Original shichao bad review

Yesterday, Bing ushered in a super heavy update.

Apart from other details of the update, a comprehensive open beta is enough.

This means that you only need to register a Microsoft account to use Bing Chat.

In this way, I’m afraid Bing is the biggest language model with the lowest usage threshold at present.

In addition to the open beta, other updates are also very exciting. Before you rush to experience it, you can find out what new tricks Microsoft has made this time.

The world super here, for everyone to sum up as follows:

1. Multi-modal content and text mapping.

2. Historical record function.

3. Open plug-in access.

4, and a bunch of ultra-practical small functions.

It should be noted that at present, not all functions are open, so I will introduce them to you one by one.

First of all, it is the first update: graphic and multimodal content.

Although Microsoft launched Wencheng Map before, it has updated more than 100 languages this time, and now you can directly ask Bing to help you generate pictures in Chinese.

If you want to experience the latest pictures, you need to adjust the dialogue style to be "more creative". After that, just click and ask.

However, after the experience of Shichao, I feel that Bing’s Wen Chengtu is still almost interesting.

Because Bing is connected to DALL·E, the generated pictures may be good before. However, compared with midjourney and Stable Diffusion, which are now popular, it’s not enough. .

Moreover, although Chinese input is supported, the understanding of Chinese in Bing drawing is almost unknown.

When Shi Chao asked a classic "braised lion head", Bing really brought me a plate of lion head. .

If we look closely, we will find that it translates "lion’s head" into "lion’s head"

Sweet and Sour Mandarin Fish painted real squirrels and real fish. .

But Shichao soon discovered that it was not that Bing couldn’t draw. .

If we ask it to translate the input into English, it will understand that the lion’s head is not a lion, but a pork ball.

After the translation is in place, there is nothing wrong with the generated picture.

From this point of view, Bing’s own Chinese understanding should be no problem.

However, Wenchengtu is based on Bing image creator, a Microsoft painting platform, which may have translated Chinese literally when drawing.

After trying Wenchengtu, we are only halfway through the first big update. Visually, Bing has another highlight this time, which is its multimodal content.

When we ask a question, the related pictures will be displayed below the text results. In this way, the results can be displayed very intuitively, saving the time of going in and watching one by one.

Also asked "Braised Lion Head", Bing’s answer was completely correct, and even introduced the practice of this dish.

Shichao thought it would be convenient to use this image output function to find expression packs.

In addition to pictures, Bing’s multimodal mode also supports video output. Moreover, when we move the mouse to the video cover, we can also preview and play it online.

After that, not only the output content supports multimodal, but also the input can be uploaded with pictures.

What can be experienced at present is almost the first big update. Because of the following contents, most of them are not open to the public yet.

Although I can’t get started yet, from the demonstration video, it seems that they are the real highlights.

For example, the second updated history function can take the conversation experience to the next level.

Every time we ask questions, we will be saved in the guide on the right. Click on the question to jump to the corresponding location.

Moreover, after clicking on the answer link, Bing Chat will shrink to the side and become a page sidebar.

This small change is quite convenient. For example, if we import a PDF, we can use Bing to help you summarize, find words and translate.

In addition, Bing will also support long conversations. Even if we quit and close the chat interface halfway, the conversation will remain. Next time you click in, you can continue from the last place.

Chat content will also support exporting and sharing, and can be shared with friends on social media with one click, or imported into applications such as Word.

If the second update is to make it more convenient for users.

The third major update, which is also the most likely function of Shichao-plug-in, is to make Bing super-evolve.

The official example says that he is about to access the takeaway platform OpenTable. This means that in a word, you can ask Bing to recommend a restaurant for you, or make a direct restaurant reservation.

If you can access other platforms in the future, you may be able to stimulate stronger functions. For example, by accessing a map, you can make a route according to your own needs.

In addition, Microsoft will build a development platform to let more people participate in the development of plug-ins.

If this road goes on, it will be more than just the work done by search engines in the past.

In addition to the above three major updates, Microsoft also showed a lot of practical small functions, such as asking Bing to find a movie for you, and after finding it, you can jump and play it directly.

The mobile version will support page context questions, for example, if you are browsing an article or a website, you can ask Bing questions about what you are browsing, and it can also answer them.

Or write a manuscript directly on the Bing page and tell it the tone, length and wording you want.

I got so cruel that I even lost my job in Microsoft 365. .

Generally speaking, this update of Bing shows the ambition of this search engine.

That is: what search engines can do, I want to do my best, and what search engines can’t do before, I want to steal it now.

Moreover, in the official blog, Microsoft said that Bing’s daily activities have exceeded 100 million, and the daily installation of APP has increased fourfold.

In addition, the share of Edge continues to grow for 8 consecutive years, and various functions are updated and added, and third-party plug-ins supplement Bing.

Establishing a new Microsoft ecosystem may, indeed, be just around the corner.

Although many functions are not online yet, the next update is not far away. Because according to the feedback uploaded by users, Microsoft will make updates and changes every week.

Although very unkind, I really miss @ Google at this moment.

Brother, others have gone to the next Level. What about yours?

Written by: Four Editors: Jiang Jiang & Noodle Cover: Xuan Xuan

Pictures and data sources:

Twitter

Announcing the next wave of AI innovation with Microsoft Bing and Edge

Original title: "NewBing suddenly opened up in an all-round way, and also updated the functions of a bunch of dead friends. 》

Read the original text

[Editor’s Note] "We should develop traditional Chinese medicine, pay attention to interpreting the principles of traditional Chinese medicine with modern science, and take the road of combining traditional Chinese and western medicine." On May 12th, General Secretary of the Supreme Leader once again asked about Chinese medicine during his inspection tour in Nanyang City, Henan Province, and put forward new and clear requirements for the further development of Chinese medicine.

Inheriting the essence, the development of traditional Chinese medicine can go back to ancient times; The development of traditional Chinese medicine will be clear and turbulent only when it is upright and innovative. Combined with the outstanding performance and experience of Chinese medicine in the treatment of COVID-19 epidemic, many Chinese medicine experts who have participated in the first-line anti-epidemic talk about their experiences, offering suggestions and suggestions for the high-quality development of Chinese medicine and protecting the health of all mankind.

Liu Qingquan, Dean of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Photo courtesy of respondents

"The future development of Chinese medicine is to be brave and dare to combine with modern science and technology, and to be good at using modern science and technology language to make the oldest theory of Chinese medicine clear and clear, so that Chinese medicine can truly become a world medicine and a medical system that can be used by all countries and ethnic groups." Combined with the treatment of COVID-19 epidemic, Liu Qingquan, president of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, said that the integration of traditional Chinese medicine and western medicine is very important for the development of traditional Chinese medicine, and it may form a new medicine in the future. It not only has the traditional theoretical advantages of Chinese medicine classics, but also embodies the connotation of modern science and technology; It is neither classical Chinese medicine nor modern western medicine, but a complete medical system with complementary advantages.

On February 15th, 2020, in beijing ditan hospital, a pharmacist dispensed medicine for COVID-19 patients in a traditional Chinese medicine pharmacy. Xinhua News Agency reporter Yan Huanzong photo

The experience of Chinese and western collaborative treatment lays the foundation for the formation of new medicine.

In the process of fighting against the epidemic in COVID-19, the effective prescription of traditional Chinese medicine-"three drugs and three parties" screened out by clinic has played an important role.

Liu Qingquan, who once served as an expert in Hubei Central Steering Group and deputy head of the national expert group on medical treatment of traditional Chinese medicine, said that "three drugs and three parties" is actually a classic theory of China traditional Chinese medicine, a treatment method based on the experience of traditional Chinese medicine in treating plague for thousands of years, and a model for coping with new diseases.

"Through the analysis of COVID-19’s clinical characteristics, we have formed the idea that we can combine various effective prescriptions to treat, thus forming the basic idea of’ three parties and three drugs’, that is, according to the changes of etiology and different stages of illness, we can adjust and combine to form effective treatment methods. This proves the greatness and correctness of the theory of traditional Chinese medicine and verifies that it conforms to scientific laws. " Liu Qingquan said.

"In the process of using’ three parties and three drugs’ treatment, we have also preliminarily explored and mastered some theoretical data of treating COVID-19 with traditional Chinese medicine. These studies prove that the basis of treating COVID-19 with traditional Chinese medicine is scientifically explained from different aspects, such as the adjustment of immune system and inflammatory system, which are the important pathological links that cause the disease to change, get worse and worse during the onset of COVID-19." Liu Qingquan analysis.

"In terms of coordinated treatment of Chinese and Western medicine, Chinese and Western medicine have their own strengths, and ultimately played a very important role in improving the success rate of severe and critical care and reducing the mortality rate, which proved the internal theoretical basis of coordinated treatment of Chinese and Western medicine and made some necessary preparations for exploring the organic integration of Chinese and Western medicine to form a new medicine." Liu Qingquan pointed out.

On February 25th, 2020, in Jiangxia Fangcang Hospital, Zhan Min (right), a medical staff member of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, performed acupoint application therapy for COVID-19 patients. Xinhua News Agency reporter Shen Bohan photo

Exploration of Traditional Chinese Medicine Shelter Hospital Model of Infectious Diseases Hospital with Integrated Traditional Chinese and Western Medicine

In the process of Chinese medicine participating in Wuhan epidemic prevention and control and clinical treatment, Fangcang Hospital has become a medical pioneering work in a special period.

Liu Qingquan, a former president of Jiangxia Fangcang Hospital, was deeply touched by the experience of Chinese medicine taking over Fangcang Hospital. He said that the establishment of the shelter hospital is a very effective way to deal with sudden large-scale infectious diseases. In the shelter hospital, the treatment of light and ordinary patients with traditional Chinese medicine can effectively speed up the improvement of patients’ condition, reduce the occurrence of severe and critical diseases and reduce the mortality rate. In addition, because the source of infection is cut off in time, the control of virus transmission also plays a very important role.

Liu Qingquan believes that the experience and achievements gained by taking over Fangcang Hospital with traditional Chinese medicine technology to treat light and ordinary patients in COVID-19 have paved the way for the state to support the establishment of infectious disease hospitals and specialized hospitals with integrated traditional Chinese and western medicine. This will enable the future to quickly form a powerful force of combining traditional Chinese and western medicine, whether dealing with common infectious diseases or sudden new infectious diseases.

On May 23, 2021, the doctor set up the automatic decocting machine in Yingkou Hospital of Integrated Traditional Chinese and Western Medicine, Liaoning Province. Xinhua News Agency reporter Pan Xiaolong photo

Increase investment to support the construction of Chinese medicine institutions and Chinese medicine research.

Nowadays, in the treatment of many local epidemics distributed in China, the treatment scheme of traditional Chinese medicine is becoming more and more perfect and mature, and has achieved very good results. The methods of classified treatment and management of traditional Chinese medicine have become more and more popular and have become the consensus of the medical community.

"Compared with this treatment effect, there are too few medical institutions of Chinese medicine, which is a limitation to the role of Chinese medicine and its future development." Liu Qingquan called on the state to increase investment in TCM research and institution building. In dealing with infectious diseases, it is hoped that the state can support the establishment of infectious disease hospitals in mature areas with traditional Chinese medicine or integrated traditional Chinese and western medicine.

