The COVID-19 epidemic has lasted for more than four years, and Covid-19 is still raging around the world. According to statistics, nearly 7 million people infected with COVID-19 around the world have died of infection. In fact, the main cause of illness deterioration and even death of most patients is not the virus itself, but the excessive inflammatory reaction and inflammatory factor storm caused by Covid-19. However, the specific mechanism of how the virus triggers such a strong inflammatory response in the lungs is still unclear.

Recently, the Chinese research team of the University of Southern California published an important achievement in the journal Nature Cell Biology. Studies have revealed that Covid-19 can trigger a stronger inflammatory response than other RNA viruses. Surprisingly, this inflammatory factor storm is not caused by the rapid replication infection of the virus to lung epithelial cells, but by the "frustration infection" of the virus to a large number of immune cells pouring into the lungs in the later stage, that is, the virus can not complete the replication infection process.

The researchers further revealed the mechanism of Covid-19 infecting immune cells and triggering the storm of inflammatory factors: Toll-like receptor 1(TLR1) on the surface of immune cells recognizes the structural proteins E (envelope glycoprotein) and M (matrix protein) of Covid-19, so that the virus is endocytosed, thus causing "frustration infection". In addition, the binding of Covid-19 envelope glycoprotein E to immune cells TLR1 can directly activate the inflammatory response of immune cells, leading to the release of pro-inflammatory factors, which is the root cause of cytokine storm caused by Covid-19.

Dr. Duan Tianhao, Dr. Xing Changsheng and Dr. Chu Junjun are the co-first authors of this paper, and Professor Wang Rongfu is the correspondent author.

In order to explore the uniqueness of Covid-19’s strong inflammatory response, scientists screened 27 kinds of protein coded by Covid-19. Studies have revealed that Covid-19-encoded protein named NSP14 can directly promote the phosphorylation of IKK, a key kinase complex in the inflammatory signaling pathway, and significantly enhance the inflammatory response.

Interestingly, another Covid-19-encoded protein named ORF6 can inhibit inflammatory reaction and can be anchored to cell membrane. ORF6 significantly inhibits the activation of inflammatory reaction by preventing the nuclear entry of inflammatory transcription factor NF-κ B..

However, NSP14 promotes inflammation and ORF6 inhibits inflammation. What will be the final result of these two actions? Scientists have noticed that there was no obvious inflammatory reaction in the early stage of Covid-19 infection, but the inflammatory reaction increased significantly in the middle and late stage. This suggests that NSP14 and ORF6 may have different expression patterns at different stages of infection, which may lead to clinical observation.

After consulting the data, scientists noticed that there was a large amount of immune cell infiltration in Covid-19’s lungs at the late stage of infection. This leads to a guess: Will these infiltrated immune cells be infected by Covid-19, and then release a large number of inflammatory factors?

To answer these questions, researchers conducted a series of experiments. They used a modified version of Covid-19 labeled with green fluorescence to infect lung epithelial cells and immune cells respectively. The results showed that only lung epithelial cells showed fluorescent signal, indicating that Covid-19 could only replicate when infected with epithelial cells, but could not replicate when infected with immune cells (frustration infection). On the contrary, although a low level of inflammatory reaction activation was detected in lung epithelial cells, a strong inflammatory signal activation was detected in immune cells.

Scientists speculate that the different expression patterns of NSP14 and ORF6 in lung epithelial cells and immune cells may lead to the inhibition of inflammatory reaction in epithelial cells and the activation of inflammatory reaction in immune cells, which may be related to Covid-19’s "frustrated infection" in immune cells.

Traditionally, lung epithelial cells are the main target of infection in Covid-19, because there is a key receptor protein ACE2 on its surface, which can bind to Covid-19 spike protein S and promote the virus to invade cells. Immune cells, on the other hand, are not considered to have ACE2 receptors, so they are usually not considered to be infected by Covid-19.

However, further research shows that Covid-19 can infect immune cells despite the lack of ACE2 receptor, but due to the lack of ACE2, the virus cannot replicate after entering immune cells (frustration infection). What is even more surprising is that this "frustration infection" causes Covid-19 to selectively express NSP14 protein which promotes inflammatory response, but not ORF6 protein which inhibits inflammation, thus aggravating the inflammatory response of immune cells and promoting the generation of inflammatory storm.

Accordingly, scientists describe the complete mechanism of inflammation induced by Covid-19:

In the early stage, Covid-19 mainly infected lung epithelial cells through ACE2 receptor, where the virus quickly replicated and released a large number of virus particles to infect other epithelial cells. Although lung epithelial cells also express a small amount of TLR1 receptor and can be activated by virus, the expression of TLR1 in epithelial cells is much lower than that in immune cells, and the activation level of inflammatory signals is weak. In addition, due to Covid-19’s massive expression of inflammatory inhibitory protein ORF6 in epithelial cells, the inflammatory reaction was effectively inhibited. Therefore, the early stage of Covid-19 infection is mainly characterized by virus replication, accompanied by weak inflammatory reaction, that is, asymptomatic infection period.

In the late stage, the viral load reached the peak, the replication speed decreased, and a large number of immune cells gathered in the lungs. Immune cells recognize and bind the structural proteins E and M of the virus through the highly expressed TLR1 receptor, which triggers the activation of severe inflammatory reaction. At the same time, the virus binding to TLR1 can enter the immune cells through endocytosis. This "frustrated infection" mode prevents the virus from forming a replication and transcription complex RTC to transcribe the subgenomic RNA of the virus. Due to the lack of subgenomic RNA, viral structural proteins and viral accessory proteins including ORF6 cannot be expressed, but the pro-inflammatory protein NSP14 can be directly translated through genomic RNA. Because only NSP14 is expressed without ORF6, the inflammatory reaction is further aggravated, and immune cells release a large number of inflammatory factors, triggering a storm of inflammatory factors.

In addition, scientists have also studied other human coronaviruses of Coronaviridae. They found that SARS-CoV-1 triggered a large number of inflammatory reactions through the same molecular mechanism as SARS-CoV-2, and even the ability of its E protein to induce inflammation in immune cells was higher than that of SARS-CoV-2. This explains why the mortality rate of SARS-CoV-1 was as high as 11% when it broke out 20 years ago, far exceeding the current epidemic of SARS-CoV-2.

In contrast, other mild human coronaviruses, such as OC43, NL63 and 229E, have weak binding ability to TLR1, which also explains that their symptoms are usually mild.

This study reveals in detail the complete molecular mechanism of Covid-19 from its early entry into the human body for replication to its late stage, which leads to severe inflammation and death of patients, and provides important theoretical guidance for the treatment of severe COVID-19 patients. At the same time, the study also found that the small molecule inhibitor of TLR1 may be a better choice for the treatment of severe COVID-19 infection.

　　I. Policy background

　　In 2016, the city implemented the decentralization of urban renewal and strong areas. According to the Decision of Shenzhen Municipal People’s Government on Implementing the Reform of Urban Renewal (Order No.288 of Shenzhen Municipal People’s Government) (hereinafter referred to as Order No.288) and the Decision of Shenzhen Municipal People’s Government on Deepening the Reform of Planning Land System and Mechanism (Order No.298 of Shenzhen Municipal People’s Government) (hereinafter referred to as Order No.298), the examination and approval authority of urban renewal projects and the implementation plan of agricultural conversion involved are adjusted to district governments (including new ones) Under the new situation of decentralization in strong areas, in order to do a good job of linking up the work among provinces, cities and districts after the reform, better guide and standardize the examination and approval of land for urban renewal projects of demolition and reconstruction, and improve the efficiency of examination and approval, the Provisions on the Examination and Approval of Land for Urban Renewal Projects of Demolition and Reconstruction in Shenzhen (hereinafter referred to as the Provisions) is formulated in combination with the relevant provisions of the state, provinces and municipalities on land management, which serves as the basis for urban renewal agencies in various districts to examine and approve the implementation plan of land for urban renewal projects and the conversion of agricultural land.

　　Second, the main content

　　The "Regulations" consists of nineteen articles, the main contents of which are as follows:

　　(A) on the scope of application of the policy

　　The "Regulations" apply to the examination and approval of the implementation plan for the development and construction land and its agricultural land conversion.

　　(B) on the division of land use approval authority

　　According to Decree No.288 and its implementation opinions and Decree No.298, the municipal competent department of planning and land is the competent department of urban renewal business, responsible for the policy formulation and business guidance of the implementation plan for the development and construction of land and its agricultural land conversion, and summarizes the examination and approval of each district every six months and reports it to the municipal government; The district government is responsible for the examination and approval of the implementation plan for the development and construction of land and its agricultural land conversion; The urban renewal agencies in each district are responsible for the specific examination and approval work, and the relevant departments do a good job of cooperation within the scope of their duties.

