Today (11th), the official announcement of the comedy film "Big Anti-Faction" will be released nationwide on April 4th. It is reported that the film has assembled more than 20 gold medal comedians, which will bring a relaxed and joyful work to the audience during the Qingming small holiday.

The movie "The Great Anti-Faction" tells the story of the little actor Bi Chao (Bao Beier) who finally got the chance to play the big villain after all the hardships. However, Bi Chao accidentally lost his memory and mistakenly thought that he was a suspect in the kidnapping case. With amnesia, he was determined to "go against the sky and change his life" and continue his plan of "kidnapping the richest man", but he did not expect to be crushed in action. Bi Chao, who was unarmed, was not only starved and beaten along the way, but also offended three gangsters who wanted money and didn’t want to die. Can Bi Chao’s goal be achieved in the end, and what kind of jokes will he encounter? It remains to be seen.

In the preview of the film’s "This villain is not very clever" version, a news report confessed that "kidnapper" Bi Chao was running around the city, but it was completely inconsistent with the description of "extremely vicious" in the report. Bi Chao not only had no money to be sent back to his original place by taxi driver, but also was caught by the security guard and ate several "big pockets" in the process of secretly stepping on the spot. The robber Bi Chao experienced all kinds of oolong events in the process of completing the goal of "kidnapping the richest man", and the unreasonable storyline also attracted the audience to burst into laughter, all of which revealed the film purpose of "making fun". And dazzling female stars, resplendent party scenes and other "eye-catching" pictures are also very eye-catching.

At the same time, there are also big scenes of "package stimulation" such as drifting around the corner and flying car blasting, which instantly boost the adrenaline of the audience. At the end of the preview, the richest man was not afraid of the robbers who caught up, and even boasted that "this is bulletproof glass", but he didn’t expect to be backhand. Bi Chao directly opened the car door, raised his pistol and said, "Get off!" It will break the game in an instant, and the relationship between the robbers and the rich will be reversed instantly. Subverting the brain hole and constantly reversing the comedy burden has also made the audience increasingly look forward to what interesting plots will follow.

The film assembled more than 20 golden comedy lineups that made people "smile", and all the performers staged a "drama in the play" that was constantly reversed. Bao Beier, the leading actor, became a distinctive "villain" this time, which was crushed by reality and brought a refreshing hilarious experience to the audience. The actors such as Xiao Spicy Li Jiaqi, Dayong Zhou, Clara, Wei Xiang, Jia Bing, Yang Haoyu and Andrew, who all appeared in the preview, are even more eye-catching. The super comedy lineup joined forces to attack, and everyone collectively shook their burdens and pulled the "laugh" fruit full.

Yangzi Evening News/Zi Niu Journalist Kong Xiaoping

　　Guangzhou Daily News (all-media reporters Jessica Fong Ching correspondent Li Xiaoyuan and Zhou Bo) On March 23rd this year, a movie-like "car-chasing and intercepting play" was staged on Jinsha Road in Haizhu District, Guangzhou. In order to stop a car, two large trucks did not hesitate to chase the car for one kilometer, cross the line, turn around and even hit the other car’s head. It turned out that the driver of this car had beaten with another car driver, Zhou, because of the problem of not giving way to each other in the narrow road. When Zhou was angry, he called relatives driving big trucks to intercept each other. On the morning of July 30th, Guangzhou Haizhu District People’s Court held a public hearing on Zhou’s case of suspected trouble-making, and pronounced a sentence in court. Zhou was sentenced to seven months’ imprisonment.

　　According to the prosecution’s allegations, at 22: 40 on March 23 this year, when the defendant Zhou drove a car out of Innovation Road via Xinmin Sixth Street in Haizhu District, he met Kuang Mouming driving a car from Innovation Road to Xinmin Sixth Street. Because of the narrow road, two cars cannot pass at the same time. Due to the problem of avoiding the car, the defendant Zhou had an argument with Kuang Mouming and his co-pilot Kuang Mouhua, and then the two sides beat each other.

　　After a "scuffle", Kuang Mouming and Kuang Mouhua drove away first, and the defendant Zhou immediately left a voice message on his relatives’ WeChat group using WeChat, claiming that he was injured in Xinmin Sixth Street and asked his relatives to come over to help chase him by car. At the same time, he also called relatives to inform them to drive to the scene.

　　Later, two large trucks called by the defendant Zhou arrived at the scene, and Zhou sat on one of the large trucks and commanded to catch up with the car for nearly one kilometer. When chasing after the Jinsha gas station near Jinsha Road in Haizhu District, Zhou’s big truck intercepted the small car driven by Kuang Mouming. When Kuang Mouming saw it, he turned around and fled. At this time, another big truck rushed from the opposite lane and crossed the line and crashed into the small car driven by Kuang Mouming, causing damage to the left front of the car and the left rear mirror.

　　After Kuang Mouming was hit and stopped, Zhou’s big truck immediately stepped forward to intercept. Zhou and others got off the cab and wanted to rush to the vehicle driven by Kuang Mouming. When Kuang Mouming saw it, he immediately drove away from the scene and called the police for help. Subsequently, the defendant Zhou was arrested by the police. After identification, the injuries of Kuang Mouming and Kuang Mouhua were all minor injuries, and the loss price of the car driven by Kuang Mouming was RMB 8663.22.

　　The prosecutor asked in court, "Do you know the consequences of chasing cars on the main road?" "Why didn’t you call the police immediately?" Zhou argued that the reason why he informed his relatives to chase and intercept Kuang Mouming’s driving vehicle was that Kuang Mouming and Kuang Mouhua beat him and fled. He didn’t remember their license plates, only recognized cars and people, "just wanted to intercept the other vehicle and call the police", but there was no alarm after the collision.

　　After trial, Haizhu District People’s Court held that the defendant Zhou chased and intercepted others, and the circumstances were bad; Arbitrary destruction of public or private property, if the circumstances are serious, has constituted the crime of stirring up trouble. The defendant Zhou confessed his crime truthfully after arriving at the case and voluntarily pleaded guilty, which can be given a lighter punishment according to law. The defendant, Zhou, had an altercation with Kuang Mouming’s party because of the meeting, and then beat each other. After Kuang Mouming’s party left, he still called others to drive the truck to catch up with and intercept the vehicle driven by Kuang Mouming. His behavior of catching up and intercepting had a great impact on traffic order, and he was given a heavier punishment as appropriate. Considering that Kuang Mouming was at fault, and the defendant Zhou had actively compensated Kuang Mouming for his losses, he was given a lighter punishment as appropriate. In the end, the court ruled that the defendant Zhou constituted a crime of seeking trouble and sentenced him to seven months in prison.

Text/Yangcheng Evening News All-Media Reporter Li Zhiwen

At 0: 50 on January 7th, the K4562/3 train with 1813 passengers left Guangzhou Station slowly. This is Guangdong-Hong Kong-Macao Greater Bay Area’s first passenger train during Spring Festival travel rush in 2023, which marks the official start of the 40-day Spring Festival travel rush.