Liu Qingquan said that infectious diseases are the public enemy of mankind, regardless of Chinese medicine and western medicine, regardless of population and race. Therefore, I hope that China can make achievements in the construction of infectious disease hospitals with traditional Chinese medicine and integrated traditional Chinese and western medicine, and set an example for promoting the development of China medicine and even the world medicine. I hope that colleagues of Chinese and Western medicine can work together in Qi Xin to seize the opportunity and let the development of traditional Chinese medicine enter a new era.

Recently, the China Breast Cancer Screening Standard (T/CPMA 014-2020) proposed by China National Cancer Center was published online in chinese journal of cancer prevention and treatment. The correspondent is Professor He Jie, director of National Cancer Center and academician of China Academy of Sciences.

As a common cancer, according to the latest global cancer burden data released by the International Agency for Research on Cancer (IARC) of the World Health Organization in 2020, there were 2.26 million new breast cancer cases in the world in 2020, surpassing lung cancer (2.21 million cases) for the first time, becoming the largest cancer in the world, accounting for 11.7% of new cancer cases. Among the newly diagnosed cancer patients, one in every eight is a breast cancer patient. China is a big country with breast cancer. In 2020, there will be about 420,000 new cases of breast cancer and nearly 120,000 deaths.

Screening, improving the detection rate of early breast cancer and precancerous lesions, and timely and effective treatment are important measures to improve the prognosis of breast cancer and reduce the risk of death. The standards put forward suggestions on the population, measures, results and management of breast cancer screening in China. We have sorted out the relevant contents, hoping to help you better understand the knowledge of breast cancer screening.

Image source: 123RF

Who should have breast cancer screening?

The standard suggests that people at high risk of breast cancer should be screened from the age of 40; The general risk population (all school-age women except the high-risk population) should be screened for breast cancer between 45 and 70 years old.

High-risk population

Women who meet any of the following conditions 1, 2 and 3 are at high risk of breast cancer.

1. Women with genetic family history, that is, women with any of the following: 1) First-degree relatives (mothers, daughters and sisters) have a history of breast cancer or ovarian cancer; 2) Among the second-degree relatives (aunts, grandmothers and grandmothers), two or more people suffered from breast cancer before the age of 50; 3) Among the second-degree relatives, 2 or more have ovarian cancer before the age of 50; 4) At least one first-degree relative carries a known pathogenic genetic mutation of BRCA1/2 gene, or carries a pathogenic genetic mutation of BRCA1/2 gene himself.

2. Have any of the following: 1) Age of menarche ≤12 years old; 2) menopausal age ≥55 years old; 3) Have a history of breast biopsy or surgery for benign breast diseases, or a history of atypical hyperplasia of breast (lobules or ducts) confirmed by pathology; 4) Use hormone replacement therapy of "estrogen and progesterone combination" for not less than half a year; 5) X-ray examination of breast after 45 years old suggests that the type of breast parenchyma (or breast density) is uneven compactness or compactness.

Note: Breast parenchyma types can be divided into fat type, scattered fibrous gland type, heterogeneous dense type (which may cover small masses) and dense type (which reduces the sensitivity of breast cancer detection).

3. Those who have any of the following two items: 1) No breast-feeding history or breast-feeding time less than 4 months; 2) No history of live birth (including never giving birth, abortion or stillbirth) or the age of first live birth ≥30 years old; 3) hormone replacement therapy using only "estrogen" for not less than half a year; 4) Abortion (including natural abortion and induced abortion) shall not be less than 2 times.

Image source: 123RF

How to screen?

General risk population: breast ultrasound examination should be performed every 1-2 years; If you do not have the conditions for breast ultrasound examination, you should use mammography.

High-risk population: breast ultrasound combined with mammography is performed once a year.

How to understand the screening results?

Classification of diagnostic results of mammography

The diagnostic results of mammography are usually classified by the Breast Imaging Reporting and Data System (BI-RADS), which is formulated by American Radiological Society (ACR) and widely used internationally.

1. BI-RADS 0: The existing image failed to complete the evaluation, and other image examinations need to be added.

2. BI-RADS 1: normal, no abnormality was found in mammography. The possibility of malignancy is 0%.

3. BI-RADS 2: Benign findings, with definite benign changes and no malignant signs. The possibility of malignancy is 0%.

4. BI-RADS 3: Benign lesions that may be large. 0% < malignant possibility ≤2%.

5. BI-RADS 4: Suspected malignant lesions, but without typical malignant signs. 2% < malignant possibility < 95%.

6. BI-RADS 4A: low-grade suspected malignancy. 2% < malignant possibility ≤10%.

7. BI-RADS 4B: moderately suspected malignant. 10% < malignant possibility ≤50%.

8. BI-RADS 4C: highly suspected malignant. 50% < malignant possibility < 95%.

9. BI-RADS 5: Highly suggestive of malignant lesions with typical imaging features of breast cancer. Malignant possibility ≥95%.

Image source: 123RF

Classification of ultrasonic diagnosis results of breast

The classification of ultrasound evaluation refers to the screening of National Comprehensive Cancer Network (NCCN) and the BI-RADS classification standard proposed by American Radiological Society.

1. BI-RADS 0: The diagnostic information obtained by ultrasound is incomplete and cannot be evaluated, and it needs to be evaluated after other imaging examinations.

2. BI-RADS 1: negative, no abnormality was found by ultrasound. The possibility of malignancy is 0%.

3. BI-RADS 2: Benign lesions, with definite benign changes and no malignant signs. The possibility of malignancy is 0%.

4. BI-RADS 3: Benign lesions that may be large. 0% < malignant possibility ≤2%.

5. BI-RADS 4: Suspected malignant lesions, but without typical malignant signs. 2% < malignant possibility < 95%.

6. BI-RADS 4A: low-grade suspected malignancy. 2% < malignant possibility ≤10%.

7. BI-RADS 4B: moderately suspected malignant. 10% < malignant possibility ≤50%.

8. BI-RADS 4C: highly suspected malignant. 50% < malignant possibility < 95%.

9. BI-RADS 5: Highly suggestive of malignant lesions with typical imaging features of breast cancer. Malignant possibility ≥95%.

Image source: 123RF

Screening result management

1. BI-RADS 1 and BI-RADS 2 need no special treatment.

2.　BI-RADS 3：

The evaluation of mammography is BI-RADS 3, so it is advisable to reexamine the breast on the lesion side at the next 6 months, and reexamine the breast on both sides at the 12th and 24th months.

If the lesion remains stable, it can continue to be reexamined, and if it has not changed for 2-3 years, it can be reduced to BI-RADS 2. If the lesion disappears or shrinks during the reexamination, it can be directly evaluated as BI-RADS 2 or BI-RADS 1. Biopsy should be considered if suspicious findings are found in the lesions during the reexamination.

The breast ultrasound evaluation is BI-RADS 3, so it is advisable to have breast ultrasound reexamination in 3-6 months, and it can be reduced to BI-RADS 2 if there is no change after 2 years of follow-up.

3. BI-RADS 4A: Further imaging examination and biopsy are needed.

4. BI-RADS 4B: Further imaging examination is needed, and biopsy is appropriate.

5. BI-RADS 4C and BI-RADS 5: Biopsy should be performed.

Image source: 123RF

tag

According to the standard, the breast physiological characteristics and breast cancer epidemic characteristics of women in China are quite different from those in western countries, so we can’t copy foreign experience. Establishing breast cancer screening standards suitable for women in China will play an important role in improving the scientificity, feasibility and practicability of breast cancer screening and reducing the incidence and mortality of breast cancer.

reference data

[1] He Jie, et al.,(2021). China female breast cancer screening standard (T/CPMA 014-2020). chinese journal of cancer prevention and treatment, DOI: 10.16073/J.CNKI.CJCPT.2021.01.02.

[2] Latest global cancer data: Cancer burden rises to 19.3 million new cases and 10.0 million cancer deaths in 2020. Retrieved Nov 16 ,2020, from https://www.iarc.fr/fr/news-events/latest-global-cancer-data-cancer-burden-rises-to-19-3-million-new-cases-and-10-0-million-cancer-deaths-in-2020/

Note: The purpose of this article is to introduce the progress of medical health research, not to recommend treatment schemes. For guidance on treatment plan, please go to a regular hospital.

　　This article was originally written by "Suning Financial Research Institute" in WeChat official account. The author is Tao Jin, Assistant Director of Macroeconomic Research Center of Suning Financial Research Institute. The first picture is from Yitu. com.

　　Recently, official website, the US Department of Commerce, issued a statement saying that the special relevant treatment for Hong Kong has been cancelled, including the suspension of export license exemption, and the differential treatment is being evaluated, while the export policy of related technologies to Hong Kong is being adjusted. These changes mean that the United States began to restrict its exports to Hong Kong.

　　Under the background of the COVID-19 epidemic, the actions of the US Department of Commerce are quite damaging to the global industrial chain system. The epidemic is wrapped in trade protectionism and continues to impact the global industrial chain system, and the risk of industrial chain interruption is accumulating.

　　Compared with the global economic recession is affected by short-term external events, the impact of the industrial chain is more worrying, because the destruction of the global industrial chain system is more like a long-term and more difficult to recover.

　　The industrial chain system has been destroyed, and the epidemic situation is only a fuse, but this fuse may evolve into a major blow to the globalization process. Today, globalization has a history of 600 years. Will it end because of this epidemic?

　　A brief history of globalization

　　Globalization originated from the great geographical discovery. During the 600 years from the 15th century to the present, globalization has been affected and hindered in various ways, but the overall trend is deepening.

　　1. Great geographical discovery

　　From the 15th century to the 17th century, European fleets appeared in the oceans all over the world, looking for new trade routes and trading partners to develop Europe’s nascent capitalism.

　　Sailors led by Columbus and da Gama have opened up many new sea routes, and also created the "era of great navigation", which is also called "geographical discovery" in history.

　　After the era of great navigation, colonialism and free trade began to appear, and globalization experienced intermittent development, reaching its peak in the 1910s, but then came World War I, when the process of globalization was paused, and then fascism appeared, which led to World War II.

　　2. Globalization after World War II

　　After World War II, many international organizations, such as GATT, have greatly reduced the barriers to international trade, especially the World Trade Organization, which evolved from GATT in 1995, has obviously accelerated the process of free trade and globalization in the past 30 years.

　　After stagflation and local wars in 1980s, globalization began to exert its strength in 1990s and continued until the global financial crisis in 2008. During this period, the proportion of global trade in the global economy increased from less than 15% to nearly 26%.

　　In 2008, the global financial crisis had a direct impact on global trade, which made countries start to consider the chain reaction of risk events brought by global contact again. However, this impact was not fatal to globalization, and trade remained large in the following years.

　　In addition to trade in goods and services, international capital flows are also a major manifestation of globalization. The core member and leader of the WTO is the United States. In fact, the United States has indeed exported dollars and economic hegemony through globalization, and gained a lot of benefits. In particular, American multinational companies have made use of low-cost production factors to produce and sell nearby all over the world and made a lot of profits.