　　(3) About the scope of land use approval

　　Urban renewal projects are based on the scope of project demolition defined by urban renewal unit planning, and land use approval is carried out according to the phased implementation timing determined by urban renewal unit planning. The "Regulations" distinguish four situations, which involve staging but not project implementation, not involving staging but sub-project implementation, sub-project implementation by stages, and sub-project implementation by stages, and clarify the units that approve the development and construction land. If a whole area contains a number of development and construction land, all development and construction land shall go through the formalities of land use examination and approval at the same time, and the subsequent procedures shall go through the formalities of signing the land use right transfer contract at the same time.

　　(four) on the land application materials and approval conditions.

　　In accordance with the Decision of the Ministry of Land and Resources on Amending the Administrative Measures for the Examination and Approval of Construction Land, the Notice of the Guangdong Provincial Department of Land and Resources on Implementing the Opinions of the State on Improving and Optimizing the Pre-examination and Review of Construction Projects, and the Notice of the Shenzhen Municipal Planning and Land Resources Committee of the Shenzhen Municipal Finance Committee on Further Defining the Payment Process of Paid Use Fees for New Construction Land, The Reply on Approving to Authorize the Shenzhen Municipal People’s Government to Exercise Relevant Land Management Authority, the Measures for Urban Renewal in Shenzhen and its detailed rules for implementation, and in combination with the provisions of relevant policies such as prevention and management of geological disasters, investigation and evaluation of soil environment, the Provisions clarify the application materials and conditions for examination and approval of development and construction land and its implementation plan for agricultural conversion.

　　(five) on the development and construction of land involved in the approved land without construction.

　　Linked to the Detailed Rules for the Implementation of the Measures for Urban Renewal in Shenzhen and the Technical Regulations for the Planning and Compilation of Urban Renewal Units for Demolition and Reconstruction in Shenzhen (hereinafter referred to as the Technical Regulations for the Planning and Compilation of Renewal Units), the Regulations stipulate the work of this situation in the stages of urban renewal unit planning approval, project implementation subject confirmation, cancellation of real property right certificate, land use approval and land transfer from the perspective of land use approval. Following the principle of equal area, equal period, equal development intensity and other functions, the area, use, plot ratio, transfer period and start date of the vacated land shall be implemented according to the agreement in the transfer contract of the land use right of the vacated land.

　　(six) the situation that the urban renewal unit contains overhead corridors, cross-street buildings or underground spaces.

　　The "Regulations" are linked with the "Technical Regulations on Updating Unit Planning", and the applicants, departments and procedures for land approval for public overhead corridors and public passages outside the scope of development and construction land are defined. At the same time, the "Regulations" clarify that the horizontal projection range, area and vertical elevation of overhead corridors, cross-street buildings or underground spaces should be clear when the construction land is approved. However, considering that it is difficult to define the specific spatial location in the stage of land use approval, the Regulations propose that in the stage of construction project planning permission, the horizontal projection range, area and vertical elevation can be appropriately adjusted according to the urban renewal unit planning and relevant standards and specifications, and a supplementary agreement on the land use right transfer contract can be signed, so it is not necessary to re-apply for construction land approval.

　　(seven) on the phased implementation of urban renewal units, there is a lack of legal land use indicators within the scope of later project demolition.

　　Urban renewal unit planning takes urban renewal unit as a unit for overall planning, and there may be insufficient legal land use indicators within the scope of later project demolition in urban renewal units implemented by stages. In this case, if the legal land use index of the later project is insufficient, the legal land use index of the signed land use right transfer contract can be used to exceed the area of the transferred development and construction land. When there are many kinds of land use categories beyond the legal land use index, they shall be used in the order of land price calculation.

　　(eight) on the urban renewal project involving non-agricultural construction land and illegal construction land left over from the history of rural urbanization.

　　In accordance with the principle of respecting history and safeguarding the rights and interests of the original rural collective, and according to the order of demarcation of non-agricultural construction land, the Regulations respectively stipulate different treatment principles for non-agricultural construction land before and after the disposal of illegal construction land left over from rural urbanization history.

　　(nine) on the situation that the urban renewal project involves the overlapping of non-agricultural construction land and old house village land.

　　For non-agricultural construction land and the old house village land overlap, the overlapping part is treated as non-agricultural construction land, and the old house village land is not included in the legal land use index; The overlapping part is treated as the land used in the old house village, and the non-agricultural construction land can be separately included in the legal land use index within the scope of demolition, and there is no need to adjust the non-agricultural construction land plan.

　　(ten) on the time limit and procedures for land use approval.

　　Combined with the relevant provisions of the administrative license, the time limit for examination and approval of development and construction land is 20 working days. The approval procedure is as follows:

　　Figure 1 Flow chart for approval of development and construction land

　　(twelve) land transfer and non-agricultural construction land index verification.

　　Urban renewal unit planning determines that the land to be handed over to the government free of charge should be handed over before the signing of the land use right transfer contract for urban renewal projects. Urban renewal projects involving non-agricultural construction land within the scope of demolition, the district urban renewal agencies shall notify the municipal competent department of planning and land to send agencies within the jurisdiction to write off non-agricultural construction land indicators before the signing of the land use right transfer contract for urban renewal projects.

　　(thirteen) the time limit and procedures for the approval of the implementation plan for the conversion of agricultural land.

　　If the development and construction land of the project involves the occupation of agricultural land and unused land, the implementation plan for the conversion of agricultural land shall be formulated by the district urban renewal agency and submitted to the district government for approval simultaneously with the development and construction land. The procedure is as follows:

　　Fig. 2 Flow chart for approval of implementation scheme of agricultural conversion

　　(fourteen) on the use of land use planning indicators.

　　Before compiling the implementation plan of agricultural land conversion for renewal projects, the district urban renewal institution shall solicit the opinions of the agencies dispatched by the competent department of city planning and land administration, and clarify the sources of new construction land indicators. The dispatched offices of the municipal competent department of planning and land shall, according to the reply issued by the district government, do a good job in the ledger management of the indicators of agricultural conversion in the jurisdiction, and report to the municipal competent department of planning and land regularly for summary as required.

　　(15) Information disclosure

　　After the district government issues the approval of construction land and the approval of the implementation plan of agricultural conversion, the district urban renewal institution shall make the approval of land use and the implementation plan of agricultural conversion public at the project site and portal website respectively.

　　(XVI) About the effective date.

　　The Regulations shall come into force as of the date of promulgation.

National Health and Wellness Commission, National Bureau for Disease Control and Prevention on Printing and Distributing

Disease prevention and control institutions, food safety and

Notice of detailed rules for nutrition and health work

Guowei Food Fa [2024] No.29??

All provinces, autonomous regions, municipalities directly under the Central Government, Health and Health Committees of Xinjiang Production and Construction Corps, CDC, China Center for Disease Control and Prevention, and National Food Safety Risk Assessment Center:

In order to implement the basic medical and health promotion law, food safety law, infectious disease prevention law and other laws and regulations, implement the food safety strategy, promote the construction of a healthy China, guide local disease prevention and control institutions to fully perform their duties of food safety and nutrition health, and strengthen capacity building, the National Health and Wellness Committee and the National Bureau for Disease Control and Prevention formulated the Detailed Rules for Food Safety and Nutrition Health of Disease Prevention and Control Institutions. Is issued to you, please implement.

National Health Commission

National Administration of Disease Prevention and Control

August 19, 2024

disease prevention and control institutions

Detailed working rules for food safety and nutrition and health

Chapter I General Principles

the first　In order to standardize the food safety and nutrition health work of disease prevention and control institutions, according to the basic medical and health promotion law, food safety law, infectious disease prevention law and other laws and regulations, the "Healthy China 2030" Planning Outline, the National Nutrition Plan (2017-2030) and the management regulations of the National Health and Wellness Commission on food safety risk monitoring, risk assessment, food-borne disease monitoring report, standard management and nutrition-related monitoring, etc.

the second　Under the unified leadership, coordination or entrustment of the health administrative department and the disease control administrative department, local disease prevention and control institutions at all levels undertake food safety risk monitoring, risk assessment, epidemiological investigation of food safety accidents, promulgation and revision of standards, national nutrition plan and reasonable diet action, nutrition health monitoring of different groups, nutrition health cohort survey, food composition monitoring, food consumption survey, total diet research, food safety and nutrition risk exchange and popular science education.

Article　Local health administrative departments at all levels shall evaluate and guide the work, and the disease prevention and control institutions at higher levels shall assist the health administrative departments to strengthen the guidance to the disease prevention and control institutions at lower levels and supervise the implementation of the work. The disease prevention and control institutions at lower levels shall complete the food safety and nutrition and health work arranged by the health administrative department and the disease prevention and control institutions at higher levels as required.