This year, Spring Festival travel rush is the first Spring Festival travel rush after the introduction of the "New Ten Articles" for epidemic prevention and control. The reporter observed in railway stations, airports, passenger stations and other transportation hubs that compared with the previous epidemic period, there have been many new changes in Spring Festival travel rush this year: the green code has not been checked, the nucleic acid has not been looked at, and the passenger pit stop process has become simpler; Wearing masks, protective clothing and gloves-there are fewer fully armed passengers or even out of sight; There are more and more passengers with their families, big bags and small bags, and smiling faces … In order to make passengers travel safely and smoothly, they do this.

Guangdong Provincial Department of Transportation

This year, the Provincial Department of Transportation further strengthened the linkage between departments, improved the working mechanism of Spring Festival travel rush, further sorted out the traffic jams and toll stations, strengthened the road network detection, dispatching and emergency response of important transportation corridors, key nodes and traffic jams and bottlenecks, and improved the rapid response capability.

In order to build a safe Spring Festival travel rush, the Provincial Department of Transportation will continue to implement the "one-day-one-judge" Spring Festival travel rush working mechanism, and coordinate the prevention and control of Spring Festival travel rush epidemic and the guarantee of transportation services. Do a good job in the dynamic intelligent monitoring of operating vehicles, focusing on strengthening the safety supervision of long-distance passenger transport, tourist chartered cars, rural passenger transport and dangerous goods transportation. Do a good job in the source management of passenger stations, and urge passenger stations to strictly implement the "three no-stops and six no-exits" system. Keep a close eye on key nodes such as "passenger ro-ro transportation in Qiongzhou Strait" and "four types of key ships" and strengthen waterway safety supervision.

In order to further improve the service level of Spring Festival travel rush, the transportation system of the whole province will actively carry out voluntary services such as "Warm Winter Action", "Warm Migrant Workers in Spring" and "Spring Breeze Action" to provide information consultation, civilized guidance, tea supply and other services for drivers and passengers in the past, so as to warm passengers’ way home. Strengthen the sanitation and cleaning of transportation stations, provide waiting areas and consulting services for pregnant women, children, sick and disabled passengers, and further improve the waiting environment for passengers. At the same time, strengthen the transportation service guarantee in key periods, and actively organize "point-to-point" transportation such as chartered cars, special trains and charter flights to meet the needs of people returning to work and returning to school.

This year, Spring Festival travel rush’s transportation system will fully implement the latest epidemic prevention and control optimization measures and "Class B and B management" measures of the joint prevention and control mechanism of the State Council, continue to do a good job in the normalization prevention and control of "two stations, one field, one port and one service area", strictly implement measures such as disinfection of passenger stations, service areas and means of transportation, and do a good job in cleaning the environment, ventilation and ventilation. In principle, disinfection and ventilation should be no less than once a day.

At the same time, strengthen the passenger flow organization of passenger stations, guide passengers to wait for passengers and sit in scattered places when conditions permit, and reduce the concentration of people. Long-distance road passenger drivers should try to fix the lines and vehicles during their work, and drivers of long-distance passenger lines and drivers and passengers of important energy transportation channels should try to arrange fixed rest places to prevent cross-infection.

All localities will further optimize the ticketing organization, actively provide contactless services such as mobile terminal ticket purchase and ID card checking, and guide passengers to wait for the bus (ship) and board the bus (ship) in an orderly manner. Strengthen the connection of various modes of transportation, effectively improve the efficiency of combined transport and continuous transfer, and effectively solve the "first and last mile" of passenger travel. Increase the organization and management of rural passenger transport and the delivery of transport capacity, improve the coverage of rural passenger transport lines, and ensure the travel needs of the masses.

Guangzhou Railway Group: The renovation and inspection of locomotives, vehicles, line equipment and station equipment have been completed in an all-round way.

In terms of hardware, Guangzhou Railway Group has strengthened the inspection and maintenance of service facilities and equipment. In front of Spring Festival travel rush, the ticket vending machines, elevators, air conditioners and seats were thoroughly inspected and rectified to ensure that basic services such as environmental sanitation, toilet use and boiled water supply were in place. At the same time, before New Year’s Day, the service "Keep Smooth" project in Guangdong Province was put into use as scheduled. For example, Guangzhou South Railway Station also completed the construction of Spring Festival travel rush Security Project, the west platform completed the optimization of compound security check and exit streamline, and eight channels were added at the security check and exit.

Increase investment in safety equipment. Spring Festival travel rush Former Group Company has completely completed the renovation and inspection of locomotives, vehicles, line equipment and station equipment, so as to ensure that these equipment can run safely and smoothly during their stay in Spring Festival travel rush.

In terms of service upgrading, we adhered to the standards of demand orientation and passenger satisfaction, coordinated Spring Festival travel rush, epidemic prevention, transportation and safety, focused on the service needs of passengers, and introduced 15 measures to facilitate the people and benefit the people, such as adjusting the preferential standard for children’s tickets to age according to their height, and canceling the restriction that students can only buy student discount tickets in winter and summer vacations.

Baiyun Airport: "Spring Breeze Service" Helps Passengers Travel Well

While ensuring the safe operation, Baiyun Airport practiced the "Spring Breeze Service" and launched a series of warm service measures in view of the "key and difficult points" in Spring Festival travel rush’s security work. All units in the frontcourt will strengthen the deployment of manpower, and the security inspection channels will be opened in advance according to the passenger flow situation, and all channels will be opened during the peak passenger flow period to quickly check and release passengers.

During the security inspection in Spring Festival travel rush, according to the actual demand on site, passages for "first passengers", "students returning from winter vacation" and "late passengers" were set up to provide convenience for special passengers such as those who arrive late for some reason and those who are old, weak, sick and pregnant.

Air Service Branch has set up a special service counter and a love counter at the duty officer’s counter at Gate 2 of Terminal 1 and the check-in counter at No.17 on M Island, respectively, to give priority to check-in procedures for passengers in need. For special international passengers, assist in making electronic health declaration and provide customs clearance guidelines.

The customer service center provides "artificial+intelligent" service, responds to passengers’ needs 24 hours a day, and patiently answers questions for passengers. The customer service counters at the airport provide convenient boxes for passengers, and the maternal and child rooms provide free emergency services of baby products for passengers returning home from Spring Festival travel rush. A number of warm-hearted measures meet the needs of the vast number of passengers for a beautiful trip.

Central South Air Traffic Control Bureau: Ensuring the Smooth Lifeline of Air Traffic Control Transmission during Spring Festival travel rush.

In view of the increase in flight volume, parallel epidemic prevention support, and outstanding complex weather during Spring Festival travel rush this year, the Central South Air Traffic Control Bureau properly formulated the support plan, set up the Spring Festival travel rush Support Working Group, organized a mobilization meeting for air traffic control support in Spring Festival travel rush, implemented safety responsibilities, paid close attention to the operation situation, rationally arranged the personnel on duty according to the characteristics of flight flow distribution in Spring Festival travel rush, and established a reserve team for key posts to respond to emergencies at all times.

