The 55th Golden Horse Poster

1905 movie network news Today, the main visual poster of the 55th Golden Horse Award was released, which once again firmly attracted the attention. This poster with blue and gold as the main color looks like staring at the sleeping sand dunes in the middle of the night from a distance. If you look closely, you will find that it is four faces lined up in turn. This poster was designed by Fang Xuzhong, the poster designer and visual director of the ceremony last year. It extends the concept of "everyone plays a supporting role in the film" and draws the facial contours of Ang Lee (Chairman of the Executive Committee of Taipei Golden Horse Film Festival), Hou Xiaoxian (Dean of Golden Horse Film Academy), Gong Li (Chairman of the Golden Horse Award Jury) and Xiao Ye (Judge of Golden Horse Venture Capital Conference) into dune shapes. The picture made up of tiny particles of light and shadow also seems to imply the ambiguous connection between retaining the instantaneous image with light and shadow and the passing time.

　

The main visual posters of the Golden Horse Awards pay attention to convey the understanding of Chinese movies with rich imagination and bold creativity, which has always been a highlight of the Golden Horse Awards. In recent years, almost all the main visual posters have paid tribute to Taiwan Province’s old films and filmmakers.

　

In 2017, the main visual posters of the 54th Golden Horse Awards were the "Shadow Idiot Edition" and "Fan Edition" posters with the stills of "Spring Breeze" as the main elements. The two posters project the pictures from the stills onto various screens to convey the real and illusory feeling brought by the film, which is similar to the 53rd brighter summer day designed by Huang Hai, in which the junior four illuminates the night sky with a flashlight to show that "the light of the film never goes out".

　"Shadow Idiot Edition" (54th edition) by square sequence

"Fan Edition" (54th session)

The 53rd Tribute to Guling Street by Yellow Sea

Even more amazing is the 50th Golden Horse, a Maggie Cheung-themed poster designed by Taiwan Province graphic designer Nie Yongzhen (who designed album covers for Jay Chou, Yoga Lin and others). The image of Maggie Cheung is partially cut to show different areas of the face, which means that the film is like a slice of time, so it can’t really keep time, so it can only intercept fragments.

　The 50th Maggie Cheung by Nie Yongzhen

In addition, it is worth noting that cartoonist Jimmy has designed the main visual poster for the Golden Horse Award twice. At the 39th Taipei Golden Horse Film Festival, he gathered his characters in the cinema and opened a small door under it. It not only means that the film blurs the boundary between reality and illusion, but also outlines the pleasant atmosphere of watching movies.

How many meters is the 39th by?

Another time was the 49th Golden Horse Award 10 years later. He created in oil painting for the first time in public and handed in three design drawings at one time. Two of them are a pair of dressed-up "hot horses and handsome horses", and the final picture is the picture of a little boy and a horse flying on the sea. According to Jimmy himself, this means "the pursuit of light and shadow".

　How many meters is the 49th by?

Next, please enjoy the main visual poster of the Golden Horse Award from 2008 to this decade — —

The 45th Session (2008), which rejected complexity and chose simple color blocks.

The 45th by Nie Yongzhen

　 　 　 　 　A camera head who is always running, 46th (2009)

The 46th by Wang Zhihong

　 　 　 　 　 Seconds of Glass Breaking, 47th (2010)

The 47th by Wang Zhihong

　 　 　 　Inspired by Hou Hsiao-hsien, the 48th session (2011) is based on the essential old camera which may be closer to gaze.

The 48th by Lin Xiaoyi (cover designer of Kawabata Yasunari series)

　 　 　 The Pursuit of Light and Shadow, 49th (2012)

The 51st by Xiao Qingyang (album cover artist)

　 　 　 　Chivalrous women with stick figures, hidden in gilded lines, 52nd (2015).

The 52nd, by Zhang Shuping.

　 　 　 　　"The Light of Movies: Looking Back, Illuminating Forward", 53rd (2016)

The 53rd Tribute to Guling Street by Yellow Sea

　 　 　 　To pay tribute to the 20th anniversary of the publication of "Spring Break", selected by Wong Kar-wai himself, the 54th (2017).

The 54th session　By square order

　 　 　 　 The 2018 Golden Horse Film Festival will be held from November 8 to 25.

　

　　Xinhua News Agency, Beijing, October 8 (Reporter Gao Jing) During the National Day holiday this year, Gao Lei, who works in Beijing, found that his hometown had changed a lot when he went home to visit relatives. Gaoyang County, Baoding City, Hebei Province, where his hometown is located, is undergoing the transformation from coal to gas. Gao Lei saw that the small coal-fired boiler used for heating in winter at home disappeared, and the kitchen was newly connected with natural gas pipelines and installed with wall-hung boilers. The home looked much cleaner and brighter than before.

　　Replacing loose coal by changing gas and electricity is one of the important measures to control air pollution in northern China.

　　Since the "Thirteenth Five-Year Plan", China’s air pollution control has achieved remarkable results. According to the data from the Ministry of Ecology and Environment, compared with 2015, the average annual concentration of fine particulate matter (PM2.5) in cities at or above the prefecture level fell by 23.1% in 2019, and the proportion of excellent days in 337 cities at or above the prefecture level reached 82%.

　　In the closing year, the achievements of the blue sky defense war were even more eye-catching. From January to August this year, the average number of excellent days in 337 cities at or above the prefecture level was 86.7%, up 5 percentage points year-on-year; The concentration of PM2.5 was 31 μ g/m3, down 11.4% year-on-year. Good weather with blue sky and white clouds is becoming the norm.

　　Behind more and more blue sky is a series of "combination boxing" that China has played to control air pollution. In recent years, China’s air pollution control work has been closely focused on key areas such as Beijing-Tianjin-Hebei and surrounding areas, the Yangtze River Delta region, and the Fenwei Plain, focusing on key pollutants such as PM2.5, focusing on key periods in autumn and winter, and key areas such as loose coal combustion and "scattered pollution" enterprises, and continuing to implement tough actions.

　　The pilot cities of clean heating in the northern region will achieve full coverage of Beijing-Tianjin-Hebei and surrounding areas and Fenwei Plain; 86% of coal-fired power units have achieved ultra-low emissions, and about 780 million tons of crude steel production capacity has been transformed into ultra-low emissions; Carry out in-depth rectification of "scattered pollution" enterprises, industrial furnaces and key industries to control volatile organic compounds; Strengthen the pollution control of diesel trucks and vigorously promote the "revolving iron"; Deepen the joint prevention and control of air pollution in key areas and strengthen the response to heavy pollution weather.

　　"The nearby village used natural gas for heating last year, which is said to be clean and warm." Gao Lei said that he believes that after coal is changed to gas, there will be more blue sky and less smog in winter.

CCTV News:People commemorate Qu Yuan on the Dragon Boat Festival. Qu Yuan’s personality charm and ideological essence, such as worrying about his home country, caring for the people, being brave in exploration, being honest and noble, have been praised through the ages. The Dragon Boat Festival embodies the profound feelings of the Chinese nation and inherits the spirit of patriotism. General Secretary of the Supreme Leader has made an important exposition on patriotism on many occasions, and repeatedly quoted Qu Yuan’s famous sentences in his speeches to elaborate his thoughts, which has far-reaching implications.

Patriotism has always been a passionate theme.

历史告诉我们，每个人的前途命运都与国家和民族的前途命运紧密相连。国家好，民族好，大家才会好。

——2012年11月，最高领袖在参观《复兴之路》展览时的讲话

图为2012年11月29日，中共中央总书记、中央军委主席最高领袖和中央政治局常委李克强、张德江、俞正声、刘云山、王岐山、张高丽等来到国家博物馆，参观《复兴之路》展览。

在中华民族几千年绵延发展的历史长河中，爱国主义始终是激昂的主旋律，始终是激励我国各族人民自强不息的强大力量。

——2013年10月，最高领袖在欧美同学会成立100周年庆祝大会上的讲话

爱国主义是中华民族精神的核心。爱国主义精神深深植根于中华民族心中，是中华民族的精神基因，维系着华夏大地上各个民族的团结统一，激励着一代又一代中华儿女为祖国发展繁荣而不懈奋斗。5000多年来，中华民族之所以能够经受住无数难以想象的风险和考验，始终保持旺盛生命力，生生不息，薪火相传，同中华民族有深厚持久的爱国主义传统是密不可分的。

——2015年12月，最高领袖在中共中央政治局第二十九次集体学习时的讲话

The general secretary quoted Qu Yuan’s famous sentences many times.

