This issue of the "Precision Frontier" column shared by Zhao Haitao’s research team published inGenome Medicine(IF =11.12) [1], a mutation signature was constructed and verified to predict the prognosis of patients receiving immunotherapy, and the potential immune response of different subtypes was studied by using multidimensional data.

Research background

Immunocheckpoint inhibitors (ICI) have changed the treatment of many cancers. However, the beneficiaries of ICI treatment are limited, so it is necessary to screen and predict biomarkers to classify patients. At present, many biomarkers, such as tumor mutation load (TMB), have been used as indicative biomarkers in clinic. However, some high TMB patients with gene mutation related to immunotherapy resistance are not sensitive to ICI treatment. Therefore, it is necessary to go beyond TMB and identify the specific genetic determinants of ICI treatment response.

research design

The study included genome and clinical data of 12,647 patients. There were 1572 cases in the training set (immunotherapy patients with 9 kinds of cancer) and 932 cases in the verification set (immunotherapy patients with 5 kinds of cancer). The training set was sequenced by MSK-IMPACT panel containing 468 genes.

The authors identified a set of 11 genes based on mutation, which can divide patients into high-risk and low-risk groups. The mutation of these 11 genes is related to the better response to ICI treatment, and this gene set has been proved to be an independent prognostic factor after ICI treatment.

research results

1. Identify mutant gene sets that can predict the outcome of immunotherapy.

Firstly, the survival differences of 468 genes in the training set were compared between wild type and mutant type, and 98 genes related to OS (global survival) were obtained. After that, LASSO COX regression analysis was further screened and 11 important genes were finally obtained. Through COX regression analysis, the risk score of each patient was quantified on the basis of 11 mutant gene sets. In the training concentration, the OS of patients in the high-risk group is shorter than that of patients in the low-risk group (Figure 1B). In order to study whether the gene set is limited to a specific population or suitable for different populations, the subgroup analysis regardless of age, drug use type and cancer species shows that the gene set is significantly related to the OS of patients treated with ICI (Figure 1C-E).

Figure 1. Generation and Verification of Gene Set Based on Mutation

2. Verification of predictable immunotherapy results

In order to further confirm the value of mutation-based gene set in predicting the results of immunotherapy, it was found that the OS of low-risk group was higher than that of high-risk group (Figure 1F). The research results of predicting ICI treatment response in gene set show that the DCB(durable clinical benefit) of ICI treatment in low-risk group is significantly increased compared with that in high-risk group (Figure 1G), and low-risk patients are more likely to respond to ICI treatment (Figure 1H). These results get the same results in the verification set (Figure 1I, J).

3. Gene set is an independent prognostic predictor of immunotherapy.

Next, the author verifies whether the gene set based on mutation is an independent predictor of immunotherapy response. In the training and validation set, univariate COX regression analysis showed that the gene set was related to OS. After adjusting for drug type, tumor type and TMB, multivariate COX regression analysis showed that the gene set was still an independent predictor, which confirmed the stability of its independent prediction of ICI prognosis (Figure 2A, B). In order to determine which factor has the best predictive performance, C-index is used to compare the performance of mutation-based gene sets with TMB and drug types. The results of C-index show that the gene set based on mutation can predict the prognosis more accurately than TMB and drug type in both training set and validation set (Figure 2C, D).

Fig. 2. Relationship between mutation-based gene sets and other characteristics

4. The clinical benefit of ICI treatment can be predicted based on the mutant gene set, disease stage, CTL and 6-IFN-g gene signature.

Considering the stage of disease, CTL and 6-gene IFN-g signature have been proved to be highly predictive of the response to ICI treatment, the authors speculate that they may play a synergistic role in predicting the response to immunotherapy. The author combined the gene set based on mutation with disease stage, CTL and 6-gene IFN-g signature through Nomotograph, and provided a method for clinicians to quantitatively predict the OS of patients treated by ICI. Fig. 2E is the nomogram of Riaz cohort construction, and the calibration curve of fig. 2F shows the consistency of actual and predicted results, indicating that these signature should be integrated into the predicted nomogram of ICI treatment.

5. Potential external immune landscape of high and low risk groups

In order to further explore the relationship between immune system and mutation-based gene set, the authors conducted a multi-group analysis of TCGA cohort, and the risk score divided TCGA cohort into high and low risk groups (Figure 3A). At the genome level, the proportion of white blood cells, lymphocytes and TIL in the low-risk group was significantly higher than that in the high-risk group (Figure 3B-D). The H&E staining results of TIL ratio are consistent with the above results (Figure 3E). In addition, the proportion of immunostimulatory cells (such as CD8 T cells) in the low-risk group is also significantly higher than that in the high-risk group (Figure 3F). The above results were further tested by Danaher et al.’ s immune infiltration score (figure 3G) and immune characteristic score (figure 3H), and it was found that the abundance of immune cells in low-risk group was higher. Then unsupervised clustering was used to cluster the immune characteristic scores of patients in TCGA cohort, and the results were clustered into two immune infiltration modes (Figure 3I), and the high immune infiltration was significantly enriched in the low-risk group (Figure 3J).

Fig. 3. Immune status of high and low risk population in TCGA cohort.

In addition, the immune signature in the low-risk group was significantly higher than that in the adjacent cancer tissue; On the contrary, the immune signature in the high-risk group was significantly lower than that in the adjacent tissues (Figure 4A). The correlation of immune activity in low-risk group was significantly higher than that in high-risk group (Figure 4B, C). GSEA results showed that 13 pathways were significantly enriched in the low-risk group, including 6 immune-related pathways, such as "cytotoxicity mediated by natural killer cells" (Figure 4D). Tumors in the low-risk group are associated with significantly higher CYT scores, and the number of fibroblasts in the high-risk group is now increasing (Figure 4E, F). According to these results, the low-risk group is rich in immune cells, which can respond to ICI treatment, and fibroblasts may help the high-risk group escape. The expression of chemokines in the low-risk group is higher (Figure 4G, H), so the author speculates that the enrichment of chemokines in the low-risk group may trigger an immune response.

Figure 4. Potential external immune landscape of high and low risk groups　

6. Potential inherent immune landscape of high and low risk groups

Some potential factors determining tumor immunogenicity between the two groups were compared. Mutation, new antigen load, TCR and BCR diversity in low-risk group were significantly higher than those in high-risk group, but CNV load and aneuploidy in high-risk group were higher than those in low-risk group (Figure 5A). This result is consistent with previous studies, that is, tumor aneuploidy is related to immunotherapy and decreased immune escape marker response. In addition, the heterogeneity of tumor in high-risk group is higher than that in low-risk group, which further supports the view that tumor will promote the development of heterogeneity in the presence of cytolytic activity and less active infiltration of immune cells. In order to further understand the mutation process of high and low risk groups, the mutation characteristics were described according to somatic mutation data, and four different mutation patterns were determined in TCGA cohort (Figure 5B). The frequency of these four mutation signals in the low-risk group is significantly higher than that in the high-risk group (Figure 5C). In addition, it was also found that immune checkpoint molecules (such as PD-1, PD-L1 and CTLA4) and costimulatory molecules were more highly expressed in the low-risk group (Figure 5E).

Figure 5. Potential innate immune response and escape landscape in high and low risk groups.　

7. Copy number characteristics of high and low risk groups

Significant differences in chromosome variation were detected in high and low risk groups (fig. 6A). Local amplification peaks of immune genes with good characteristics, such as PD-L1 (9p24.1) and PD-L2 (9p24.1), were observed in the low-risk group (fig. 6B, C). GO function annotation of the specifically amplified genes showed that the low-risk group was significantly enriched in two immune-related biological processes, while the high-risk group was significantly enriched in the biological process of "positive regulation of fibroblast proliferation", but not in any immune-related biological processes (Figure 6E). At the level of mRNA expression in TCGA cohort, the expression of PD-L1 and PD-L2 mRNA in low-risk group increased significantly (Figure 6G), which was consistent with CNV data. This finding suggests that CNVs in tumor contributes to the observed difference in immune infiltration.

Figure 6. Variation of copy number in high and low risk groups

discuss

This study is the first time to use an independent cohort to study the comprehensive mutant gene sets of different tumor types. Through PSM algorithm, hierarchical analysis and multivariate COX regression analysis, the application performance of mutation-based gene sets in different types of tumors was tested, and the results showed that mutation-based gene sets were reliable.

This study has the following innovation and practical application value. First, different types of tumors (such as NSCLC (non-small cell lung cancer), melanoma and renal cell carcinoma) are used, which represent the most common types of cancer treated with ICI. Secondly, the application of multiple biomarker prediction model needs to understand the factors that affect the accuracy and precision of Qualcomm analysis in clinical practice. The risk score formula and threshold of mRNA expression calculation are not suitable for verification with other types of data. Therefore, this study developed a gene set based on mutation to predict the clinical efficacy of ICI treatment. The composition of the above mutations is neither affected by tissue types nor adjusted by any other biomarkers. The risk score formula and threshold of gene set based on mutation can be verified by other tumor analysis methods, such as DNA sequencing and single nucleotide polymorphism microarray analysis. Therefore, mutation-based gene sets are not affected by technological changes, even when different platforms are used in different centers. Thirdly, in practice, gene sets based on mutations avoid exposing patients to potential immune-related adverse reactions when they are unlikely to respond, and enable patients to match to potentially more effective treatments more quickly. Fourthly, the prediction performance of gene set based on mutation is compared with other factors that can predict immunotherapy, and it is found that the prediction performance of gene set based on mutation is better than all these factors.