The Technical Support Center ensures the stability and reliability of air traffic control equipment. Before Spring Festival travel rush, the new version of "Equipment Image Recognition System" was upgraded and deployed to realize intelligent monitoring of air traffic control equipment status and build a "firewall" for equipment support. The Communication Network Center will carry out special inspection of Spring Festival travel rush for air traffic control equipment, strengthen inspection of transmission pipelines, closely monitor the safety of pipelines and cables in construction sections, and ensure the smooth "lifeline" of air traffic control transmission during Spring Festival travel rush.

The Central South Air Traffic Control Bureau is also actively doing a good job in publicizing and training the new version of the emergency plan system and emergency handling cards to ensure that Spring Festival travel rush is foolproof.

Guangzhou Maritime Department: Provide 24-hour information supervision service.

It is understood that the Guangzhou Maritime Department has carried out a comprehensive safety "physical examination" on 105 passenger ferry vessels that have been put into Spring Festival travel rush, focusing on passenger-related vessels and material transport vessels such as Pearl River cruise ships and high-speed passenger ships, preventing vessels from operating "with diseases", and making full use of information means such as VTS, CCTV video surveillance system and supervision and command system, strengthening dynamic control of vessels, and releasing early warning information of bad weather in time to ensure the safety of navigation.

At the same time, we will open up a green channel for the transportation of key materials, strengthen the water transportation organization, provide 24-hour all-weather information supervision service, improve the efficiency of ship turnover and operation, ensure the safe and smooth transportation of key materials such as electric coal and grain, and ensure the production of enterprises and the living needs of residents during Spring Festival travel rush.

In addition, combined with the navigation situation of ships in the jurisdiction, Guangzhou Maritime Department rationally deployed emergency rescue forces in key waters such as the Pearl River Estuary, and did a good job in duty and emergency response to emergencies to fully ensure the safety of people’s water travel.

China Eastern Airlines: Improve the service guarantee for special passengers and actively assist passengers.

During Spring Festival travel rush, the number of elderly tourists and unaccompanied children tourists is expected to increase significantly. China Eastern Airlines has improved various service guarantees from the ground to the air since passengers purchased tickets; At present, an electronic system has been established for unaccompanied children. During the flight, flight attendants record and photograph the details and photos of small passengers, and parents can know the flight situation in real time through China Eastern Airlines official website.

This year, in Spring Festival travel rush, Shenzhen Base of China Eastern Airlines Guangdong Branch cooperated with Shenzhen Airport to launch an accurate tracing service for late-arrival passengers. During the morning rush hour, a special tracing post was set up to accurately find late-arrival passengers through the tracing system based on passengers’ appearance characteristics and security check time, and the attendants at the tracing post and boarding gate formed an effective linkage to actively assist passengers to make the trip.

In addition, passengers who take China Eastern Airlines flights at Shenzhen Airport, if they find that their ID cards and paper boarding passes have been lost after security check, can make a trip smoothly with their electronic boarding passes, and there is no need to leave the airport control area and reissue their boarding passes at the check-in counter.

Air China: Strengthen operation supervision, and continue to do a good job in production organization and emergency response under complex operation environment.

Air China scientifically co-ordinates aircraft, crew and other operational resources, strengthens flight plan management, and formulates detailed flight support plans and emergency plans in combination with weather characteristics such as frequent low temperature, rain, snow and low visibility in winter. By strengthening meteorological accurate forecast, strict flight release standards, and strengthening flight dynamic monitoring and information notification, it integrates Excellence, professionalism, efficiency and sincere service into every link of ensuring passengers’ travel, and fully guarantees the safe, stable and smooth flight operation during Spring Festival travel rush.

With the expectation of the Fed’s interest rate hike gradually declining, and it is almost certain that it will stop raising interest rates this year, small and medium-sized pharmaceutical stocks with historically low valuations are expected to usher in a wave of mergers and acquisitions this year. Combined with the merger situation in 2022, we believe that ten companies such as Argenx, Apellis and Sarepta have great potential to be merged by large pharmaceutical companies.

In addition to the ten pharmaceutical companies listed in this article, the following pharmaceutical companies or technical fields deserve attention:

ADC domain：Mersana Therapeutics、ImmunoGen；

CNS domain：Intra-cellular、Neurocrine、Sage Therapeutics;

Rare disease field：Mirum、Krystal Biotech；

Other fields：Halozyme、Prometheus、Viridian Therapeutics.

1、Argenx(NASDAQ:ARGX)

ARGX is a Dutch pharmaceutical company specializing in the research and development of alpaca-derived antibodies. It has three patented technologies related to the transformation of antibody Fc region, namely SIMPLE Antibody platform, NHance, ABEDEG and POTELLIGENT, and has the property of technology platform.

The drug VYVGART, which has been marketed by ARGX for treating myasthenia gravis, sells well, recording a sales income of US$ 131 million only in the third quarter of last year. It is estimated that the annual income will reach US$ 402 million, and the rights and interests of VYVGART in China have also beenZaiding medicineTake it. In 2023, ARGX also had some important milestones:

The company has submitted the subcutaneously injected version (SC) of EFGARTIMOD, which will be listed for approval on June 20th. Considering that VYVGART has been listed and sold well, the subcutaneously injected version of EFGARTIMOD has a high probability of being approved, and the sales revenue is more considerable.

In the second quarter, the SC version of efgartigimod will also release the phase III data for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP).

ARGX-113, a drug under research, will release two three-phase heavy data on the treatment of primary immune thrombocytopenia (ITP) and pemphigus vulgaris (PV) in the second half of the year.

ARGX is rich in pipelines, its technology platform has been verified, its sales revenue has risen rapidly, and with the blessing of many heavy catalysts this year, many Wall Street investment banks have listed ARGX as one of the promising biomedical enterprises this year.

2、Apellis(NASDAQ:APLS)

APLS is a biomedical company with complement technology, and its main drug is C3 inhibitor APL-2. At present, the drug has been approved for two indications: paroxysmal hemoglobinuria (PNH) and geographic atrophy (GA) secondary to age-related macular degeneration, among which the PNH indication was approved in mid-2021, and it sold for 65.1 million US dollars in the United States only last year (authorized to SOBI outside the United States).

APL-2 was recently approved for the treatment of GA, with a wide range of labels (including foveal and extrafoveal), and GA has a large market. The Wall Street investment bank even gave a peak sales forecast of $5 billion. At the same time, the doctor survey conducted by the investment bank showed that doctors and patients had high expectations for APL-2. It is estimated that doctors will use the drug in 20-50% of patients, with an estimated EOD of 70-80%.

In addition to the above-mentioned approved indications, the company has a layout in the fields of rare diseases, ophthalmology, nervous system, gene therapy, etc., among which gradual freezing disease (ALS) in cooperation with SOBI is the most important. APLS is a very suitable choice for large pharmaceutical companies that want to enter the field of complement technology or GA.

3、Alnylam(NASDAQ:ALNY)

Founded in 2002, Alnylam is a leading enterprise in the field of RNAi therapy. In the past five years, it has successfully brought five RNAi drugs to the market, and in 2022, it achieved sales revenue of 892 million US dollars, up 35% year-on-year.