"The road is long and Xiu Yuan is awkward, and I will search up and down." Comrades of the whole party must not forget their initial intentions, move on, always maintain the style of modesty, prudence, arrogance and rashness, always maintain the style of hard struggle, be brave in change and innovation, never be rigid and never stagnate, continue to stand the test in this historic exam, and strive to hand over new and better answers to history and the people!

— — In July 2016, the Supreme Leader’s speech at the celebration of the 95th anniversary of the founding of the Communist Party of China (CPC).

● The source of the allusion: "The road is long, and Xiu Yuan is awkward. I will go up and down to seek" comes from Qu Yuan’s Li Sao.

The picture shows the statue of Qu Yuan.

China people’s War of Resistance against Japanese Aggression is extremely tragic, from strategic defense to strategic stalemate, and then to strategic counterattack. Whether on the frontal battlefield or the battlefield behind enemy lines, the people of China shared the same enemy and went to the national disaster together, and their iron bones clanked and died, playing a heroic victory. Yang Jingyu, Zhao Shangzhi, Zuo Quan, Peng Xuefeng, Tong Linge, Zhao Dengyu, Zhang Zizhong, Dai Anlan and many other heroic groups are outstanding representatives of the Chinese people who are fearless of violence and die for their country. As the saying goes, "Honesty is brave and brave, but ultimately strong and unyielding." The body is dead, the gods are spiritual, and the soul is awkward. "

— — In September 2014, the Supreme Leader’s Speech at the Symposium to Commemorate the 69th Anniversary of China People’s War of Resistance against Japanese Aggression and the Victory of the World Anti-Fascist War.

● The source of the allusion: "Sincerity is brave and brave, and it will eventually be strong and unyielding. The body is dead, the gods are spiritual, and the soul is awkward. " From Qu Yuan’s "Nine Songs of National Mourning"

Qu Yuan’s "Breathing too much to hide tears, lamenting the hardships of the people’s lives", Du Fu’s "There are thousands of spacious buildings, which greatly protect the world’s poor people’s faces", "Zhu Men’s wine and meat stink, and the road is frozen to death", Li Shen’s "Who knows that every meal is hard", and Zheng Banqiao’s "Some small officials in Caozhou County always care about their feelings" and so on.

— — In October 2014, the Supreme Leader hosted a symposium on literary and artistic work in Beijing and delivered an important speech.

● The source of the allusion: "I take a long breath to hide my tears and mourn the hardships of the people’s lives" comes from Qu Yuan’s Li Sao.

The picture shows Qu Yuan’s hometown in Zigui, Hubei.

As one of the ancient civilizations in the world, China has made great contributions to the development of astronomy. Our ancestors began to observe and explore the mysteries of the universe very early in the work of sunrise and sunset. As early as more than 2,300 years ago, Qu Yuan, a great poet in China, wrote, "Who preached it at the beginning of ancient times? Up and down are shapeless, why should we test them? " The famous "Tian Wen".

— — Speech by the Supreme Leader at the Opening Ceremony of the 28th General Assembly of the International Astronomical Union in August 2012

● The source of the allusion: "Who preached it at the beginning of ancient times? Up and down are shapeless, why should we test them? " From Qu Yuan’s "Tian Wen"

Qu Yuan, a great patriotic poet.

Qu Yuan is a great patriotic poet in the history of China and the founder of China’s romantic literature. He is known as "the ancestor of Chinese poetry" and "the ancestor of Ci Fu" and is called "the soul of poetry" by later generations. His main works include Li Sao, Nine Songs, Nine Chapters and Tian Wen. The Songs of the South, written by him, is the source of China’s romantic literature, and is also called "coquettish" with the Book of Songs, which has a far-reaching influence on later poetry.

The picture shows Miluo River.

Qu Yuan was an important politician in Chu State. He was trusted by Chu Huaiwang in his early years, and served as a Zuotu and a doctor in San Lv, in charge of internal and external affairs. He advocated that the reform plan should be strong, that is, he should promote talents and improve statutes internally, and that he should unite with external forces to fight against Qin. Being slandered by the nobles, he was exiled to Hanbei and Yuanxiang Valley successively. In 278 BC, the Qin general attacked Chu Duying (now Jiangling, Hubei Province) in vain, and Qu Yuan was filled with grief and indignation. Huai Shi sank in the Miluo River and died.

(Comprehensive source: People’s Daily, Xinhuanet)

　　(This article comes from WeChat WeChat official account’s "No.1 Online", which is a new media platform for promoting major themes of CCTV, and is operated by the Publicity and Coordination Department of the editorial office. )

　　The Beijing Municipal Health and Health Commission, the Municipal Education Commission and the Municipal People’s Social Security Bureau jointly released the work plan for influenza vaccination in Beijing in 2022. The influenza vaccination work in this city will be implemented in batches in mid-September, and the free vaccination work is initially scheduled to end at the end of November.

　　Free influenza vaccination population is — —

　　Older people over the age of 60 with the city’s resident ID card/social security card;

　　All primary and secondary school students (including domestic and foreign students in primary schools, general middle schools, technical secondary schools, vocational high schools, technical colleges, reform schools and special education schools);

　　Emergency support personnel for major activities identified by the health administrative departments of all districts (including frontline personnel for epidemic prevention and control in COVID-19).

　　Routine immunization clinics in all districts are responsible for providing self-funded and free influenza vaccination services, and actively organizing qualified medical institutions and medical personnel within their respective jurisdictions to provide self-funded influenza vaccination services. In areas with large vaccination needs, at least one qualified secondary and above medical institution should be organized to provide vaccination services during this year’s influenza vaccination. Choose suitable places in each district to set up temporary inoculation points reasonably, and when necessary, open temporary inoculation points of COVID-19 vaccine to meet the population’s centralized inoculation demand. Each district should take various measures to further improve the vaccination service capacity in its jurisdiction, such as setting up district-level mobile vaccination teams, extending the vaccination time of vaccination clinics, setting up weekend clinics, and encouraging physical examination centers to set up vaccination clinics.

　　In 2022, the city will further promote the influenza vaccine appointment vaccination system under the situation of epidemic prevention and control in COVID-19. Each district is responsible for organizing primary and secondary schools, secondary specialized schools, technical colleges, old-age care institutions, villages/neighborhood committees and other units under the guidance of the district CDC to make an appointment and docking with the vaccination clinics in the jurisdiction for free vaccination. Citizens who are willing to vaccinate can make an appointment at the vaccination clinic through various appointment methods such as internet, telephone and on-site appointment.

　　The first batch of vaccination work is scheduled to start in mid-September, mainly for the elderly aged 60 and above in Beijing, and the vaccination publicity and mobilization of students in primary and secondary schools, secondary specialized schools and technical colleges will be started simultaneously.The second batch is scheduled to start in late September, mainly for students in primary and secondary schools, secondary specialized schools and technical colleges, and simultaneously start the self-funded vaccination of influenza vaccine in the city. The third batch is scheduled to start in early October, mainly for emergency support personnel of major events (including front-line personnel of epidemic prevention and control in COVID-19). If there is no special reason, the free vaccination of influenza vaccine in the city is initially scheduled to end at the end of November.

　　All vaccination clinics should arrange the vaccination work of schools, old-age care institutions and other collective units in advance to avoid large-scale vaccination in concentrated periods. At the same time, do a good job in registering the demand for pneumococcal vaccination, arrange vaccination reasonably, and provide joint vaccination services for pneumococcal polysaccharide vaccine and influenza vaccine for the elderly.

　　All vaccination clinics should strengthen vaccine management, standardize vaccination operations, strictly implement epidemic prevention and control measures such as daily ventilation and disinfection, temperature measurement, code test, negative nucleic acid test, and keeping a one-meter line at the vaccination site to ensure vaccination safety. At the same time, they should take various convenient service measures such as cold protection, rain protection and anti-skid, and do a good job in vaccination warm-hearted service and humanistic care for key groups such as the elderly and students, so as to further enhance the comfort and satisfaction of the citizens.