Several limitations of this study. First of all, because some mutations may be enriched in some tumor types, the initial goal of this study is to create a panel instead of identifying a single gene (such as BRAF), because the former can contain more genes to predict the prognosis of different types of tumors. Secondly, although the immune landscape of 11 genes in the gene set based on mutation has been explored, it is still necessary to clarify the molecular mechanism of each gene affecting immunotherapy in vivo and in vitro functional experiments. Thirdly, the enrichment scores of carcinogenic pathways and the expression patterns of immune checkpoints should also be detected by immunohistochemistry.

tag

The mutation-based gene set proposed in this study is the first comprehensive genomic marker systematically identified, which can be used to evaluate the ICI treatment effect of pan-cancer species. This study is also the largest prognostic model discovery project for cancer patients receiving ICI treatment (whether single drug treatment or combined treatment of anti-PD-1 and anti-CTLA-4). Nomoto, which combines mutation-based gene set with TMB and drug types, can help clinicians choose patients who may have a strong response to ICI treatment. In addition, it also reveals the different immune conditions of high and low risk groups, and specific genomic changes may drive the formation of these microenvironments. In a word, this work puts forward a new tumor classification method, which may guide the decision-making of ICI treatment.　END　

References:

[1]　Long, J., Wang, D., Wang, A. et al. A mutation-based gene set predicts survival benefit after immunotherapy across multiple cancers and reveals the immune response landscape. G enome Med 14, 20 (2022). https://doi.org/10.1186/s13073-022-01024-y

Write Liu Hua Hua

Editing and typesetting SX

　　How do new Chinese immigrants overcome the difficulty of studying?

　　When new Chinese immigrants come to foreign countries and work hard, it is often difficult to take care of their children’s studies. In recent years, some young Chinese immigrants have gone abroad to study, but they are also faced with challenges such as different study environments in foreign countries and family financial difficulties, resulting in some dropouts. Let the children of new immigrants and young new immigrants better integrate into the new learning environment and ensure their academic success, which requires better home-school cooperation and better system design at the social level.

　　It is not common to play truant and work.

　　When new Chinese immigrants first arrive in the United States, they face many difficulties, and the education of their children is one of them.

　　According to the US "World Journal" report, due to the large number of young shop assistants recruited by Chinese restaurants and retail stores in new york, the problem of many new immigrant Chinese students dropping out of school is more serious.

　　According to Zhao Hongfang, a bilingual psychological counselor at Jiangbang High School in Flushing, some Chinese students are in Internet cafes all day and night. When they are familiar with the store, they actually help to watch the store at night. When asked by their parents how they have money to spend, they lie about working after class.

　　Some Chinese students don’t get along well with their parents, so they moved out at the age of 17 and watched the shop at night to earn living expenses. In particular, the owners of new Chinese restaurants in Flushing are looking for young clerks who know English, attracting a large number of dropouts. The school said that they would go to the restaurant to bring these students back.

　　However, the lack of diplomas will only bring more difficulties for new immigrants to seek a living in the United States in the future. According to the report, a survey in new york in 2015 showed that the annual salary of those without a high school diploma was only $21,121, those with a high school diploma was $31,038 and those with a bachelor’s degree was about $60,000.

　　It is worth noting that although new Chinese immigrants have played truant, worked or even dropped out of school, this is not the norm.

　　In an interview with this newspaper, Liang Guanjun, chairman of the American East Asian Association, believes that some students in every school play truant or drop out of school for some reason. "Flushing is so big, and employment opportunities are still limited. We can only say that this phenomenon exists among the new immigrants in new york, but the size of the’ large number’ in the report is debatable."

　　Even so, the difficulty in adapting to new Chinese immigrants still needs attention.

　　Inadvertence in discipline and difficulty in adaptation

　　Different from the "Chinese" born and raised in the United States, behind the new Chinese immigrants who came to the United States to work and play truant is the helplessness of their families’ inability to discipline and adapt to the environment.

　　"This is an old problem, which exists in big cities in the east and west of the United States and is quite difficult to solve." Chinese lawyer Sun Lantao said in an interview with this newspaper that Chinese in the United States often choose school districts to send their children to school. All the above phenomena occur in bad school districts. There, parents are forced to survive, sometimes working hard for 12 hours every day, and have no time to ask about their children’s learning. Children’s own English is not enough, and they are under bilingual pressure, so they are discouraged and unwilling to learn.

　　For new immigrant students, the financial hardship of their families is also a major incentive to play truant and work. "Nowadays, in the United States, it is not easy for restaurants to recruit people, so the salaries are relatively high." Liang Guanjun introduced that the monthly salary of Flushing Restaurant is about 2,800 dollars, which attracts students who can’t go on studying, and there are also cases where individual families have financial difficulties and need their children to make money.

　　The educational environment and allocation of educational resources in American society are also very different from those in China.

　　Sun Lantao introduced that the US Constitution and the constitutions of all states stipulate that any school-age children must receive compulsory education before the age of 18, regardless of whether they or their parents have immigration status. That is to say, even the children of illegal immigrants, as long as they are school-age children, no matter where they live, public schools must accept them and must not refuse them to go to school on the grounds of poor English and insufficient test scores. However, at the implementation level, the imbalance of educational resources has greatly reduced the effect of ensuring the enrollment rate of immigrant children.

　　"American culture is different from that of China, where the whole people attach importance to education. Ordinary public schools often have poor basic education. Psychological counseling and bilingual guidance advocated by the education department cannot be put in place at all because of the lack of human resources. " Sun Taotao introduced.

　　The negligence of family discipline and the difference of social environment bring poor communication between home and school, which eventually leads to inefficiency in the academic management cooperation of new immigrant children. "Chinese immigrants, Chinese new immigrants, survival is a problem, and the language is unreasonable. I don’t know how to start." Sun Lantao said that the communication information between parents and school teachers is seriously poor, which reduces the effectiveness of cooperation between schools and parents.

　　Multi-party cooperation to promote studies together

　　How to help new Chinese immigrants better integrate into the new learning environment and ensure their enrollment rate? Experts said that the joint efforts and effective cooperation of all parties are needed.

　　On the one hand, new immigrant families need to integrate into the new study environment more actively. Cai Wenyao, consultant of the American Chinese Chamber of Commerce, said in an interview with this newspaper: "Children need to get out of the comfort zone and consult more local students. Parents can also make good use of community resources and communicate with other immigrant parents who have experienced difficult stages instead of resting on their laurels."

　　At the same time, home and school also need to better cooperate, psychologically appease their children, and more effectively prevent students who want to skip classes and work from drilling loopholes in the system.

　　In an interview with the World Journal, Zhao Hongfang said that parents can take the initiative to provide contact information to the school and learn to check attendance records and grades online. If parents leave their children completely unattended, the school can report it and ask the Children’s Service Administration to intervene in the investigation.

　　On the other hand, the society can also make efforts in promoting the children of Chinese new immigrants to study.

　　"In a short time, it is still a luxury to solve the problem of young Chinese immigrants going to school." Lawyer Sun Lantao said that despite this, from the legislative point of view, with the increasing proportion of Chinese in politics, this phenomenon will attract the attention of political circles, and the education department will also strengthen investment in this group and training bilingual teachers. With the increase of corresponding educational resources and infrastructure, the current situation may gradually change.

　　On June 1st, several experts attending the 13th Oriental Cardiology Conference (OCC) held a live breakfast in the Oriental Live Room. Why did the experts at the cardiology conference talk about breakfast first?

　　In April 2019, a study published by JACC, an authoritative academic journal, prospectively proved that skipping breakfast is related to higher cardiovascular mortality. Eating the right breakfast can protect your heart! Let’s listen to the advice of these experts.

　　Academician Ge Junbo of Zhongshan Hospital affiliated to Fudan University: Eating the right breakfast can protect your heart.

　　Someone once called breakfast "the first expectation in a day", but with the acceleration of the pace of life, we have less expectation for breakfast. In order to catch up with the time, we either make do with two people or have two meals with lunch and make one meal.

　　Previous studies have shown that skipping breakfast may lead to the risk of obesity, diabetes and hyperlipidemia. OCC held an activity such as "Healthy Heart Breakfast" at the meeting, inviting cardiovascular experts and nutrition experts to interpret the reasonable diet structure together. On the one hand, it popularized the importance of breakfast to the public, and at the same time, it released a reference recipe of "Healthy Heart Breakfast" for the general public to refer to and improve the level of cardiovascular disease prevention in China. On the other hand, it also reminds doctors and media reporters not to forget to eat breakfast when they are busy with their work.

　　Professor Huo Yong of Peking University First Hospital: Eat breakfast like an emperor.

　　"As the saying goes, you should eat like an emperor for breakfast, like a commoner for lunch and like a beggar for dinner." Why do you value breakfast so much? Because for most people, this meal is about ten hours away from the last meal and needs more energy. Fasting for a long time will lead to an increase in blood pressure in the morning. Not eating breakfast all the year round will inevitably lead to the disorder of related hormones, making it easier to overeat and obesity, and also causing fluctuations in blood lipid levels.

