to make music with the voice of athletes’ bodies. I have been touched myself, and I can also touch everyone in the world.

　　Bidding: Do you do physical exercise after work? What’s your favorite sport? Who is your favorite athlete?

　　Tan Dun: I insist on swimming every day after work, which is why I always try to have a swimming pool in my hotel when I am on a world tour. I like to brew melodies while swimming, so I often swim for half an hour without knowing it. Conceiving in water makes me feel immersed in the source of inspiration, because water is a symbol of hope and regeneration.

　　My favorite athletes are Guo Jingjing, Yao Ming and Liu Xiang. In my mind, all three of them are musicians, because I saw music and heard colors in their sports. The rhythm and intensity of their movements make me feel as if even the earth can be shocked and reversed. I’m doing research in this field recently, and I plan to turn Guo Jingjing’s diving sound, Yao Ming’s racket sound and Liu Xiang’s starting rhythm into rock music. I hope I can turn the athletes’ hard work and unparalleled shock into a very poetic music, which is the voice of their bodies and the rhythm of their hearts. How romantic it is to make music with their body sounds. I have been touched myself and I can touch everyone in the world.

　　Tan Dun Olympic Dream

　　I dream that Beijing Olympic Games is a world full of poetry, romance and love.

　　Competitive bidding: I heard that recently, IOC President Rogge watched the "Zen Shaolin Music Festival" created and planned by you at the Shaolin Temple in Songshan, the birthplace of Zen, and he excitedly raised your hands and said to all the audience and the media, "It’s so beautiful, this program deserves an Olympic gold medal! Composer Tan Dun should win the Olympic champion! " Is it true?/You don’t say.

　　Tan Dun: It’s true. We were all very excited at that time. This is the IOC’s great appreciation of Wushu and the traditional culture of China-Zen philosophy. Since I wrote Crouching Tiger, Hidden Dragon, I have been continuing my feelings, trying to bring China traditional sports-Wushu to a poetic and romantic realm through music. I dream that the Olympic Games in Beijing is also a world full of poetry, romance and love.

　　Tan Dun’s "Root" of Creation

　　Only new "creativity" can connect the contemporary world with the future China.

　　Competition: You once said that you hoped that orchestras all over the world could play your works to promote China culture and make China culture a big step forward in the 21st century. Is this an important part of your musical ideal?

　　Tan Dun: Yes.

　　My music is in sync with the world, which challenges my creation, and I must also try my best to bring surprises to the world. Can you imagine growing tea and making a tea ceremony in the desert? I just staged my new opera Tea in the desert of New Mexico. It’s so Zen. Everyone was drunk by China in the desert. I’m trying to attract a jade, which requires all art institutions at home and abroad to pay attention to the recognition of "China’s creative culture" and let the whole world know more about Chinese, so that we can have a dialogue with the world. Creativity is a bridge, and only new creativity can connect the contemporary world with the future China. Only in this way can people love a modern China.

　　Competitive newspaper: You said that China is the "root" of your creation. Is this an important reason why your music is widely praised in the world?

　　Tan Dun: This year, my new concept of "Organic Music and Green Rhythm" will be invited to tour 17 countries. The more praise the world gives me, the more I appreciate China culture. I feel that instead of praising me, I should be grateful for this magical land behind me. It is this fertile soil that gave me a golden key, which opened the doors of the metropolitan opera, the Vienna "Golden Music" Hall and the Berlin Philharmonic, the most famous art halls in the world. I believe that we can also use this "golden key" to open the holy door of the Olympic Games.

　　In your opinion, how will the opportunity of hosting the Olympic Games in Beijing promote the spread and promotion of China culture in the world?

　　Tan Dun: As I said, I have a golden key in my hand, which is a magic key made of special materials. It contains China’s profound philosophy, intelligent tradition and creative people, and I am proud to be a member of this group of people. As long as we never forget to excavate and inherit our traditional culture, we will always get inspiration and harvest from it. We must not neglect our own value, because this is precisely the reason why the whole world respects China, and it is also the capital for us to host the Olympic Games and participate in the Olympic culture.

　　Tan Dun Olympic Songs

　　A successful Olympic song, first of all, should be "mind-wandering", which is my advice to all Olympic song creators.

　　Bidding: Beijing is collecting Olympic songs. Is there an Olympic song that impresses you now? What advice do you have for the creators of the songs? What characteristics do you think a successful work should have?