According to product classification, ONPATTRO and AMVUTTRA, which have the same indications, recorded revenues of $122 million and $69 million respectively in the fourth quarter of last year, with annual revenues of $558 million and $94 million respectively.

GIVLAARI recorded a revenue of $47 million in the fourth quarter of last year and achieved a revenue of $173 million in the whole year; OXLUMO recorded a revenue of $24 million in the fourth quarter of last year and achieved a revenue of $70 million for the whole year.

In addition to the strong performance of existing products, relying on the RNAi therapy technology platform, ALNY is rich in research pipelines, and many pipelines are in the later stage, which has great commercialization potential in the short term:

Patisiran’s supplementary marketing application for the treatment of ATTR amyloidosis cardiomyopathy, and the approval time is October 8; This year, the third phase data of Fitusiran in treating hemophilia and the third phase data of Vutrisiran in treating ATTR amyloidosis cardiomyopathy will also be released.

In addition, the market for indications of some early pipelines of the company is extremely broad, such as Zilebesiran for treating mild and moderate hypertension, ALN-APP for treating Al Harmo’s disease, ALN-KHK for treating NASH, etc.

Whether it is the technology platform, sales performance, and future potential, ALNY is the target of mergers and acquisitions by large pharmaceutical companies.

4、Axsome Therapeutics(NASDAQ:AXSM)

AXSM is a model of Biotech in the field of central nervous system in recent years. Its share price has risen more than 30 times in the past four years, and it has also enabled CFO Nick Pizzie, who defected from Pierre Fabre USA in 2018, to gain wealth freedom. At that time, the market value of AXSM was less than 100 million US dollars.

Behind the stock price rise is AXSM’s successive clinical trials:

The third phase trial of AXS-05 in the treatment of major depression (MDD) and bipolar disorder in Az Harmo was successful, and the indication of MDD has been approved for marketing.

The third phase trial of AXS-07 for migraine was successful, and it is planned to submit NDA； this year;

The drug AXS-12, which is used to treat narcolepsy, has also been certified by FDA as a breakthrough therapy. It is currently in the second phase of clinical practice, and data will be released this year.

In addition to its own research and development, the company is also adept at business development (BD): in March 2022, AXSM bought Sunosi, a listed drug for treating narcolepsy, from JAZZ for $53 million, and in February this year, AXSM announced that it would grant Sunosi’s rights and interests in Europe, the Middle East and North Africa to Pharmanovia, and AXSM would receive an advance payment of $66 million and a milestone payment of up to $101 million.

For large pharmaceutical companies that favor the commercialization stage, AXSM with two CNS drugs on sale and multiple later pipelines is undoubtedly one of the most worthy M&A targets.

5、Ascendis(NASDAQ:ASND)

Ascendis Pharma is a long-acting drug company with a long-acting drug technology platform TransCon. At present, it mainly focuses on various rare diseases, reducing the frequency of drug use, improving patients’ compliance, reducing side effects, and thus improving the treatment effect. With the success of the third phase clinical trials of several drugs, the technical platform of ASND has also been verified.

At present, the company has three drugs under research: TransCon hGH (long-acting growth hormone), TransCon PTH (treatment of hypothyroidism) and TransCon CNP (treatment of achondroplasia).

In 2021, Skytrofa, the company’s drug for treating children’s growth hormone deficiency (GHD), has been approved for marketing. On April 30 this year, the FDA will approve the marketing of TransCon PTH, the company’s drug for treating adult hypoparathyroidism, and will also release Phase III data of TransCon hGH for treating adult growth hormone deficiency before the end of the year. In addition, the company also has pipeline promotion in the field of achondroplasia and tumor, and will provide updates of related clinical trials this year.

The performance of Skytrofa, a drug listed by ASND, grew well. In 2022, it achieved a revenue of 35.7 million euros, with a quarterly revenue growth rate of 39%.

In 2018, ASND also co-founded VISEN Pharmaceuticals with Vivo Capital, and Visen Pharmaceuticals acquired the rights and interests of ASND in Greater China. In November 2022, Weisheng Pharmaceutical submitted a prospectus to the Hong Kong Stock Exchange, intending to be listed on the main board of Hong Kong. In view of the vast domestic long-acting growth hormone market, Changchun Gaoxin, anke biotechnology and other companies have already laid out, and the arrival of Weisheng Pharmaceutical will intensify the competition in the industry.

In view of the company’s long-term drug technology platform and the pipeline in the late stage of commercialization and research and development, Ascendis Pharma is also one of the potential acquisition targets of large pharmaceutical companies.

6、Sarepta(NASDAQ:SRPT)

Sarepta Therapeutics is a leading enterprise in the field of treating Duchenne muscular dystrophy (DMD). At present, the company has three approved DMD drugs: EXONDYS 51, AMONDYS 45 and Vyondys 53. In addition to the drugs already on the market, the company is developing new therapeutic drugs such as gene therapy and gene editing around DMD, and at the same time, it has a layout for the indications such as limb muscular dystrophy (LGMD).

In the third quarter of 2022, the company recorded a product sales income of 207 million US dollars, and it is estimated that the annual income will reach 843 million US dollars, a year-on-year increase of 38%. In addition to strong sales performance, the company’s R&D pipeline is also worth looking forward to.

In the third quarter of last year, the company submitted the application for the marketing of gene therapy drug SRP-9001 for treating DMD, which was jointly developed with Roche. The FDA granted it priority approval, and the approval time was May 29th. The marketing application of SRP-9001 is supported by many clinical trial data, and the probability of approval is high.

For large pharmaceutical companies that want to enter the DMD field, SRPT is the best choice. However, the overseas rights and interests of SRP-9001 were authorized to Roche, which may lower the expectations of the acquirer.

7、Karuna Therapeutics(NASDAQ:KRTX)

KRTX is a company that develops drugs for the treatment of nervous system diseases. KarXT, its main drug, is an oral first-choice muscarinic agonist for M1/M4. It consists of xanomeline, a muscarinic agonist, and trospium, a muscarinic antagonist. It aims to preferentially stimulate muscarinic receptors in the central nervous system, and has the potential to treat serious mental diseases without relying on dopaminergic or serotonin, including schizophrenia and psychosis in Alzheimer’s disease.

In August, 2022, the company released the phase III clinical data of KARST in the treatment of schizophrenia, which not only reached the end of the trial, but also was superior to the existing therapies in terms of therapeutic effect, safety and patient coverage, and solved the problems of poor compliance and less coverage in the existing therapies, especially the clinical P value of KARST < 0.0001, which is extremely rare in the CNS field.

This data has been released, and KarXT is regarded as a game changer in the field of schizophrenia by investment banks such as Mizuho. It is estimated that it will reach $1.7 billion by 2028, and its peak sales will be above $5 billion.

The company plans to submit the listing application of KarXT in the middle of this year, and release the results of another phase III test named Buergent-3 in the first quarter of this year. This experiment is similar to the previous studies of EMERGENT1(Ph2b) and EMERGENT-2(Ph3), with a high probability of success, but initially the experiment was mainly conducted in Ukraine, and now most of the research is transferred to the United States, which has certain uncertainties.