　　Related studies have found that eating breakfast helps to lower blood pressure, thus preventing various cardiovascular events such as blood vessel blockage.

　　Qian Juying, Chairman of Cardiovascular Branch of Shanghai Medical Association: Regulating blood lipid can’t rely solely on diet therapy.

　　It is generally believed that the increase of low density lipoprotein cholesterol (LDL-C) will increase cardiovascular risk. Will improving eating habits significantly improve blood lipid levels?

　　Diet therapy and lifestyle improvement are the basic measures for the treatment of dyslipidemia, and they are "fighting" together. Diet control and active exercise should be continued even after medication, but lifestyle intervention should not be relaxed because of medication. But we should also avoid entering a misunderstanding, that is, we only hope that diet can improve blood lipids. (Yin Wei)

　　Director Gao Jian, Department of Nutrition, Zhongshan Hospital affiliated to Fudan University: An excellent breakfast must contain four kinds of food.

　　The choice of breakfast in different regions is rich and varied. The traditional breakfast food provided by restaurants outside is single, mostly high-calorie food. Although it can satisfy the stomach, its nutritional value is not high. An excellent breakfast should include the following four kinds of food:

　　The first kind of food should be a bit like whole wheat bread and coarse grains. Because breakfast should have a staple food first, but now the staple food is too fine, so eat some miscellaneous grains for breakfast.

　　The second category of food, there is an animal food, such as boiled eggs.

　　The third category of food is soybean milk and milk. Generally, a bag of milk basically meets this requirement.

　　The fourth category of food is vegetables and fruits, so today we have some fruits.

　　All four are called excellent breakfasts, only three are called good breakfasts, and only two and one are called poor breakfasts. At present, many people have only one or two kinds of breakfast, so it is suggested that breakfast should be as diverse as possible, at least there are some of the four categories of food. (Yin Wei)

Cctv newsOn the afternoon of May 24th, Beijing held the 344th press conference on epidemic prevention and control to introduce the situation and answer questions from reporters. Wu Hao, head of the expert group of the community prevention and control group of the leading group for epidemic prevention and control in COVID-19, Beijing, gave epidemic prevention tips to the citizens when they went shopping in supermarkets, vegetable markets and other places. He said that supermarkets, vegetable markets and other public places are relatively closed, people are easy to gather, and there is a great risk of epidemic spread, which is the focus and difficulty of community epidemic prevention and control. In the past, many epidemics were spread and infected in these places.

It is necessary to strictly implement the epidemic prevention management in public places. Under the current situation that the social situation is not completely cleared, citizens should strictly do personal protection when going shopping, and prepare protective equipment such as masks and disinfectants. It is best to list the purchase list in advance and strictly control the number of people who go out to purchase. It is recommended that infants and the elderly try not to participate in shopping. Choose the nearest shopping spot, travel at the wrong peak, and try to avoid taking public transport. It is recommended to choose travel modes such as self-driving, cycling and walking.

When entering the vegetable market, supermarkets and other public places, you should cooperate with epidemic prevention measures such as temperature measurement and code inspection, wear a mask all the time, avoid pulling down the mask to communicate with the stall owner or taste food, and do not touch your eyes, mouth and nose directly with your hands. You should quickly select materials according to the list to minimize the stay time. Don’t go to the shelves and stalls where people gather, try to choose self-checkout and contactless payment to keep a safe social distance of more than one meter from others.

After purchasing, the used masks should be put into the relevant trash can, and hand disinfection should be done in time. If the packaging is suspected of being contaminated, disinfection should be done.

　　In 2021, China’s economy will continue to recover steadily, economic development and epidemic prevention and control will maintain a leading position in the world, the main indicators will achieve the expected goals, fixed assets investment will recover steadily, and the structure will continue to be optimized; The scale of market sales continued to expand, and the consumption structure was optimized and upgraded; The total population has maintained growth and the level of urbanization has steadily increased; The employment situation is generally stable, and the employment situation of migrant workers is constantly improving; Residents’ income continued to grow steadily; Prices in the consumer sector rose moderately.

　　Continuous optimization of investment structure

　　Zhai Shanqing, Director of Statistics Department of Fixed Assets Investment of National Bureau of Statistics

　　In 2021, investment in fixed assets recovered steadily and the structure continued to be optimized. The investment in fixed assets (excluding farmers) was 54,454.7 billion yuan, an increase of 4.9% over the previous year, and the growth rate was 2.0 percentage points higher than that of the previous year; Taking 2019 as the base period, the average growth rate is 3.9% in two years.

　　The scale of investment in the first and third industries continued to expand.

　　In 2021, the investment in the primary industry was 1,427.5 billion yuan, an increase of 9.1% over the previous year; The average growth rate was 13.7% in two years, and the growth rate was 0.7 percentage points faster than that from January to November. The investment in the secondary industry was 16,739.5 billion yuan, an increase of 11.3% over the previous year; The average growth rate was 5.8% in two years, and the growth rate was accelerated by 0.6 percentage points. The investment in the tertiary industry was 36,287.7 billion yuan, an increase of 2.1% over the previous year; The average growth rate in two years was 2.7%, and the growth rate dropped by 0.2 percentage points.

　　Second, the investment in the three major areas has recovered steadily.

　　In 2021, manufacturing investment increased by 13.5% over the previous year; Average growth of 4.8% in two years. Investment in real estate development increased by 4.4% over the previous year; Average growth of 5.7% in two years. Infrastructure investment increased by 0.4% over the previous year; Average growth of 0.3% in two years.

　　Third, investment in high-tech industries plays an obvious role.

　　In 2021, the investment in high-tech industries increased by 17.1% over the previous year, the growth rate was 0.5 percentage points faster than that from January to November, 12.2 percentage points higher than that of the total investment, and the total investment increased by 1.2 percentage points.

　　Investment in high-tech manufacturing increased by 22.2%, which was the same as that from January to November. Investment in high-tech service industry increased by 7.9%, and the growth rate was 1.5 percentage points faster than that from January to November.

　　Fourth, the investment in the short-board area of people’s livelihood continued to increase.

　　In 2021, investment in social fields increased by 10.7% over the previous year. Investment in agriculture, forestry, animal husbandry and fishery increased by 9.3% over the previous year, and the growth rate was 0.1 percentage point faster than that from January to November. Investment in transportation, warehousing and postal services increased by 1.6% over the previous year, and the growth rate was 0.5 percentage points faster than that from January to November. Investment in the production and supply of electricity, heat, gas and water increased by 1.1% over the previous year, and the growth rate was 0.9 percentage points faster than that from January to November.

　　V. Steady growth of private investment

　　In 2021, private investment increased by 7.0% over the previous year; The average growth rate in two years was 3.8%, and the growth rate was the same as that from January to November. Among them, private investment in education increased by 24.9%, private investment in manufacturing increased by 14.7%, private investment in infrastructure increased by 12.0%, and private investment in agriculture, forestry, animal husbandry and fishery increased by 9.9%.

　　The consumer market maintained a recovery trend.

　　Dong Lihua, Director of the Department of Foreign Trade and Economic Statistics of the National Bureau of Statistics

　　In 2021, the scale of market sales continued to expand, the consumption structure was optimized and upgraded, and the overall consumer market maintained a recovery trend.

　　I. The scale of the consumer market has steadily expanded.

　　In 2021, the total retail sales of social consumer goods was 44.1 trillion yuan, an increase of 12.5% over the previous year and 8% over 2019. After deducting the price factor, the total retail sales of social consumer goods actually increased by 10.7%.

　　In the first quarter, due to the low base in the same period of last year, the total retail sales of social consumer goods increased by 33.9% year-on-year, with an average growth rate of 4.2% in two years; In the second quarter, the market sales accelerated, and the average growth rate in two years was 0.4 percentage points faster than that in the first quarter; In the third quarter, the two-year average growth rate declined; In the fourth quarter, the consumer market continued to recover, and the total retail sales of social consumer goods increased by 4% on average for two years.

　　Second, the urban market continued to recover.

　　In 2021, the retail sales of urban consumer goods increased by 12.5% over the previous year, with an average increase of 3.9% in two years. Quarterly, the urban market in the fourth quarter increased by 3.3% over the same period of last year, with an average growth rate of 3.9% in two years, and the average growth rate was 1 percentage point faster than that in the third quarter. In 2021, the per capita disposable income of rural residents actually increased by 9.7% over the previous year, and the growth rate was 2.6 percentage points higher than that of urban residents.

　　Third, the retail sales of goods grew steadily

　　The growth of retail sales of commodities is good. In 2021, the retail sales of commodities increased by 11.8% over the previous year, by 9.2% over 2019, and by 4.5% on average in two years. From the two-year average growth rate, the retail sales of all categories of goods have maintained growth.

　　In 2021, catering revenue increased by 18.6% compared with the previous year, decreased by 1.1% compared with 2019, and decreased by 0.5% on average in two years. The scale of catering consumption has not yet recovered to the pre-epidemic level. In the fourth quarter, the catering revenue decreased by 0.5% on average for two years, which was 1.1 percentage points narrower than that in the third quarter, and the recovery of catering consumption was accelerated.