　　Tan Dun: To be a successful Olympic song, we must first "take the heart" and be able to sing the heartfelt desire and passion. This is also my advice to all Olympic song creators (including myself). In addition to "mind-wandering", we should also "be innovative" and innovate a new skill, new structure and new language, pointing directly at people’s spiritual world. We should be international, ethnic and have the courage to innovate.

　　Bidding: Do you have any plans to create theme songs or other musical works for Beijing 2008 Olympic Games?

　　Tan Dun: Like all my colleagues who participated in the creation, I have exhausted my mind in the creation of Olympic music. Before that, I specially went to some cradles of China traditional culture to collect folk songs. The resources there inspired me. There, I heard the world’s expectations for China culture. Olympic songs are hymns written by God through our hands. This is the voice from heaven and the dream of harmony between heaven and earth.

　　Brief introduction of Tan Dun

　　Tan Dun, born in Hunan, was admitted to Beijing Central Conservatory of Music in 1978 and obtained a master’s degree in music. After going to the United States in 1986, he obtained a doctorate in music from Columbia University. Now living in new york.

　　Tan Dun’s major works include: Symphonic Drama Series, which includes five symphonic works. Among them, Tan Dun tried to bring China’s ancient witch culture into modern symphony performance; Organic music series, which integrates natural timbre into symphony, and its representative works include Water Music, Paper Music and Tao Le; Multimedia series, exploring audio-visual structure and creating new media across time and space and culture, with representative works such as Map.

　　Tan Dun, a composer and conductor famous for his innovation, is currently the music planner for the opening ceremony of the Beijing 2008 Olympic Games. He has been involved in the music creation of films about Beijing’s Olympic bid since 2000.

　　Tan Dun has crossed many boundaries between tradition and modernity, between East and West, between classics and pop. For music lovers all over the world, Tan Dun is undoubtedly a cultural banner with rich oriental colors, paving a bridge for the integration of Chinese and Western cultures. Tan Dun has won the most influential and prestigious music awards in the world, including the Grammy Award and the Oscar Award for Best Original Music, and was awarded the "Composer of the Year" by the American Music Association. He was also named one of the ten Chinese who influenced the world in 2006 by the ten most important Chinese media in the world, such as Phoenix TV.

　　Tan Dun Olympic Fate

　　I am an Olympic volunteer, and I hope I can provide my knowledge and experience in music creation without reservation.

　　Bidding: Please tell us about the cultural and promotional activities related to the Beijing Olympic Games in the past.

　　Tan Dun: I have always had a relationship with the Olympic Games. Seven years ago, I participated in the music creation of China’s Olympic bid film. When it was announced in Moscow that China had won the right to host the Olympic Games, I felt honored, because my music also played a small role in China’s successful bid for the Olympic Games. I feel that I have studied music all my life. If I can participate in this once-in-a-century activity, it is our fate, and it is my fate with China culture.

　　Competitive bidding: What other Olympic-related work will you do now or in the coming year? In what way will you participate in the Beijing Olympic Games?

　　Tan Dun: I am honored to be invited by BOCOG to be the music planner for the Beijing Olympic Games. In my work, I have been looking for inspiration from eastern and western cultures, and at the same time, with the help of my friends all over the world, I have attracted these "world leaders" to this sacred work. Apart from composing theme songs, I am also planning some other Olympic-related music, such as Olympic logo music and award music. This is a huge echelon project, in which everyone is silently contributing. I am an Olympic volunteer. I hope I can provide my knowledge and experience in music creation without reservation. I hope our small contribution can contribute to the success of the Olympic Games. I am very proud of being a volunteer of the Olympic Games.

　　Tan Dun Beijing Impression

　　During the Olympic Games, Beijing should have fresh air, cool breeze and unparalleled enthusiasm.

　　Competitive newspaper: Do you feel that the Olympic Games have brought changes to Beijing? What do you think of this change?

　　Tan Dun: This is a rare opportunity in a century. With this opportunity, we will work harder to change the living environment and realize our green dream. It is indeed a very difficult task to make our sky bluer and our water cleaner, so that our future generations can live in a better environment. However, hosting the Olympic Games has greatly touched us, and people should take improving the environment as a top priority by supporting the Olympic Games. Our efforts now will be the greatest wealth for the future.