Today, the new energy vehicle market is surging. As an emerging force, Xiaomi Automobile has attracted much attention in every step. Recently, the news that Xiaomi plans to launch a model with a price of up to 800,000 yuan, Ultra Prototype, has triggered a wide discussion in the market. This model not only has excellent performance and high-end configuration, but also carries the strategic intention of high-end brand, market expansion and technological innovation of Xiaomi automobile.

Xiaomi SU7 Ultra Prototype, as a flagship model in Xiaomi SU7 plan, has remarkable performance parameters. According to related reports, the car is equipped with dual V8s+V6s three-motor all-wheel drive system, with an output power of 1,548 HP and an acceleration time of 0-100km/h of only 1.97 seconds, which is comparable to many top-class supercars. At the same time, its braking system is also excellent, and the braking distance of 100-0km/h is only 25 meters, showing excellent handling performance. In addition, the body is made of carbon fiber, which not only greatly reduces the weight of the car, but also improves the handling and endurance, bringing drivers a more extreme driving experience.

The high performance of Xiaomi SU7 Ultra Prototype undoubtedly provides strong support for its high price. In the high-end electric vehicle market, consumers’ pursuit of performance is often directly proportional to the price. Therefore, from the point of view of product performance and configuration, it is reasonable to price 800,000 yuan.

In addition, Xiaomi has been committed to enhancing the high-end image of the brand. The launch of the high-priced Xiaomi SU7 Ultra Prototype not only helps to consolidate Xiaomi’s position in the high-end market, but also enhances the overall value and influence of the brand. In the market competition pattern, there have been successful cases of high-priced models such as Tesla Model Slaid and Porsche Taycan Turbo GT, indicating that consumers have a certain degree of acceptance for high-priced high-end electric vehicles. Therefore, Xiaomi’s introduction of high-priced models is also in line with the trend of market competition.

Goldman Sachs’ prediction of Xiaomi SU7 Ultra Prototype also provides a basis for market recognition for its high selling price. Goldman Sachs predicts that this model will sell 4,000 units in 2025, with an average price of 800,000 yuan. Although this is only a forecast, it also reflects the market’s expectation and recognition of the high price of Xiaomi SU7 Ultra Prototype to some extent.

Xiaomi SU7 Ultra Prototype is not only a further promotion of the high-end strategy of its own brand, but also a strong impetus to the active expansion of market space and technological innovation. First of all, the introduction of high-priced models will help to enhance the brand image and overall value of Xiaomi Automobile. In the global automobile market, high-end brands often represent higher quality and technical level. Xiaomi can further enhance its popularity and influence in the global market by launching high-priced models.

Secondly, with the increasing awareness and acceptance of electric vehicles by consumers, the high-end electric vehicle market is gradually emerging. Xiaomi’s introduction of high-priced models will help to occupy a place in this emerging market, expand market space, and achieve sales growth and market share improvement.

Finally, high-priced models often need higher technical content and added value to support their selling prices. Therefore, Xiaomi’s launch of high-priced models will promote its research and development and innovation in core technology fields such as battery technology, drive system and intelligent driving. This will not only help to enhance the overall competitiveness of Xiaomi automobile, but also bring consumers a more advanced and intelligent driving experience.

Xiaomi will launch the SU7 Ultra Prototype with a price of 800,000 yuan. Although the pricing has not been officially confirmed, it is possible and reasonable to price it at 800,000 yuan in terms of product performance, high-end brand demand, market competition pattern and Goldman Sachs forecast. This move will have a positive impact on the brand image, market space and technological innovation of Xiaomi Automobile, and lay a solid foundation for the future development of Xiaomi Automobile.

Today (11th), the official announcement of the comedy film "Big Anti-Faction" will be released nationwide on April 4th. It is reported that the film has assembled more than 20 gold medal comedians, which will bring a relaxed and joyful work to the audience during the Qingming small holiday.

The movie "The Great Anti-Faction" tells the story of the little actor Bi Chao (Bao Beier) who finally got the chance to play the big villain after all the hardships. However, Bi Chao accidentally lost his memory and mistakenly thought that he was a suspect in the kidnapping case. With amnesia, he was determined to "go against the sky and change his life" and continue his plan of "kidnapping the richest man", but he did not expect to be crushed in action. Bi Chao, who was unarmed, was not only starved and beaten along the way, but also offended three gangsters who wanted money and didn’t want to die. Can Bi Chao’s goal be achieved in the end, and what kind of jokes will he encounter? It remains to be seen.

In the preview of the film’s "This villain is not very clever" version, a news report confessed that "kidnapper" Bi Chao was running around the city, but it was completely inconsistent with the description of "extremely vicious" in the report. Bi Chao not only had no money to be sent back to his original place by taxi driver, but also was caught by the security guard and ate several "big pockets" in the process of secretly stepping on the spot. The robber Bi Chao experienced all kinds of oolong events in the process of completing the goal of "kidnapping the richest man", and the unreasonable storyline also attracted the audience to burst into laughter, all of which revealed the film purpose of "making fun". And dazzling female stars, resplendent party scenes and other "eye-catching" pictures are also very eye-catching.

At the same time, there are also big scenes of "package stimulation" such as drifting around the corner and flying car blasting, which instantly boost the adrenaline of the audience. At the end of the preview, the richest man was not afraid of the robbers who caught up, and even boasted that "this is bulletproof glass", but he didn’t expect to be backhand. Bi Chao directly opened the car door, raised his pistol and said, "Get off!" It will break the game in an instant, and the relationship between the robbers and the rich will be reversed instantly. Subverting the brain hole and constantly reversing the comedy burden has also made the audience increasingly look forward to what interesting plots will follow.

The film assembled more than 20 golden comedy lineups that made people "smile", and all the performers staged a "drama in the play" that was constantly reversed. Bao Beier, the leading actor, became a distinctive "villain" this time, which was crushed by reality and brought a refreshing hilarious experience to the audience. The actors such as Xiao Spicy Li Jiaqi, Dayong Zhou, Clara, Wei Xiang, Jia Bing, Yang Haoyu and Andrew, who all appeared in the preview, are even more eye-catching. The super comedy lineup joined forces to attack, and everyone collectively shook their burdens and pulled the "laugh" fruit full.

Yangzi Evening News/Zi Niu Journalist Kong Xiaoping

　　Guangzhou Daily News (all-media reporters Jessica Fong Ching correspondent Li Xiaoyuan and Zhou Bo) On March 23rd this year, a movie-like "car-chasing and intercepting play" was staged on Jinsha Road in Haizhu District, Guangzhou. In order to stop a car, two large trucks did not hesitate to chase the car for one kilometer, cross the line, turn around and even hit the other car’s head. It turned out that the driver of this car had beaten with another car driver, Zhou, because of the problem of not giving way to each other in the narrow road. When Zhou was angry, he called relatives driving big trucks to intercept each other. On the morning of July 30th, Guangzhou Haizhu District People’s Court held a public hearing on Zhou’s case of suspected trouble-making, and pronounced a sentence in court. Zhou was sentenced to seven months’ imprisonment.

　　According to the prosecution’s allegations, at 22: 40 on March 23 this year, when the defendant Zhou drove a car out of Innovation Road via Xinmin Sixth Street in Haizhu District, he met Kuang Mouming driving a car from Innovation Road to Xinmin Sixth Street. Because of the narrow road, two cars cannot pass at the same time. Due to the problem of avoiding the car, the defendant Zhou had an argument with Kuang Mouming and his co-pilot Kuang Mouhua, and then the two sides beat each other.

　　After a "scuffle", Kuang Mouming and Kuang Mouhua drove away first, and the defendant Zhou immediately left a voice message on his relatives’ WeChat group using WeChat, claiming that he was injured in Xinmin Sixth Street and asked his relatives to come over to help chase him by car. At the same time, he also called relatives to inform them to drive to the scene.

　　Later, two large trucks called by the defendant Zhou arrived at the scene, and Zhou sat on one of the large trucks and commanded to catch up with the car for nearly one kilometer. When chasing after the Jinsha gas station near Jinsha Road in Haizhu District, Zhou’s big truck intercepted the small car driven by Kuang Mouming. When Kuang Mouming saw it, he turned around and fled. At this time, another big truck rushed from the opposite lane and crossed the line and crashed into the small car driven by Kuang Mouming, causing damage to the left front of the car and the left rear mirror.