Chapter II Work Contents

Article 4　Provincial disease prevention and control institutions should do a good job in food safety and nutrition and health, including:

(a) to undertake the food safety risk monitoring work in this area, to be responsible for the collection, summary, analysis, quality control and management of monitoring data in this area, and to undertake emergency monitoring tasks;

(2) Undertaking or participating in national and local food safety risk assessment;

(three) to undertake the monitoring of food-borne diseases and the epidemiological investigation and sanitary treatment of food safety accidents;

(four) to undertake or participate in the formulation and revision of national and local food safety standards, food safety standards tracking evaluation, publicity training, guidance and answer, and food enterprise standards filing management and other related work;

(five) to carry out food safety and nutrition publicity and education and health promotion activities, as well as business guidance and training on food safety risk monitoring, food-borne disease prevention and control and nutrition and health work in this area;

(six) the implementation of national and provincial nutrition improvement plans and programs, undertake the national nutrition plan and reasonable diet action to promote the implementation of related tasks, and carry out nutrition-related work such as the construction of nutrition policy standard system, the improvement of nutrition work ability, and the evaluation and improvement of nutrition health status;

(VII) Undertaking tasks related to the construction of nutrition monitoring system and information system, undertaking nutrition health assessment, carrying out nutrition health monitoring of different groups of people, cohort survey and food composition monitoring, and organizing special scientific research on nutrition and health foundation such as nutrient requirement research of residents with regional characteristics;

(eight) to carry out total diet research and food consumption survey;

(nine) to undertake other food safety and nutrition health work designated or assigned by the provincial health administrative department and the superior business organization;

(ten) to carry out guidance and training on food safety, nutrition and health related business work of disease prevention and control institutions at lower levels.

Article 5　Prefecture (city) level disease prevention and control institutions shall do a good job in food safety and nutrition and health, including:

(a) to undertake the food safety risk monitoring work in this area, and to be responsible for the collection, summary, analysis and quality control of monitoring data in this area;

(two) to participate in food safety risk assessment related work, to carry out food safety risk judgment;

(three) to carry out food safety and nutrition publicity and education and health promotion activities;

(four) to undertake the monitoring of food-borne diseases and the epidemiological investigation and sanitary treatment of food safety accidents in this area;

(five) to undertake or participate in the formulation and revision of local food safety standards, the filing management of food enterprise standards, the follow-up evaluation of food safety standards, publicity training, guidance and answers and other related work;

(VI) Implementing nutrition improvement plans and programs, implementing national nutrition plans and rational dietary actions, promoting the implementation of related tasks, participating in the formulation, revision and dissemination of nutrition policy standards, promoting the ability of nutrition work, evaluating and improving nutrition health status, building nutrition information systems, building and promoting nutrition health places, and participating in the investigation and disposal of major nutrition-related events;

(seven) to undertake nutrition monitoring and evaluation, to carry out nutrition and health monitoring of different groups, cohort survey and food composition monitoring, and to carry out special scientific research on nutrition and health of residents with regional characteristics;

(eight) to carry out total diet research and food consumption survey;

(nine) to undertake other food safety and nutrition health work assigned by the health administrative department at the prefecture (city) level and the superior business organization;

(ten) to carry out guidance and training on food safety, nutrition and health related business work of disease prevention and control institutions at lower levels.

Article 6　County (District) level disease prevention and control institutions shall do a good job in food safety and nutrition and health, including:

(a) to undertake the task of food safety risk monitoring, and to be responsible for the collection, summary and analysis of monitoring data in this area;

(two) to undertake the monitoring of food-borne diseases and the epidemiological investigation and sanitary treatment of food safety accidents in this area;

(three) to participate in the formulation and revision of local food safety standards, food enterprise standards filing management, food safety standards publicity training, follow-up evaluation, guidance and answer and other related work;

(four) to carry out publicity, education and promotion activities on food safety and nutrition health;

(5) Implementing nutrition improvement plans and programs, implementing national nutrition plans and rational dietary actions, promoting the implementation of related tasks, participating in the promotion of nutrition policy standards, the improvement of nutrition work ability, the evaluation and improvement of nutrition health status, the construction and promotion of nutrition health places, and participating in the investigation and disposal of major nutrition-related events;

(six) to undertake nutrition monitoring and evaluation and health guidance for residents, organize nutrition education and guidance for urban and rural residents, carry out nutrition health monitoring, cohort survey and food composition monitoring for different groups of people, and participate in the special basic investigation of nutrition;

(seven) to participate in the total diet research and food consumption survey;

(eight) to undertake other food safety and nutrition health work assigned by the county (district) level health administrative department and the superior business organization.

Article 7　Disease prevention and control institutions with national reference laboratories for food safety risk monitoring, national laboratories for etiological identification of food-borne diseases and key laboratories for nutrition and health (including iodine reference laboratories) shall undertake corresponding reference, identification, technical guidance and training.

Chapter III Food Pollution and Harmful FactorsMonitoring and risk assessment

Article 8　Local disease prevention and control institutions at all levels shall, according to the food safety risk monitoring plan and monitoring scheme, complete monitoring work such as sampling, testing, data analysis and verification, data reporting, data verification and risk hidden danger report, and carry out corresponding quality management work. The monitoring data of food pollution and harmful factors shall be audited at different levels and reported step by step. If the monitoring results are analyzed and judged to have potential food safety hazards, the health administrative department at the same level and the superior business organization shall be reported in time.

Article 9　Provincial disease prevention and control institutions shall assist in the formulation and implementation of the monitoring plan in this area, undertake sample collection and index detection, and be responsible for the collection, collation, analysis and reporting of information; To carry out the technical capacity confirmation and quality management of the food safety risk monitoring laboratory, and submit the annual analysis summary report and quality management summary report of food safety risk monitoring; Responsible for the technical guidance, training and research of food safety risk monitoring in the area, and the promotion of appropriate technologies.

The disease prevention and control institutions at the prefecture (city) level are responsible for assisting in the formulation and implementation of the monitoring plan in this area; Take charge of sample collection, index detection, data collection, summary, analysis, quality control, prediction and early warning of food pollution and harmful factors monitoring; Responsible for the technical guidance, training and research of food safety risk monitoring in the area, and the promotion of appropriate technologies.

County (district) level disease prevention and control institutions undertake the task of food safety risk monitoring, assist relevant departments to carry out food safety risk monitoring, and mainly undertake the work of sample collection, index detection, data collection, summary, analysis and quality control of food pollution and harmful factors monitoring; Conduct business training for risk monitoring staff.

Article 10　Disease prevention and control institutions undertaking risk monitoring tasks shall timely summarize and analyze food safety monitoring data to support the needs of risk assessment.

Article 11　Provincial disease prevention and control institutions to carry out the following food safety risk assessment and risk judgment related technical support work:

(a) according to the needs of local standards formulation and revision, food safety supervision and risk communication in this area, formulate an assessment plan, report it to the provincial health administrative department and the national competent business organization, carry out food safety risk assessment, and report the risk assessment results to the provincial health administrative department and the national competent business organization in a timely manner;

(2) When analyzing and judging the risk monitoring data, it is found that matters requiring risk assessment need to be carried out, and timely put forward technical opinions to the provincial health administrative department that suggest the country or its jurisdiction to implement risk assessment;

(three) according to the needs of local food safety risk management, with reference to the risk assessment technical guidelines to organize risk judgment;

(four) according to the results of food safety risk assessment of the country or its jurisdiction, combined with the pollution level and dietary characteristics of its jurisdiction, put forward suggestions on food safety risk management;

(five) responsible for the technical guidance, training and appropriate technology promotion of food safety risk assessment in this area;

(six) according to the needs of national and provincial risk assessment, to carry out food consumption survey, total diet research, food toxicology research, etc., to establish the work database in this area.

Article 12　Prefecture (city) level disease prevention and control institutions shall undertake the collection, summary, analysis, prediction and early warning of relevant data and information on risk assessment in their respective jurisdictions; County (district) level disease prevention and control institutions shall assist in collecting data and information related to food safety risk assessment according to the arrangement of superior business institutions.

Article 13　Provincial disease prevention and control institutions shall undertake the national food safety risk assessment task entrusted by the national competent business institutions, formulate the assessment technical scheme according to the characteristics of the assessment project, complete the risk assessment report within the prescribed time limit, and put forward risk management suggestions.

Chapter IV Food-borne Disease Monitoring Report andEpidemiological investigation of food safety accidents

Article 14　Local disease prevention and control institutions at all levels shall, jointly with medical institutions, monitor, investigate and report food-borne diseases in their respective jurisdictions.

Article 15　Local disease prevention and control institutions at all levels should establish a food-borne disease monitoring report management system, and determine the departments and personnel responsible for the food-borne disease monitoring report; To be responsible for reviewing, summarizing, analyzing and reporting the monitoring information submitted by medical institutions undertaking food-borne disease monitoring in this area; When food-borne clustering cases that may be related to food production and operation are found, they shall promptly report to the health administrative department at the same level and the superior business institutions (among them, the provincial disease prevention and control institutions report to the National Food Safety Risk Assessment Center).