　　Bidding: What do you think Beijing is like during the Olympic Games?

　　Tan Dun: At that time, Beijing should have fresh air, cool breeze and unparalleled enthusiasm. The whole city was full of love, and the whole world was intoxicated and crazy about it. (Source: Competitive Newspaper)

Editor: Zhu Xinrui

　　Cctv newsAccording to the website of the National Bureau of Statistics, in May, the total retail sales of social consumer goods was 3,594.5 billion yuan, a year-on-year increase of 12.4%; It increased by 9.3% compared with May 2019, with an average growth rate of 4.5% in two years. Among them, the retail sales of consumer goods other than automobiles reached 3,225.7 billion yuan, an increase of 13.2%. After deducting the price factor, the total retail sales of social consumer goods actually increased by 10.1% in May, with an average growth of 3.0% in two years. From the ring comparison, the total retail sales of social consumer goods increased by 0.81% in May.

　　1&mdash; In May, the total retail sales of social consumer goods reached 17,431.9 billion yuan, a year-on-year increase of 25.7%, with an average growth rate of 4.3% in two years. Among them, the retail sales of consumer goods other than automobiles reached 15,630.4 billion yuan, an increase of 24.4%.

　　According to the location of business units, in May, the retail sales of urban consumer goods reached 3,131.3 billion yuan, up 12.3% year-on-year, with an average growth of 4.5% in two years. The retail sales of rural consumer goods reached 463.2 billion yuan, an increase of 13.2%, with an average increase of 4.7% in two years. 1&mdash; In May, the retail sales of urban consumer goods reached 15,154.6 billion yuan, a year-on-year increase of 26.0%, with an average increase of 4.4% in two years. The retail sales of rural consumer goods reached 2,277.2 billion yuan, an increase of 23.5%, with an average increase of 3.7% in two years.

　　By consumption type, in May, the retail sales of commodities reached 3,212.9 billion yuan, up 10.9% year-on-year, with an average increase of 4.9% in two years. The catering revenue was 381.6 billion yuan, an increase of 26.6%, with an average increase of 1.4% in two years. 1&mdash; In May, the retail sales of commodities reached 15,652.9 billion yuan, a year-on-year increase of 22.9%, with an average increase of 4.8% in two years. Catering revenue was 1,778.9 billion yuan, up 56.8%, with an average decline of 0.3% in two years.

　　1&mdash; In May, the national online retail sales reached 4,823.9 billion yuan, a year-on-year increase of 24.7%, with an average increase of 14.2% in two years. Among them, the online retail sales of physical goods was 3,937.7 billion yuan, an increase of 19.9%, with an average increase of 15.6% in two years, accounting for 22.6% of the total retail sales of social consumer goods; In the online retail sales of physical goods, food, clothing and consumer goods increased by 24.2%, 28.2% and 17.0% respectively, with an average increase of 30.5%, 9.3% and 15.9% respectively in two years.

　　 [Expert Comments]

　　 Intangible heritage is an important part of excellent traditional culture. Protecting and inheriting intangible cultural heritage plays an important role in forging a solid sense of the Chinese nation’s community and enhancing cultural self-confidence. In December 2022, General Secretary of the Supreme Leader made important instructions on the protection of intangible cultural heritage, emphasizing the need to do a solid job in the systematic protection of intangible cultural heritage, better meet the people’s growing spiritual and cultural needs, and promote cultural self-confidence.

　　 According to the data of the Ministry of Culture and Tourism, up to now, there are 1,557 national intangible heritage projects and 3,062 national intangible heritage inheritors in China. There are 43 projects in China listed in the UNESCO Intangible Cultural Heritage List, ranking first in the world. China’s overall protection of intangible heritage has achieved fruitful results.

　　 Intangible heritage protection is not easy. Because intangible cultural heritage itself has no physical form, and it has to rely on live transmission, it has become very fragile in the rapid changes of society. It is often futile to protect intangible cultural heritage projects and inheritors. In this context, the concept of "cultural and ecological protection zone" came into being. The Measures for the Administration of National Cultural and Ecological Protection Zones, which was implemented in 2019, pointed out that national cultural and ecological protection zones refer to specific areas with the protection of intangible cultural heritage as the core and the overall protection of cultural forms with rich historical and cultural accumulation, good survival status, important values and distinctive characteristics, and approved by the Ministry of Culture and Tourism.