　　After Kuang Mouming was hit and stopped, Zhou’s big truck immediately stepped forward to intercept. Zhou and others got off the cab and wanted to rush to the vehicle driven by Kuang Mouming. When Kuang Mouming saw it, he immediately drove away from the scene and called the police for help. Subsequently, the defendant Zhou was arrested by the police. After identification, the injuries of Kuang Mouming and Kuang Mouhua were all minor injuries, and the loss price of the car driven by Kuang Mouming was RMB 8663.22.

　　The prosecutor asked in court, "Do you know the consequences of chasing cars on the main road?" "Why didn’t you call the police immediately?" Zhou argued that the reason why he informed his relatives to chase and intercept Kuang Mouming’s driving vehicle was that Kuang Mouming and Kuang Mouhua beat him and fled. He didn’t remember their license plates, only recognized cars and people, "just wanted to intercept the other vehicle and call the police", but there was no alarm after the collision.

　　After trial, Haizhu District People’s Court held that the defendant Zhou chased and intercepted others, and the circumstances were bad; Arbitrary destruction of public or private property, if the circumstances are serious, has constituted the crime of stirring up trouble. The defendant Zhou confessed his crime truthfully after arriving at the case and voluntarily pleaded guilty, which can be given a lighter punishment according to law. The defendant, Zhou, had an altercation with Kuang Mouming’s party because of the meeting, and then beat each other. After Kuang Mouming’s party left, he still called others to drive the truck to catch up with and intercept the vehicle driven by Kuang Mouming. His behavior of catching up and intercepting had a great impact on traffic order, and he was given a heavier punishment as appropriate. Considering that Kuang Mouming was at fault, and the defendant Zhou had actively compensated Kuang Mouming for his losses, he was given a lighter punishment as appropriate. In the end, the court ruled that the defendant Zhou constituted a crime of seeking trouble and sentenced him to seven months in prison.

　　On May 24 this year, a newborn finless porpoise cub was separated from its mother and ran aground on the beach. Its fate touched the hearts of countless Nanjing people. But after 18 hours of emergency rescue, the "smiling angel" left us. "Even with artificial assistance, it is still difficult for cubs who leave their mothers to survive." Professor Yang Guang, Dean of the School of Life Sciences of Nanjing Normal University, told a cruel truth: the fate of this little finless porpoise may have been doomed. He believes that the only way to avoid the recurrence of the tragedy is to improve the ecological environment of the Yangtze River in all aspects, one of which is to restore the bait resources and prevent the finless porpoise from starving.

　　Yesterday morning in Nanjing Jiangbin Park, all the 1 million fry subscribed by deji plaza were put into the Yangtze River. The reporter learned that this is the first time in China that an enterprise has initiated a release activity for the protection of finless porpoises.

　　Intern Xu Linchen Yangzi Evening News All-Media Reporter Zhang Ke

　　A rescue that was doomed from the beginning.

　　The latest hot event about the finless porpoise was the "beaching incident of finless porpoise cubs" in Nanjing at the end of last month. This little finless porpoise was found by the public on the river beach of Yanziji Wharf at 4 pm that day. It was born about two or three days ago, but it hasn’t opened its eyes yet, and its breath is weak. At that time, the people involved in the rescue contacted the experts of Nanjing Underwater World, and on the other hand, the water police drove speedboats to patrol the river to find the trace of the female finless porpoise. "The finless porpoise is a mammal, and the newborn calf must be with its mother. This little finless porpoise must have been separated from its mother when it appeared alone, and the mother finless porpoise is likely to come back to find the child." Jiang Meng, secretary-general of the Nanjing finless porpoise protection association who participated in the rescue at that time, said.

　　Until 8 o’clock in the evening, the female finless porpoise was still not found, and the little finless porpoise was forced to transfer to the underwater world for treatment. Regrettably, at 10 o’clock the next morning, the little finless porpoise died unfortunately before he opened his eyes to see the world. At that time, Jiang Meng waited all night in the underwater world and witnessed the whole process. He told the Yangzi Evening News reporter that the finless porpoise was once in good condition and could eat and breathe with artificial assistance. "But in the end, it was short of breath and emotional anxiety, and experts took various emergency measures. All have no effect." Jiang Meng said.

　　The finless porpoise is a clever but fragile creature. Its intelligence is close to that of gorillas, and it knows how to hunt and prey collectively. However, the underage or newborn finless porpoise has almost no ability to live independently. Professor Yang Guang, dean of the School of Life Sciences of Nanjing Normal University, told the Yangzi Evening News reporter that the cub can’t eat and prey independently without its mother, and it must rely on breast milk for nutrition. "About half a year after birth, cubs can learn to live independently."

　　The Yangzi Evening News reporter learned that the adult finless porpoise had survived under artificial rescue, but the cubs have not been successfully rescued so far. "The finless porpoise is too sensitive to the outside world. The artificial environment is different from nature, which will make it nervous. If the tension continues, it will lead to endocrine disorders and illness, which is fatal to the cubs." Professor Yang Guang said.

　　What caused the little finless porpoise to be separated from its mother? "It may be a sudden encounter with a jet stream or an undercurrent, or it may be a human activity such as a ship sailing, a sudden whistle or a sudden increase in the sound of a motor, which may cause fright." Professor Yang Guang believes that the impact of human activities on the ecology of the Yangtze River is really interfering with the normal life and reproduction of finless porpoises.

　　Finless porpoises at the top of the food chain but not enough to eat.

　　Jiang Meng, secretary-general of Nanjing finless porpoise protection association, often observes finless porpoises on the upper and lower reaches of the Yangtze River Bridge, and organizes volunteers to assist fishery administration departments to release finless porpoises’ food such as fry and bait into the Yangtze River. "Many times when feeding, we found that the finless porpoise soon emerged on the nearby river." The water of finless porpoise is called "Jiang Zhu worships the wind", which was once a unique scenery on the Yangtze River. Today, however, there is something bitter behind such a scene. He believes that the gathering and appearance of finless porpoises during feeding, on the one hand, shows that finless porpoises are very smart creatures, on the other hand, also shows that finless porpoises are starving and very hungry for food. Jiang Meng once paid attention to the records of finless porpoises found in recent years. He found that "finless porpoises were originally round and chubby, but many bodies were salvaged and found to be very thin, and after dissection, they found that their stomachs were empty."

　　Relevant data show that the natural catch of fisheries in the Yangtze River is decreasing year by year, from 540,000 tons in 1954 to 70,000 tons in 2012. There are 175 endemic species in the Yangtze River, and more than half of them have been lost in the past five years. The long-term monitoring data of many scientific research institutions, such as the Institute of Aquatic Sciences of Chinese Academy of Sciences, show that the number of fry of the "four big fish" in the Yangtze River has dropped sharply, from more than 30 billion in the 1950s to less than 100 million in 2013.

　　The reporter learned that in 2016, the closed fishing period of the Nanjing section of the Yangtze River was adjusted from March 1 to June 30, and it was extended from the past three months to four months. This move was to strengthen the protection of finless porpoises and other aquatic organisms in the Yangtze River. However, before the effective intervention of government departments, the phenomenon of cool fishing and overfishing in the Yangtze River was more serious. Illegal fishing activities such as fish frying, electric fishing, "ecstasy" and homeless nets are draining the fishery resources in the Yangtze River.

　　"finless porpoises have no natural enemies in the Yangtze River. They can be said to be creatures at the top of the food chain. They are not very picky eaters, as long as they are fish within 20 cm in length. However, due to the exhaustion of fisheries in the Yangtze River, finless porpoises are in a state of starvation. " Professor Yang Guang said that in addition to accidental incidents such as accidental injuries caused by ship navigation and water pollution, the continuous decrease in the number of finless porpoises is ultimately caused by insufficient food resources.