　　Fourth, online consumption maintained rapid growth.

　　In 2021, the national online retail sales increased by 14.1% over the previous year. Judging from the development of postal express delivery industry closely related to online shopping, driven by the rapid growth of online consumption, the express delivery business volume and business income in 2021 maintained a double-digit rapid growth compared with 2020.

　　5. The retail sales of basic life commodities are growing well.

　　Sales of grain, oil, food and daily necessities increased rapidly. In 2021, the retail sales of grain, oil, food and daily necessities of units above designated size increased by 10.8% and 14.4% respectively over the previous year, with an average annual increase of 10.4% and 10.9% respectively.

　　The level of urbanization has steadily increased.

　　Wang Pingping, Director of Population and Employment Statistics Department of National Bureau of Statistics.

　　In 2021, China’s total population maintained growth, the growth rate continued to slow down, the degree of aging further deepened, and the level of urbanization steadily improved.

　　First, the total population maintained growth.

　　By the end of 2021, the national population was 1,412.6 million, an increase of 480,000 over the end of 2020; The annual birth population was 10.62 million, a decrease of 1.4 million compared with 2020; The death toll was 10.14 million, an increase of 160,000 compared with 2020.

　　In 2021, the natural population growth rate will be 0.34‰ , down 1.11 thousandths from 2020. The continuous slowdown in population growth is due to the continuous decline in the number of births, which is mainly affected by two factors: first, the number of women of childbearing age continues to decrease; Second, the fertility level continues to decline. The total fertility rate of women of childbearing age will continue to decline in 2021 due to the change of fertility concept and the delay of the age of first marriage and first childbearing.

　　Second, the short-term increase in the working-age population

　　By the end of 2021, the population aged 0-15 was 263.02 million, accounting for 18.6% of the national population. The population aged 16 to 59 is 882.22 million, accounting for 62.5%; The population aged 60 and over is 267.36 million, accounting for 18.9%. Compared with 2020, the population aged 0-15 decreased by 5.28 million, the population aged 16-59 increased by 2.47 million, and the population aged 60 and over and the population aged 65 and over increased by 3.29 million and 9.92 million respectively. The increase in the working-age population aged 16 to 59 is mainly due to the small number of people born in 1961. The proportion of the population aged 60 and over and the population aged 65 and over increased by 0.2 and 0.7 percentage points respectively compared with 2020, and the degree of aging further deepened.

　　It is predicted that the number and proportion of working-age population will continue the previous downward trend in the future. Although the working-age population tends to decrease, the total number is still nearly 900 million, and the labor resources are still abundant. From the quality point of view, the quality of the working-age population has improved significantly, and the average length of education has increased from 9.67 years in 2010 to 10.75 years in 2020, and the new advantages of talent bonus have gradually emerged.

　　Third, the level of urbanization has steadily improved.

　　By the end of 2021, China’s urban resident population reached 914.25 million, an increase of 12.05 million over the end of 2020; The resident population in rural areas was 498.35 million, a decrease of 11.57 million. The urbanization rate of permanent residents was 64.72%, an increase of 0.83 percentage points over the end of 2020.

　　Employment improvement of key groups

　　Wang Pingping, Director of Population and Employment Statistics Department of National Bureau of Statistics.

　　In 2021, with the sustained recovery of the national economy and the implementation of the employment priority policy, the national urban survey unemployment rate was lower than the expected target, and the employment situation was generally stable.

　　First, the urban survey unemployment rate remained generally stable

　　In 2021, the average urban unemployment rate was 5.1%, which was lower than the macro-control target of about 5.5%. In the first quarter, affected by the Spring Festival and the epidemic situation in some areas, the urban unemployment rate was relatively high, rising to a high of 5.5% in February. After the holiday, with the stable recovery of enterprise production and operation, the unemployment rate gradually declined. In the second quarter, the urban survey unemployment rate remained in the range of 5.0% to 5.1% in each month; In the third quarter, affected by the graduation season and the epidemic situation in some areas, the unemployment rate fluctuated. With the graduates entering jobs one after another and the impact of the epidemic situation weakened, the urban survey unemployment rate fell back to 4.9% in September. In the fourth quarter, the survey unemployment rate remained in the range of 4.9% to 5.1%.

　　Second, the overall improvement of the employment situation of key groups

　　In 2021, various policies and measures to stabilize employment and promote employment continued to be implemented, and the policy of reducing burdens, stabilizing posts and expanding employment continued to be implemented, and all-round employment services continued to exert strength. In the second half of 2021, the unemployment rate of the employed population aged 25 to 59 has been stable below 4.5%, which is lower than the same period of last year.

　　The employment situation of migrant workers has been continuously improved. After the Spring Festival in 2021, the unemployment rate of foreign agricultural registered population continued to fall, and by December, the unemployment rate of foreign agricultural registered population was 4.6%. By the end of 2021, the number of migrant workers nationwide had reached 292.51 million, an increase of 6.91 million over the end of last year, and it has returned to the same level in 2019. The employment situation of college graduates is generally stable. From June to July, the unemployment rate of young people aged 16 to 24 increased significantly due to the concentrated job hunting of college graduates. After September, with the implementation of graduate work, the youth unemployment rate gradually declined.

　　Third, employment stability still faces challenges

　　We must see that employment stability still faces challenges and pressures. Increased downward pressure on the economy will have a certain impact on employment. At the same time, the impact of the epidemic continues, and the production and operation of some industries and enterprises may be affected or impacted. It should also be noted that the number of college graduates will reach 10.76 million in 2022, an increase of 1.67 million over the previous year, with both scale and increment reaching record highs; The long-standing structural contradictions in some employment fields such as "difficulty in recruiting workers" and "difficulty in finding jobs" have not been fundamentally alleviated.

　　In 2022, it is necessary to continue to strengthen the employment priority policy, promote the implementation of measures to reduce burdens, stabilize posts and expand employment, increase employment assistance for key groups such as college graduates, strengthen vocational skills training, promote entrepreneurship to drive employment, and ensure a stable employment situation.

　　Residents’ consumption demand is gradually released.

　　Fang Xiaodan, Director of Household Survey Department of National Bureau of Statistics.

　　In 2021, the per capita disposable income growth of the national residents is basically synchronized with economic growth, the consumption expenditure of residents continues to recover, and the basic living consumption grows rapidly, realizing the mutual promotion and common progress of steady growth and benefiting people’s livelihood.

　　First, the per capita disposable income growth of residents is basically in sync with economic growth.

　　Residents’ income growth is basically synchronized with economic growth. In 2021, the per capita disposable income of the national residents was 35,128 yuan, a nominal increase of 9.1% over the previous year. After deducting the price factor, the per capita disposable income of the national residents actually increased by 8.1%, faster than the per capita GDP growth rate, and the income growth of the residents was basically in sync with the economic growth.

　　Second, the steady growth of wage income and transfer income lays the foundation for the steady growth of urban and rural residents’ income.

　　Wage income continued to grow steadily. In 2021, the per capita wage income of the national residents was 19,629 yuan, an increase of 9.6% over the previous year, with an average increase of 6.9% in two years. In terms of urban and rural areas, the per capita wage income of urban residents increased by 8.0%, with an average increase of 5.5% in two years. The per capita wage income of rural residents increased by 14.1%, with an average increase of 9.9% in two years.

　　Third, residents’ consumption expenditure continued to recover, and basic living consumption continued to grow rapidly.

　　Consumer spending continued to recover. With the continuous recovery growth of residents’ income, residents’ consumption demand is gradually released, and consumption expenditure keeps a recovery rebound trend. In 2021, the per capita consumption expenditure of the national residents was 24,100 yuan, a nominal increase of 13.6% on the basis of a low base in the previous year; After deducting the price factor, the actual increase was 12.6%.

　　Basic living consumption continued to grow rapidly. In 2021, the average per capita expenditure on food, tobacco and alcohol in China increased by 8.6% in two years, which was 2.9 percentage points faster than the average growth rate of all consumption expenditure in two years. The implementation of the policy of ensuring supply and stabilizing prices has been continuously strengthened, the food supply in the market is sufficient, and the food consumption of residents continues to grow steadily.

　　Prices in the consumer sector have risen moderately.

　　Wang Youfen, Director of Urban Social and Economic Investigation Department of National Bureau of Statistics.

　　In 2021, people’s livelihood security was strong and effective, the consumer market was generally stable, and CPI rose moderately; Actively respond to the sharp rise in energy and raw material prices, and the PPI rose at a high level.

　　First, prices in the consumer sector have risen moderately.

　　The monthly CPI is generally fluctuating upward year-on-year. In 2021, the CPI rose by 0.9%, which was 1.6 percentage points lower than the previous year, and the overall operation was in a reasonable range.

　　The rise in non-food prices pushed CPI up moderately. In 2021, non-food prices rose by 1.4%, an increase of 1.0 percentage points over the previous year, which affected the increase of CPI by about 1.17 percentage points.

　　The decline in food prices slows down the increase in CPI. In 2021, the price of food changed from 10.6% in the previous year to 1.4%, which affected the decrease of CPI by about 0.26 percentage points, mainly driven by the change of pork price.