8、Revance(NASDAQ:RVNC)

RVNC is a pharmaceutical company dedicated to developing cosmetic medical products. Relying on the unique TransMTS? peptide technology, it has developed a differentiated botulinum toxin for injection, which was approved in the third quarter of last year.

Different from the existing Dysport, Xeomin, Jeuveau and other products on the market, DAXXIFY is a new product that is truly different from BOTOX, the number one product in the field of botulinum toxin. In the treatment of brow wrinkles, the curative time of DAXXIFY is almost 1.5 to 2 times that of BOTOX, while the annual income of the latter is 14.6 billion US dollars.

Because of its remarkable effect, DAXXIFY aims at the top one-third of the existing users. Investment banks predict that DAXXIFY will occupy 30% of the US market and its annual sales will exceed $1 billion. In the first quarter (the fourth quarter of last year) just after it was approved, the sales of DAXXIFY experience users were already expected to be between $10.5 million and $11.5 million.

In addition to DAXXIFY, the company also has RHA fillers with less side effects and better effects than hyaluronic acid. The sales revenue in the first year after listing was more than 70 million US dollars, and the growth rate last year remained at 40%+. Different from other small pharmaceutical companies, the company also has a commercial platform OPUL?, which is a cloud platform integrating customer relationship maintenance and financial payment functions, providing services for all kinds of medical and beauty businesses. As of the third quarter of last year, the total platform GPV in the past 12 months exceeded 630 million US dollars.

In the environment of raising interest rates, large pharmaceutical companies facing the cliff of heavy drug patents are likely to be interested in mergers and acquisitions of RVNC with great sales revenue potential and quick results.

9、Krystal Biotech(NASDAQ:KRYS)

KRYS is a unique gene therapy company, which does not use the common adeno-associated virus or lipid nanoparticles to deliver genetic material, but loads the gene into herpes simplex virus (HSV-1) to make it reach its target in vivo. HSV-1 has higher carrying capacity than other gene therapy technologies, which not only broadens the scope of potential diseases that KRYS may treat, but also can realize repeated administration.

KRYS has developed a series of drugs for dermatoses and respiratory diseases on its gene therapy technology platform, among which the most important one is B-VEC for the treatment of dystrophic epidermolysis bullosa (DEB), which is currently in the waiting stage for PDUFA.

B-VEC has obtained the priority evaluation qualification granted by FDA. Due to CMC, the approval time was postponed to May 19th this year, and the probability of approval was high. If approved, this will be the first approved gene therapy for DEB.

Although the market of DEB is not very large, B-VEC has proved the feasibility of the company’s technology platform to some extent. Besides the skin diseases and respiratory diseases that have been laid out at present, the company has also started clinical trials to treat cystic fibrosis. In addition, Jeune Aesthestics, a subsidiary of KRYS, is still trying to enter the field of medical beauty.

With its unique technology platform value and several promising research pipelines, KRYS is expected to become an M&A option for large pharmaceutical companies.

10、Xenon(NASDAQ:XENE)

XENE is a company that focuses on the treatment of neurological diseases by regulating ion channels. The main indication is epilepsy. At present, there are four drugs under research in the pipeline, XEN1101, XEN496, XEN901 and XEN007, which have cooperated with well-known enterprises in CNS field, Neurocrine and Alexion (acquired by AstraZeneca).

In October, 2021, the company announced that XEN1101, the main pipeline, announced the success of the second phase of the clinical treatment of adult local epilepsy, and the FDA required the company to make another third phase to apply for listing. XEN496, another treatment for infantile epilepsy, is also in the third clinical stage, and it also needs a greater probability of success.

In addition, the company’s drug XEN1101 is still in the second phase of clinical treatment for major depression (MDD), and the market of MDD is bigger than that of epilepsy. If the data released in the second half of the year is good, it will increase the probability of the company being acquired.

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　　Cctv newsAccording to the website of the National Bureau of Statistics, in May, the total retail sales of social consumer goods was 3,594.5 billion yuan, a year-on-year increase of 12.4%; It increased by 9.3% compared with May 2019, with an average growth rate of 4.5% in two years. Among them, the retail sales of consumer goods other than automobiles reached 3,225.7 billion yuan, an increase of 13.2%. After deducting the price factor, the total retail sales of social consumer goods actually increased by 10.1% in May, with an average growth of 3.0% in two years. From the ring comparison, the total retail sales of social consumer goods increased by 0.81% in May.

　　1&mdash; In May, the total retail sales of social consumer goods reached 17,431.9 billion yuan, a year-on-year increase of 25.7%, with an average growth rate of 4.3% in two years. Among them, the retail sales of consumer goods other than automobiles reached 15,630.4 billion yuan, an increase of 24.4%.

　　According to the location of business units, in May, the retail sales of urban consumer goods reached 3,131.3 billion yuan, up 12.3% year-on-year, with an average growth of 4.5% in two years. The retail sales of rural consumer goods reached 463.2 billion yuan, an increase of 13.2%, with an average increase of 4.7% in two years. 1&mdash; In May, the retail sales of urban consumer goods reached 15,154.6 billion yuan, a year-on-year increase of 26.0%, with an average increase of 4.4% in two years. The retail sales of rural consumer goods reached 2,277.2 billion yuan, an increase of 23.5%, with an average increase of 3.7% in two years.

　　By consumption type, in May, the retail sales of commodities reached 3,212.9 billion yuan, up 10.9% year-on-year, with an average increase of 4.9% in two years. The catering revenue was 381.6 billion yuan, an increase of 26.6%, with an average increase of 1.4% in two years. 1&mdash; In May, the retail sales of commodities reached 15,652.9 billion yuan, a year-on-year increase of 22.9%, with an average increase of 4.8% in two years. Catering revenue was 1,778.9 billion yuan, up 56.8%, with an average decline of 0.3% in two years.

　　1&mdash; In May, the national online retail sales reached 4,823.9 billion yuan, a year-on-year increase of 24.7%, with an average increase of 14.2% in two years. Among them, the online retail sales of physical goods was 3,937.7 billion yuan, an increase of 19.9%, with an average increase of 15.6% in two years, accounting for 22.6% of the total retail sales of social consumer goods; In the online retail sales of physical goods, food, clothing and consumer goods increased by 24.2%, 28.2% and 17.0% respectively, with an average increase of 30.5%, 9.3% and 15.9% respectively in two years.

　　Cctv news Lancome, Saint Laurent YSL, helena rubinstein HR, Armani … these well-known brands are all owned by L ‘Oreal Group. On the morning of February 21st, "New Era and New Opportunities &mdash; &mdash; The online theme promotion activity of "Multinational Enterprises in China" came to the headquarters of L ‘Oré al North Asia. In an interview, Fabry, President of L ‘Oré al North Asia and CEO of China, said that L ‘Oré al has been close to consumers for 25 years and is looking forward to more sparks with the consumer market in China.

　　Fashion and beauty combine the feast of sight and smell.