Article 16　Provincial disease prevention and control institutions should assist in formulating and organizing the implementation of food-borne disease monitoring programs in their respective jurisdictions according to the national food-borne disease monitoring plan, and build a provincial food-borne disease monitoring traceability platform and database; To undertake and guide the laboratory inspection, result review and quality control of molecular typing and drug sensitivity test of bacteria (virus) strains in the jurisdiction; To undertake the identification, verification and reporting of food-borne cluster cases across the jurisdiction; Regularly analyze the basic situation of food-borne diseases in the jurisdiction and draft an annual analysis summary report; To carry out the guidance, training, research and popularization of food-borne disease monitoring and prevention and control technology in the jurisdiction.

Article 17　Prefecture (city) level disease prevention and control institutions are responsible for the implementation of food-borne disease monitoring programs in their respective jurisdictions, undertake the review of bacterial (virus) strains submitted by county (district) level disease prevention and control institutions and medical institutions, and carry out laboratory tests and analysis such as molecular typing and drug sensitivity testing; To undertake the identification, verification and reporting of food-borne cluster cases across counties (districts) in the jurisdiction; Carry out technical guidance, training and promotion of food-borne disease prevention and control technology to disease prevention and control institutions and medical institutions at the county (district) level in the jurisdiction.

Article 18　County (district) level disease prevention and control institutions shall be responsible for the implementation of food-borne disease monitoring programs in their respective jurisdictions, and undertake the collection, submission and specimen inspection of isolated bacteria (virus) strains in medical institutions in their respective jurisdictions; To undertake the identification, verification and reporting of food-borne clustering cases in the jurisdiction; Provide technical guidance and training to medical institutions in the jurisdiction.

Article 19　The principle of territorial management and graded responsibility shall be implemented in the monitoring and reporting of food-borne diseases. Food-borne disease monitoring information, laboratory test data and investigation reports shall be reviewed and reported at different levels as required.

Article 20　When information related to food safety is found in handling infectious diseases or other public health emergencies, food-borne diseases or food safety risk information shall be reported to the health administrative department at the same level and the superior business institutions in a timely manner.

Article 21　Local disease prevention and control institutions at all levels shall, in accordance with laws, regulations and relevant provisions, and in accordance with the requirements of the health administrative department at the same level, organize on-site health treatment and epidemiological investigation of food safety accidents, as well as training, drills, evaluation and research on the above work. Where the relevant food safety supervision and management departments need to cooperate in controlling the site and preserving samples, the disease prevention and control institutions shall report to the health administrative department at the same level for coordination.

Article 22　Local disease prevention and control institutions at all levels shall, after the epidemiological investigation of food safety accidents is completed, submit an epidemiological investigation report to the food supervision and administration department and the health administrative department at the same level. If it is an outbreak of food-borne diseases, it shall report the epidemiological investigation information through the national food-borne disease outbreak monitoring system within 7 working days after the end of the investigation. To meet the requirements of public health emergencies related information reporting, according to the provisions of the disease prevention and control information system for network direct reporting.

Chapter V Technical Management of Food Safety Standards

Article 23　In accordance with the provisions of the "Three Decisions", local disease prevention and control institutions at all levels that have corresponding responsibilities or are entrusted by the health administrative department, in combination with the actual work of local disease prevention and control institutions, carry out technical management of local food safety standards, filing management of food enterprise standards, follow-up evaluation of food safety standards, training and guidance on food safety standards, and other related work.

Provincial disease prevention and control institutions undertake the technical management of local food safety standards, the filing management of food enterprise standards, the follow-up evaluation of food safety standards, the training and guidance of food safety standards, and undertake other tasks related to food safety standards assigned by provincial health administrative departments and superior business institutions.

The disease prevention and control institutions at the prefecture (city) level shall undertake or participate in the formulation and revision of local food safety standards, the filing management of food enterprise standards, the follow-up evaluation of food safety standards, the training and guidance of food safety standards, and undertake other tasks related to food safety standards assigned by the health administrative department at the prefecture (city) level and the superior business institutions.

County (district) level disease prevention and control institutions participate in the formulation and revision of local food safety standards, the filing management of food enterprise standards, the follow-up evaluation of food safety standards, the training and guidance of food safety standards, and undertake other tasks related to food safety standards assigned by county (district) level health administrative departments and superior business institutions.

Article 24　Provincial disease prevention and control institutions participate in the formulation of local standards for food safety; Organize the implementation of local food safety standards project, public consultation, review, approval, filing and other technical management work; Timely release information on local food safety standards. To undertake the daily management responsibilities of the secretariat or secretariat office of the expert committee for the evaluation of local food safety standards, improve the management system, standardize the work flow, and organize the evaluation of local food safety standards. Disease prevention and control institutions at prefecture (city) and county (district) levels participate in soliciting opinions on local food safety standards, consulting on standards and other related work.

Article 25　Provincial disease prevention and control institutions, under the management of the health administrative department at the same level, participate in the formulation of the food enterprise standard filing management system and clarify the filing process and other requirements; Establish a filing information disclosure mechanism, and timely publish the filed standard information on relevant platforms for social supervision; Strengthen the standard technical service of food enterprises, and carry out filing consultation and post-filing management. The disease prevention and control institutions at the prefecture (city) and county (district) levels shall undertake or assist the provincial level to carry out the filing work of food enterprise standards and provide filing consulting services according to the needs of the work.

Article 26　Provincial disease prevention and control institutions shall organize the follow-up evaluation of national and local standards for food safety, draw up a work plan or plan for the follow-up evaluation of national and local standards for food safety in their respective jurisdictions according to the work plan for the follow-up evaluation of national standards for food safety, and report it to the health administrative department at the same level for approval and organize its implementation. Local disease prevention and control institutions at all levels shall, in accordance with the requirements of the national and provincial food safety standards follow-up evaluation work plan or plan, organize the follow-up evaluation of food safety standards and complete various follow-up evaluation tasks. Local disease prevention and control institutions at all levels should strengthen coordination, combine the task of tracking and evaluating food safety standards with the implementation of food safety risk monitoring programs in their respective jurisdictions, reflect the implementation of standards through monitoring data, and provide scientific basis for timely revision of food safety standards. Local disease prevention and control institutions at all levels shall timely grasp the implementation of food safety standards, scientifically analyze the problems existing in the implementation of food safety standards, put forward opinions and suggestions to solve the problems, and report the follow-up evaluation work to the health administrative department at the same level and the superior business institutions.

Article 27　Provincial disease prevention and control institutions undertake or participate in the formulation of food safety standards publicity and training work plan, strengthen the information construction of food safety standards, and provide services such as food safety standards inquiry, publicity and exchange. The disease prevention and control institutions at the prefecture (city) and county (district) levels shall, according to the work requirements of the health administrative department at the same level and the publicity and training work plan of the superior business organization, formulate the implementation plan for the publicity and training of food safety standards at the same level and carry out related work.

Chapter VI National Nutrition PlanAnd reasonable diet action.

Article 28　Local disease prevention and control institutions at all levels shall, under the leadership of the health administrative department at the same level, undertake the relevant tasks of promoting the implementation of the national nutrition plan and reasonable dietary action in their respective areas.

Article 29　Provincial disease prevention and control institutions are responsible for promoting the implementation of the national nutrition plan and reasonable dietary action in their respective jurisdictions, strengthening the construction of nutrition and health standard system, improving nutrition work ability, evaluating and improving nutrition and health status, and carrying out related work such as the construction of nutrition and health information system, the construction and promotion of nutrition and health places, the guidance of nutrition and health work, the quality control of nutrition instructor training and the investigation and handling of major nutrition-related events.

Article 30　The disease prevention and control institutions at the prefecture (city) level are responsible for promoting the implementation of the national nutrition plan and reasonable diet action in their respective areas, strengthening the improvement of nutrition work ability, the evaluation and improvement of nutrition and health status, and carrying out related work such as the construction of nutrition and health information system, the construction and promotion of nutrition and health places, the guidance and consultation of nutrition and health work, and the investigation and handling of major nutrition-related events.

Article 31　County (district) level disease prevention and control institutions are responsible for promoting the implementation of the national nutrition plan and reasonable diet action in their respective jurisdictions, strengthening the improvement of nutrition work ability, evaluation and improvement of nutrition and health status, and carrying out related work such as the construction of nutrition and health places, guidance and consultation on nutrition and health work, and investigation and handling of major nutrition-related events.

Chapter VII Nutrition Monitoring and Evaluation

Article 32　Local disease prevention and control institutions at all levels shall carry out their work according to the requirements of the project work plan for nutrition and health monitoring, cohort survey and food composition monitoring of different populations organized by the relevant competent departments of the National Health and Wellness Commission, and strictly implement quality control. Use the information platform to complete data collection, reporting and analysis in time, and regularly submit work reports to the health administrative department at the same level.