　　Second, the price in the production field fell back at a high level.

　　The monthly year-on-year increase of PPI showed a downward trend. In 2021, PPI changed from 1.8% in the previous year to 8.1%.

　　The structural rise is obvious. In 2021, the price of means of production changed from 2.7% in the previous year to 10.7%, which affected the PPI increase by about 7.97 percentage points, exceeding 98% of the total increase. The price of means of subsistence rose by 0.4%, which was 0.1 percentage points lower than that of the previous year, affecting the PPI to rise by about 0.09 percentage points, and the overall situation was relatively stable.

　　Input factors boosted PPI. Since 2021, the demand for international commodities has recovered faster than the supply, and with the influence of abundant liquidity and other factors, the prices of crude oil and non-ferrous metals in the international market have risen, pushing up the ex-factory prices of related domestic industries and driving up the PPI.

　　Tight supply pushes PPI up. In the second half of the year, due to the tight supply and relatively strong demand, the price of coal mining and washing industry rose sharply, and the year-on-year increase expanded from 37.4% in June to 103.7% in October.

Hunan Provincial Department of Financepiece

Xiang Cai Gou [2015] No.5

Hunan Provincial Department of Finance on Further Standardization

Notice of government procurement work

Provincial budget units:

The Regulations on the Implementation of the Government Procurement Law of People’s Republic of China (PRC) (hereinafter referred to as the Regulations) came into force on March 1, 2015. forFurther standardize the government procurement work, improve the efficiency of government procurement, and build a standardized and transparent government procurement mechanism with fair competition, proper supervision and strict accountability.The relevant matters concerning the standardization of government procurement of provincial budget units (hereinafter referred to as purchasers) are hereby clarified as follows, please follow them.

First, clear responsibilities and establish an effective internal control mechanism for government procurement.

1, the implementation should be exhausted.The purchaser’s use of fiscal funds (that is, funds included in budget management) to purchase goods, projects and services within the centralized procurement catalogue or above the procurement limit standard should be included in government procurement. Borrowing funds with fiscal funds as the source of repayment are regarded as fiscal funds; If the procurement project uses both financial funds and non-financial funds, the part purchased with financial funds is applicable to government procurement; Where fiscal funds and non-fiscal funds cannot be purchased separately, government procurement shall be uniformly applied.

Should the project of government procurement be implemented without government procurement according to law, the Provincial Department of Finance shall not go through the government procurement procedures, and shall not pay the procurement funds, and shall be investigated for the legal responsibility of the relevant units and responsible persons according to law. Procurement projects involving national security and secrets shall be identified by the Provincial State Secrecy Bureau, and the purchaser shall report to the Provincial Department of Finance for the record.

2. Purchase in strict accordance with the law.The purchaser should establish the concept of "legal duty must be, and the law cannot be authorized", carry out government procurement activities in strict accordance with the provisions of the Government Procurement Law and its implementing regulations and relevant rules and regulations, and implement the relevant duties of the procurement subject.

The purchaser shall, in accordance with the provisions of the government centralized procurement catalogue and procurement quota standards promulgated by the Provincial Department of Finance, implement centralized procurement and decentralized procurement according to law. For the procurement projects within the centralized government procurement catalogue, if the system of agreed supply, fixed-point service, online bidding, electronic mall or batch centralized procurement is not implemented, and the single purchase amount does not exceed 50,000 yuan, and the annual cumulative amount does not exceed 200,000 yuan, the purchaser can organize the procurement by himself.

3. Establish internal control mechanism.The purchaser should follow the principle of "exercising power in different cases and establishing power in different posts".Clear procurement, finance, business related departments in government procurement activitiesJob responsibilities, set up incompatible posts such as demand confirmation, organization review and contract acceptance, and strengthen internal process control of government procurement. The purchaser shall strengthen the demand research, and the demand of the procurement project shall be confirmed by the purchaser in writing. The purchaser’s representative shall be authorized in writing by the unit to participate in the evaluation activities, and legal documents such as procurement documents, contracts and questions and answers shall be made after the legality audit in the unit.

4、Establish a dispute handling mechanism.The purchaser should seriously deal with,appropriateHandle supplier inquiries,Questioning and reporting cases, establishingPrevention and communication mechanism to resolve disputes according to law and avoid escalation of disputes; When dealing with procurement disputes, the purchaser should seek the opinions of the legal institution of the unit or the entrusted lawyer. If the procurement agency is entrusted to answer questions, it must be confirmed in writing before the reply is issued.

5. Strengthen file management.The purchaser and the procurement agency shall properly keep the procurement documents of each procurement activity. After the procurement activities are completed, the procurement agency shall hand over the procurement documents to the purchaser for archiving. Procurement documents can be saved in the form of electronic files.

Two, standardize the operation, establish a transparent and efficient government procurement mechanism.

6. Strengthen budget management.The purchaser shall, in accordance with the requirements of "all the staff should be compiled", compile the government procurement budget of the procurement project in the current year in the departmental budget, confirm the source of funds for the procurement project, clarify the procurement demand, and refine the procurement items to the last level of the Catalogue of Government Procurement Items. For the procurement projects included in the government procurement budget at the beginning of the year, the purchaser shall strictly follow the approved government procurement budget and be responsible for the implementation results according to law.

If the purchaser adds new government procurement projects, changes or adjusts the procurement items, procurement quantity and budget amount of the approved government procurement projects, it shall correspondingly add and adjust the government procurement budget within the total budget expenditure of the approved department, and shall fill in the Adjustment Form for the Implementation of Government Procurement Budget (Annex 1) and submit it to the Provincial Department of Finance for examination and approval before implementation. Involving future annual departmental budget funding arrangements or the use of fiscal funds for repayment of borrowing funds procurement projects, it is necessary to obtain the consent of the budget management offices of the relevant departments of the Provincial Department of Finance, and implement the funding sources before filing the government procurement implementation plan.

The unused government procurement budget and departmental budget at the end of the year are carried forward synchronously, and the approved government procurement budget will be cancelled if the budget indicators are recovered; If the budget indicators are agreed to be carried forward, the purchaser shall implement it according to the government procurement budget issued after the carry-forward, and apply the centralized government procurement catalogue and procurement quota standard and open tender amount standard in the new budget year.

7. Strict planning and management.The purchaser shall prepare the government procurement implementation plan according to the approved government procurement budget and approved fund plan (see Annex 2 for the format), and report it to the Provincial Department of Finance for the record and obtain the plan number. The procurement items, quantity, budget amount and other contents of the government procurement implementation plan should be consistent with the approved government procurement budget and fund plan. The purchaser’s filing of engineering (Class B) projects shall also be in accordance with the "Implementation Measures for the Evaluation and Management of Financial Investment in Hunan Province"(Xiang Cai Ban [2011] No.16)Conduct financial investment review, and determine the budget amount of the procurement project implementation plan according to the conclusion of the financial investment review.

The purchaser’s adjustment of the implementation plan should be re-filed in time, and the budget adjustment and approval procedures should be performed first if it involves the adjustment of the government procurement budget.

8. Strict examination and approval management.Government procurement projects that meet the standard of public bidding amount need to adopt procurement methods other than public bidding, and purchase imported products, should be submitted to the Provincial Department of Finance for examination and approval in writing before the preparation of the government procurement implementation plan. The Provincial Department of Finance implements the time-limited settlement: from the date of receiving the application, it will give a written reply within 10 working days; If the material does not meet the requirements, it shall be revised and supplemented within 3 working days.

If the government procurement project intends to adopt the bidding procurement method, the purchaser shall specify the bid evaluation method in the procurement implementation plan; The lowest bid evaluation method should be adopted for goods and services with uniform standards such as technology and services; If the comprehensive scoring method is adopted, the score setting in the evaluation criteria should correspond to the quantitative indicators of the evaluation factors. If the government procurement project intends to adopt the non-tendering procurement method, the purchaser shall clearly invite suppliers in the procurement implementation plan.

9. Standardize agency behavior.The projects in the centralized procurement catalogue should be entrusted to the government procurement center of Hunan provincial organs to organize procurement; The project purchaser outside the catalogue may entrust a procurement agency to purchase, or organize the procurement by itself. Entrust a procurement agency, should comprehensively consider the client’s professional ability, management level and fees, and choose the best. The purchaser shall organize the procurement activities by himself, and shall not charge the supplier for the cost of procurement documents.

When the purchaser entrusts a procurement agency, it shall sign an agency agreement (for the format, see the Detailed Rules for the Implementation of the Measures for the Administration of Non-tendering Procurement by Hunan Provincial Government) to clarify the entrusted matters and the rights and responsibilities of both parties. The legal responsibilities of the purchaser, such as confirming the procurement documents, recommending suppliers, confirming the evaluation report, and confirming the successful bidder (transaction), shall not be entrusted to the procurement agency.

If a procurement agency collects agency service fees from the successful bidder (clinch a deal), it shall clearly inform the supplier of the limit and collection method of agency service fees in the tender (supplier invitation) announcement and project procurement documents.