"Floating in Time and Space" in Shanghai Exhibition Center: the world’s first exhibition of Armani Gaoding’s private fragrance

　　"Floating in time and space &mdash; &mdash; The first exhibition of Armani Gaoding Fragrance in the world was recently exhibited in the West Hall of Shanghai Exhibition Center. In this limited-time feast of fashion and beauty, several sets of rare Armani haute couture fashions were presented, which complemented the perfume bottles with corresponding smells.

　　It is reported that the exhibition receives 2,000-2,500 visitors every day, and the exhibition will last until February 26th, and then move to South Korea, France and other places to continue the "global tour".

　　Fabry said that in the past few years, L ‘Oré al has made due contributions to the recovery and development of China’s consumer market. The world premiere of Armani in Shanghai not only reflects the strong resilience of China’s economy, but also reflects L ‘Oré al’s confidence and determination to develop in China.

　　"We will continue to create beauty, move China consumers and enlighten the world."

　　Technology empowerment seizes the new opportunity of personalized beauty.

　　Less than 500 meters away from the exhibition is the headquarters building of L ‘Oré al Group in North Asia. Since L ‘Oré al entered the China market in 1997, it currently operates 31 brands in China.

　　Fei Borui said that diversification is the next development trend of the beauty industry. Consumers are not limited to "one thousand people" who only choose a single product. In the future, more diversified choices and expressions will realize "one person and one thousand faces". How to meet the needs of consumers more accurately will bring great business opportunities to the development of L ‘Oré al beauty and technology.

L ‘Oré al staff demonstrated the intelligent colorimeter of "lipstick printer"

　　It is understood that L ‘Oré al has made its debut in China International Import Expo(CIIE) for five years in a row, exhibiting 16 new international brands and a number of personalized beauty technologies, and its influence on new products is constantly expanding to the whole country.

　　Investment overweight is full of confidence in Shanghai’s development.

　　"Shanghai naturally has some of the most cutting-edge characteristics of beauty consumption." Fei Borui said that Shanghai has good prospects in innovation, consumption and economic growth, and he is full of confidence in Shanghai’s development.

Fabry (right), President of L ‘Oré al North Asia and CEO of China, was interviewed.

　　Over the years, L ‘Oré al has witnessed the continuous development and evolution of Shanghai, and in the process, L ‘Oré al has also deeply felt the strong support of the Shanghai government and relevant institutions. L ‘Oré al has always maintained close cooperation with the government and received a lot of support from the policy level, thus bringing more innovation to consumers. At the China International Import Expo(CIIE) in 2019, L ‘Oré al demonstrated the personalized service of Xiuliko Essence. In this year’s pilot project in Pudong, the personalized service of Xiuliko Essence will be listed in China; In 2022, the clean workshop of L ‘Oré al Suzhou Factory was officially launched, and the foundation stone of the world’s first self-built intelligent operation center was launched in Suzhou, which is expected to be officially put into operation in September this year; In addition, L ‘Oré al also set up its first investment company in China market &mdash; &mdash; Shanghai Meicifang Investment Co., Ltd. will strengthen co-creation with China’s industry partners.

　　"The fields that China is developing are in perfect harmony with the fields that L ‘Oré al can contribute to," Fabry said. L ‘Oré al has been witnessing the opening of the market and the demand for policies. During the gradual recovery of the consumer market in China, L ‘Oré al is very much looking forward to colliding with Shanghai for more innovation sparks.

Cctv newsRecently, sporadic cases have appeared in many places in China, and the situation of epidemic prevention and control in winter is grim. There is still more than one month before the Spring Festival. In order to reduce the large-scale personnel flow during the Spring Festival, recently, many places across the country issued the initiative of "not returning home during the Spring Festival" to encourage enterprises and institutions to arrange flexible vacations and celebrate the New Year on the spot when conditions permit.

Do not return home unless necessary.

As the Spring Festival approaches, the domestic epidemic prevention and control work is facing a big test of personnel mobility and gathering.

On December 25, 2020, the Beijing conference on epidemic prevention and control mentioned that "it is not necessary to leave Beijing, and it is not necessary to leave the country", and the citizens are encouraged to spend the New Year in Beijing. The cadres of the party and government organs take the lead in celebrating the holidays in Beijing, and those who really need to leave Beijing must be strictly examined and approved.

The Shanghai Health Promotion Center also reminds the general public to arrange their trips reasonably during the Spring Festival, and not to travel unless necessary, so as to encourage them to return home and return to their posts. If you must travel across regions, you must know the local epidemic situation and prevention and control policies in advance, and know whether there are any cases or epidemics in the destination in the near future, and suspend travel in medium and high-risk areas.

On December 30, 2020, the Shenzhen Municipal Health and Wellness Committee issued a notice that civil servants, institutions and employees of state-owned enterprises must apply for leaving Shenzhen, and other companies should try their best to take holidays at the wrong peak and encourage them to stay in Shenzhen for the New Year.

In addition, in order to reduce the large-scale population flow, Henan, Anhui, Sichuan, Hunan and other major labor exporting provinces have recently issued notices, demanding "not to return home unless necessary".

For example, the disease control departments of Kaifeng City and Xinxiang City in Henan Province issued tips to encourage migrant workers and scholars to stay in the local festivals as much as possible to reduce the pressure of prevention and control in the two places; Linquan County, Fuyang City, Anhui Province, and Xiaoxian County, Suzhou City suggest that migrant workers stay in their places of work for the New Year, and they can use WeChat, Internet, telephone, etc. Yuyao and Yinzhou in Ningbo City, Zhejiang Province encourage and guide teachers and students to stay in the local winter vacation, and report to the school in advance if they really need to leave.

Earlier, the State Council issued a notice to encourage enterprises and institutions to flexibly arrange vacations according to their production, work conditions and employees’ wishes, and guide employees to take vacations at their workplaces as much as possible during the Spring Festival, and pay overtime wages and leave for employees who work overtime during the Spring Festival according to law.

On January 1, 2021, Academician Zhang Boli said in an interview that the cold season is very suitable for the virus to survive, and this winter and next spring will be the key period to prevent and control the epidemic. "During the National Day in 2020, hundreds of millions of people in China will have nothing to do with the flow. You may say that the Spring Festival can still flow, but &lsquo; No &rsquo; Because the seasons are different. " Therefore, it is recommended that you gather less during the Spring Festival and try not to arrange travel without special circumstances.

Those who really need to return home: nucleic acid test+health code+pass code.

For those who really need to return home, Henan, Anhui, Sichuan, Hunan and other regions have also made clear requirements. Among them, nucleic acid test report, health code and pass code are basic standards, such as Suzhou City, Anhui Province, Ganxian County, Shaanxi Province, etc. It is clear that all returnees need to report to the town (street) or unit in the destination area in advance or at the first time, and hold a valid nucleic acid test report within 7 days to verify the health code and pass code.

In some areas, it is specifically mentioned that migrant workers engaged in the cold chain logistics industry should report to their communities in advance before returning home. For example, Taiyuan City, Shanxi Province requires those who are studying, traveling, taking vacations, working outside the province (especially those engaged in importing cold chain food), planning to come and visit relatives, etc., please report their personal itinerary and contact information to the community (village) and unit where the destination is located in advance.