Article 33　Provincial disease prevention and control institutions shall formulate implementation plans and work requirements for nutrition and health monitoring, cohort investigation and food composition monitoring of different populations in their respective jurisdictions, be responsible for personnel training, organization and implementation, evaluation and quality control, and complete corresponding tasks. Participate in or undertake basic scientific research and appropriate technology promotion of nutrition health monitoring and evaluation.

Article 34　Prefecture (city) level disease prevention and control institutions to implement the on-site investigation, technical guidance, quality control and on-site staff training of residents’ nutritional health monitoring and evaluation in this area, and review and analyze the data; Implement the monitoring of food ingredients in the jurisdiction, and participate in the investigation of food resources, the collection of monitoring samples and the laboratory tests undertaken; Participate in basic scientific research on nutrition health monitoring and evaluation and the promotion of appropriate technologies.

Article 35　County (district) level disease prevention and control institutions shall set up working groups for nutritional health assessment of different groups of people, train investigators, cooperate with relevant departments to implement on-site investigation of nutritional health monitoring and assessment of residents in their respective jurisdictions, organize laboratory testing, strictly implement quality control, and implement food resource investigation, sample collection and index monitoring within their respective jurisdictions. Use information platform to input and report data in time, feedback survey results in time, and standardize the management of original monitoring and evaluation data.

Article 36　Local disease prevention and control institutions at all levels should regularly form reports on the monitoring and evaluation of nutrition and health of residents in different regions and the monitoring of food composition, analyze and evaluate the nutrition and health status and food composition characteristics of residents in their jurisdictions, submit them to the health administrative department at the same level and relevant government departments, and submit them to the superior business institutions.

Article 37　Provincial disease prevention and control institutions shall undertake the national nutrition and health assessment task entrusted by the national competent business institutions, formulate the assessment technical scheme according to the characteristics of the assessment project, organize and carry out the research on the dietary nutrient requirements of residents with regional characteristics, provide technical support for scientific assessment, complete the monitoring and evaluation report within the prescribed time limit, and put forward suggestions on nutrition and health management.

Chapter VIII Food Safety and Nutrition and HealthScience popularization and health promotion work

Article 38　Local disease prevention and control institutions at all levels should carry out the popularization and dissemination of standard knowledge and food-borne disease prevention and control knowledge, the communication of food safety risk assessment results, risk exchange and nutrition and health-related popular science propaganda work in accordance with the technical guidelines for food safety risk communication of the National Health and Wellness Commission and the requirements for food safety and nutrition and health publicity.

Article 39　Provincial disease prevention and control institutions shall be responsible for formulating provincial food safety and nutrition science popularization and health promotion work plans or programs and organizing their implementation; Carry out popular science education and dietary guidance on food safety and nutrition health, and set up a popular science education team at the same level; To be responsible for the formulation, organization and implementation of the provincial plan for the investigation of residents’ awareness rate of nutrition and health knowledge, and to carry out training, data collation and reporting; Construct the communication system of food safety and nutrition risk in this area, set up and train professional talents, and do a good job in communication and training.

Prefecture (city) level disease prevention and control institutions shall be responsible for formulating municipal food safety and nutrition science education and health promotion work plans or programs and organizing their implementation; Carry out popular science education on food safety and nutrition and health, and set up a popular science education team at the same level; Responsible for the formulation, organization and implementation of the municipal plan for the investigation of residents’ nutrition and health knowledge, and carry out training, data collation and reporting.

County (district) level disease prevention and control institutions shall, in accordance with the work plan of food safety and nutrition science education and health promotion, carry out food safety and nutrition health science education and set up a science education team at the same level; To investigate the awareness rate of residents’ nutrition and health knowledge.

Article 40　Local disease prevention and control institutions at all levels should pay attention to food safety and nutrition public opinion, collect information related to food safety and nutrition, analyze and judge, and report to the health administrative department at the same level in time and put forward opinions and suggestions.

Chapter IX Laboratory Capacity Building and Management

Article 41　In accordance with the relevant national laws and regulations, local disease prevention and control institutions at all levels set up professional laboratories matching their inspection functions, equipped with necessary personnel and equipment to ensure operating conditions, and provide technical support for food safety and nutrition health work within their respective jurisdictions and timely response to major food safety and nutrition accidents.

Article 42　Provincial disease prevention and control institutions are equipped according to local actual conditions and regional characteristics, and have the inspection ability of corresponding food physical and chemical, radiation, microorganism and certain toxicological indicators specified in the national food safety risk monitoring plan and food safety standards; It has a high level of inspection ability related to the epidemiological investigation of food-borne diseases, and can investigate, identify and trace the causes of unexplained food-borne diseases; It can provide technical guidance for lower-level disease prevention and control institutions and medical institutions in this area.

Article 43　Provincial disease prevention and control institutions shall organize and carry out the comparison of inspection technical capabilities of food safety-related technical institutions in their respective jurisdictions. Should have the ability of laboratory testing related to nutrition and health monitoring and evaluation of human biochemical indicators and physical and chemical indicators of food components.

Article 44　The disease prevention and control institutions at the prefecture (city) level shall have the ability to test the physical, chemical and microbial indexes of common foods specified in the national food safety risk monitoring plan and food safety standards; Should have nutrition and health monitoring and evaluation of common human biochemical indicators and physical and chemical indicators of food ingredients related laboratory testing capabilities; It has the general inspection ability related to the epidemiological investigation of food-borne diseases, and can screen and identify the causes of outbreaks of important food-borne diseases, and conduct drug resistance detection and molecular typing of food-borne pathogens; It can provide technical guidance for county (district) level disease prevention and control institutions and medical institutions in this area.

Article 45　County (district) level disease prevention and control institutions should have the ability to solve the physical and chemical and microbial problems of common foods in the region; Being able to test the routine indicators specified in the national food safety risk monitoring plan; It has the basic inspection ability of food-borne disease epidemiological investigation, can collect samples and screen the causes of food-borne disease outbreaks, and can inspect and identify common food-borne pathogens; Can provide technical guidance for medical institutions in this area.

Article 46　Local disease prevention and control institutions at all levels shall establish their own food safety and quality management system and ensure its effective operation, and participate in the quality control assessment and comparison organized by superior business institutions as required. The superior business institutions regularly carry out technical training and result verification, quality control assessment, technical supervision and other quality evaluation work for the subordinate institutions. Local disease prevention and control institutions at all levels should establish and improve the biosafety management system of their pathogenic microorganism laboratories, regularly check the implementation of the biosafety management system of laboratories, strengthen personnel training, and ensure the biosafety of laboratories. Newly-built laboratories, if there are pathogenic microorganism projects, shall be approved or put on record according to law.

Article 47　The national reference laboratory for food safety risk monitoring, the national laboratory for etiological identification of food-borne diseases and the iodine reference laboratory shall carry out inspection method development and technical training activities; Develop quality control products; Regularly organize the comparison of quality control assessment and result verification; Organize technical supervision and work quality evaluation of institutions undertaking tasks in related fields.

Chapter X Safeguard Measures

Article 48　Local disease prevention and control institutions at all levels shall, according to their responsibilities, tasks, geographical location, serving population and other factors, rationally allocate corresponding professional and management personnel, and equip them with instruments and equipment suitable for their work functions. Local health administrative departments at all levels should provide support and guarantee for disease prevention and control institutions to carry out food safety and nutrition and health work, ensure that local disease prevention and control institutions at all levels perform their duties smoothly, and ensure the smooth development of food safety and nutrition and health work.

Article 49　Provincial disease prevention and control institutions shall set up an expert group composed of professionals related to food safety and nutrition and health, such as nutrition and food hygiene, epidemiology, food inspection, radiation hygiene, health education, toxicology, etc., to undertake professional training, business guidance, social consultation, publicity and education, etc. Local disease prevention and control institutions at all levels shall, according to the needs of work, formulate plans for personnel training and team building of food safety and nutrition health, strengthen education and training, and continuously improve the political quality and professional level of food safety and nutrition health staff.

Article 50　Epidemiological investigators of food safety accidents are responsible for carrying out epidemiological investigations of food-borne diseases, and can enter relevant edible agricultural products cultivation and breeding places, food production and business premises and collective feeding and dining units to collect samples and collect relevant data according to law.

Article 51　Local disease prevention and control institutions at all levels shall, under the organization and coordination of the health administrative department at the same level, establish a smooth and effective linkage mechanism between food safety and nutrition and health with all relevant units, and hold regular work consultations.

Article 52　Local disease prevention and control institutions at all levels shall establish and improve the evaluation system of food safety and nutrition health, and organize the investigation of food safety and nutrition health in a timely manner.