10. Standardize expert extraction.In addition to the provisions of the Ministry of Finance, the evaluation experts should be drawn from the government procurement expert database. The purchaser and the procurement agency shall submit the extraction application online 3 working days in advance, and the system will randomly extract it within 24 hours before the evaluation and notify the evaluation experts. The evaluation of bidding documents, the demonstration of imported products and the demonstration of single-source procurement need not be drawn from the expert database of government procurement.

11. Relax access conditions.The purchaser and procurement agency shall clearly define the basic qualifications of suppliers participating in government procurement in strict accordance with paragraph 1 of Article 22 of the Government Procurement Law and paragraph 1 of Article 17 of the Regulations. Only the conditions mandated by laws and regulations or set for realizing the functions of government procurement policies can be regarded as specific qualification conditions. The purchaser and the procurement agency shall not require the supplier to provide certification materials other than the basic qualifications and specific qualifications for any reason. The registered capital, total assets, operating income, employees, profits, tax payment and authorization of manufacturers shall not be set as supplier qualification conditions, and small and medium-sized enterprises shall not be hindered or restricted from freely entering the government procurement market in their own regions and industries.

12, standardize the project review.In addition to the qualification examination identified errors, score summary calculation errors, sub-item scores beyond the scope of scoring standards, objective scores are inconsistent, and the evaluation committee unanimously identified the scores as abnormally high and abnormally low, the purchaser and procurement agency shall not organize re-evaluation. Under the above circumstances, if the result of winning the bid (clinch a deal) is changed after the purchaser reorganizes the review, or if the result of winning the bid (clinch a deal) is changed due to the query reply, the purchaser shall timely report the relevant information to the Provincial Department of Finance for the record, and inform the suppliers involved in the procurement activities and announce the reasons.

13. Implement policy functions.The purchaser shall implement the relevant policy functions of government procurement in the process of government procurement budget preparation and project review. The compulsory procurement items in the List of Government Procurement of Energy-saving Products shall be subject to government compulsory procurement; The products of prison enterprises and welfare enterprises can be given targeted support by setting specific qualifications; Non-mandatory procurement items in the List of Government Procurement of Energy-saving Products, products in the List of Government Procurement of Environmental Labeling Products, products listed in the Catalogue of Government Procurement of Two-type Products in Hunan Province and products of small and medium-sized enterprises shall be subject to preferential evaluation measures such as price deduction and extra points in bid evaluation in accordance with relevant policies and regulations. At the same time, for energy saving, environmental labeling and two-type products, the supplier shall choose one of them to enjoy the preferential evaluation; Only those who meet the national policy of promoting the development of small and medium-sized enterprises can enjoy the preferential review again. Only part of the products in the same project belong to the scope of preferential policies for evaluation, and only this part of the products will be given preferential treatment during evaluation.

14. Standardize the agreed supply and fixed-point procurement.Except that the designated intermediary service for official travel abroad (border) is changed to the designated official air ticket, the agreed supply and designated procurement of provincial units will continue to be implemented until June 2016.It ends on the 30th of June. When the purchaser selects the short-listed supplier or the short-listed supplier with the lowest quotation according to the regulations, it shall announce the closing result and contract within 2 working days from the date of closing, and put the contract on record within 7 working days from the date of signing the contract. The scattered fixed-point procurement with a cumulative amount of no more than 50,000 yuan can be announced and put on record after being merged regularly. The purchaser can organize the bidding of the shortlisted suppliers by himself, or entrust the government procurement center of the provincial government of Hunan Province to organize it.

Third, strengthen supervision and establish a strict accountability supervision mechanism for government procurement

15. Promote information disclosure.The purchaser and procurement agency shall, within 2 working days from the date of determining the supplier who won the bid (clinch a deal), announce the result of winning the bid (clinch a deal) and the tender documents, competitive negotiation documents or inquiry notice on the Hunan government procurement website, and the announcement period shall not be less than 3 working days; Within 2 working days from the date of signing the government procurement contract, the government procurement contract will be announced on the Hunan government procurement website, except for the contents involving state secrets and commercial secrets. If the purchaser entrusts an agency to issue an announcement, it shall review the contents of the announcement and bear corresponding responsibilities.

The contents of the announcement of the winning bid (transaction) results shall include:

(1) the name, address and contact information of the purchaser and the procurement agency, the project name and project number, the name and address of the supplier who won the bid (clinch a deal) and the bid (clinch a deal) amount;

(2) For goods procurement projects, the name, specifications, brand, manufacturer, quantity, unit price and service requirements of the goods shall be announced; For service procurement projects, the service list, service content and staffing list shall be published; For engineering procurement projects, the bill of quantities, material quantity and unit price, labor cost, etc. shall be published;

(3) List of suppliers participating in procurement activities, quotation, rating and qualification, compliance review and list of review experts. If the supplier is recommended in writing to participate in procurement activities, the recommendation opinions of the purchaser and evaluation experts shall also be announced.

The publicity of single-source procurement that meets the standard of public bidding amount, and the announcements of goods and services procurement projects with more than 10 million yuan (including: bidding announcement, pre-qualification announcement, competitive negotiation, invitation of inquiry procurement suppliers, announcement of bid winning and transaction results, announcement of procurement contract, etc.) shall be released simultaneously on Hunan Provincial Government Procurement Network (www.ccgp-hunan.gov.cn) and Red Net Government Procurement Channel (zfcg.rednet.cn).

The purchaser shall complete the contract filing within 7 working days from the date of signing the procurement contract, and the original method of signing the electronic contract online shall be stopped.

For government procurement construction projects and goods and services procurement projects related to the project construction to which the tendering and bidding law is applicable, the purchaser shall issue tender announcements, pre-qualification announcements and publicity of successful candidates in accordance with the regulations for the implementation of the tendering and bidding law, and provide links to relevant information for simultaneous reprinting on Hunan government procurement network. The purchaser shall, in accordance with the provisions of this notice, publish the winning contract online and put it on record.

16. Strengthen daily supervision.The Provincial Department of Finance will strengthen the supervision and inspection of government procurement activities of purchasers and procurement agencies according to law. Specific methods include: organizing special inspections, regularly sampling the bid-winning (clinched) projects, and irregularly checking the procurement activities of purchasers and agencies. The competent budget unit of the purchaser shall strengthen the guidance of the government procurement work in this system and perform the corresponding supervisory duties.

17. Build a credit system.The Provincial Department of Finance further refines relevant measures and formulates government procurement agencies and evaluation experts.andSupplier credit record standard; The establishment of bad behavior record management and publicity system, the illegal agency, evaluation experts.And suppliers, included in the list of bad behavior records, and to the public.

18, strict accountability.For violations of laws and regulations found in supervision and inspection, the Provincial Department of Finance will promptly handle and report them according to law, and urge rectification; For serious illegal acts and dishonesty in government procurement activities, the Provincial Department of Finance will jointly implement joint punishment with relevant departments according to law.

This notice shall be implemented as of the date of promulgation. The Hunan Provincial Government Procurement Work Standard (Xiangcai Purchase [2012No.14), "Detailed Rules for the Implementation of the Measures for the Administration of Non-tendering Procurement of Hunan Provincial Government Procurement" (Xiangcai Purchase [2014] No.15) and other documents that are inconsistent with the "Regulations" and the provisions of this notice shall be suspended.

Attachment: 1. Adjustment Table of Government Procurement Budget Implementation

2, the government procurement implementation plan for the record table

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 Hunan Provincial Department of Finance

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 July 10th, 2015

　　Influenza, as we often say, is an acute respiratory infectious disease caused by influenza virus, which usually causes many people to be infected in a certain season or time period, with obvious seasonality. According to the estimation of the World Health Organization, the seasonal epidemic of influenza virus can lead to an average of about 3 million to 5 million severe cases and 290,000 to 650,000 respiratory disease-related deaths worldwide every year.

　　Today, let’s talk about the difference between influenza and common cold, why respiratory infectious diseases are prone to occur in autumn, winter, winter and spring, what are the common respiratory infectious diseases, and how to jointly prevent respiratory infectious diseases.

　　1. What’s the difference between the flu and the common cold?

　　Although influenza and common cold are both respiratory diseases, they are completely different. The follow table lists that difference between influenza and common cold:

　　Second, why are respiratory infectious diseases prone to high incidence in autumn and winter and winter and spring?

　　Mainly includes the following reasons: First, the cold season is more conducive to the survival of most pathogens; Second, doors and windows are often closed in autumn, winter, winter and spring, and indoor air circulation is reduced. Once there is a source of infection, it is easy to cause the spread of diseases; Third, the resistance of nasal mucosa decreases in cold season, and pathogens are more likely to invade the human body; Fourth, there are many indoor activities in the cold season, which increases the chance of infection.

　　3. What are the common respiratory infectious diseases?

　　Common respiratory infectious diseases include influenza, Covid-19 infection, measles, mumps, rubella, chickenpox, epidemic cerebrospinal meningitis, whooping cough and mycoplasma pneumoniae infection. With the coming of autumn and winter, influenza activities may increase, and the risk of cluster epidemics in schools and other crowded places will increase. The risk of common or alternate epidemics of mycoplasma pneumoniae infection, respiratory syncytial virus infection, adenovirus infection, common coronavirus infection and rhinovirus infection is high.

　　Fourth, how to carry out multi-disease prevention of respiratory infectious diseases?