　　 Up to now, there are 16 national cultural and ecological protection zones in China. Cultural and ecological reserves bear the internal motivation and suitable environment for the formation and development of intangible cultural heritage. Building cultural and ecological reserves is an important practice to implement the systematic protection of intangible cultural heritage.

　　 The main protection contents of the cultural ecological protection zone are: first, to protect the intangible cultural heritage projects and representative inheritors; second, to protect the natural environment and human environment related to intangible cultural heritage; third, to protect and repair the cultural ecological system, and to maintain the balance of the cultural ecological system, so as to coordinate it with the regional natural ecological protection and economic and social development. To this end, we must adhere to the "two combinations" and build a cultural ecological protection zone that conforms to China’s national conditions, completely covers material and cultural heritage such as cultural relics protection units and historical and cultural cities, towns and villages, and takes intangible cultural heritage protection as the core. At the same time, it will link up national cultural parks and major national cultural engineering construction projects, activate the use of cultural heritage, and let intangible cultural heritage "see people, see things and see life".

　　 (Author: Zhou Jianming, a professor-level senior urban planner of China Urban Planning and Design Institute)

First, the central state organs, newspapers and periodicals management separation list

1. Newspapers (50 kinds)

China economic herald, China Reform News, China Education News, Science and Technology Daily, china ethnic news, People’s Public Security News, China Social News, Legal Daily, China Finance News, China Personnel News, China Labor Security News, China Land and Resources News, China Construction News, etc. Farmers Daily, China Township Enterprise News, China Agricultural Machinery Safety News, International Business News, China Culture News, China Heritage News, Health News, China Population News, Financial Times, China Audit News, China Tax News, China Environment News and China Civil Aviation News. China Quality News, China Guomen Times, China Medicine News, China Work Safety News, China Coal News, China Intellectual Property News, China Surveying and Mapping News, China Traditional Chinese Medicine News, China Discipline Inspection and Supervision News, China Archives News, China Ocean News, China Meteorological News, China

2. Journals (75 kinds)

Macroeconomic Management, China Economic and Trade Guide, China Price Yearbook, People’s Education, China Nationalities (Chinese, Mongolian, Uygur, Kazakh, North Korea, English version), Ethnic Pictorial (Chinese, Mongolian, Tibetan, Uygur, Kazakh, North Korea), China Ethnic Work Yearbook, People’s. Legal Publicity Materials, China Finance, China Talents, Labor Security Newsletter, Land and Resources Newsletter, China Land and Resources Yearbook, Urban and Rural Construction, Rural Work Newsletter, WTO Economic Guide, chinese heritage, China Health, Population and Family Planning, and China Family Planning Yearbook., China Civil Aviation, Administration for Industry and Commerce, Yearbook of China Administration for Industry and Commerce, China Forestry, China Quality and Technical Supervision, China Inspection and Quarantine, China Drug Administration, China Drug Administration Yearbook, China Religion, Logistics of Chinese Organs, Taiwan Work Newsletter, China Food Economy, etc. Foreign Exchange Management in China, Research on Party Building, Party Building, Current Affairs Report, Current Affairs-Current Affairs Report for Middle School Students, Current Affairs Report for College Students, China United Front, Tibet, China (Chinese, Tibetan and English versions), Contemporary World, Ziguangge, Party Building in Zhongzhi, etc.

Two, the local party and government departments of the journal management separation list (185 kinds)