　　Similar to international trade, the scale of foreign direct investment in countries around the world has been increasing since the 1990s. Despite the impact of events such as the bursting of the Internet bubble, the September 11th incident and the global financial crisis, the general trend of increasing capital flows has not changed.

　　3. Globalization and China’s Reform and Opening-up.

　　The accelerated globalization in recent decades has just matched the process of reform and opening up in China. China’s economic growth has experienced a rare high-speed growth in human history.

　　After the reform and opening up, China actively integrated into the global free trade system led by the United States, and continued to enhance its economic strength through the strategies of "export orientation" and "import substitution". At that time, the United States was busy with the cold war with the Soviet Union. After the disintegration of the Soviet Union, it was busy exporting political, military and economic hegemony, cleaning up the "backyard" of South America, fighting two Gulf wars and catching bin Laden everywhere, which made it "too busy to look east" and its attitude towards China’s integration into the global economy was open and welcome.

　　In the process of integrating into the free trade system, China’s trade scale has continued to grow, even reaching 4.62 trillion US dollars in 2018, surpassing the United States (4.28 trillion US dollars) to become the world’s largest trading country, which is quite a bit like "doing something for another". It should be said that China may be one of the countries that have benefited most from globalization in recent decades.

　　Epidemic situation impacts trade and industrial chain.

　　Under the epidemic, production activities in many places around the world stagnated, which directly hit trade. Since March, the increase in unemployment, the decrease in income and the suspension of production activities have caused the trade between the United States and the European Union to shrink significantly. Even Japan, which has done a good job in epidemic prevention and control, has experienced a relatively obvious decline.

　　In the case of global recession and trade contraction, although China’s current domestic demand accounts for a larger proportion, it can resist the greater impact of external demand, but it is still inevitably impacted in both demand and industrial chain. What is even more worrying is that the contraction of foreign trade has caused a large number of enterprises in the foreign trade field, especially small and medium-sized enterprises, to go bankrupt and potential unemployment.

　　From the historical data, the fluctuation of China’s export growth is highly consistent with the fluctuation of GDP growth. According to statistics, if the global economic growth rate drops by 1 percentage point, China’s export growth rate will drop by 6-8 percentage points. Such a large-scale contraction of export business will inevitably lead to the contraction and even bankruptcy of a large number of foreign trade enterprises.

　　Because China and the global industrial chain system have formed a criss-crossing deep connection, the blow to the industrial chain also involves a very wide range of industries in China. In a large number of industries (especially automobile industry and electronics industry), China is an exporter of other countries in some links, but in other links, China is an importer of other countries. The stagnation of one link may affect the normal production of the whole industry.

　　Here, give an example of my personal experience to illustrate:

　　Once, the author took Didi, talked with the driver’s master, and learned that he was a builder working in a nearby construction site. He used to use his spare time to start Didi, but after the epidemic came, the construction site stopped working and he began to start Didi full-time.

　　He said that the shutdown was not due to the fact that it was not allowed to resume work at home, but because a foreign key device manufacturer stopped working. Without this device, the construction process had to be suspended.

　　This subverts the author’s understanding of the degree of integration of the global industrial chain, because when it comes to international trade, it is often not associated with the construction industry, but even the construction industry is now deeply bound to the global industrial chain.

　　In addition, there are two factors that aggravate this influence:

　　First, in the process of globalization, China is more and more deeply involved in the transmission process of global value chain. China’s participation in global value chains has reached 62% in 2017. Therefore, all kinds of raw materials and energy are cut off due to the global epidemic, which has also brought a big impact to China’s industrial chain.

　　Second, China is downstream in the global value chain. The upstream degree of China in the global value chain is 1%, far lower than the 4% of open economies and 29% of the United States (in 2017). The interruption of import supply chain of upstream products, especially energy and raw materials, will have a great impact on some industries in China.

　　From the import data over the years, it can be found that the import scale of raw materials, energy and primary products in China shows an overall upward trend, and a large number of export products in China are manufactured goods. It can be seen that China’s trade field is highly dependent on foreign upstream products, and the risk of "grain shortage" in China’s industrial production caused by supply shortage is still relatively high.

　　Behind the impact of industrial chain: anti-globalization

　　The impact of industrial chain not only comes from external events such as epidemic situation, but also is the result of intensified anti-globalization in recent years.

　　1, the epidemic is the fuse.

　　In January and February, after China’s production activities stopped due to the epidemic, the European and American economies were greatly affected. The supply of intermediate products and materials needed for production activities in many countries was interrupted, and more seriously, the supply of final consumer goods was interrupted, which affected the basic consumption of residents.

　　In March and April, European and American countries urgently needed masks, protective clothing, ventilators and other anti-epidemic materials, but suddenly found that not only did they not have the production capacity of ventilators, but even the simplest masks could not be produced, and finally they had to rely on China for export, which not only led to an increase in prices, but also failed to guarantee the supply in time. At this time, European and American countries were alert: "You can’t put eggs in the basket of China".

　　2. Trade protectionism is on the rise

　　In recent years, in developed countries, due to their own reasons, such as the solidification of social class and the widening gap between the rich and the poor, most ordinary people have not enjoyed the benefits brought by globalization, and more benefits have been divided by large industrial groups and multinational companies.

　　In order to safeguard the interests of the people, leaders of many countries have opposed free trade and global industrial division of labor, which has led to the rise of populism and trade protectionism, and also the phenomenon of anti-globalization. The global epidemic will inevitably lead to more intensified internal contradictions and increased social instability in Europe and the United States. This will in turn stimulate populism and trade protectionism, further aggravating the degree of anti-globalization. China has gained great benefits from globalization after its accession to the WTO, and these benefits may be reduced by the above changes in the future.

　　How serious will the industrial chain impact be?

　　Generally speaking, there are three forms of industrial chain impact: manufacturing industry moves to emerging markets such as India and Southeast Asia; The manufacturing industry in developed countries has returned and the industrial chain has been localized; Western countries’ restrictions on China’s imports and exports in certain fields.

　　However, these three forms of shocks either have conditions that do not fully meet the reality, or have corresponding countermeasures. In the long run, China still has great opportunities and space to meet these challenges.

　　1. Manufacturing industry moves out.

　　Now it seems that the destination of manufacturing migration is nothing more than India, Vietnam and other markets. However, there are more or less three fatal problems in these markets: First, although the labor cost is low, the scale and quality of the labor force cannot be compared with China in the short term, the economies of scale are not obvious, and the production efficiency is not high; Second, poor infrastructure conditions, poor transportation, production equipment and other facilities, production quality can not be guaranteed; Third, the lack of producer services can not provide high-quality supporting services for the manufacturing industry. Therefore, in the short term, these countries cannot effectively undertake large-scale manufacturing.

　　2. The return of manufacturing industry in developed countries.

　　After the outbreak, Japan plans to allocate 243.5 billion yen from the economic stimulus plan to adjust its production line in China, of which 220 billion yen will be used to help Japanese enterprises move their production lines back to China.

　　Developed countries, such as the United States, have been calling on their manufacturing enterprises to move back, but the effect is not very satisfactory. Because this kind of relocation faces two problems: first, because foreign capital has been invested in China, the cost of relocation is very large. Of course, this "moving fee" enterprise is unwilling to bear, and even the government will feel great financial pressure; Second, the cost and benefit evaluation often does not support relocation. Under the huge relocation cost, the cost of local manpower and supporting services after relocation is obviously higher than that of China, and the products produced are sold to China, and there is an extra tariff out of thin air, which is not cost-effective.

　　In addition, for China, after the economy developed to a certain level, the proportion of service industry increased, while the proportion of manufacturing industry decreased, and the overall impact brought by the relocation of manufacturing industry was also discounted.

　　3. Western countries’ restrictions on China’s imports and exports in certain fields.

　　This may be the most intractable problem facing China in the short term, and the US Department of Commerce’s actions against Hong Kong fall into this category. However, China has a relatively complete industrial system, which can resist this risk to some extent.

　　In the United Nations industrial classification, all industries can be divided into 39 industrial categories, 191 medium categories and 525 subcategories. China has 39 industrial categories, 191 middle categories and 525 sub-categories, making it the only country in the world with all the industrial categories listed in the United Nations Industrial Classification, and all the industrial categories listed in the United Nations Industrial Classification can be found in China. Among more than 500 major industrial products announced by the United Nations, China ranks first in the world in terms of output of about 220 kinds.

　　Therefore, it is preliminarily judged that the impact of global supply chain interruption on China’s industrial production can be controlled in the field of foreign trade, and the risk of spreading to internal larger-scale manufacturing industry is still controllable.

　　How to deal with it?

　　Although in the long run, the impact of industrial chain can be effectively alleviated, but in the short term, China’s economy, especially China’s enterprises, still have to face the challenges of trade and industrial chain turmoil. In addition to the government’s hedging and rescue policies, China enterprises can adjust their business and development strategies in the face of increasingly harsh internal and external environment in order to tide over the difficulties through the following methods.

　　1. Streamline business and shrink the development front.

　　Faced with the shrinking demand and the interruption of supply chain, enterprises need to strictly control the business content, strengthen the management of the main business, and at the same time shrink the development front, so as to avoid more potential risks. If enterprises increase investment against the trend and implement diversified development, they may face operational risks in many fields. For example, failure in a specific market often leads to a chain reaction, which breaks through the cash flow of enterprises, resulting in damage to the main business.

　　Streamlining business, at the same time, also means "reducing expenditure", strictly controlling investment, eliminating redundant phenomena, and even involving appropriate downsizing and salary reduction, so as to retain more concentrated energy to develop major businesses and enhance core competitiveness.

　　2. Adjust the target market to meet the change of market direction.

　　In a worse external environment, a large number of foreign trade enterprises are facing the challenge of exporting to domestic sales. Fortunately, the domestic demand market in China is constantly expanding, and new market demands are constantly emerging. Enterprises need to seize these opportunities, find the right market direction on the basis of their own operating advantages, and actively cater to the future development trend of emerging industries, such as offline to online, and seize opportunities such as Internet and platform transformation.

　　3. Maintain cash flow and persist in survival.

　　China’s role as a safe haven for financial assets is more obvious. Under the logic of economic development, China’s economy and assets are more attractive than before, and foreign capital continues to flow into China. It is obviously less difficult for China to stabilize its economy than other countries. Once the economy stabilizes, it is still possible for China to upgrade its position in the global economy, and continue to maintain the first position in the global consumer market scale and economic activity. At that time, China enterprises will also have broad demand again.

This article was first published on WeChat WeChat official account: Suning Financial Research Institute. The content of the article belongs to the author’s personal opinion and does not represent Hexun.com’s position. Investors should operate accordingly, at their own risk.