　　Vaccination is the most economical and effective way to prevent infectious diseases. At present, the respiratory infectious diseases that can be prevented by vaccines in China include influenza, measles, mumps, rubella, chickenpox, epidemic cerebrospinal meningitis, whooping cough, diphtheria, pneumococcal infection and Haemophilus influenzae infection. At present, it is the best time for influenza vaccination. All people aged 6 months and above who have no vaccination contraindications can get influenza vaccination, especially the elderly, children, patients with chronic basic diseases and other high-risk groups.

　　Taking daily protection and public health measures can also effectively achieve multi-disease prevention of respiratory infectious diseases, including:

　　1. Pay attention to cough etiquette and hand hygiene, and develop good hygiene habits;

　　2. Enhance physical fitness, pay attention to balanced nutrition, improve physical resistance and develop a healthy lifestyle;

　　3. Try to go to crowded public places as little as possible, especially closed places with poor air flow;

　　4. Reduce contact with people with respiratory symptoms, and pay attention to personal protection when contacting;

　　5. Do a good job in indoor ventilation.

CCTV News:The Regional Comprehensive Economic Partnership Agreement will come into effect on January 1, 2022 for 10 countries that have completed the approval procedures, which will also provide many opportunities for the development of China’s agricultural trade. In this context, Guangdong’s agricultural sector has built an international trading center for agricultural products in six major high-quality fruit producing areas to boost the quality and efficiency of the entire industrial chain of agricultural products.

During this period, fruits in many places in Guangdong entered a concentrated picking period. Deqing County is the main producing area of citrus in Guangdong. The fruit farm operated by the grower Xu Junwei has a planting area of 120 mu, and this year’s output has reached 500,000 Jin. In the past two years, the output of citrus has been increased by improving varieties and planting techniques. This year, he aimed at overseas markets.

Citrus grower Xu Junwei:The sales channels have been expanded, and the sales prices have also increased, so that the benefits of our fruit farmers in the production process have been better guaranteed.

Under the policy background of "Regional Comprehensive Economic Partnership Agreement", at present, Guangdong agricultural departments have successively established international trading centers for agricultural products in six high-quality agricultural products planting areas, including citrus, litchi and longan, so as to let high-quality agricultural products go out and promote the high-quality development of Guangdong agriculture.

Huang Weihua, Director of Exchange and Cooperation Department of Guangdong Provincial Department of Agriculture and Rural Affairs:We aim at RCEP, which will take effect early next year, and take the lead in guiding and supporting the construction of a number of international trading centers for agricultural products. We can promote the ability of our agricultural products to enter the international market, thus promoting the quality improvement and efficiency improvement of the whole industrial chain of agricultural products from breeding production and logistics processing.

　　BEIJING, April 18 (Reporter Cheng Chunyu) On April 17, the People’s Bank of China decided to reduce the deposit reserve ratio of some financial institutions from April 25 to replace the medium-term lending facilities. Experts believe that this move will reduce the cost of bank capital and corporate financing, benefit the bond market, and help stabilize the stock market and the macro economy.

　　On the 17th, the People’s Bank of China decided to lower the deposit reserve ratio of some financial institutions to replace the medium-term lending facilities. Photo by Yang Mingjing

　　Which banks are involved in this move?

　　According to the notice of the central bank, the RMB deposit reserve ratio will be lowered by 1 percentage point from 25th, involving large commercial banks, joint-stock commercial banks, city commercial banks, non-county rural commercial banks and foreign banks.

　　At present, the benchmark level of these banks’ deposit reserve ratio is relatively high at 17% or 15%, and institutions that borrow MLF are also among these banks.

　　At the same time, the central bank requires that on the same day, the above-mentioned banks will use the funds released by the RRR cut to repay the medium-term lending facilities (MLF) borrowed by the central bank in the order of "borrowing first and returning first".

　　Pan Xiangdong, chief economist of New Era Securities, thinks that MLF cannot completely replace RRR cut. Specifically, MLF has a time limit, which will aggravate liquidity stratification, and MLF needs to pay interest, and financial institutions will pass the cost on to enterprises. By replacing MLF with RRR reduction, the interest payment cost of commercial banks is reduced, which is conducive to reducing the financing cost of enterprises.

　　Why is this time point implemented?

　　The relevant person in charge of the central bank said that at present, China’s small and micro enterprises still face the problem of financing difficulties and expensive financing. In order to increase support for small and micro enterprises, we can replace part of the central bank’s borrowing funds by appropriately lowering the statutory deposit reserve ratio, further increase the stability of the banking system’s funds, optimize the liquidity structure, and appropriately release incremental funds.

　　Pan Xiangdong told reporters that the reason for not lowering the RRR in recent two years is to prevent risks. However, after deleveraging, China’s macro leverage ratio has been controlled, and the RMB exchange rate has been relatively stable and even appreciated since 2017. China’s economic and financial risks have been well controlled, and the constraints on monetary policy have been alleviated.

　　According to Zhang Ming, chief economist of Ping An Securities, the central bank’s move is a "neutral" RRR cut. He believes that the timing of the relaxation of the central bank’s liquidity operation is advanced, which makes the probability of possible tightening of financial regulatory policies in the second quarter decline.

　　How much incremental funds will be released?

　　The relevant person in charge of the central bank said that based on the data at the end of the first quarter of 2018, the MLF was repaid about 900 billion yuan on the day of operation, and the incremental funds were released about 400 billion yuan. Most of the incremental funds were released to city commercial banks and non-county rural commercial banks.

　　The person in charge pointed out that this measure will increase the long-term capital supply and reduce the cost of bank funds. The replacement of MLF can reduce the interest payment cost of commercial banks and help reduce the financing cost of enterprises. The released incremental funds have increased the low-cost sources of loans for small and micro enterprises.

　　Pan Xiangdong also pointed out that cost reduction is the focus of supply-side structural reform this year, and reducing the financing cost of enterprises is the top priority. Previously, the central bank has been implementing the targeted cuts to required reserve ratios, but the release of liquidity is limited, and the problems of difficult and expensive financing for small and micro enterprises have not been effectively solved. This RRR cut can increase the support for small and micro enterprises.

　　What is the impact on financial markets such as the stock market?

　　Zhang Ming said that the direct impact of the central bank’s move is to benefit the bond market and help stabilize the stock market and the macro economy. Pan Xiangdong expressed the same view that the RRR cut is conducive to economic stability and the capital market.

　　Pan Xiangdong added: First, the RRR cut will help ease the pressure on banks’ debt side, reduce the financing costs of enterprises, expand investment and increase the growth rate of manufacturing investment, which has been at a low level for a long time. Second, the RRR cut is conducive to expanding domestic demand and hedging the uncertainty faced by China’s external demand. Third, while supplementing liquidity, it will stimulate the capital market.

　　On the 17th, the four major A-share indexes in China all fell, and the representative Shanghai Composite Index fell 1.41% to close at 3,066.80 points, a record low for the year.

　　Yang Delong, chief economist of Qianhai Kaiyuan, said that the economic fundamentals have not changed. Recently, many high-quality stocks in the A-share market have been wrongly killed. The central bank’s downgrade will boost market confidence, and the market outlook is expected to rebound and gradually repair the previous downward trend.

　　Does the RRR cut mean that the orientation of monetary policy has changed?

　　The reporter noted that some institutions believe that the loose space of monetary policy is open, "the central bank’s move means that monetary policy is fine-tuning."

　　Pan Xiangdong believes that risk prevention is one of the three major battles in 2018, and the prudent neutral monetary policy will not change. In March, the central bank followed the Federal Reserve to raise the short-term money market interest rate, and the government proposed structural deleveraging, all of which have clearly conveyed the determination to prevent risks.

　　"The stable and neutral monetary policy orientation remains unchanged." The relevant person in charge of the central bank made it clear that most of the funds released by the RRR cut were used to repay the medium-term loan facilities, which were substitutes for two liquidity adjustment tools, while the remaining small amount of funds were hedged with the tax period in the middle and late April. Therefore, while optimizing the liquidity structure, the total amount of liquidity in the banking system remained basically unchanged and remained neutral.

　　At the same time, the person in charge said that China is a developing country, and in order to prevent financial risks, it still needs to maintain a relatively high deposit reserve ratio. The People’s Bank of China will continue to implement a prudent and neutral monetary policy, maintain a reasonable and stable liquidity, guide a steady and moderate increase in the scale of monetary credit and social financing, and create a suitable monetary and financial environment for high-quality development and supply-side structural reform. (End)

　　Now we all have a common problem, that is, we always feel that the mobile phone traffic is not enough. In the past, when there was no unlimited traffic card such as Unicom Dawang Card, the traffic in the package was very small, and it was very expensive to deduct the excess traffic. In order to save money, we controlled ourselves to brush less videos and browse less websites, but the traffic for one month was enough. At that time, the sign was to set the mobile phone to automatically disconnect from the network after the monthly traffic was exceeded to prevent yourself from being charged a high fee.

　　Now, after the unlimited traffic card comes out, we let go of our constraints, and dozens of GB of traffic a month can’t meet our needs. And once you let go of the constraints on yourself and then want to go back to the past, according to the maximum amount of traffic you use every day, turn off the traffic after using it to control your life, and you will never go back. This is the so-called "from frugality to luxury, from luxury to frugality." Because of this, our monthly traffic charges are much higher than before, but the telephone charges have not increased much, which may be the result that major operators want to see most.