For people returning from overseas and high-risk areas, nucleic acid detection and isolation measures are required in many places. For example, Huangchuan County, Xinyang City, Henan Province issued a notice, and returnees from overseas and medium-and high-risk areas must report their trips to their jurisdictions in advance, and implement nucleic acid testing and 14-day centralized isolation measures.

Railway Department: Tickets purchased before 24: 00 on January 6 will be refunded free of charge.

Recently, sporadic cases and local epidemic have occurred in some parts of the country. In order to cooperate with the implementation of epidemic prevention and control policies of local governments, the railway departments have made the following adjustments to the provisions on passenger train ticket refund:

From 0: 00 on January 7, 2021, when passengers refund valid tickets of trains purchased before 24: 00 on January 6, 2021 at stations, railway 12306 websites (including mobile phone clients) and other channels, no refund fee will be charged, and the purchased railways will be handled together with accident insurance.

A number of airlines: flights involving key epidemic prevention and control areas are returned and changed free of charge.

Recently, a number of airline companies have issued policies on the cancellation of flights in key epidemic prevention and control areas. Up to now, China International Airlines, China Southern Airlines, Hainan Airlines, Xiamen Airlines, Shandong Airlines, etc. have released plans for returning flights involving Beijing’s inbound and outbound flights; Hainan Airlines, Grand China Airlines, Hebei Airlines, Shandong Airlines, Spring Airlines, etc. have issued special handling plans for Shijiazhuang’s inbound and outbound flight tickets.

　　Cctv news(Reporter Wei Junhao) As the first dictionary in China, how many words are included in Shuo Wen Jie Zi? How to build a bridge between ancient characters and later generations?

　　On February 20th, "Freehand brushwork in China &mdash; &mdash; Exploring the Origin of Chinese Characters ",the online theme propaganda interview group entered the Xu Shen Cultural Park in Luohe City, Henan Province, to see how Xu Shen, the sage of Chinese characters, explained Chinese characters and opened the door to Chinese characters.

　　In September 121 AD, Xu Chong, the son of Xu Shen, a famous Confucian scholar and philologist in the Eastern Han Dynasty, presented Shuo Wen Jie Zi to Emperor Han An. China’s first dictionary came out.

　　This book, which took Xu Shen’s life’s efforts, has 15 volumes, including 9353 words, 1163 "tautology" (i.e. variant characters), and 133441 words for explanation and explanation. Zhang Han, deputy director of Xu Shen Cultural Research and Protection Center, said that Xu Shen put the original scattered Chinese characters into 540 radicals by analyzing the font structure, and created a dictionary compilation method with radicals as the command, which made the shape, sound and meaning of Chinese characters tend to be standardized and unified.

　　Since then, there has been a unified standard and norm for Chinese character writing, both official and folk, which has been followed by future generations and has been used to this day.

　　According to reports, the earliest writing system in China, represented by Oracle Bone Inscriptions, has undergone profound changes for thousands of years and has written a profound history of Chinese civilization, among which Shuo Wen Jie Zi played an important role.

　　Shuo Wen Jie Zi has also become the first most authoritative Chinese dictionary in China. It is highly praised by emperors and literati in previous dynasties for its ladder and bridge to study pre-Qin characters. After reading this book, Zeng Guofan in Qing Dynasty spoke highly of it: "Xu Shu has only 200 words, and the ancient mirror has swept away the dust for thousands of years. Seal script has become popular, and the explanation is especially refreshing. The old Confucianism in Ganjia is elegant and elegant, and the strict section in the southeast is unparalleled. " After reading this set of Shuowen Jiezi, you will be familiar with the history of languages for thousands of years.

　　Xu Shen was also honored as "the sage of Chinese characters" and "the master of Chinese characters" by later generations. Today, more than 1000 years later, in order to carry forward Xu Shen culture and inherit Chinese character civilization, Luohe, the hometown of Zisheng, has built Xu Shen Cultural Park, a national 4A-level cultural tourist attraction, held many international seminars on Xu Shen culture, organized and carried out projects such as Xu Shen culture entering the campus, family and community all the year round, started the construction of a famous Chinese character cultural city, and promoted Chinese characters and Xu Shen spirit with the help of the whole city.

　　Chinese pays attention to traditional etiquette, and the Prime Minister is no exception. On February 13th and 25th of the twelfth lunar month, Li Keqiang walked into Pudong Village, a Dong stockade deep in the mountains of Liping County, and brought a rich "New Year Gift Package" to the villagers.

　　1. Send special products out of your own pocket

　　What’s in the "spree"? First of all, of course, those local specialties that the Prime Minister personally selected and bought out of his own pocket. On the morning of 13th, when Li Keqiang inspected the supply of Spring Festival market in Liping market, Guizhou, he also prepared a "gift package" for visiting poor households in mountainous areas in the afternoon.

　　In order to ensure that these new year’s goods really meet the needs of villagers in Dongzhai, the Prime Minister never forgets to ask every time he passes a booth: What should the local people prepare for the New Year? What sells best? Finally, under the enthusiastic "sales promotion" of the stall owners, the Prime Minister paid several times and purchased several large packages of local specialties.

　　In the afternoon, Lin Xianping, a poor villager in Pudong Village, took over from the Prime Minister in his drafty wooden building.Pickled fish, Ciba, rice wine, Dong fruit, melon seeds, fried rice and other local specialties..

　　However, despite consulting local market vendors, the Prime Minister is still a little uneasy about his "gift package".

　　"How’s your mouth? Can these be chewed? " He asked Lin Xianping’s parents who were over seventy. After receiving a positive reply, the Prime Minister showed a satisfied smile.

　　2. Dangerous houses in villages will be rebuilt.

　　In addition to the "visible" special products of the New Year, Li Keqiang also brought some invisible "gifts" to the villagers. Next to the charcoal stove in Lin Xianping’s kitchen, the Prime Minister and the Lins sat around chatting and asked them how much land they had, whether the food was enough, how much the minimum living allowance was every month, and whether they had joined the medical insurance.

　　He also specially opened the rice jar for storing surplus grain, grabbed a handful of grain and rubbed it: "This is glutinous rice! No wonder you just said that you can only play 400 kilograms per mu of land. "

　　A village cadre next to him smiled and said: "The Prime Minister has been a branch secretary of the brigade, and he is familiar with these!"

　　Lin Xianping told the Prime Minister that he now has a minimum living allowance and joined the new rural cooperative medical system, and the harvest of farming can also guarantee food rations, but the biggest difficulty at home is that the house is too shabby and has no money to repair it.

　　"You show me!" Li Keqiang got up at once, climbed up the second floor along the shabby wooden stairs and frowned at the leaking windows and old wires.

　　"If this catches up with mountain torrents and windstorms, how can people live in a tight place? It will be even worse in case of fire! " He said, "this is a pain in our hearts!" "

　　After leaving the Lins’ wooden house, Li Keqiang told the local person in charge that Pudong Village must be included in the system arrangement of centralized contiguous poverty alleviation and development and precise poverty alleviation.