The 55th Golden Horse Poster

1905 movie network news Today, the main visual poster of the 55th Golden Horse Award was released, which once again firmly attracted the attention. This poster with blue and gold as the main color looks like staring at the sleeping sand dunes in the middle of the night from a distance. If you look closely, you will find that it is four faces lined up in turn. This poster was designed by Fang Xuzhong, the poster designer and visual director of the ceremony last year. It extends the concept of "everyone plays a supporting role in the film" and draws the facial contours of Ang Lee (Chairman of the Executive Committee of Taipei Golden Horse Film Festival), Hou Xiaoxian (Dean of Golden Horse Film Academy), Gong Li (Chairman of the Golden Horse Award Jury) and Xiao Ye (Judge of Golden Horse Venture Capital Conference) into dune shapes. The picture made up of tiny particles of light and shadow also seems to imply the ambiguous connection between retaining the instantaneous image with light and shadow and the passing time.

The main visual posters of the Golden Horse Awards pay attention to convey the understanding of Chinese movies with rich imagination and bold creativity, which has always been a highlight of the Golden Horse Awards. In recent years, almost all the main visual posters have paid tribute to Taiwan Province’s old films and filmmakers.

In 2017, the main visual posters of the 54th Golden Horse Awards were the "Shadow Idiot Edition" and "Fan Edition" posters with the stills of "Spring Breeze" as the main elements. The two posters project the pictures from the stills onto various screens to convey the real and illusory feeling brought by the film, which is similar to the 53rd brighter summer day designed by Huang Hai, in which the junior four illuminates the night sky with a flashlight to show that "the light of the film never goes out".

　"Shadow Idiot Edition" (54th edition) by square sequence

"Fan Edition" (54th session)

The 53rd Tribute to Guling Street by Yellow Sea

Even more amazing is the 50th Golden Horse, a Maggie Cheung-themed poster designed by Taiwan Province graphic designer Nie Yongzhen (who designed album covers for Jay Chou, Yoga Lin and others). The image of Maggie Cheung is partially cut to show different areas of the face, which means that the film is like a slice of time, so it can’t really keep time, so it can only intercept fragments.

　The 50th Maggie Cheung by Nie Yongzhen

In addition, it is worth noting that cartoonist Jimmy has designed the main visual poster for the Golden Horse Award twice. At the 39th Taipei Golden Horse Film Festival, he gathered his characters in the cinema and opened a small door under it. It not only means that the film blurs the boundary between reality and illusion, but also outlines the pleasant atmosphere of watching movies.

How many meters is the 39th by?

Another time was the 49th Golden Horse Award 10 years later. He created in oil painting for the first time in public and handed in three design drawings at one time. Two of them are a pair of dressed-up "hot horses and handsome horses", and the final picture is the picture of a little boy and a horse flying on the sea. According to Jimmy himself, this means "the pursuit of light and shadow".

　How many meters is the 49th by?

Next, please enjoy the main visual poster of the Golden Horse Award from 2008 to this decade &mdash; &mdash;

The 45th Session (2008), which rejected complexity and chose simple color blocks.

The 45th by Nie Yongzhen

　 　 　 　 　A camera head who is always running, 46th (2009)

The 46th by Wang Zhihong

　 　 　 　 　 Seconds of Glass Breaking, 47th (2010)

The 47th by Wang Zhihong

　 　 　 　Inspired by Hou Hsiao-hsien, the 48th session (2011) is based on the essential old camera which may be closer to gaze.

The 48th by Lin Xiaoyi (cover designer of Kawabata Yasunari series)

　 　 　 The Pursuit of Light and Shadow, 49th (2012)

The 51st by Xiao Qingyang (album cover artist)

　 　 　 　Chivalrous women with stick figures, hidden in gilded lines, 52nd (2015).

The 52nd, by Zhang Shuping.

　 　 　 　　"The Light of Movies: Looking Back, Illuminating Forward", 53rd (2016)

The 53rd Tribute to Guling Street by Yellow Sea

　 　 　 　To pay tribute to the 20th anniversary of the publication of "Spring Break", selected by Wong Kar-wai himself, the 54th (2017).

The 54th session　By square order

　 　 　 　 The 2018 Golden Horse Film Festival will be held from November 8 to 25.

CCTV News:On May 24th, 2025, the Guangdong-Hong Kong-Macao Greater Bay Area Maozhou River Dragon Boat Race started.

This dragon boat race is the first provincial dragon boat race in Guangdong-Hong Kong-Macao Greater Bay Area this year. There are 24 professional teams from Greater Bay Area, which are divided into three groups: Bay Area Men’s Team, Bay Area Women’s Team and Shenzhen Team. After two hours of fierce competition, the Chenpi Dragon Boat Team of Hongdatang, Xinhui, Jiangmen, the Hong Kong, China Women’s Dragon Boat Team and the Xiayong Jiangxia Huang Dragon Boat Team of Yanluotang won the first place in each group respectively.

Tongxiang, Zhejiang: Dragon Boat Race, Visiting the Market, Colorful Folk Customs and Celebrating the Dragon Boat Festival

On the 24th, in Tongxiang City, Jiaxing City, Zhejiang Province, citizens gathered at the bank of the Beijing-Hangzhou Grand Canal to watch the dragon boat race and experience the folklore of the Dragon Boat Festival.

At 10 o’clock in the morning, more than 10 beautifully decorated dragon boats are ready to go in the Chongfu section of Tongxiang of the Beijing-Hangzhou Grand Canal. As the drums sounded, the dragon boats split the waves in pairs on the water. Dragon boat race on the river, the oars flying over, the team members joined forces to paddle in the drums and applause, bravely competing for the first place.

There are not only dragon boat races, but also folk cultural projects such as fish lantern performances, canal encouragement and lion dance performances. In Beitangzhi Street beside the Grand Canal, tourists visit the Song Yun Market, have a long table feast on the Dragon Boat Festival and experience interactive games. The colorful traditional Dragon Boat Festival folk customs are deeply loved by everyone.

Shiqian, Guizhou: skillfully making tea-scented sister dumplings to convey neighborhood feelings

In Xinhua Village, Shiqian County, Tongren County, Guizhou Province, villagers are working together in Qi Xin to make tea-scented sister zongzi with unique local characteristics, so that the thick zongzi fragrance is intertwined with the neighborhood.

Early in the morning, the villagers in Xinhua Village of Wude Town were busy. Pick the fresh leaves of the day, wash and dry them, prepare local glutinous rice, chestnut, straw and other materials, and wrap the sister dumplings according to the method passed down by the older generation. First, fold the leaves into a funnel shape, add stuffing such as glutinous rice and chestnut, and wrap them into triangular dumplings. Then, take a small piece of rice dumpling leaves and repeat the above steps. Place the small triangular rice dumpling next to the big triangular rice dumpling, cover it with the same rice dumpling leaf, and finally tie it tightly with straw, and a sister rice dumpling with unique shape will be completed.

Later, the villagers set up firewood and started to cook the sister dumplings with iron cooking utensils, which took two and a half hours. The secret of the unique flavor of sister zongzi lies in putting in the newly picked moss tea in that year. Under the slow stew of firewood, the fragrance of moss tea blends with the fragrance of zongzi, emitting an attractive aroma.

In Xinhua Village, Bao Sisters Zongzi is not only a food production and cultural heritage, but also a bond of neighborhood friendship. When a pot of steaming tea-scented sister dumplings comes out of the pot, the villagers will distribute them to their neighbors and relatives to share the joy and warmth of this festival.

Changning, Yunnan: The special zongzi "Xiang" is about the unique and popular flavor of the Dragon Boat Festival.

In Changning County, Baoshan City, Yunnan Province, there are many kinds of special zongzi, such as tea zongzi, alkaline zongzi and ham zongzi, which satisfy the taste buds of different diners with their unique flavors.

Early in the morning, Shaojuan, a tea farmer, began to select local high-quality old-tree black tea, boil a reddish-brown tea soup, let it cool, and then pour it into the washed glutinous rice. After the glutinous rice was soaked, everyone sat around and wrapped zongzi, and then cooked it with a big fire. Soon, the angular and fragrant tea zongzi were freshly baked.

In addition to tea dumplings, alkaline dumplings are also deeply loved by local people. This kind of zongzi is made by burning corn stalks into ash, adding boiling water and filtering to make alkaline water. Then, the glutinous rice and alkaline water are mixed and soaked for 5 to 6 hours to color and enhance the fragrance of the glutinous rice. After the dumplings are wrapped in alkaline water, they need to be cooked for about 4 hours on high fire, and the taste is the best.

When wrapping rice dumplings with alkaline water, local people will also add ham produced in Yunnan to make a unique ham dumpling. After eating it in one bite, the salty flavor of ham and the sweetness of glutinous rice will be perfectly integrated, and the lips and teeth will remain fragrant.

Kunming, Yunnan: All kinds of zongzi are freshly listed, packaged and sold with old flavor.

In the major farmers’ markets in Kunming, Yunnan Province, all kinds of special zongzi are on the market, especially the dumplings now packaged are very popular.

In this large-scale farmer’s market in Kunming, the Dragon Boat Festival Zongzi has entered a hot-selling period, and the special Zongzi from Kunming, Honghe and Xishuangbanna have been placed in the obvious position of the stalls.

After shopping around, this zongzi from Guizhou also attracted many consumers to buy it. The boss said that this time he brought more than a dozen kinds of zongzi, all of which were sent from Guizhou, focusing on characteristics and freshness.

Zongzi with various new flavors has become the darling of the market, but many people still like the old flavor of being packaged and sold now.

There are people who buy finished zongzi, but some consumers still like to buy zongzi leaves and materials to wrap at home, so that the Dragon Boat Festival zongzi is full of home flavor.

　　Beijing, July 31 (Reporter Tang Ming) According to World Finance, the economic voice of the Central Radio and Television General Station, the data released by the National Bureau of Statistics showed that in the first half of this year, the per capita consumption expenditure of the national residents reached 10,330 yuan, and consumption is still an important driving force to lead the stable economic growth. With the release of economic data of provinces (autonomous regions and municipalities) in the first half of the year, a more detailed "consumption map" is presented to people: where do residents spend the most money? Where is the fastest growth in consumption?

　　The per capita consumption expenditure is generally higher than last year.

　　In the first half of this year, the ranking of per capita consumption expenditure of residents in various provinces (autonomous regions and municipalities) was basically the same as last year, and the amount of consumption expenditure generally increased compared with last year. The data shows that the top rankings of per capita consumption expenditure in the first half of this year were Shanghai, Beijing, Tianjin, Zhejiang and Guangdong, which were consistent with the first half of last year.

　　Among them, Beijing’s per capita consumption expenditure exceeded 20,000 yuan, Hubei, Chongqing and Inner Mongolia exceeded 10,000 yuan. In the first half of this year, the per capita consumption expenditure exceeded 10,000 yuan, an increase of three compared with the same period last year.

　　The southeast coastal market is huge, and the western region is growing rapidly.

　　Looking at the "consumption map" in the first half of the year, the strong economic provinces in the southeast coast are generally stable and the consumer market is huge. Among the top 10 provinces (autonomous regions and municipalities) in the first half of the year, the southeast coastal provinces and municipalities accounted for half of the country, and the per capita consumption expenditures of Shanghai, Zhejiang, Guangdong, Jiangsu and Fujian all exceeded the national average, ranking in the forefront.