Chapter XI Supplementary Provisions

Article 53　The provincial health administrative department may, according to the actual work, formulate and implement the specific provisions of these rules in conjunction with the disease control administrative department.

Article 54　These rules shall come into force as of the date of promulgation.

Schedule: 1. Suggested list of laboratory instruments and equipment.

　　　2. Suggested list of on-site equipment for nutrition investigation

(The above schedule is omitted, please visit the website of the National Health and Wellness Commission for details.)

　　BEIJING, March 1st (Xinhua)-On the 1st, at the press conference on the theme of "Authoritative Department Begins" held by the State Council Office, Jin Zhuanglong, Minister of Industry and Information Technology, said that the Ministry of Industry and Information Technology would anchor the strategic goals of manufacturing power, network power and digital China, take digital technology innovation breakthrough and application expansion as the main direction, and increase the integrated development of informationization and industrialization. Generally speaking, it is mainly in three aspects: one is the network platform, the other is the digital industry, and the other is the integrated development.

　　The first aspect is to solidly promote the construction of network infrastructure. China has built the world’s largest and technologically advanced network infrastructure, with Gigabit access capacity covering all prefecture-level cities. This year, the Ministry of Industry and Information Technology will further implement the construction of Gigabit cities. Not long ago, the Ministry of Industry and Information Technology held a Gigabit City Summit Forum to guide all localities and enterprises to speed up construction investment and accelerate the deep coverage of 5G and Gigabit optical networks. Study and formulate an action plan for the development of computing infrastructure and strengthen the construction of industrial Internet infrastructure.

　　The second aspect is to accelerate the development of the core industries of the digital economy. In 2022, China’s electronic information manufacturing industry achieved an operating income of 15.4 trillion yuan, and the software business income reached 10.8 trillion yuan, which laid a solid industrial and technical foundation for the integrated development of informationization and industrialization. The Ministry of Industry and Information Technology will accelerate the development of emerging digital industries such as artificial intelligence, big data, blockchain, cloud computing and network security, guide and support enterprises to increase investment in research and development, and improve the industrial level of communication equipment, core electronic components and ultra-high definition display. Promote the high-quality development of integrated circuits and industrial software industries. Build characteristic software colleges with high standards and create a number of famous software parks in China.

　　The third aspect is to vigorously promote the digital transformation of manufacturing industry. Study and formulate a roadmap for digital transformation of key industries and cultivate a number of digital transformation benchmarks. Promote the 5G Sailing Action Plan, deepen the integrated application of "5G+ Industrial Internet", promote the popularization and application of industrial Internet to industrial parks, and build a number of 5G fully connected factories. We will implement the smart manufacturing partner program and standard pilot actions, build a number of world-leading smart factories and smart supply chains, and develop new models and formats such as service-oriented manufacturing.

[Editor’s Note] "We should develop traditional Chinese medicine, pay attention to interpreting the principles of traditional Chinese medicine with modern science, and take the road of combining traditional Chinese and western medicine." On May 12th, General Secretary of the Supreme Leader once again asked about Chinese medicine during his inspection tour in Nanyang City, Henan Province, and put forward new and clear requirements for the further development of Chinese medicine.

Inheriting the essence, the development of traditional Chinese medicine can go back to ancient times; The development of traditional Chinese medicine will be clear and turbulent only when it is upright and innovative. Combined with the outstanding performance and experience of Chinese medicine in the treatment of COVID-19 epidemic, many Chinese medicine experts who have participated in the first-line anti-epidemic talk about their experiences, offering suggestions and suggestions for the high-quality development of Chinese medicine and protecting the health of all mankind.

Liu Qingquan, Dean of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Photo courtesy of respondents

"The future development of Chinese medicine is to be brave and dare to combine with modern science and technology, and to be good at using modern science and technology language to make the oldest theory of Chinese medicine clear and clear, so that Chinese medicine can truly become a world medicine and a medical system that can be used by all countries and ethnic groups." Combined with the treatment of COVID-19 epidemic, Liu Qingquan, president of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, said that the integration of traditional Chinese medicine and western medicine is very important for the development of traditional Chinese medicine, and it may form a new medicine in the future. It not only has the traditional theoretical advantages of Chinese medicine classics, but also embodies the connotation of modern science and technology; It is neither classical Chinese medicine nor modern western medicine, but a complete medical system with complementary advantages.

On February 15th, 2020, in beijing ditan hospital, a pharmacist dispensed medicine for COVID-19 patients in a traditional Chinese medicine pharmacy. Xinhua News Agency reporter Yan Huanzong photo

The experience of Chinese and western collaborative treatment lays the foundation for the formation of new medicine.

In the process of fighting against the epidemic in COVID-19, the effective prescription of traditional Chinese medicine-"three drugs and three parties" screened out by clinic has played an important role.

Liu Qingquan, who once served as an expert in Hubei Central Steering Group and deputy head of the national expert group on medical treatment of traditional Chinese medicine, said that "three drugs and three parties" is actually a classic theory of China traditional Chinese medicine, a treatment method based on the experience of traditional Chinese medicine in treating plague for thousands of years, and a model for coping with new diseases.

"Through the analysis of COVID-19’s clinical characteristics, we have formed the idea that we can combine various effective prescriptions to treat, thus forming the basic idea of’ three parties and three drugs’, that is, according to the changes of etiology and different stages of illness, we can adjust and combine to form effective treatment methods. This proves the greatness and correctness of the theory of traditional Chinese medicine and verifies that it conforms to scientific laws. " Liu Qingquan said.

"In the process of using’ three parties and three drugs’ treatment, we have also preliminarily explored and mastered some theoretical data of treating COVID-19 with traditional Chinese medicine. These studies prove that the basis of treating COVID-19 with traditional Chinese medicine is scientifically explained from different aspects, such as the adjustment of immune system and inflammatory system, which are the important pathological links that cause the disease to change, get worse and worse during the onset of COVID-19." Liu Qingquan analysis.

"In terms of coordinated treatment of Chinese and Western medicine, Chinese and Western medicine have their own strengths, and ultimately played a very important role in improving the success rate of severe and critical care and reducing the mortality rate, which proved the internal theoretical basis of coordinated treatment of Chinese and Western medicine and made some necessary preparations for exploring the organic integration of Chinese and Western medicine to form a new medicine." Liu Qingquan pointed out.

On February 25th, 2020, in Jiangxia Fangcang Hospital, Zhan Min (right), a medical staff member of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, performed acupoint application therapy for COVID-19 patients. Xinhua News Agency reporter Shen Bohan photo

Exploration of Traditional Chinese Medicine Shelter Hospital Model of Infectious Diseases Hospital with Integrated Traditional Chinese and Western Medicine

In the process of Chinese medicine participating in Wuhan epidemic prevention and control and clinical treatment, Fangcang Hospital has become a medical pioneering work in a special period.

Liu Qingquan, a former president of Jiangxia Fangcang Hospital, was deeply touched by the experience of Chinese medicine taking over Fangcang Hospital. He said that the establishment of the shelter hospital is a very effective way to deal with sudden large-scale infectious diseases. In the shelter hospital, the treatment of light and ordinary patients with traditional Chinese medicine can effectively speed up the improvement of patients’ condition, reduce the occurrence of severe and critical diseases and reduce the mortality rate. In addition, because the source of infection is cut off in time, the control of virus transmission also plays a very important role.

Liu Qingquan believes that the experience and achievements gained by taking over Fangcang Hospital with traditional Chinese medicine technology to treat light and ordinary patients in COVID-19 have paved the way for the state to support the establishment of infectious disease hospitals and specialized hospitals with integrated traditional Chinese and western medicine. This will enable the future to quickly form a powerful force of combining traditional Chinese and western medicine, whether dealing with common infectious diseases or sudden new infectious diseases.

On May 23, 2021, the doctor set up the automatic decocting machine in Yingkou Hospital of Integrated Traditional Chinese and Western Medicine, Liaoning Province. Xinhua News Agency reporter Pan Xiaolong photo

Increase investment to support the construction of Chinese medicine institutions and Chinese medicine research.

Nowadays, in the treatment of many local epidemics distributed in China, the treatment scheme of traditional Chinese medicine is becoming more and more perfect and mature, and has achieved very good results. The methods of classified treatment and management of traditional Chinese medicine have become more and more popular and have become the consensus of the medical community.

"Compared with this treatment effect, there are too few medical institutions of Chinese medicine, which is a limitation to the role of Chinese medicine and its future development." Liu Qingquan called on the state to increase investment in TCM research and institution building. In dealing with infectious diseases, it is hoped that the state can support the establishment of infectious disease hospitals in mature areas with traditional Chinese medicine or integrated traditional Chinese and western medicine.