　　Deji plaza subscribed for 1 million fry to demonstrate scientific "release"

　　Yesterday morning, at the Virescence Expo Aquatic Release Platform, deji plaza held the activity of "Yangtze River Aquatic Proliferation and Release". One million fry subscribed by deji plaza were all put into the Yangtze River. The Yangzi Evening News reporter learned that this is the first proliferation and release activity initiated by social forces in China for the protection of finless porpoises. Deji plaza made a scientific demonstration under the guidance of Nanjing Fishery Administration and Fishing Port Supervision and Management Office and Nanjing finless porpoise Protection Association.

　　The so-called "proliferation and release" is the activity of releasing aquatic species or their parents into public waters such as oceans, rivers and lakes by artificial means. Proliferation and release can replenish and restore the population of biological resources, improve the population structure of organisms, and help maintain biodiversity and protect endangered species. According to statistics, in the past three years, Jiangsu has invested 230 million yuan in proliferation and release. In 2015, the province invested more than 79 million yuan, releasing more than 2.1 billion species, including 815 million marine economic species, 1.281 billion inland economic species and 8.48 million rare and endangered species.

　　The subscription of Deji this time includes the fry of four major fishes in the Yangtze River (black carp, grass carp, silver carp and bighead carp) and the national second-class protected wild animal Myxocyprinus asiaticus. The Yangzi Evening News reporter saw at the scene that the fry were transported to the scene by special transport vehicles from the cultivation base cooked in Jiangning Lake. According to the breeder, these fry were specially bred for this proliferation and release, and cold oxygen transportation was used on the way to fully ensure their survival rate. Under the guidance of the staff of Nanjing Fishery Administration and Fishing Port Supervision and Management Office, the volunteers from deji plaza carefully dumped the fry, and along the long discharge embankment, countless fry swam across the slope and merged into the waves by the river. Fish fry are like countless black lines. As soon as they touch the water, they instantly swim away and go to the middle reaches of the river.

　　The release activity was sponsored by deji plaza and Nanjing finless porpoise protection association. Jia Wei, deputy general manager of deji plaza, introduced the original intention of choosing the theme of "Saving Endangered Animals" on the occasion of the 10th anniversary. "The Yangtze finless porpoise is one of the closest endangered animals to us. We hope that through the release of the Yangtze River and the efforts of all sectors of society, more people will pay attention to the living conditions and protect the finless porpoise. To contribute to the protection of the Yangtze finless porpoise, improve the water quality of the Yangtze River and protect the biodiversity of the mother river. " Jia Wei said.

　　Professor Yang Guang told reporters that finless porpoises mainly eat all kinds of fish in the Yangtze River, and they have no choice about the types of fish they eat, mainly depending on their size. "You don’t see it has teeth, but its teeth can only bite, not like people’s teeth have the ability to chew, so it eats fish, and generally fish within 20 cm can be eaten. "Therefore, the fry released this time, on the one hand, are four local fish, which enriches the fishery resources of the Yangtze River, on the other hand, it is also very suitable for finless porpoises to eat."

　　So which fish or aquatic animals are suitable for release? At the scene, the fishery department also listed a list. Freshwater fish include: herring, grass carp, silver carp, bighead carp, bream, Eriocheir sinensis, fugu obscurus and other indigenous species with regional characteristics; Marine fish include: Pseudosciaena crocea, jellyfish, Cynoglossus semilaevis, swimming crab, prawn, Sole Sole, Meretrix meretrix, Sparus macrocephalus, etc. Rare and endangered aquatic animals: Chinese sturgeon, mullet, etc.

　　Expert reminder > >

　　Don’t throw these creatures into the Yangtze River again.

　　"When volunteers of our association patrol the river, they often see citizens who spontaneously organize release activities in the river or along the Yangtze River." Jiang Meng told the Yangzi Evening News reporter that because the public does not know much about species knowledge, in many cases, the released species can not only improve the ecology and enrich fishery resources, but also cause damage. He listed the three most common creatures that were released by the people.

　　Crocodile turtle: It is huge, up to 70 cm long. In the folk concept, releasing such a large turtle is a matter of "accumulating merits" and is favored by domestic enthusiasts. But in fact, the snapping turtle has nothing to do with compassion. It is extremely aggressive and has few natural enemies except alligators. "The most important thing is that the snapping turtle originated in the southeastern United States. If it is put into the Yangtze River, it will become a veritable intruder. Once it enters the Yangtze River, it will become a’ overlord’ and will take away the already scarce food source of the finless porpoise." Jiang Meng said.

　　Snakehead: It is what we often call "mullet". Unlike snapping turtles, snakehead is a common local fish, which is distributed in all major river systems in China. It is also a delicious food on the table of the citizens and can be easily bought in the food market. "But what people often overlook is that snakehead is fierce, fertile and has a huge appetite, and can often eat all other fish in a lake or pond." Jiang Meng told reporters that because finless porpoises are at a disadvantage in quantity, they are unable to compete with snakehead, the "king of big stomachs", for limited bait resources.

　　Brazilian tortoise: The most widely reared reptile in the world, but it is also listed as one of the most dangerous invasive species in the world because it plunders a lot of living resources. In China, many pet markets can see Brazilian tortoises on sale. Jiang Meng appealed that if citizens keep Brazilian tortoises for viewing, they should not be released into the wild or in the river. "Once they reach a brand-new ecological environment without a sufficient number of natural enemies, they will become a scourge and become an ecological disaster there." Jiang Meng said.

　　Nanjing will launch the first "census" of finless porpoises this summer.

　　At present, how many finless porpoises are there in Nanjing section of the Yangtze River? The statistics of the fishery administration department are "twenty or thirty", but there is no more accurate standard answer. Liu Jun, deputy director of Nanjing Fishery and Fishing Port Supervision and Management Office, told Yangzi Evening News reporter at the site of the proliferation and release activities held in deji plaza yesterday that this summer, the fishery administration department will launch the first "population census" of the Yangtze River finless porpoise in Nanjing, the top university in the United Nations for finless porpoise protection.

　　The Yangzi Evening News reporter learned that the latest data about the Yangtze finless porpoise still comes from the 2012 Yangtze River Freshwater Dolphin Investigation Report. At that time, the population of Yangtze finless porpoises was about 1040, less than half of that before 2006, less than that of giant pandas, and showed an accelerated downward trend. However, the details about the finless porpoise in Nanjing section are still vague. Liu Jun introduced that in this survey, besides finding out the latest accurate data, we should also find out the "destructive factors" that affect the normal reproduction of finless porpoises, so as to provide scientific basis for future artificial protection. "The special funds for the current investigation have been approved and will be launched after the parties are properly prepared."

　　Professor Yang Guang from Nanjing Normal University introduced that on October 9, 2014, Nanjing Yangtze finless porpoise nature reserve was established, covering 90% of the waters of Nanjing Yangtze River. He believes that it is essential to further strengthen the protection of Nanjing finless porpoise population and conduct a systematic scientific investigation. "The original data of 20 to 30 finless porpoises are very vague. As a provincial protected area, how many finless porpoises are there in this place, what are the activities of finless porpoises, and what changes have been made in the range of activities in spring and summer? Mastering some basic information of finless porpoises is the premise for us to effectively protect finless porpoises."

　　Expert opinion > >

　　Nanjing should also establish a "finless porpoise protection base"

　　The finless porpoise is the flagship species of the Yangtze River ecosystem, and it is also an indicator species of biodiversity and ecosystem health in the Yangtze River. The survival crisis of the finless porpoise itself is like a wake-up call, warning the deterioration of the entire Yangtze River ecosystem. Professor Yang Guang believes that from the perspective of long-term protection of finless porpoises, Nanjing should refer to the model of "giant panda breeding base" and establish a "finless porpoise protection base". "Since there is such a finless porpoise population in Nanjing, if we want to better carry out protection and rescue work, we can consider establishing a finless porpoise protection center. At the beginning, we can use the resources and facilities of the underwater world to help the finless porpoise, but in the future, we need to set up a special finless porpoise protection center. " Professor Yang said that after the investigation, with scientific consideration and demonstration, the finless porpoise can be better protected through protection, rescue and artificial breeding.

　　Deji celebrates its 10th anniversary.