　　Although the consumption market in the central and western regions is not as large as that in the southeast coast, the growth rate is generally faster. Among them, the total retail sales of social consumer goods in Sichuan Province in the first half of the year increased by 10.5% year-on-year, and the growth rate was 2.1 percentage points higher than the national average.

　　Expanding consumption scenes in various places to stimulate consumption vitality

　　In order to further stimulate the vitality of consumption, many regions have expanded the consumption scene. Recently, Beijing residents have fully felt the changes brought by the "night economy" to people’s lives. Guangdong has issued the Implementation Plan for Improving the System and Mechanism of Promoting Consumption in Guangdong Province, and put forward 29 specific measures in nine aspects in view of the outstanding problems that restrict consumption at present. Among them, in order to optimize the automobile consumption environment, measures such as gradually relaxing the car lottery and auction indicators in Guangzhou and Shenzhen and expanding the scale of quasi-purchase were put forward.

　　Service-oriented, development-oriented, and experience-oriented consumption are featured.

　　With the development of mobile Internet technology, in the "consumption map" in the first half of the year, service-oriented consumption, developmental consumption and experiential consumption have become the consumption characteristics of all localities. For example, in the first half of the year, Shanghai’s retail sales without stores reached 117.3 billion yuan, an increase of 20.4% over the same period last year; The contribution rate of service consumption in Beijing to the total consumption growth reached 70.4%, and the contribution rate of upgrading consumption such as communication to the total consumption growth reached 60%.

　　Xing Ziqiang, chief economist of Morgan Stanley China, believes that in the future, 5G will inject new vitality into consumption. "The application of 5G is expected to help smart cities, the Internet of Things, the Internet of Vehicles and other applications to a big step, and finally make those more close to consumers. The vitality of tailor-made services, experiences, shopping and medical consumption will be further released, which may be the next stage."

　　On May 24 this year, a newborn finless porpoise cub was separated from its mother and ran aground on the beach. Its fate touched the hearts of countless Nanjing people. But after 18 hours of emergency rescue, the "smiling angel" left us. "Even with artificial assistance, it is still difficult for cubs who leave their mothers to survive." Professor Yang Guang, Dean of the School of Life Sciences of Nanjing Normal University, told a cruel truth: the fate of this little finless porpoise may have been doomed. He believes that the only way to avoid the recurrence of the tragedy is to improve the ecological environment of the Yangtze River in all aspects, one of which is to restore the bait resources and prevent the finless porpoise from starving.

　　Yesterday morning in Nanjing Jiangbin Park, all the 1 million fry subscribed by deji plaza were put into the Yangtze River. The reporter learned that this is the first time in China that an enterprise has initiated a release activity for the protection of finless porpoises.

　　Intern Xu Linchen Yangzi Evening News All-Media Reporter Zhang Ke

　　A rescue that was doomed from the beginning.

　　The latest hot event about the finless porpoise was the "beaching incident of finless porpoise cubs" in Nanjing at the end of last month. This little finless porpoise was found by the public on the river beach of Yanziji Wharf at 4 pm that day. It was born about two or three days ago, but it hasn’t opened its eyes yet, and its breath is weak. At that time, the people involved in the rescue contacted the experts of Nanjing Underwater World, and on the other hand, the water police drove speedboats to patrol the river to find the trace of the female finless porpoise. "The finless porpoise is a mammal, and the newborn calf must be with its mother. This little finless porpoise must have been separated from its mother when it appeared alone, and the mother finless porpoise is likely to come back to find the child." Jiang Meng, secretary-general of the Nanjing finless porpoise protection association who participated in the rescue at that time, said.

　　Until 8 o’clock in the evening, the female finless porpoise was still not found, and the little finless porpoise was forced to transfer to the underwater world for treatment. Regrettably, at 10 o’clock the next morning, the little finless porpoise died unfortunately before he opened his eyes to see the world. At that time, Jiang Meng waited all night in the underwater world and witnessed the whole process. He told the Yangzi Evening News reporter that the finless porpoise was once in good condition and could eat and breathe with artificial assistance. "But in the end, it was short of breath and emotional anxiety, and experts took various emergency measures. All have no effect." Jiang Meng said.

　　The finless porpoise is a clever but fragile creature. Its intelligence is close to that of gorillas, and it knows how to hunt and prey collectively. However, the underage or newborn finless porpoise has almost no ability to live independently. Professor Yang Guang, dean of the School of Life Sciences of Nanjing Normal University, told the Yangzi Evening News reporter that the cub can’t eat and prey independently without its mother, and it must rely on breast milk for nutrition. "About half a year after birth, cubs can learn to live independently."

　　The Yangzi Evening News reporter learned that the adult finless porpoise had survived under artificial rescue, but the cubs have not been successfully rescued so far. "The finless porpoise is too sensitive to the outside world. The artificial environment is different from nature, which will make it nervous. If the tension continues, it will lead to endocrine disorders and illness, which is fatal to the cubs." Professor Yang Guang said.

　　What caused the little finless porpoise to be separated from its mother? "It may be a sudden encounter with a jet stream or an undercurrent, or it may be a human activity such as a ship sailing, a sudden whistle or a sudden increase in the sound of a motor, which may cause fright." Professor Yang Guang believes that the impact of human activities on the ecology of the Yangtze River is really interfering with the normal life and reproduction of finless porpoises.

　　Finless porpoises at the top of the food chain but not enough to eat.

　　Jiang Meng, secretary-general of Nanjing finless porpoise protection association, often observes finless porpoises on the upper and lower reaches of the Yangtze River Bridge, and organizes volunteers to assist fishery administration departments to release finless porpoises’ food such as fry and bait into the Yangtze River. "Many times when feeding, we found that the finless porpoise soon emerged on the nearby river." The water of finless porpoise is called "Jiang Zhu worships the wind", which was once a unique scenery on the Yangtze River. Today, however, there is something bitter behind such a scene. He believes that the gathering and appearance of finless porpoises during feeding, on the one hand, shows that finless porpoises are very smart creatures, on the other hand, also shows that finless porpoises are starving and very hungry for food. Jiang Meng once paid attention to the records of finless porpoises found in recent years. He found that "finless porpoises were originally round and chubby, but many bodies were salvaged and found to be very thin, and after dissection, they found that their stomachs were empty."

　　Relevant data show that the natural catch of fisheries in the Yangtze River is decreasing year by year, from 540,000 tons in 1954 to 70,000 tons in 2012. There are 175 endemic species in the Yangtze River, and more than half of them have been lost in the past five years. The long-term monitoring data of many scientific research institutions, such as the Institute of Aquatic Sciences of Chinese Academy of Sciences, show that the number of fry of the "four big fish" in the Yangtze River has dropped sharply, from more than 30 billion in the 1950s to less than 100 million in 2013.

　　The reporter learned that in 2016, the closed fishing period of the Nanjing section of the Yangtze River was adjusted from March 1 to June 30, and it was extended from the past three months to four months. This move was to strengthen the protection of finless porpoises and other aquatic organisms in the Yangtze River. However, before the effective intervention of government departments, the phenomenon of cool fishing and overfishing in the Yangtze River was more serious. Illegal fishing activities such as fish frying, electric fishing, "ecstasy" and homeless nets are draining the fishery resources in the Yangtze River.

　　"finless porpoises have no natural enemies in the Yangtze River. They can be said to be creatures at the top of the food chain. They are not very picky eaters, as long as they are fish within 20 cm in length. However, due to the exhaustion of fisheries in the Yangtze River, finless porpoises are in a state of starvation. " Professor Yang Guang said that in addition to accidental incidents such as accidental injuries caused by ship navigation and water pollution, the continuous decrease in the number of finless porpoises is ultimately caused by insufficient food resources.

　　Deji plaza subscribed for 1 million fry to demonstrate scientific "release"

　　Yesterday morning, at the Virescence Expo Aquatic Release Platform, deji plaza held the activity of "Yangtze River Aquatic Proliferation and Release". One million fry subscribed by deji plaza were all put into the Yangtze River. The Yangzi Evening News reporter learned that this is the first proliferation and release activity initiated by social forces in China for the protection of finless porpoises. Deji plaza made a scientific demonstration under the guidance of Nanjing Fishery Administration and Fishing Port Supervision and Management Office and Nanjing finless porpoise Protection Association.

　　The so-called "proliferation and release" is the activity of releasing aquatic species or their parents into public waters such as oceans, rivers and lakes by artificial means. Proliferation and release can replenish and restore the population of biological resources, improve the population structure of organisms, and help maintain biodiversity and protect endangered species. According to statistics, in the past three years, Jiangsu has invested 230 million yuan in proliferation and release. In 2015, the province invested more than 79 million yuan, releasing more than 2.1 billion species, including 815 million marine economic species, 1.281 billion inland economic species and 8.48 million rare and endangered species.

　　The subscription of Deji this time includes the fry of four major fishes in the Yangtze River (black carp, grass carp, silver carp and bighead carp) and the national second-class protected wild animal Myxocyprinus asiaticus. The Yangzi Evening News reporter saw at the scene that the fry were transported to the scene by special transport vehicles from the cultivation base cooked in Jiangning Lake. According to the breeder, these fry were specially bred for this proliferation and release, and cold oxygen transportation was used on the way to fully ensure their survival rate. Under the guidance of the staff of Nanjing Fishery Administration and Fishing Port Supervision and Management Office, the volunteers from deji plaza carefully dumped the fry, and along the long discharge embankment, countless fry swam across the slope and merged into the waves by the river. Fish fry are like countless black lines. As soon as they touch the water, they instantly swim away and go to the middle reaches of the river.

　　The release activity was sponsored by deji plaza and Nanjing finless porpoise protection association. Jia Wei, deputy general manager of deji plaza, introduced the original intention of choosing the theme of "Saving Endangered Animals" on the occasion of the 10th anniversary. "The Yangtze finless porpoise is one of the closest endangered animals to us. We hope that through the release of the Yangtze River and the efforts of all sectors of society, more people will pay attention to the living conditions and protect the finless porpoise. To contribute to the protection of the Yangtze finless porpoise, improve the water quality of the Yangtze River and protect the biodiversity of the mother river. " Jia Wei said.

　　Professor Yang Guang told reporters that finless porpoises mainly eat all kinds of fish in the Yangtze River, and they have no choice about the types of fish they eat, mainly depending on their size. "You don’t see it has teeth, but its teeth can only bite, not like people’s teeth have the ability to chew, so it eats fish, and generally fish within 20 cm can be eaten. "Therefore, the fry released this time, on the one hand, are four local fish, which enriches the fishery resources of the Yangtze River, on the other hand, it is also very suitable for finless porpoises to eat."

　　So which fish or aquatic animals are suitable for release? At the scene, the fishery department also listed a list. Freshwater fish include: herring, grass carp, silver carp, bighead carp, bream, Eriocheir sinensis, fugu obscurus and other indigenous species with regional characteristics; Marine fish include: Pseudosciaena crocea, jellyfish, Cynoglossus semilaevis, swimming crab, prawn, Sole Sole, Meretrix meretrix, Sparus macrocephalus, etc. Rare and endangered aquatic animals: Chinese sturgeon, mullet, etc.