　　He said loudly to the villagers who gathered around him: "The government is determined to transform your village, and you must live in a safe and comfortable new house and live a real’ new countryside’ life!"

　　3. Drinking water is safe and secure

　　Pudong Village is a national first-class poverty-stricken village. More than 43% of the people in the village are poor, and the annual per capita net income is only 2160 yuan. Many houses are leaking everywhere.

　　"Yes, the water is still very clear." He nodded and said.

　　In last year’s "Government Work Report", Li Keqiang promised to solve the problem of drinking water safety for another 60 million rural people throughout the year. During his inspection in Pudong Village, he was particularly concerned about whether these promises were really fulfilled and whether the policies were really implemented.

　　The prime minister told the responsible person that the government promised not only to complete the task in quantity, but also to stand the test in quality. He said: "Let the people drink safe and secure drinking water, which is a hard promise of the government and must not be discounted!"

　　Also receiving the "gift package" are two village doctors in the village health center.

　　Li Keqiang has always attached importance to the irreplaceable role of village doctors. Last year, in the grass-roots investigation in Chifeng, Inner Mongolia, after discussing with the accompanying department heads, Li Keqiang decided to use all the basic public health service fees newly added by the central government in that year to subsidize village doctors.

　　During this visit, Li Keqiang asked two village doctors whether they had received the new subsidies from the state and whether the income from practicing medicine every month could guarantee their living. A village doctor replied that his income has improved, but he still needs to plant some fields when there are no patients, subsidy income.

　　After listening to this, the Prime Minister said with emotion that the government should make efforts to make you feel at ease and seek medical treatment! He revealed at the scene that the new basic public health service fees at the grassroots level this year will still be fully subsidized to village doctors.

　　"Village doctors are the’ first line of defense’ for villagers’ health. You are carrying a medicine box and wading through the mountains, reflecting the feelings of doctors to save the world." Li Keqiang said, "The government should completely eliminate your worries and let you go all out to seek medical care!"

　　5. Student loan scheme.　

　　Li Keqiang conducted a "market survey" for college students and graduates who returned home for the Spring Festival before sending out the "gift package". When sitting around the Dong Drum Tower to communicate with everyone, the Prime Minister directly asked: "What is your biggest difficulty? Speak out boldly! "

　　A girl said that she was admitted to a university in Shanghai and applied for a student loan. However, after being admitted to a graduate school in Guizhou University, she found that the student loan could not be transferred across provinces, so she had to find a way to repay the loan while attending graduate school.

　　"She hasn’t got a job yet. How can she repay the loan?" Li Keqiang turned to ask the person in charge of the relevant departments of his peers, "This issue is not a trivial matter, but a big one involving educational equity and coordinated regional development. We encourage college students to go home and go back to the west after graduation, but objectively, the income in the west is indeed lower than that in the east, and the pressure on these graduates to repay loans will be even greater. "

　　He promised at the scene that the State Council would study and formulate new policies for this purpose. The college students who received the "gift package" immediately clapped their hands and cheered.

　　6. Villagers return gifts to the Prime Minister

　　In addition to bringing these generous "New Year’s Gift Packages" to the villagers, Li Keqiang also received gifts from the villagers.

　　After learning that her dangerous house will be rebuilt, Lin Xianping’s mother excitedly took out a pack of "Baba" made by herself, hoping to give it to the Prime Minister to express her feelings.

　　Li Keqiang quickly waved his hand: "Your family is very difficult. I can’t accept this gift!"

　　Unexpectedly, the 70-year-old man chased all the way to the small bridge at the entrance of the village, saying that he would put BaBa into the hands of the Prime Minister.

　　"All right, but there are too many bags. I can only take one." Unable to overcome the enthusiasm of the old man, Li Keqiang finally accepted a small piece of Baba. This is actually a heavy heart.

　　The Prime Minister said: "I have taken away your thoughts and will always miss you. The government will definitely complete the renovation of your dangerous houses as soon as possible, and it will also give more children in the village the opportunity to go to college and let you all live a good life! "

　　CCTV News:In the first quarter of this year, the total import and export value of China’s goods trade reached 9.89 trillion yuan, a year-on-year increase of 4.8%. The import and export of foreign trade improved month by month and achieved a good start. The accumulated new advantages and the sustained growth of new kinetic energy have also made the foreign trade industry draw more surprising trajectories.

　　Starting today (April 20th), we will launch a series of reports on "New Routes of Foreign Trade", so as to follow the pace of foreign trade, embark on "new routes" and explore more possibilities along new directions. Today, first of all, focus on the "new three" products with outstanding export performance: electric manned vehicles, lithium batteries and solar cells in new energy vehicles.

　　At noon, at the Haitong Wharf outside Shanghai, a car ro-ro ship slowly berthed, and one new energy vehicle sailed on board one after another, which was about to be sent to Thailand.

　　Zhong Xiaogang, head of customs affairs at BYD:There are two deliveries this week, and tomorrow we will also send 900 cars from here to Australia.

　　CCTV reporter lin li:This is a car yard about two kilometers away from the dock, and most of the exported cars will come here three to five days in advance. Just now, the staff made a simple calculation for me. At present, there are more than 10,000 cars waiting for export every day, of which about 40% are new energy vehicles.

　　Xie Xiaoqing, Director of SAIC International Purchasing Department:The growth rate of new energy (export) is still relatively large. In 2022, the proportion of new energy should be around 16%, and it may increase to nearly 25% in 2023.

　　Also hot is the export of lithium batteries. In a battery enterprise in Taizhou, Jiangsu Province, a batch of lithium batteries are being packaged and will be sent to South Africa soon. The person in charge of the enterprise told the reporter that this year, overseas customers’ demand for household energy storage has further increased, so they have added a production line for lithium batteries.

　　Wang Shuai, Manager of Delivery Department of Lithium Battery Product Line of Shuangdeng Group Co., Ltd.:This year, our household energy storage output has gradually reached expectations, and the output has increased by more than 60% compared with the same period last year.

　　It is understood that clothing, furniture and household appliances were once called the "old three" in the foreign trade industry to promote export growth; Nowadays, while the "old three kinds" industries are constantly upgrading, the "new three kinds" have also sprung up: electric manned vehicles, lithium batteries and solar cells in new energy vehicles have further enhanced the driving force for exports. According to customs statistics, in the first quarter of this year, the total export of "new three products" increased by 66.9%, with a year-on-year increase of more than 100 billion yuan, which increased the overall export growth rate by 2 percentage points.

　　Li Jirong, Deputy Director of Statistics and Analysis Department of Shanghai Customs:Our country has also made good use of the advantage that the traditional manufacturing industry chain is relatively close and the supporting facilities are relatively complete, and has quickly achieved very good advantages in the new three industries. In the first quarter of this year, the export of electric manned vehicles in Shanghai more than doubled year-on-year, the export of lithium-ion batteries increased by more than 200%, and the export of solar batteries also increased by 57%.