Liu Qingquan said that infectious diseases are the public enemy of mankind, regardless of Chinese medicine and western medicine, regardless of population and race. Therefore, I hope that China can make achievements in the construction of infectious disease hospitals with traditional Chinese medicine and integrated traditional Chinese and western medicine, and set an example for promoting the development of China medicine and even the world medicine. I hope that colleagues of Chinese and Western medicine can work together in Qi Xin to seize the opportunity and let the development of traditional Chinese medicine enter a new era.

　　On May 13th, on the first day of Tmall’s pre-emptive purchase of 618 countries, Taobao took the lead in playing the marketing strategy of "Wang Fried"-Kenny Lin, a national artist of "900 million girls’ dream", was officially declared as the brand ambassador of Taobao countries, and magical advertisements were placed in CCTV, online mainstream APP and offline over 50 cities, brainwashing consumers across the country: "Pay close attention to Taobao and receive state subsidies!" The big promotion policy of "national subsidy+Tmall 618 subsidy as low as 50% off" has strongly reached hundreds of millions of consumers.

　　In this year’s 618 event, Taobao also launched the "National Supplement Surprise Coupon" for the first time: users can grab the "National Supplement Surprise Coupon" which was launched for the first time and has the largest overlapping subsidy, and also participate in the interesting interaction of Kenny Lin, the brand ambassador of Taobao National Supplement; At the same time, watch the live broadcast of Kenny Lin on May 19th, and you will have a better chance to win the opportunity of "up to 10,000 yuan for national exemption". This "618" marketing campaign, which is based on policies, with stars as the guide, welfare as the spear and brand as the shield, once again breaks the routine and "updates" new marketing ideas, and also makes Taobao the first entrance for consumers to receive state subsidies.

　　"Hurry up and update" TVC’s magical brushing screen, releasing the whole world and detonating the country’s mind.

　　Consumers are blown in mid-air by strong winds, grabbing mobile phones passing by; The person at the forefront of the team reached out and grabbed Kenny Lin’s skirts, and shouted with joy, "Hurry up and update!"

　　The magic advertisement in just 15 seconds directly visualizes the core idea of Taobao’s national compensation marketing: "People are blown by strong winds" vividly interprets "the wind of Taobao’s national compensation is too strong"; All kinds of home appliances that have been blown away intuitively show the rich categories of Taobao’s national supplement; The action of "Hurry up to update" is a pun, which skillfully connects the homonym of the name of Kenny Lin, the ambassador of Taobao’s national subsidy brand, with "Hurry up to receive the national subsidy from Taobao", and makes a heavy discount of "make up for it, as low as 50% off", which quickly attracts users’ attention and grabs users’ minds.

　　In addition, Taobao also released several other magical TVCs, such as "Catch Kenny Lin in mid-air", "Kenny Lin City Gate Catch New Household Appliances" and "Delivery Master Catch Kenny Lin". Together with Dafeng Creative TVC, it interestingly explained the four core points of this national supplement: supplement and supplement, rich categories, new products and service mentality, which directly highlighted the interesting marketing style of this 618 Taobao.

　　As the ambassador of Taobao’s national subsidy brand, Kenny Lin’s label setting has always been highly consistent with Taobao’s "affordable and interesting" platform image, and its name of "update" has formed a natural memory point with "grasping Taobao’s national subsidy". In addition, the audience flow brought by last year’s hot works such as "The Story of a Rose" and "With the Phoenix" has contributed to the spread of "grasping the update".

　　In order to detonate the communication potential, Taobao released a global bombing combination boxing: CCTV launched to strengthen the credibility of the policy, covering all ages and nationwide markets; Online mainstream apps open screens and information flow advertisements accurately attack young users; The offline 50+ city business circle will be launched to create an immersive "updated" advertising experience.

　　Long-term marketing drives brand value to upgrade, grasps policy dividend and highlights brand responsibility.

　　When the demonic brainwashing "hurry to update" TVC swept the business circle of 50 cities across the country, Taobao’s national compensation marketing offensive became stronger and stronger-on May 19th, Taobao’s national compensation brand ambassador Kenny Lin will conduct a live broadcast. At that time, Kenny Lin will carry out a series of interesting interactions around the national subsidy, and will also give users a bonus of 10,000 yuan, star signatures, 50 rounds of red packets of rain and other super benefits, so as to create a saturated communication of "offline detonation+online fission" and continue to create a 618 marketing fever.

　　Behind the lively entertainment marketing is Taobao’s deep response to the national subsidy policy: whether it is a big promotion discount, extra subsidies for trade-in, more brands and categories, more urban coverage, or the service of subsidizing 10,000 new products, large and small household appliances and home improvement, users can feel the peace of mind of Taobao’s in-depth implementation of the national subsidy policy as long as they log on to Taobao. This kind of play that turns policy potential energy into brand long-term value also adds weight to Taobao’s "good heart" as a user.

　　It is worth noting that this time, Taobao, the national supplement, assembled 100 head brands for the first time to jointly make profits. Under the call of the platform, many brands actively responded to the national subsidy activities, and strongly conveyed the mind of "leading the country to make up for Taobao" by directly benefiting consumers. The collective call of many merchants not only enriched the lineup of activities, but also helped improve Taobao’s national compensation strategy. Especially under the premise that the national subsidy policy has restrictions on each citizen’s eligibility and quota, Taobao, which has gathered the most comprehensive categories, the best subsidies and exclusive service rights, has naturally become the "first entrance" for consumers to choose to receive national subsidies.

　　Just like this magical TVC advertisement, Taobao’s combination of "national dividend+traffic leverage+global communication" has once again "updated" the new example of e-commerce platform 618 marketing.

　　Recently, according to the China Youth Daily, "Ginger Soaks Foot" and "Drinking Tea for Beauty" … … With the increasing pressure of life, not only the post-90s generation who entered the workplace, but also many college students have begun to try various methods of health preservation. Health preservation is no longer the exclusive word of the elderly or middle-aged people, and the young campus groups represented by college students are constantly adjusting their lifestyles and advocating a healthier life and rest. Why are this wave of college students "trapped in health care" and "selling the old"? Many college students said that this is a way of "self-mockery" to fight anxiety and pressure.

　　In many people’s cognition, college students are relaxed and chic, and can have fun relatively freely. But in fact, many college students are very bitter and tired now. It is not unusual to do homework, research and activities in class until early morning or even later.

　　Under such a realistic background, it is not difficult to understand that many college students are "trapped in health preservation". Recently, a "2018 Life Consumption Trend Report" shows that based on the search volume of "Lycium barbarum" on the e-commerce platform of all ages, the proportion of search volume after 1995 increased significantly in September 2017. Honey, Lycium barbarum, whey protein, health tea and enzymes are the health foods that are keen on after 1995.

　　When I was in college, I was also a "busy maniac". I was really working hard. My meals and sleep were irregular, and I also had a tendency to overeat. At that time, I thought I was still young, so I indulged myself too much and was indifferent to some early warning signals of my body. But now, nearly a year after graduation, all kinds of physical and mental discomforts have emerged, and I realize that "karma" has come and I want to "pay my debts". Therefore, now I will also force myself to keep fit, such as drinking more hot water, going to massage, eating more healthy food and running to and from work.

　　The meaning of life is not temporary, but long-term. To quote a very fashionable online buzzword recently, "People who work too hard can’t run far". Who doesn’t want to "run away" on the road of life? So, please do it and cherish it.

　　Of course, it is not enough to rely solely on the self-awakening of young people, but also to exert efforts at the social level. To put it bluntly, in addition to focusing on the "burden reduction" of primary and secondary school students, the social level should also focus on the "burden reduction" of young people represented by college students. There is no denying that the latter should be under pressure and responsible, and strive hard to realize their own value and social value, but all this should not be at the expense of health. It should be a social consensus that only a good body and a healthy lifestyle can create more shocking values.

　　Mocheng

The extinction at the end of Permian 252 million years ago caused the extinction of about 81% marine species and 89% terrestrial species. The main reason is believed to be the environmental change caused by large-scale volcanic eruption, but there is still no direct evidence that environmental factors affect terrestrial ecosystems. In cooperation with foreign counterparts, researchers in China discovered the direct evidence that the destruction of the ozone layer led to the extinction of terrestrial life at the end of Permian by studying the changes of "sunscreen" content in fossil pollen grains during this period.

The research results were published online in the internationally renowned journal Science Advances on January 6, 2023.

Black shale at the end of Permian in Qubu section of southern Tibet. Photo courtesy of Nanjing Institute of Geology and Paleontology, CAS

Pollen fossils found in Permian-Triassic transitional strata in Qubu section. Photo courtesy of Nanjing Institute of Geology and Paleontology, CAS

Volcanic eruption led to mass extinction of land? There was a lack of direct evidence

The extinction event at the end of Permian was the largest extinction event in Phanerozoic. Scientists generally believe that the increase of global greenhouse gases caused by the eruption of Siberian igneous province at the end of Permian, global warming and ocean acidification may be the main causes of this extinction. However, there are still many debates about how these environmental factors affect terrestrial ecosystems.