　　Give the stage to the endangered animals around you

　　Jia Wei, deputy general manager of deji plaza, introduced that deji plaza will celebrate its 10th anniversary on June 26th this year. As a shopping center with humanistic care, deji plaza takes "saving endangered animals" as its theme, hoping to arouse Nanjing citizens’ concern for the environment. Yangzi Evening News reporter learned that in addition to subscribing for breeding, breeding and releasing, around the 10th anniversary, deji plaza also held a series of themed activities to protect finless porpoises and endangered animals.

　　The largest finless porpoise sculpture in Nanjing was exhibited on the first floor of deji plaza.

　　The 10th anniversary of deji plaza, with the theme of "Saving Endangered Animals", presented a series of themed activities. Among them, the artistic sculpture of finless porpoise named "Watch and Smile" is the most thought-provoking. The finless porpoise in the sculpture is smiling, but there are sad tears in his eyes. In the list of "Saving Endangered Animals" in the 10th anniversary of deji plaza, the Yangtze finless porpoise is an endangered animal living around us. This finless porpoise sculpture art exhibition is also to arouse more people’s awareness of caring for and protecting finless porpoises through more shocking art forms.

　　The overall size of the work is 10 meters ×3.8 meters, which is nearly seven times the size of the real finless porpoise, showing its process from beginning to end, from real to virtual until it disappears, just like a sketch drawn by a pen that is about to break ink, and finally disappears into a line. After the neck of the finless porpoise, there are a lot of mottled plastic marks, just like the wounds on the finless porpoise, which are shocking; The rising tail is made of more than 2,000 meters of steel bars, which gradually becomes sparse backwards until the lines disappear in the air, symbolizing the process of the disappearance and extinction of the finless porpoise.

　　On the 10th anniversary of deji plaza, the joint artists jointly presented the artistic sculpture of "Watching and Smiling" finless porpoise, which showed the status quo of the gradual disappearance of "smiling angel" finless porpoise with powerful artistic expression. Deji plaza said that through such soul-shaking works of art and theme activities, he hoped that more people could reflect on their indifference to nature and life, and called on more people to cry out from the bottom of their hearts: protect these "angels" who bring smiles to the world, coexist with every equal life and share the warmth from this world.

　　The "Noah’s Ark" came to Deji Outdoor Square to show all kinds of endangered animals.

　　At the same time, a huge boat-shaped device-"Noah’s Ark" also appeared in deji plaza Outdoor Square. This huge "Noah’s Ark" covers an area of about 600 square meters and has a double hull structure, with a total length of about 40 meters, a width of about 18 meters and a height of about 8 meters. In terms of material application, the hull uses a lot of wood grain plates, which truly restores the effect of wood grain hull and people’s original modeling imagination of Noah’s Ark. There are more than 1100 meters of steel and more than 1800 square meters of wood in the cabin, which makes it more in line with the hull structure and more integrated.

　　"Ark" has a video viewing and experience space of 150 square meters. Through 10 sets of world-class projection and audio equipment and the overall super-large screen in the cabin, the public welfare propaganda film for saving endangered animals is broadcast, bringing an immersive audio-visual experience to the audience. On the deck at the top of the Ark, highly restored models of dozens of endangered animals, such as Asian elephants, mountain zebras, polar bears, South China tigers and elk, were also exhibited.

　　Guarding the Yangtze River Beach and Opening the "Popular Science Lecture Hall for Endangered Animals"

　　Deji plaza has also launched a large-scale public welfare environmental protection activity along the Yangtze River "Yangtze River Beauty Plan", recruiting volunteers to go to the beaches along the Yangtze River to collect and sort garbage, contributing to changing the environmental status of the mother river and improving the living environment of the Yangtze finless porpoise. Up to now, four activities have been held. Volunteers, mainly parents and children, went to Qiaobei River Beach, Daqiao Park and Yanziji River Beach in Muyan Scenic Area to carry out activities such as garbage collection and biological knowledge popularization. Deji plaza hopes that the accumulated collection can create a clean home for the finless porpoise.

　　In addition, during the 10th anniversary celebration, deji plaza will carefully select ten premium charity gift packages, each of which contains single items provided by several brands, and the amount of gift packages ranges from 6,000 yuan to 35,000 yuan. All the proceeds from the sales will be donated to the Nanjing finless porpoise protection association for the Yangtze finless porpoise protection project.

　　Recently, deji plaza will also open a special "Popular Science Lecture Hall for Endangered Animals", which will be built into a classroom for children by opening up a space in the square. Experts from Nanjing finless porpoise protection association will come to the scene to explain the knowledge about endangered animals to children. Join the live interactive session to make the class more rich and interesting.

In the domestic household scooter market, it is a hot model. Since then, this car has been favored by many consumers because of its close price and good product strength. At present, 16 models have been launched for consumers to choose from, and the price range is 99,800-145,800 yuan. So is this car suitable for starting? Today, we will take the entry-level model with a price of 99,800 yuan-2024 Plus 310 Xingyao Edition as an example to analyze with you.

First of all, look at the appearance. As a new energy vehicle, AION Y does not adopt a closed front face like many pure electric vehicles, but retains the design of the air intake grille. The front of the car adopts front headlights with split design, and the interior presents a fan-shaped arrangement, which improves the recognition of the front of the car.

The side of the car body benefits from its short suspension and long wheelbase design, so when you look at it from the side, there will be an MPV atmosphere. The style of the hub is relatively simple, and it is equipped with 215/55 R17 specifications.

In the rear part, the word "AION Y" is placed in the middle of the tailgate, which looks more conspicuous. The rear design of "AION Y" is simpler, with a rich sense of hierarchy and a fuller look. The tail wing with the same color as the car body at the top has been hollowed out, and the shape of the taillight is relatively slender.

Entering the car, the interior design of AION Y is relatively simple. The center console is mainly covered by a black plaque, and the air outlet of the air conditioner is hidden under this plaque, which looks very regular. It adopts the design style of flat bottom and double spokes, and it feels good to hold. The main driver is equipped with a 10.25-inch full LCD instrument panel, and the display effect is relatively clear.

In addition, AION Y is also equipped with a 14.6-inch central control screen with built-in ADiGO 4.0 intelligent interconnection ecosystem, which supports navigation system, navigation road information display, service, Bluetooth/car phone and other functions. Moreover, the response speed of this system is relatively fast, and it is very convenient for daily use.

In terms of other configurations, AION Y comes standard with practical functions such as body stability system, brake assist, keyless start, remote start, uphill assist, and remote control of mobile App. At the same time, the whole system comes standard, which can detect the working state of tires in real time, and its performance in safety is quite good.

In terms of seats, AION Y is made of imitation leather, the front seats all support manual four-way adjustment, and the main driving seat is equipped with the function of height adjustment. The rear seats support a 40:60 ratio, which can further expand the space of the luggage compartment.

In terms of space, AION Y has a body length of 4,535 mm, a width of 1,870 mm, a height of 1,650 mm and a wheelbase of 2,750 mm. Although it is positioned as a compact SUV, such data performance has reached the new standard. Therefore, the ride space of this car is relatively spacious. The experiencer with a height of 1.75 meters sits in the front row, and after adjusting the seat to a suitable position, the head space is about one punch and three fingers. At this time, the seat is kept still and comes to the back row. There are still more than two punches in the head space and more than two punches in the legs.

In terms of storage capacity, AION Y’s luggage compartment has a volume of 405 liters, a depth of 880 mm, a width of 1020 mm and a height of 700 mm. After putting down two 28-inch suitcases, there is still room for some small items. In addition, the second row of seats in this car can be almost flat after being put down, and it can be easily handled if you need to pull some big items occasionally.

In terms of chassis, AION Y adopts the body structure, the front suspension is McPherson type, and the rear suspension is longitudinal arm torsion beam type. This configuration is also a common configuration at this price. When passing through the potholed road, AION Y’s shock absorption effect is still quite good, without the feeling of "hitting hard", and the comfort performance is not bad. However, due to the high center of gravity, this car will have obvious inclination when cornering at high speed, and its handling is relatively average.