Greening and Life, Tide of Science and Technology, Urban Management and Technology, Healthy Youth Pictorial, Beijing Geology, Tourism, Sports Expo, Beijing Yearbook, Beijing Agriculture, Beijing Planning and Construction, New Script, Capital Economy, Beijing Statistics, Tianjin Agriculture and Forestry. Hebei Agriculture, Hebei Education, Shanxi Water Conservancy, Shanxi Forestry, Shanxi Science and Technology, Fighting, Shanxi Economic Yearbook, Taiyuan Yearbook, Shanxi Education, China Journal of Ethnic Medicine, Inner Mongolia Medical Journal, Inner Mongolia Radio and Television Technology, Inner Mongolia Water Conservancy, Contemporary. Inner Mongolia Statistics, Liaoning Yearbook, Dalian Yearbook, Everybody’s Health, Jilin Medicine, Jilin Agriculture, Jilin Yearbook, Jilin Building Materials, jilin water resources, Jilin Forestry Science and Technology, Jilin Animal Husbandry and Veterinary Medicine, China Hospital Management, Friends of Farmers Becoming Rich, and Contemporary Sports., Jiangsu Yearbook, Science Popular, Jiangsu Traditional Chinese Medicine, Nanjing Yearbook, Changzhou Yearbook, Jiangsu Agricultural Mechanization, Jiangsu Labor Protection, Drama Monthly, Jiangsu Education, Jiangsu Higher Education, Jiangsu Health Management, Zhejiang Yearbook, Lawyers and the Legal System, and Journal of huaihai medicine, Anhui Science and Technology, Fujian Agriculture, Fujian Forestry, Fujian Education, Audit and Financial Management, Social Work, Price Monthly, Jiangxi Education, Family Health, Travel World, New Airlines, Shandong Industrial Technology, Shandong Water Conservancy, etc. Zhongzhou Construction, Henan Water Conservancy, Henan Land Resources, Henan Agriculture, Green World, Hunan Safety and Disaster Prevention, Hunan Education, Junior Middle School Students, Primary School Guide, Hunan Forestry, Hunan Agriculture, Contemporary Nurses, International Medical and Health Herald, Guangdong Science and Technology of Shenzhen Special Zone, beginning of life, Guangdong Education, Sports Boutique, Guangxi Education, National Art, Selected Medical Works, Youjiang Medicine, andJournal of Guangxi Agriculture, Guangxi Water Conservancy and Hydropower, Southern Land Resources, Friends of Farmers, Guangxi Forestry, Great Science and Technology, Business, Sichuan Education, Sichuan Provincial Situation, Film Review, Guizhou Yearbook, Guizhou Agricultural Mechanization, Guizhou Geology and Yunnan Forestry. Practical Radiology, Shaanxi Forestry, Shaanxi Water Conservancy, Disaster Science, Shaanxi Education, Agricultural Science and Technology and Information, Gansu Traditional Chinese Medicine, Health Vocational Education, Gansu Agriculture, Gansu Forestry, Yinchuan Yearbook, Science and Technology Outlook, Ningxia Education and Ningxia Medical Journal. Xinjiang Culture (D), Inland Earthquake, Xinjiang Animal Husbandry, Xinjiang Animal Husbandry (D), Xinjiang Animal Husbandry (Ha), Xinjiang Animal Husbandry (Mongolia), Xinjiang Agricultural Science and Technology, Xinjiang Agricultural Science and Technology (D), Xinjiang Forestry (D)

Shandong Agriculture and Agricultural Knowledge were merged into one kind of separation of management and management, while Farmer Friends and Northwest Horticulture were merged into one kind of separation of management and management.

　　In view of the pronunciation of the place name Lu ‘an, Anhui Province, which caused controversy recently, the Division of Geographical Names of the Ministry of Civil Affairs gave an authoritative statement.

　　On May 15th, a netizen left a message on the portal of the Ministry of Civil Affairs asking about the pronunciation of the word "six" in Lu ‘an City, Anhui Province: "According to the phonetic notation of Lu ‘an City in the Administrative Division of the People’s Republic of China 2015, &lsquo; Luan Shi&rsquo; According to the latest edition of the administrative divisions of the People’s Republic of China, Lu ‘an City, Anhui Province &lsquo; Six &rsquo; Has there been any change in the speech? Are you still studying for six (Lu) Ann? "

　　In this regard, on May 19, the Division of Geographical Names of the Ministry of Civil Affairs replied that in the "Administrative Division of the People’s Republic of China 2020", the pinyin of Lu’ an was "Lu&rsquo; an Shi”。

　　Located in the west of Anhui Province, Lu ‘an, commonly known as "West Anhui", is a regional central city in Dabie Mountain, a sub-central city in Hefei Economic Circle, a connecting city in Wanjiang City, an industrial transfer and radiation city in Yangtze River Delta, and a national land transportation hub city.

　　Recently, Lu ‘an City has attracted social attention due to the local COVID-19 epidemic, while its pronunciation has also caused controversy. In recent news programs broadcast by CCTV News Channel, many anchors read Lu ‘an as "Li Φ ā n", while in news programs of anhui tv and Lu ‘an Radio and Television Station, anchors still read Lu ‘an as "Li Φ ā n".