Some palynologists have found some deformed spores and pollen in the continental Permian-Triassic transition section. It is speculated that these deformed spores or pollen may be caused by the increase of ultraviolet radiation induced by the destruction of the global ozone layer caused by halogen elements ejected from the Siberian igneous province. However, the study of abnormal spores and pollen produced in modern plants shows that the environmental background of these abnormal pollen and spores is very complicated, and drought, air pollution and plant trauma may all induce abnormal spores or pollen to be produced in plants. Therefore, the discovery of a small number of abnormal spores and pollen in the continental Permian-Triassic transition section cannot directly prove that there was an increase in ultraviolet radiation caused by the global ozone hole during the extinction at the end of Permian.

Using the content of "sunscreen" to deduce the intensity of atmospheric ultraviolet radiation

Plants need sunlight for photosynthesis to provide energy for plant growth, but at the same time, it is necessary to avoid the damage of harmful ultraviolet rays in sunlight to genetic information in plants, especially in plant reproductive cells (spores and pollen). In order to adapt to the terrestrial radiation environment, terrestrial plants have evolved some regulatory mechanisms to reduce the damage of ultraviolet rays to plants. In the germ cells of plants, this mechanism is manifested in that there are a large number of compounds-coumaric acid and ferulic acid-in the outer walls of plant spores and pollen, which are very similar in function to "sunscreen cream". These compounds can form resonance-stable phenol free radicals and resist the oxidation caused by ultraviolet rays, thus protecting fragile spores and pollen and providing guarantee for the spread and reproduction of terrestrial plants.

Modern botanists have observed that plants can automatically adjust the content of "sunscreen" on the outer wall of their germ cells according to the surrounding ultraviolet radiation environment, and these "sunscreen" can be stored in the outer wall of inert spores and pollen for a long time. Therefore, in theory, researchers can determine the content of "sunscreen" in these spores and pollen, and deduce the intensity of atmospheric ultraviolet radiation in geological history.

"Sunscreen" is difficult to digest and has low nutrition, or leads to the extinction of insects.

According to Liu Feng, a researcher at Nanjing Institute of Geology and Paleontology, Chinese Academy of Sciences, the research team quantitatively measured coumaric acid and ferulic acid in 1011 pollen grains from Permian-Triassic transition section in southern Tibet, China. Through the big data analysis of infrared spectra produced by these pollen, the research team found that during the extinction at the end of Permian, the contents of coumaric acid and ferulic acid in the outer wall of pollen in the stratum were significantly higher than those in fossil pollen before and after extinction, which directly proved that there was an increase in global ultraviolet radiation during the extinction at the end of Permian.

The increase of ultraviolet radiation in the air has a far-reaching impact on the whole terrestrial ecosystem. Because ultraviolet rays not only have a strong killing effect on plant germ cells, but also cause damage to plant mesophyll cells. In order to resist the damage of ultraviolet rays to mesophyll cells, plants will synthesize lutein, coumaric acid and ferulic acid in their leaves, which will reduce the synthesis of chlorophyll accordingly, leading to the weakening of photosynthesis of plants, which will further weaken the absorption capacity of plants for greenhouse gases, further aggravating the global greenhouse gas increase caused by volcanic eruption at the end of Permian.

In addition, lutein, coumaric acid and ferulic acid in mesophyll are compounds that are difficult to digest and have low nutritional value for herbivores and insects, so the increase of ultraviolet radiation indirectly affects the terrestrial food chain, which may be the main reason for the extinction of terrestrial herbivores and insects at the end of Permian.

Beijing News reporter Zhang Lu

Editor Liu Qianxian proofreads Wu Xingfa.

　　The brand awareness of Haier refrigerator is very high. Many people have heard that Haier Commander Refrigerator and Haier Refrigerator are the same. What is the difference between Haier Commander Refrigerator and Haier Refrigerator? Why is the price gap so big? The following small series will give you a specific analysis. Let’s take a look.

　　Haier tongshuai refrigerator

　　Commander-in-Chief is the third sub-brand of Haier Group after Haier and casarte, and it is a customized home appliance brand launched by Haier Group under the background of the Internet era. In 1998, the commander-in-chief brand was exported to the European market as an overseas marketing platform.

　　Haier Group products have three brands, Haier, casarte and Commander-in-Chief. Haier refrigerator and Haier Commander refrigerator are both brands of Haier refrigerators, but they are put into different markets. Commander series belongs to Haier’s low-end and mid-end brands. In the early stage, home appliances went to the countryside as Commander refrigerators, and casarte series was the high-end brand of refrigerators.

　　The product appearance of Haier refrigerator and Haier commander refrigerator may be different. Haier staff said that Haier’s commander-in-chief brand and Haier brand refrigerator are the same in terms of development and production technology, but the brands are different and the materials of some refrigerators are different. The product quality is the same, and the commander-in-chief also provides product customization.

　　Generally, Haier refrigerators have refrigerator specification labels (or refrigerator nameplates) attached to the inner wall of the refrigerating room or the back of the refrigerator, which indicate the specifications, models (such as "BCD-216YH silver gray" for a 216-liter silver gray refrigerator), power, circuit diagram and so on. Haier’s products exclusively used in urban and rural areas are generally not fully labeled or not labeled at all, but the performance of the products is the same as other products. For the refrigerators exclusively used, only the refrigerators are more suitable for the supply and demand sides.

　　The difference between Haier commander refrigerator and Haier refrigerator is here for everyone. You should be able to distinguish between the two refrigerators now, and also introduce the relationship between them. In the future, you can clearly distinguish when buying Haier refrigerator. I hope the content introduced above can help those in need.

A single mother with cancer turned to the government for help. Source: Leader Message Board official website screenshot

　　Recently, a single mother suffering from cancer in Changgou Village, Dashuiquan Town, Xinglong County, Chengde City, Hebei Province left a message on People’s Daily Online "Local Leaders Message Board" asking for help, hoping that the government could help her find a rescue agency to raise and take care of her adopted daughter with intellectual disability.

　　The Social Situation and Public Opinion Office of Chengde Municipal Committee has replied at the bottom of the message board that the relevant units of Chengde Civil Affairs Bureau and Xinglong County have carefully checked. After active coordination, relevant issues have been properly solved.

　　On July 5, a staff member of the Civil Affairs Bureau of Xinglong County, Chengde City told The Paper that at present, the child has been sent to Chengde Welfare Institute, which is responsible for his daily life; The mother of the child still needs regular medical treatment. At present, in view of the above situation, relevant problems have been arranged to be solved.

　　On July 5th, a staff member of Xinglong County Party Committee Office told The Paper that the mother was divorced, suffering from advanced cervical cancer, and her adopted child was mentally disabled. A month ago, they raised about 6,000 yuan for it and have completed the last phase of chemotherapy. At present, the mother is in good health and will be reviewed in three months. "The follow-up cost is not very high. She is now working with her friends and earning a little money. There is nothing wrong with life at present. " The staff member said that in the next step, after her body recovered, the mother was going to set up a stall in the market.

　　The above-mentioned staff said that they would continue to follow up her physical condition and provide corresponding help.

　　The staff member also mentioned that at first, the mother had no time to rest because she needed to take care of her children alone for 24 hours. She thought she had no hope of recovery, so she gave up treatment and went through the procedure of donating her body. At present, the child has been arranged to be taken care of by Chengde Welfare Institute. He said that local volunteers will also be regularly organized to go to the welfare home with the mother to see the children.

　　On the same day, a staff member in charge of subsistence allowances in Xinglong County said that they had raised the low premiums of mother and daughter to the highest standard. Originally, the mother’s monthly fee was 245 yuan, and the daughter’s monthly fee was 255 yuan. Now, both of them have been raised to 400 yuan per person per month.

　　The Paper noticed that the aforementioned single mother wrote on the message board that in 2006, she lost her fertility due to tubal blockage and ectopic pregnancy surgery; In 2013, her mother adopted a baby girl from a pair of Tianjin parents under the age of 18. Subsequently, the baby girl was raised by her, but unfortunately she suffered from encephalitis, which caused secondary mental disability. To this end, she borrowed 300,000 yuan to treat her children.

　　She also wrote that she divorced her husband in 2019. Because the opposite sex was not related by blood, her ex-husband could not be the guardian of her adopted daughter alone, and the court awarded her custody of the child. The child is 9 years old this year. He can’t take care of himself and needs long-term care. In July 2020, she was diagnosed with advanced cervical cancer. After radiotherapy and chemotherapy, she is still receiving follow-up treatment. However, because she found it too late to surgically remove the lesion, she was extremely weak and thus lost her ability to work.

　　"Give the child a chance to live when I have to say goodbye to this world." The single mother wrote.