In terms of power, the AION Y we test-drive is equipped with a permanent magnet synchronous single motor, with a total power of 100 kW and a total horsepower of 136, with a total of 176. The transmission system is matched with an electric vehicle single-speed gearbox. The battery pack has a capacity of 37.9 kWh and a pure electric cruising range of 310km, which is enough for urban transportation, and the cost of daily vehicles will be much lower than that of fuel vehicles.
From the perspective of vehicle driving, AION Y provides a smooth, comfortable and sporty driving experience, which is suitable for daily home and work. It has a variety of driving modes and steering modes to meet different driving needs. Suspension system and chassis are tuned to comfort, which can effectively filter road vibration and provide a comfortable ride experience. The power output is linear and delicate, providing a good push back feeling at low speed, and the influence of wind noise and tire noise is relatively amplified at high speed. I-PEDAL mode can adjust the strength of kinetic energy recovery in real time, realize reasonable control of vehicle speed by opening and closing the accelerator pedal in low-speed traffic jams, and provide different driving experiences. The adjustment of accelerator pedal and accelerator pedal is linear, which makes AION Y very comfortable to drive as a whole. Summary: Through this test drive of AION Y, we found that this car does have a good performance in terms of space, and both the riding space and the loading space meet the needs of most people. In terms of driving experience, the power output of this car is relatively linear, and the steering feel is also very light, so it is not difficult to drive. For novice drivers who just got their driver’s license, AION Y should be a good choice. Of course, if you just want to buy a daily scooter, then AION Y is also worth considering.

With the expectation of the Fed’s interest rate hike gradually declining, and it is almost certain that it will stop raising interest rates this year, small and medium-sized pharmaceutical stocks with historically low valuations are expected to usher in a wave of mergers and acquisitions this year. Combined with the merger situation in 2022, we believe that ten companies such as Argenx, Apellis and Sarepta have great potential to be merged by large pharmaceutical companies.

In addition to the ten pharmaceutical companies listed in this article, the following pharmaceutical companies or technical fields deserve attention:

ADC domain：Mersana Therapeutics、ImmunoGen；

CNS domain：Intra-cellular、Neurocrine、Sage Therapeutics;

Rare disease field：Mirum、Krystal Biotech；

Other fields：Halozyme、Prometheus、Viridian Therapeutics.

1、Argenx(NASDAQ:ARGX)

ARGX is a Dutch pharmaceutical company specializing in the research and development of alpaca-derived antibodies. It has three patented technologies related to the transformation of antibody Fc region, namely SIMPLE Antibody platform, NHance, ABEDEG and POTELLIGENT, and has the property of technology platform.

The drug VYVGART, which has been marketed by ARGX for treating myasthenia gravis, sells well, recording a sales income of US$ 131 million only in the third quarter of last year. It is estimated that the annual income will reach US$ 402 million, and the rights and interests of VYVGART in China have also beenZaiding medicineTake it. In 2023, ARGX also had some important milestones:

The company has submitted the subcutaneously injected version (SC) of EFGARTIMOD, which will be listed for approval on June 20th. Considering that VYVGART has been listed and sold well, the subcutaneously injected version of EFGARTIMOD has a high probability of being approved, and the sales revenue is more considerable.

In the second quarter, the SC version of efgartigimod will also release the phase III data for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP).

ARGX-113, a drug under research, will release two three-phase heavy data on the treatment of primary immune thrombocytopenia (ITP) and pemphigus vulgaris (PV) in the second half of the year.

ARGX is rich in pipelines, its technology platform has been verified, its sales revenue has risen rapidly, and with the blessing of many heavy catalysts this year, many Wall Street investment banks have listed ARGX as one of the promising biomedical enterprises this year.

2、Apellis(NASDAQ:APLS)

APLS is a biomedical company with complement technology, and its main drug is C3 inhibitor APL-2. At present, the drug has been approved for two indications: paroxysmal hemoglobinuria (PNH) and geographic atrophy (GA) secondary to age-related macular degeneration, among which the PNH indication was approved in mid-2021, and it sold for 65.1 million US dollars in the United States only last year (authorized to SOBI outside the United States).

APL-2 was recently approved for the treatment of GA, with a wide range of labels (including foveal and extrafoveal), and GA has a large market. The Wall Street investment bank even gave a peak sales forecast of $5 billion. At the same time, the doctor survey conducted by the investment bank showed that doctors and patients had high expectations for APL-2. It is estimated that doctors will use the drug in 20-50% of patients, with an estimated EOD of 70-80%.

In addition to the above-mentioned approved indications, the company has a layout in the fields of rare diseases, ophthalmology, nervous system, gene therapy, etc., among which gradual freezing disease (ALS) in cooperation with SOBI is the most important. APLS is a very suitable choice for large pharmaceutical companies that want to enter the field of complement technology or GA.

3、Alnylam(NASDAQ:ALNY)

Founded in 2002, Alnylam is a leading enterprise in the field of RNAi therapy. In the past five years, it has successfully brought five RNAi drugs to the market, and in 2022, it achieved sales revenue of 892 million US dollars, up 35% year-on-year.

According to product classification, ONPATTRO and AMVUTTRA, which have the same indications, recorded revenues of $122 million and $69 million respectively in the fourth quarter of last year, with annual revenues of $558 million and $94 million respectively.

GIVLAARI recorded a revenue of $47 million in the fourth quarter of last year and achieved a revenue of $173 million in the whole year; OXLUMO recorded a revenue of $24 million in the fourth quarter of last year and achieved a revenue of $70 million for the whole year.

In addition to the strong performance of existing products, relying on the RNAi therapy technology platform, ALNY is rich in research pipelines, and many pipelines are in the later stage, which has great commercialization potential in the short term:

Patisiran’s supplementary marketing application for the treatment of ATTR amyloidosis cardiomyopathy, and the approval time is October 8; This year, the third phase data of Fitusiran in treating hemophilia and the third phase data of Vutrisiran in treating ATTR amyloidosis cardiomyopathy will also be released.

In addition, the market for indications of some early pipelines of the company is extremely broad, such as Zilebesiran for treating mild and moderate hypertension, ALN-APP for treating Al Harmo’s disease, ALN-KHK for treating NASH, etc.

Whether it is the technology platform, sales performance, and future potential, ALNY is the target of mergers and acquisitions by large pharmaceutical companies.

4、Axsome Therapeutics(NASDAQ:AXSM)

AXSM is a model of Biotech in the field of central nervous system in recent years. Its share price has risen more than 30 times in the past four years, and it has also enabled CFO Nick Pizzie, who defected from Pierre Fabre USA in 2018, to gain wealth freedom. At that time, the market value of AXSM was less than 100 million US dollars.

Behind the stock price rise is AXSM’s successive clinical trials:

The third phase trial of AXS-05 in the treatment of major depression (MDD) and bipolar disorder in Az Harmo was successful, and the indication of MDD has been approved for marketing.

The third phase trial of AXS-07 for migraine was successful, and it is planned to submit NDA； this year;

The drug AXS-12, which is used to treat narcolepsy, has also been certified by FDA as a breakthrough therapy. It is currently in the second phase of clinical practice, and data will be released this year.

In addition to its own research and development, the company is also adept at business development (BD): in March 2022, AXSM bought Sunosi, a listed drug for treating narcolepsy, from JAZZ for $53 million, and in February this year, AXSM announced that it would grant Sunosi’s rights and interests in Europe, the Middle East and North Africa to Pharmanovia, and AXSM would receive an advance payment of $66 million and a milestone payment of up to $101 million.

For large pharmaceutical companies that favor the commercialization stage, AXSM with two CNS drugs on sale and multiple later pipelines is undoubtedly one of the most worthy M&A targets.

5、Ascendis(NASDAQ:ASND)

Ascendis Pharma is a long-acting drug company with a long-acting drug technology platform TransCon. At present, it mainly focuses on various rare diseases, reducing the frequency of drug use, improving patients’ compliance, reducing side effects, and thus improving the treatment effect. With the success of the third phase clinical trials of several drugs, the technical platform of ASND has also been verified.

At present, the company has three drugs under research: TransCon hGH (long-acting growth hormone), TransCon PTH (treatment of hypothyroidism) and TransCon CNP (treatment of achondroplasia).

In 2021, Skytrofa, the company’s drug for treating children’s growth hormone deficiency (GHD), has been approved for marketing. On April 30 this year, the FDA will approve the marketing of TransCon PTH, the company’s drug for treating adult hypoparathyroidism, and will also release Phase III data of TransCon hGH for treating adult growth hormone deficiency before the end of the year. In addition, the company also has pipeline promotion in the field of achondroplasia and tumor, and will provide updates of related clinical trials this year.