　　Expert reminder > >

　　Don’t throw these creatures into the Yangtze River again.

　　"When volunteers of our association patrol the river, they often see citizens who spontaneously organize release activities in the river or along the Yangtze River." Jiang Meng told the Yangzi Evening News reporter that because the public does not know much about species knowledge, in many cases, the released species can not only improve the ecology and enrich fishery resources, but also cause damage. He listed the three most common creatures that were released by the people.

　　Crocodile turtle: It is huge, up to 70 cm long. In the folk concept, releasing such a large turtle is a matter of "accumulating merits" and is favored by domestic enthusiasts. But in fact, the snapping turtle has nothing to do with compassion. It is extremely aggressive and has few natural enemies except alligators. "The most important thing is that the snapping turtle originated in the southeastern United States. If it is put into the Yangtze River, it will become a veritable intruder. Once it enters the Yangtze River, it will become a’ overlord’ and will take away the already scarce food source of the finless porpoise." Jiang Meng said.

　　Snakehead: It is what we often call "mullet". Unlike snapping turtles, snakehead is a common local fish, which is distributed in all major river systems in China. It is also a delicious food on the table of the citizens and can be easily bought in the food market. "But what people often overlook is that snakehead is fierce, fertile and has a huge appetite, and can often eat all other fish in a lake or pond." Jiang Meng told reporters that because finless porpoises are at a disadvantage in quantity, they are unable to compete with snakehead, the "king of big stomachs", for limited bait resources.

　　Brazilian tortoise: The most widely reared reptile in the world, but it is also listed as one of the most dangerous invasive species in the world because it plunders a lot of living resources. In China, many pet markets can see Brazilian tortoises on sale. Jiang Meng appealed that if citizens keep Brazilian tortoises for viewing, they should not be released into the wild or in the river. "Once they reach a brand-new ecological environment without a sufficient number of natural enemies, they will become a scourge and become an ecological disaster there." Jiang Meng said.

　　Nanjing will launch the first "census" of finless porpoises this summer.

　　At present, how many finless porpoises are there in Nanjing section of the Yangtze River? The statistics of the fishery administration department are "twenty or thirty", but there is no more accurate standard answer. Liu Jun, deputy director of Nanjing Fishery and Fishing Port Supervision and Management Office, told Yangzi Evening News reporter at the site of the proliferation and release activities held in deji plaza yesterday that this summer, the fishery administration department will launch the first "population census" of the Yangtze River finless porpoise in Nanjing, the top university in the United Nations for finless porpoise protection.

　　The Yangzi Evening News reporter learned that the latest data about the Yangtze finless porpoise still comes from the 2012 Yangtze River Freshwater Dolphin Investigation Report. At that time, the population of Yangtze finless porpoises was about 1040, less than half of that before 2006, less than that of giant pandas, and showed an accelerated downward trend. However, the details about the finless porpoise in Nanjing section are still vague. Liu Jun introduced that in this survey, besides finding out the latest accurate data, we should also find out the "destructive factors" that affect the normal reproduction of finless porpoises, so as to provide scientific basis for future artificial protection. "The special funds for the current investigation have been approved and will be launched after the parties are properly prepared."

　　Professor Yang Guang from Nanjing Normal University introduced that on October 9, 2014, Nanjing Yangtze finless porpoise nature reserve was established, covering 90% of the waters of Nanjing Yangtze River. He believes that it is essential to further strengthen the protection of Nanjing finless porpoise population and conduct a systematic scientific investigation. "The original data of 20 to 30 finless porpoises are very vague. As a provincial protected area, how many finless porpoises are there in this place, what are the activities of finless porpoises, and what changes have been made in the range of activities in spring and summer? Mastering some basic information of finless porpoises is the premise for us to effectively protect finless porpoises."

　　Expert opinion > >

　　Nanjing should also establish a "finless porpoise protection base"

　　The finless porpoise is the flagship species of the Yangtze River ecosystem, and it is also an indicator species of biodiversity and ecosystem health in the Yangtze River. The survival crisis of the finless porpoise itself is like a wake-up call, warning the deterioration of the entire Yangtze River ecosystem. Professor Yang Guang believes that from the perspective of long-term protection of finless porpoises, Nanjing should refer to the model of "giant panda breeding base" and establish a "finless porpoise protection base". "Since there is such a finless porpoise population in Nanjing, if we want to better carry out protection and rescue work, we can consider establishing a finless porpoise protection center. At the beginning, we can use the resources and facilities of the underwater world to help the finless porpoise, but in the future, we need to set up a special finless porpoise protection center. " Professor Yang said that after the investigation, with scientific consideration and demonstration, the finless porpoise can be better protected through protection, rescue and artificial breeding.

　　Deji celebrates its 10th anniversary.

　　Give the stage to the endangered animals around you

　　Jia Wei, deputy general manager of deji plaza, introduced that deji plaza will celebrate its 10th anniversary on June 26th this year. As a shopping center with humanistic care, deji plaza takes "saving endangered animals" as its theme, hoping to arouse Nanjing citizens’ concern for the environment. Yangzi Evening News reporter learned that in addition to subscribing for breeding, breeding and releasing, around the 10th anniversary, deji plaza also held a series of themed activities to protect finless porpoises and endangered animals.

　　The largest finless porpoise sculpture in Nanjing was exhibited on the first floor of deji plaza.

　　The 10th anniversary of deji plaza, with the theme of "Saving Endangered Animals", presented a series of themed activities. Among them, the artistic sculpture of finless porpoise named "Watch and Smile" is the most thought-provoking. The finless porpoise in the sculpture is smiling, but there are sad tears in his eyes. In the list of "Saving Endangered Animals" in the 10th anniversary of deji plaza, the Yangtze finless porpoise is an endangered animal living around us. This finless porpoise sculpture art exhibition is also to arouse more people’s awareness of caring for and protecting finless porpoises through more shocking art forms.

　　The overall size of the work is 10 meters ×3.8 meters, which is nearly seven times the size of the real finless porpoise, showing its process from beginning to end, from real to virtual until it disappears, just like a sketch drawn by a pen that is about to break ink, and finally disappears into a line. After the neck of the finless porpoise, there are a lot of mottled plastic marks, just like the wounds on the finless porpoise, which are shocking; The rising tail is made of more than 2,000 meters of steel bars, which gradually becomes sparse backwards until the lines disappear in the air, symbolizing the process of the disappearance and extinction of the finless porpoise.

　　On the 10th anniversary of deji plaza, the joint artists jointly presented the artistic sculpture of "Watching and Smiling" finless porpoise, which showed the status quo of the gradual disappearance of "smiling angel" finless porpoise with powerful artistic expression. Deji plaza said that through such soul-shaking works of art and theme activities, he hoped that more people could reflect on their indifference to nature and life, and called on more people to cry out from the bottom of their hearts: protect these "angels" who bring smiles to the world, coexist with every equal life and share the warmth from this world.

　　The "Noah’s Ark" came to Deji Outdoor Square to show all kinds of endangered animals.

　　At the same time, a huge boat-shaped device-"Noah’s Ark" also appeared in deji plaza Outdoor Square. This huge "Noah’s Ark" covers an area of about 600 square meters and has a double hull structure, with a total length of about 40 meters, a width of about 18 meters and a height of about 8 meters. In terms of material application, the hull uses a lot of wood grain plates, which truly restores the effect of wood grain hull and people’s original modeling imagination of Noah’s Ark. There are more than 1100 meters of steel and more than 1800 square meters of wood in the cabin, which makes it more in line with the hull structure and more integrated.

　　"Ark" has a video viewing and experience space of 150 square meters. Through 10 sets of world-class projection and audio equipment and the overall super-large screen in the cabin, the public welfare propaganda film for saving endangered animals is broadcast, bringing an immersive audio-visual experience to the audience. On the deck at the top of the Ark, highly restored models of dozens of endangered animals, such as Asian elephants, mountain zebras, polar bears, South China tigers and elk, were also exhibited.

　　Guarding the Yangtze River Beach and Opening the "Popular Science Lecture Hall for Endangered Animals"

　　Deji plaza has also launched a large-scale public welfare environmental protection activity along the Yangtze River "Yangtze River Beauty Plan", recruiting volunteers to go to the beaches along the Yangtze River to collect and sort garbage, contributing to changing the environmental status of the mother river and improving the living environment of the Yangtze finless porpoise. Up to now, four activities have been held. Volunteers, mainly parents and children, went to Qiaobei River Beach, Daqiao Park and Yanziji River Beach in Muyan Scenic Area to carry out activities such as garbage collection and biological knowledge popularization. Deji plaza hopes that the accumulated collection can create a clean home for the finless porpoise.

　　In addition, during the 10th anniversary celebration, deji plaza will carefully select ten premium charity gift packages, each of which contains single items provided by several brands, and the amount of gift packages ranges from 6,000 yuan to 35,000 yuan. All the proceeds from the sales will be donated to the Nanjing finless porpoise protection association for the Yangtze finless porpoise protection project.

　　Recently, deji plaza will also open a special "Popular Science Lecture Hall for Endangered Animals", which will be built into a classroom for children by opening up a space in the square. Experts from Nanjing finless porpoise protection association will come to the scene to explain the knowledge about endangered animals to children. Join the live interactive session to make the class more rich and interesting.

With the expectation of the Fed’s interest rate hike gradually declining, and it is almost certain that it will stop raising interest rates this year, small and medium-sized pharmaceutical stocks with historically low valuations are expected to usher in a wave of mergers and acquisitions this year. Combined with the merger situation in 2022, we believe that ten companies such as Argenx, Apellis and Sarepta have great potential to be merged by large pharmaceutical companies.

In addition to the ten pharmaceutical companies listed in this article, the following pharmaceutical companies or technical fields deserve attention:

ADC domain：Mersana Therapeutics、ImmunoGen；

CNS domain：Intra-cellular、Neurocrine、Sage Therapeutics;

Rare disease field：Mirum、Krystal Biotech；

Other fields：Halozyme、Prometheus、Viridian Therapeutics.

1、Argenx(NASDAQ:ARGX)

ARGX is a Dutch pharmaceutical company specializing in the research and development of alpaca-derived antibodies. It has three patented technologies related to the transformation of antibody Fc region, namely SIMPLE Antibody platform, NHance, ABEDEG and POTELLIGENT, and has the property of technology platform.

The drug VYVGART, which has been marketed by ARGX for treating myasthenia gravis, sells well, recording a sales income of US$ 131 million only in the third quarter of last year. It is estimated that the annual income will reach US$ 402 million, and the rights and interests of VYVGART in China have also beenZaiding medicineTake it. In 2023, ARGX also had some important milestones:

The company has submitted the subcutaneously injected version (SC) of EFGARTIMOD, which will be listed for approval on June 20th. Considering that VYVGART has been listed and sold well, the subcutaneously injected version of EFGARTIMOD has a high probability of being approved, and the sales revenue is more considerable.

In the second quarter, the SC version of efgartigimod will also release the phase III data for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP).

ARGX-113, a drug under research, will release two three-phase heavy data on the treatment of primary immune thrombocytopenia (ITP) and pemphigus vulgaris (PV) in the second half of the year.