　　Of course, there are other reasons for insufficient traffic, such as:

　　1. The performance of mobile phones is better than before, and the software package is bigger than before;

　　2. Now the frequency of software update is faster than before;

　　3. Now that mobile phones can bring more entertainment software, we spend more time playing mobile phones than before;

　　4. The current network transmission speed is faster than before, and the clearer the video and pictures, the more traffic it costs;

　　With the reform of information technology, a lot of work and study have been transferred to the network, so the traffic used is naturally more than before, and so on.

　　So do you think your monthly traffic is enough? What can we do to get enough traffic every month? Now I have summarized 17 ways to solve the problem of insufficient traffic, and listed them for you one by one. Let’s take a look.

　　The first one uses less data traffic and more WiFi.

　　The way to use less traffic is to try to connect to WiFi before you start playing mobile phones at home, at work or at friends’ homes, instead of letting you reduce traffic. If you have a lot of software to update, or want to download a TV series or movie, when you need several GB of traffic, you can control yourself first and wait until we connect to WiFi. In this way, we can save ourselves the next traffic fee every month. As time goes on, it will be a considerable sum in a few years.

　　The second option is to choose an operator with cheap traffic.

　　There are three domestic operators: China Mobile, China Unicom and China Telecom. The charging standards for traffic, voice calls and short messages are different from each other. At present, the charging standards for traffic are probably as follows:

　　If you don’t want to change the number but want to use more traffic, you can handle the port number transfer service, so that everything tied to your number will not be affected, and your friends can contact you.

　　The third way is to do a package with more traffic.

　　Open WeChat to search for [card bubble] and you can apply for a large-flow package of 200G per month. The traffic in the package is very cheap, much cheaper than the traffic refueling package outside the package, so we try to choose those packages with a lot of traffic. At present, the flow of the large flow card package is the cheapest, with 200G almost as long as 19 yuan per month. It can be used not only for surfing the Internet, but also for making phone calls and sending short messages. It can also be used as an auxiliary card, and the main card uses the previous mobile phone card. Secondly, the package with streaming-free software is cheaper, because this package often contains dozens of GB of free directional exclusive traffic. Finally, compared with the first two kinds, the ordinary package charges with traffic are much more expensive, so we don’t recommend you to handle them.　　

　　The fourth is to participate in the activities of giving away traffic from operators.

　　Each operator will launch various activities in its own APP and WeChat official account, and get some traffic for free through these activities, such as traffic grabbing activities released irregularly by Mobile, traffic checking activities, traffic signing activities and so on. Pay attention to WeChat WeChat official account [Card Bubble] and you can get it. Some of them are used in the software required by operators, such as mobile migu music and Mi Gu video. Some are national general traffic, which can be used in any APP and anywhere. Participating more and using these traffic according to the requirements of operators can help you save a lot of traffic fees.

　　Fifth, multi-purpose streaming-free software disables non-streaming-free software from networking with data traffic.

　　Each free-stream package has its own exclusive free-stream software, and the traffic consumed in the process of using these softwares is given away for free. You can get it by following WeChat WeChat official account [Card Bubble], but the traffic consumed by using software other than these softwares and the traffic given away for free will be deducted after use. Only one network is allowed for each software. For example, users of Tencent Dawang Card want to browse the web, only one QQ browser without streaming is allowed to connect to the network, and other browsers are set to prohibit using data traffic to connect to the network. Each streaming-free package has its own platform to view this streaming-free software. Take Tencent King Card as an example. The query entry is: Click on the "Wangka Assistant" WeChat official account-Privilege-Streamless Application Center-drop-down page and click on the "Streamless Description" at the bottom to view all the streaming-free software of Tencent King Card.　　

　　The sixth way is to set the pictures and videos to low-color mode or no-picture mode in the software settings.

　　In the process of data transmission, the traffic occupied by words is very small, and most of them are consumed by large files such as pictures and videos. Reducing their image quality can help us save a lot of traffic, sacrifice a small part of the experience, and save a lot of traffic fees.　　

　　The seventh current-saving mode of opening software

　　The software itself also has a flow saving mode. When this function is turned on, the software will automatically help us save the flow consumed during use. However, this function also retains our sense of experience in the process of use, that is, it saves the flow without affecting our visual experience. It is much better than the graph-free mode of opening the software, but the disadvantage is that the flow saving effect is not obvious.　　

　　Eighth, turn on the advertisement filtering function

　　In the process of using mobile phones, advertisements are the last thing we like to see. Turning on the advertisement filtering function in software settings can not only help us save the traffic consumed by advertisements, but also make us feel more happy in the process of using mobile phones.　　

　　The ninth kind of shutdown software uses traffic synchronization information.

　　Many software will synchronize our data to the background, especially the network disk, which is a software that specially backs up our data. Every time we synchronize data, it will take us as little as a few GB and as much as dozens of GB. Turning off the software and using traffic synchronization information, and then synchronizing when there is WiFi, can help us save a lot of traffic.　　

　　Tenth, open the WiFi-only networking function.

　　Many softwares have the setting that only WiFi networking is turned on. When it is turned on, the software automatically does not use data traffic. When we have enough traffic, we can turn this function off, and when we have finished the traffic consumption, we can turn this function on, which can save us a lot of traffic.　　

　　Eleventh download navigation software offline map and offline voice.

　　Navigation software is one of the most frequently used software in our life, especially when we are in a new environment, we are unfamiliar with the roads around us, and we can’t move without navigation software. Friends who often use navigation software and friends who often drive must remember to download offline maps. In most cases, every time we quit using navigation software, we will consume dozens of MB of traffic, and the number will be even greater if we use it with multiple frequencies and for a long time. Find a WiFi to download the offline maps and voice packets in the navigation software, which can save you a lot of traffic.

　　Twelfth, turn off the functions of listening to live broadcast in the background and playing live broadcast automatically.

　　Many live broadcast software and shopping software have the function of listening to live broadcast in the background and playing live broadcast automatically. As long as we browse to the page containing live broadcast, it will play live broadcast automatically. And after we click back, this live broadcast is still playing in the background, consuming our traffic. Turning off these two functions can help us save a lot of traffic.

　　Thirteenth message notification that it doesn’t matter to close the software.

　　Under normal circumstances, each software will push us at least 2-3 notifications a day. Every day, the mobile phone vibrates in the bag and keeps ringing. Every time we thought that someone was on WeChat, QQ, or someone sent a text message to find us. In order not to miss important information, we found that it was a spam notice after opening the lock screen, which made us feel very annoyed.

　　It is not important to close the software, which can not only help us save the traffic consumed by the software background networking, but also make our mood happier.　　

　　Fourteenth, buy a portable WiFi.

　　Portable WiFi is a small electronic device, which is equivalent to a mobile router. It can send out WiFi signals at any time and anywhere with signals. Provide network connection for your mobile phone, tablet computer, notebook computer, and all the devices that can connect to WiFi of your friends and company. It can’t make phone calls or send text messages, which is similar to putting a pure flow card in a rechargeable electronic device, and whether there is a plug-in version with a built-in pure flow card is on sale. Its price is cheap, generally around 100-300. You can get it for free by paying attention to WeChat WeChat official account [Card Bubble], and the traffic charge is very low. Long-term use can save you a lot of traffic charges, which is very suitable for people with many electronic products, high traffic consumption and frequent business trips.　　

　　The fifteenth type has some flow-free VPN, which can be connected without flow.

　　In the past, many IT masters built many VPNs, some of which were charged, but most of them were free. When the mobile phone is connected, all the traffic generated is free, and the traffic in the operator’s package will not be reduced by 1MB. However, with the introduction of the national policy to crack down on illegal VPN, all kinds of VPN software disappeared in the whole network, so it is difficult to find such software again, and we don’t recommend that you do anything illegal.　　

　　Sixteenth, change to a mobile phone with average performance

　　If the performance of the mobile phone can only be used for making phone calls, texting, handling work and studying, we can reduce the use of the mobile phone, because it will get stuck playing games and brushing videos, which will lead to insufficient storage of the mobile phone. This will not only help us save traffic, but also help us quit the internet. Why not kill two birds with one stone?　　

　　Seventeenth, put down your mobile phone and raise your head to get rid of the bad habit of playing with your mobile phone often.

　　Playing mobile phones often not only harms our eyesight, but also shrinks our brains, and eventually our ability to concentrate, think and remember will gradually decline. Moreover, it will gradually reduce our contact with family and friends and eventually become a lonely person. And it also wasted a lot of our precious time. "There will be a reopening day, and no one will be a teenager." I hope everyone will cherish every moment of life, do more things that interest them, or learn something that interests them. The content on the mobile phone will only bring us short-term happiness, but it can’t change the status quo in our lives. We still have to face our real life when we put down the mobile phone. So, please come back to real life and leave the virtual world. Habits are formed, the bad habit of playing mobile phones often is formed, and the good habit of playing mobile phones less is also formed. As long as you are strict with yourself, you will naturally feel that it doesn’t matter if you don’t play mobile phones after a long time.