The performance of Skytrofa, a drug listed by ASND, grew well. In 2022, it achieved a revenue of 35.7 million euros, with a quarterly revenue growth rate of 39%.

In 2018, ASND also co-founded VISEN Pharmaceuticals with Vivo Capital, and Visen Pharmaceuticals acquired the rights and interests of ASND in Greater China. In November 2022, Weisheng Pharmaceutical submitted a prospectus to the Hong Kong Stock Exchange, intending to be listed on the main board of Hong Kong. In view of the vast domestic long-acting growth hormone market, Changchun Gaoxin, anke biotechnology and other companies have already laid out, and the arrival of Weisheng Pharmaceutical will intensify the competition in the industry.

In view of the company’s long-term drug technology platform and the pipeline in the late stage of commercialization and research and development, Ascendis Pharma is also one of the potential acquisition targets of large pharmaceutical companies.

6、Sarepta(NASDAQ:SRPT)

Sarepta Therapeutics is a leading enterprise in the field of treating Duchenne muscular dystrophy (DMD). At present, the company has three approved DMD drugs: EXONDYS 51, AMONDYS 45 and Vyondys 53. In addition to the drugs already on the market, the company is developing new therapeutic drugs such as gene therapy and gene editing around DMD, and at the same time, it has a layout for the indications such as limb muscular dystrophy (LGMD).

In the third quarter of 2022, the company recorded a product sales income of 207 million US dollars, and it is estimated that the annual income will reach 843 million US dollars, a year-on-year increase of 38%. In addition to strong sales performance, the company’s R&D pipeline is also worth looking forward to.

In the third quarter of last year, the company submitted the application for the marketing of gene therapy drug SRP-9001 for treating DMD, which was jointly developed with Roche. The FDA granted it priority approval, and the approval time was May 29th. The marketing application of SRP-9001 is supported by many clinical trial data, and the probability of approval is high.

For large pharmaceutical companies that want to enter the DMD field, SRPT is the best choice. However, the overseas rights and interests of SRP-9001 were authorized to Roche, which may lower the expectations of the acquirer.

7、Karuna Therapeutics(NASDAQ:KRTX)

KRTX is a company that develops drugs for the treatment of nervous system diseases. KarXT, its main drug, is an oral first-choice muscarinic agonist for M1/M4. It consists of xanomeline, a muscarinic agonist, and trospium, a muscarinic antagonist. It aims to preferentially stimulate muscarinic receptors in the central nervous system, and has the potential to treat serious mental diseases without relying on dopaminergic or serotonin, including schizophrenia and psychosis in Alzheimer’s disease.

In August, 2022, the company released the phase III clinical data of KARST in the treatment of schizophrenia, which not only reached the end of the trial, but also was superior to the existing therapies in terms of therapeutic effect, safety and patient coverage, and solved the problems of poor compliance and less coverage in the existing therapies, especially the clinical P value of KARST < 0.0001, which is extremely rare in the CNS field.

This data has been released, and KarXT is regarded as a game changer in the field of schizophrenia by investment banks such as Mizuho. It is estimated that it will reach $1.7 billion by 2028, and its peak sales will be above $5 billion.

The company plans to submit the listing application of KarXT in the middle of this year, and release the results of another phase III test named Buergent-3 in the first quarter of this year. This experiment is similar to the previous studies of EMERGENT1(Ph2b) and EMERGENT-2(Ph3), with a high probability of success, but initially the experiment was mainly conducted in Ukraine, and now most of the research is transferred to the United States, which has certain uncertainties.

8、Revance(NASDAQ:RVNC)

RVNC is a pharmaceutical company dedicated to developing cosmetic medical products. Relying on the unique TransMTS? peptide technology, it has developed a differentiated botulinum toxin for injection, which was approved in the third quarter of last year.

Different from the existing Dysport, Xeomin, Jeuveau and other products on the market, DAXXIFY is a new product that is truly different from BOTOX, the number one product in the field of botulinum toxin. In the treatment of brow wrinkles, the curative time of DAXXIFY is almost 1.5 to 2 times that of BOTOX, while the annual income of the latter is 14.6 billion US dollars.

Because of its remarkable effect, DAXXIFY aims at the top one-third of the existing users. Investment banks predict that DAXXIFY will occupy 30% of the US market and its annual sales will exceed $1 billion. In the first quarter (the fourth quarter of last year) just after it was approved, the sales of DAXXIFY experience users were already expected to be between $10.5 million and $11.5 million.

In addition to DAXXIFY, the company also has RHA fillers with less side effects and better effects than hyaluronic acid. The sales revenue in the first year after listing was more than 70 million US dollars, and the growth rate last year remained at 40%+. Different from other small pharmaceutical companies, the company also has a commercial platform OPUL?, which is a cloud platform integrating customer relationship maintenance and financial payment functions, providing services for all kinds of medical and beauty businesses. As of the third quarter of last year, the total platform GPV in the past 12 months exceeded 630 million US dollars.

In the environment of raising interest rates, large pharmaceutical companies facing the cliff of heavy drug patents are likely to be interested in mergers and acquisitions of RVNC with great sales revenue potential and quick results.

9、Krystal Biotech(NASDAQ:KRYS)

KRYS is a unique gene therapy company, which does not use the common adeno-associated virus or lipid nanoparticles to deliver genetic material, but loads the gene into herpes simplex virus (HSV-1) to make it reach its target in vivo. HSV-1 has higher carrying capacity than other gene therapy technologies, which not only broadens the scope of potential diseases that KRYS may treat, but also can realize repeated administration.

KRYS has developed a series of drugs for dermatoses and respiratory diseases on its gene therapy technology platform, among which the most important one is B-VEC for the treatment of dystrophic epidermolysis bullosa (DEB), which is currently in the waiting stage for PDUFA.

B-VEC has obtained the priority evaluation qualification granted by FDA. Due to CMC, the approval time was postponed to May 19th this year, and the probability of approval was high. If approved, this will be the first approved gene therapy for DEB.

Although the market of DEB is not very large, B-VEC has proved the feasibility of the company’s technology platform to some extent. Besides the skin diseases and respiratory diseases that have been laid out at present, the company has also started clinical trials to treat cystic fibrosis. In addition, Jeune Aesthestics, a subsidiary of KRYS, is still trying to enter the field of medical beauty.

With its unique technology platform value and several promising research pipelines, KRYS is expected to become an M&A option for large pharmaceutical companies.

10、Xenon(NASDAQ:XENE)

XENE is a company that focuses on the treatment of neurological diseases by regulating ion channels. The main indication is epilepsy. At present, there are four drugs under research in the pipeline, XEN1101, XEN496, XEN901 and XEN007, which have cooperated with well-known enterprises in CNS field, Neurocrine and Alexion (acquired by AstraZeneca).

In October, 2021, the company announced that XEN1101, the main pipeline, announced the success of the second phase of the clinical treatment of adult local epilepsy, and the FDA required the company to make another third phase to apply for listing. XEN496, another treatment for infantile epilepsy, is also in the third clinical stage, and it also needs a greater probability of success.

In addition, the company’s drug XEN1101 is still in the second phase of clinical treatment for major depression (MDD), and the market of MDD is bigger than that of epilepsy. If the data released in the second half of the year is good, it will increase the probability of the company being acquired.

[Disclaimer]

1. The information of some articles in "New Kangjie" comes from the network for the purpose of transmitting more information, which does not mean agreeing with their views or confirming the authenticity of their contents. If you have any questions about the content, please contact us in time.　

2. "Xinkangjie" is committed to providing reasonable, accurate and complete information, but does not guarantee the rationality, accuracy and completeness of the information, and will not be responsible for any loss or damage caused by unreasonable, inaccurate or omitted information.　

3. All the information of "Xinkangjie" is for reference only, and it is not the basis for any commercial transaction or medical service. If the content of "Xinkangjie" is deviated by itself, our company will not bear any responsibility, including but not limited to legal liability and compensation liability.

4. For issues not covered in this statement, please refer to relevant national laws and regulations. In case of conflict between this statement and national laws and regulations, national laws and regulations shall prevail.