ARGX is rich in pipelines, its technology platform has been verified, its sales revenue has risen rapidly, and with the blessing of many heavy catalysts this year, many Wall Street investment banks have listed ARGX as one of the promising biomedical enterprises this year.

2、Apellis(NASDAQ:APLS)

APLS is a biomedical company with complement technology, and its main drug is C3 inhibitor APL-2. At present, the drug has been approved for two indications: paroxysmal hemoglobinuria (PNH) and geographic atrophy (GA) secondary to age-related macular degeneration, among which the PNH indication was approved in mid-2021, and it sold for 65.1 million US dollars in the United States only last year (authorized to SOBI outside the United States).

APL-2 was recently approved for the treatment of GA, with a wide range of labels (including foveal and extrafoveal), and GA has a large market. The Wall Street investment bank even gave a peak sales forecast of $5 billion. At the same time, the doctor survey conducted by the investment bank showed that doctors and patients had high expectations for APL-2. It is estimated that doctors will use the drug in 20-50% of patients, with an estimated EOD of 70-80%.

In addition to the above-mentioned approved indications, the company has a layout in the fields of rare diseases, ophthalmology, nervous system, gene therapy, etc., among which gradual freezing disease (ALS) in cooperation with SOBI is the most important. APLS is a very suitable choice for large pharmaceutical companies that want to enter the field of complement technology or GA.

3、Alnylam(NASDAQ:ALNY)

Founded in 2002, Alnylam is a leading enterprise in the field of RNAi therapy. In the past five years, it has successfully brought five RNAi drugs to the market, and in 2022, it achieved sales revenue of 892 million US dollars, up 35% year-on-year.

According to product classification, ONPATTRO and AMVUTTRA, which have the same indications, recorded revenues of $122 million and $69 million respectively in the fourth quarter of last year, with annual revenues of $558 million and $94 million respectively.

GIVLAARI recorded a revenue of $47 million in the fourth quarter of last year and achieved a revenue of $173 million in the whole year; OXLUMO recorded a revenue of $24 million in the fourth quarter of last year and achieved a revenue of $70 million for the whole year.

In addition to the strong performance of existing products, relying on the RNAi therapy technology platform, ALNY is rich in research pipelines, and many pipelines are in the later stage, which has great commercialization potential in the short term:

Patisiran’s supplementary marketing application for the treatment of ATTR amyloidosis cardiomyopathy, and the approval time is October 8; This year, the third phase data of Fitusiran in treating hemophilia and the third phase data of Vutrisiran in treating ATTR amyloidosis cardiomyopathy will also be released.

In addition, the market for indications of some early pipelines of the company is extremely broad, such as Zilebesiran for treating mild and moderate hypertension, ALN-APP for treating Al Harmo’s disease, ALN-KHK for treating NASH, etc.

Whether it is the technology platform, sales performance, and future potential, ALNY is the target of mergers and acquisitions by large pharmaceutical companies.

4、Axsome Therapeutics(NASDAQ:AXSM)

AXSM is a model of Biotech in the field of central nervous system in recent years. Its share price has risen more than 30 times in the past four years, and it has also enabled CFO Nick Pizzie, who defected from Pierre Fabre USA in 2018, to gain wealth freedom. At that time, the market value of AXSM was less than 100 million US dollars.

Behind the stock price rise is AXSM’s successive clinical trials:

The third phase trial of AXS-05 in the treatment of major depression (MDD) and bipolar disorder in Az Harmo was successful, and the indication of MDD has been approved for marketing.

The third phase trial of AXS-07 for migraine was successful, and it is planned to submit NDA； this year;

The drug AXS-12, which is used to treat narcolepsy, has also been certified by FDA as a breakthrough therapy. It is currently in the second phase of clinical practice, and data will be released this year.

In addition to its own research and development, the company is also adept at business development (BD): in March 2022, AXSM bought Sunosi, a listed drug for treating narcolepsy, from JAZZ for $53 million, and in February this year, AXSM announced that it would grant Sunosi’s rights and interests in Europe, the Middle East and North Africa to Pharmanovia, and AXSM would receive an advance payment of $66 million and a milestone payment of up to $101 million.

For large pharmaceutical companies that favor the commercialization stage, AXSM with two CNS drugs on sale and multiple later pipelines is undoubtedly one of the most worthy M&A targets.

5、Ascendis(NASDAQ:ASND)

Ascendis Pharma is a long-acting drug company with a long-acting drug technology platform TransCon. At present, it mainly focuses on various rare diseases, reducing the frequency of drug use, improving patients’ compliance, reducing side effects, and thus improving the treatment effect. With the success of the third phase clinical trials of several drugs, the technical platform of ASND has also been verified.

At present, the company has three drugs under research: TransCon hGH (long-acting growth hormone), TransCon PTH (treatment of hypothyroidism) and TransCon CNP (treatment of achondroplasia).

In 2021, Skytrofa, the company’s drug for treating children’s growth hormone deficiency (GHD), has been approved for marketing. On April 30 this year, the FDA will approve the marketing of TransCon PTH, the company’s drug for treating adult hypoparathyroidism, and will also release Phase III data of TransCon hGH for treating adult growth hormone deficiency before the end of the year. In addition, the company also has pipeline promotion in the field of achondroplasia and tumor, and will provide updates of related clinical trials this year.

The performance of Skytrofa, a drug listed by ASND, grew well. In 2022, it achieved a revenue of 35.7 million euros, with a quarterly revenue growth rate of 39%.

In 2018, ASND also co-founded VISEN Pharmaceuticals with Vivo Capital, and Visen Pharmaceuticals acquired the rights and interests of ASND in Greater China. In November 2022, Weisheng Pharmaceutical submitted a prospectus to the Hong Kong Stock Exchange, intending to be listed on the main board of Hong Kong. In view of the vast domestic long-acting growth hormone market, Changchun Gaoxin, anke biotechnology and other companies have already laid out, and the arrival of Weisheng Pharmaceutical will intensify the competition in the industry.

In view of the company’s long-term drug technology platform and the pipeline in the late stage of commercialization and research and development, Ascendis Pharma is also one of the potential acquisition targets of large pharmaceutical companies.

6、Sarepta(NASDAQ:SRPT)

Sarepta Therapeutics is a leading enterprise in the field of treating Duchenne muscular dystrophy (DMD). At present, the company has three approved DMD drugs: EXONDYS 51, AMONDYS 45 and Vyondys 53. In addition to the drugs already on the market, the company is developing new therapeutic drugs such as gene therapy and gene editing around DMD, and at the same time, it has a layout for the indications such as limb muscular dystrophy (LGMD).

In the third quarter of 2022, the company recorded a product sales income of 207 million US dollars, and it is estimated that the annual income will reach 843 million US dollars, a year-on-year increase of 38%. In addition to strong sales performance, the company’s R&D pipeline is also worth looking forward to.

In the third quarter of last year, the company submitted the application for the marketing of gene therapy drug SRP-9001 for treating DMD, which was jointly developed with Roche. The FDA granted it priority approval, and the approval time was May 29th. The marketing application of SRP-9001 is supported by many clinical trial data, and the probability of approval is high.

For large pharmaceutical companies that want to enter the DMD field, SRPT is the best choice. However, the overseas rights and interests of SRP-9001 were authorized to Roche, which may lower the expectations of the acquirer.

7、Karuna Therapeutics(NASDAQ:KRTX)

KRTX is a company that develops drugs for the treatment of nervous system diseases. KarXT, its main drug, is an oral first-choice muscarinic agonist for M1/M4. It consists of xanomeline, a muscarinic agonist, and trospium, a muscarinic antagonist. It aims to preferentially stimulate muscarinic receptors in the central nervous system, and has the potential to treat serious mental diseases without relying on dopaminergic or serotonin, including schizophrenia and psychosis in Alzheimer’s disease.

In August, 2022, the company released the phase III clinical data of KARST in the treatment of schizophrenia, which not only reached the end of the trial, but also was superior to the existing therapies in terms of therapeutic effect, safety and patient coverage, and solved the problems of poor compliance and less coverage in the existing therapies, especially the clinical P value of KARST < 0.0001, which is extremely rare in the CNS field.

This data has been released, and KarXT is regarded as a game changer in the field of schizophrenia by investment banks such as Mizuho. It is estimated that it will reach $1.7 billion by 2028, and its peak sales will be above $5 billion.

The company plans to submit the listing application of KarXT in the middle of this year, and release the results of another phase III test named Buergent-3 in the first quarter of this year. This experiment is similar to the previous studies of EMERGENT1(Ph2b) and EMERGENT-2(Ph3), with a high probability of success, but initially the experiment was mainly conducted in Ukraine, and now most of the research is transferred to the United States, which has certain uncertainties.

8、Revance(NASDAQ:RVNC)

RVNC is a pharmaceutical company dedicated to developing cosmetic medical products. Relying on the unique TransMTS? peptide technology, it has developed a differentiated botulinum toxin for injection, which was approved in the third quarter of last year.

Different from the existing Dysport, Xeomin, Jeuveau and other products on the market, DAXXIFY is a new product that is truly different from BOTOX, the number one product in the field of botulinum toxin. In the treatment of brow wrinkles, the curative time of DAXXIFY is almost 1.5 to 2 times that of BOTOX, while the annual income of the latter is 14.6 billion US dollars.

Because of its remarkable effect, DAXXIFY aims at the top one-third of the existing users. Investment banks predict that DAXXIFY will occupy 30% of the US market and its annual sales will exceed $1 billion. In the first quarter (the fourth quarter of last year) just after it was approved, the sales of DAXXIFY experience users were already expected to be between $10.5 million and $11.5 million.

In addition to DAXXIFY, the company also has RHA fillers with less side effects and better effects than hyaluronic acid. The sales revenue in the first year after listing was more than 70 million US dollars, and the growth rate last year remained at 40%+. Different from other small pharmaceutical companies, the company also has a commercial platform OPUL?, which is a cloud platform integrating customer relationship maintenance and financial payment functions, providing services for all kinds of medical and beauty businesses. As of the third quarter of last year, the total platform GPV in the past 12 months exceeded 630 million US dollars.

In the environment of raising interest rates, large pharmaceutical companies facing the cliff of heavy drug patents are likely to be interested in mergers and acquisitions of RVNC with great sales revenue potential and quick results.

9、Krystal Biotech(NASDAQ:KRYS)

KRYS is a unique gene therapy company, which does not use the common adeno-associated virus or lipid nanoparticles to deliver genetic material, but loads the gene into herpes simplex virus (HSV-1) to make it reach its target in vivo. HSV-1 has higher carrying capacity than other gene therapy technologies, which not only broadens the scope of potential diseases that KRYS may treat, but also can realize repeated administration.

KRYS has developed a series of drugs for dermatoses and respiratory diseases on its gene therapy technology platform, among which the most important one is B-VEC for the treatment of dystrophic epidermolysis bullosa (DEB), which is currently in the waiting stage for PDUFA.

B-VEC has obtained the priority evaluation qualification granted by FDA. Due to CMC, the approval time was postponed to May 19th this year, and the probability of approval was high. If approved, this will be the first approved gene therapy for DEB.

Although the market of DEB is not very large, B-VEC has proved the feasibility of the company’s technology platform to some extent. Besides the skin diseases and respiratory diseases that have been laid out at present, the company has also started clinical trials to treat cystic fibrosis. In addition, Jeune Aesthestics, a subsidiary of KRYS, is still trying to enter the field of medical beauty.

With its unique technology platform value and several promising research pipelines, KRYS is expected to become an M&A option for large pharmaceutical companies.

10、Xenon(NASDAQ:XENE)

XENE is a company that focuses on the treatment of neurological diseases by regulating ion channels. The main indication is epilepsy. At present, there are four drugs under research in the pipeline, XEN1101, XEN496, XEN901 and XEN007, which have cooperated with well-known enterprises in CNS field, Neurocrine and Alexion (acquired by AstraZeneca).

In October, 2021, the company announced that XEN1101, the main pipeline, announced the success of the second phase of the clinical treatment of adult local epilepsy, and the FDA required the company to make another third phase to apply for listing. XEN496, another treatment for infantile epilepsy, is also in the third clinical stage, and it also needs a greater probability of success.

In addition, the company’s drug XEN1101 is still in the second phase of clinical treatment for major depression (MDD), and the market of MDD is bigger than that of epilepsy. If the data released in the second half of the year is good, it will increase the probability of the company being acquired.

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Tan Dun

Tan Dun won the 73rd Academy Award for Best Composition.

Tan Dun directed the Song Mountain Music Festival "Zen Shaolin" in China

　　What kind of music will the world hear at the 2008 Beijing Olympic Games? Is it rock music that stirs Guo Jingjing’s diving sound, Yao Ming’s dribbling sound and Liu Xiang’s starting rhythm? Or the Shaolin Zen music of Zhong Mingshan Forest and Crouching Tiger, Hidden Dragon? Or the mysterious music of a village tribe in China?

　　Tan Dun, an international musician who is famous for his innovation, always blends rich oriental charm with western pop elements.

　　This background undoubtedly made him a popular music planner for the opening ceremony of the Beijing 2008 Olympic Games. Recently, our reporter interviewed Tan Dun, who has just successfully completed the planning and creation of "Zen Shaolin Music Grand Ceremony", by email, hoping to give you an answer.

　　Tan Dun Music Creativity

　　How romantic it is to make music with the voice of athletes’ bodies. I have been touched myself, and I can also touch everyone in the world.

　　Bidding: Do you do physical exercise after work? What’s your favorite sport? Who is your favorite athlete?

　　Tan Dun: I insist on swimming every day after work, which is why I always try to have a swimming pool in my hotel when I am on a world tour. I like to brew melodies while swimming, so I often swim for half an hour without knowing it. Conceiving in water makes me feel immersed in the source of inspiration, because water is a symbol of hope and regeneration.

　　My favorite athletes are Guo Jingjing, Yao Ming and Liu Xiang. In my mind, all three of them are musicians, because I saw music and heard colors in their sports. The rhythm and intensity of their movements make me feel as if even the earth can be shocked and reversed. I’m doing research in this field recently, and I plan to turn Guo Jingjing’s diving sound, Yao Ming’s racket sound and Liu Xiang’s starting rhythm into rock music. I hope I can turn the athletes’ hard work and unparalleled shock into a very poetic music, which is the voice of their bodies and the rhythm of their hearts. How romantic it is to make music with their body sounds. I have been touched myself and I can touch everyone in the world.

　　Tan Dun Olympic Dream

　　I dream that Beijing Olympic Games is a world full of poetry, romance and love.

　　Competitive bidding: I heard that recently, IOC President Rogge watched the "Zen Shaolin Music Festival" created and planned by you at the Shaolin Temple in Songshan, the birthplace of Zen, and he excitedly raised your hands and said to all the audience and the media, "It’s so beautiful, this program deserves an Olympic gold medal! Composer Tan Dun should win the Olympic champion! " Is it true?/You don’t say.

　　Tan Dun: It’s true. We were all very excited at that time. This is the IOC’s great appreciation of Wushu and the traditional culture of China-Zen philosophy. Since I wrote Crouching Tiger, Hidden Dragon, I have been continuing my feelings, trying to bring China traditional sports-Wushu to a poetic and romantic realm through music. I dream that the Olympic Games in Beijing is also a world full of poetry, romance and love.

　　Tan Dun’s "Root" of Creation

　　Only new "creativity" can connect the contemporary world with the future China.

　　Competition: You once said that you hoped that orchestras all over the world could play your works to promote China culture and make China culture a big step forward in the 21st century. Is this an important part of your musical ideal?

　　Tan Dun: Yes.

　　My music is in sync with the world, which challenges my creation, and I must also try my best to bring surprises to the world. Can you imagine growing tea and making a tea ceremony in the desert? I just staged my new opera Tea in the desert of New Mexico. It’s so Zen. Everyone was drunk by China in the desert. I’m trying to attract a jade, which requires all art institutions at home and abroad to pay attention to the recognition of "China’s creative culture" and let the whole world know more about Chinese, so that we can have a dialogue with the world. Creativity is a bridge, and only new creativity can connect the contemporary world with the future China. Only in this way can people love a modern China.

　　Competitive newspaper: You said that China is the "root" of your creation. Is this an important reason why your music is widely praised in the world?

　　Tan Dun: This year, my new concept of "Organic Music and Green Rhythm" will be invited to tour 17 countries. The more praise the world gives me, the more I appreciate China culture. I feel that instead of praising me, I should be grateful for this magical land behind me. It is this fertile soil that gave me a golden key, which opened the doors of the metropolitan opera, the Vienna "Golden Music" Hall and the Berlin Philharmonic, the most famous art halls in the world. I believe that we can also use this "golden key" to open the holy door of the Olympic Games.

　　In your opinion, how will the opportunity of hosting the Olympic Games in Beijing promote the spread and promotion of China culture in the world?

　　Tan Dun: As I said, I have a golden key in my hand, which is a magic key made of special materials. It contains China’s profound philosophy, intelligent tradition and creative people, and I am proud to be a member of this group of people. As long as we never forget to excavate and inherit our traditional culture, we will always get inspiration and harvest from it. We must not neglect our own value, because this is precisely the reason why the whole world respects China, and it is also the capital for us to host the Olympic Games and participate in the Olympic culture.

　　Tan Dun Olympic Songs

　　A successful Olympic song, first of all, should be "mind-wandering", which is my advice to all Olympic song creators.

　　Bidding: Beijing is collecting Olympic songs. Is there an Olympic song that impresses you now? What advice do you have for the creators of the songs? What characteristics do you think a successful work should have?

　　Tan Dun: To be a successful Olympic song, we must first "take the heart" and be able to sing the heartfelt desire and passion. This is also my advice to all Olympic song creators (including myself). In addition to "mind-wandering", we should also "be innovative" and innovate a new skill, new structure and new language, pointing directly at people’s spiritual world. We should be international, ethnic and have the courage to innovate.

　　Bidding: Do you have any plans to create theme songs or other musical works for Beijing 2008 Olympic Games?

　　Tan Dun: Like all my colleagues who participated in the creation, I have exhausted my mind in the creation of Olympic music. Before that, I specially went to some cradles of China traditional culture to collect folk songs. The resources there inspired me. There, I heard the world’s expectations for China culture. Olympic songs are hymns written by God through our hands. This is the voice from heaven and the dream of harmony between heaven and earth.

　　Brief introduction of Tan Dun

　　Tan Dun, born in Hunan, was admitted to Beijing Central Conservatory of Music in 1978 and obtained a master’s degree in music. After going to the United States in 1986, he obtained a doctorate in music from Columbia University. Now living in new york.

　　Tan Dun’s major works include: Symphonic Drama Series, which includes five symphonic works. Among them, Tan Dun tried to bring China’s ancient witch culture into modern symphony performance; Organic music series, which integrates natural timbre into symphony, and its representative works include Water Music, Paper Music and Tao Le; Multimedia series, exploring audio-visual structure and creating new media across time and space and culture, with representative works such as Map.

　　Tan Dun, a composer and conductor famous for his innovation, is currently the music planner for the opening ceremony of the Beijing 2008 Olympic Games. He has been involved in the music creation of films about Beijing’s Olympic bid since 2000.

　　Tan Dun has crossed many boundaries between tradition and modernity, between East and West, between classics and pop. For music lovers all over the world, Tan Dun is undoubtedly a cultural banner with rich oriental colors, paving a bridge for the integration of Chinese and Western cultures. Tan Dun has won the most influential and prestigious music awards in the world, including the Grammy Award and the Oscar Award for Best Original Music, and was awarded the "Composer of the Year" by the American Music Association. He was also named one of the ten Chinese who influenced the world in 2006 by the ten most important Chinese media in the world, such as Phoenix TV.

　　Tan Dun Olympic Fate

　　I am an Olympic volunteer, and I hope I can provide my knowledge and experience in music creation without reservation.

　　Bidding: Please tell us about the cultural and promotional activities related to the Beijing Olympic Games in the past.

　　Tan Dun: I have always had a relationship with the Olympic Games. Seven years ago, I participated in the music creation of China’s Olympic bid film. When it was announced in Moscow that China had won the right to host the Olympic Games, I felt honored, because my music also played a small role in China’s successful bid for the Olympic Games. I feel that I have studied music all my life. If I can participate in this once-in-a-century activity, it is our fate, and it is my fate with China culture.

　　Competitive bidding: What other Olympic-related work will you do now or in the coming year? In what way will you participate in the Beijing Olympic Games?

　　Tan Dun: I am honored to be invited by BOCOG to be the music planner for the Beijing Olympic Games. In my work, I have been looking for inspiration from eastern and western cultures, and at the same time, with the help of my friends all over the world, I have attracted these "world leaders" to this sacred work. Apart from composing theme songs, I am also planning some other Olympic-related music, such as Olympic logo music and award music. This is a huge echelon project, in which everyone is silently contributing. I am an Olympic volunteer. I hope I can provide my knowledge and experience in music creation without reservation. I hope our small contribution can contribute to the success of the Olympic Games. I am very proud of being a volunteer of the Olympic Games.

　　Tan Dun Beijing Impression

　　During the Olympic Games, Beijing should have fresh air, cool breeze and unparalleled enthusiasm.

　　Competitive newspaper: Do you feel that the Olympic Games have brought changes to Beijing? What do you think of this change?

　　Tan Dun: This is a rare opportunity in a century. With this opportunity, we will work harder to change the living environment and realize our green dream. It is indeed a very difficult task to make our sky bluer and our water cleaner, so that our future generations can live in a better environment. However, hosting the Olympic Games has greatly touched us, and people should take improving the environment as a top priority by supporting the Olympic Games. Our efforts now will be the greatest wealth for the future.

　　Bidding: What do you think Beijing is like during the Olympic Games?

　　Tan Dun: At that time, Beijing should have fresh air, cool breeze and unparalleled enthusiasm. The whole city was full of love, and the whole world was intoxicated and crazy about it. (Source: Competitive Newspaper)

Editor: Zhu Xinrui